Angeliki Louvi

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Notch and disease: a growing field
    Angeliki Louvi
    Department of Neurosurgery and Neurobiology, Program on Neurogenetics, Yale School of Medicine, New Haven, CT, United States
    Semin Cell Dev Biol 23:473-80. 2012
  2. pmc Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology
    Angeliki Louvi
    Department of Neurosurgery, Yale Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:3737-42. 2011
  3. ncbi request reprint Presenilin 1 in migration and morphogenesis in the central nervous system
    Angeliki Louvi
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 E 58th Street, Chicago, IL 60637, USA
    Development 131:3093-105. 2004
  4. ncbi request reprint The derivatives of the Wnt3a lineage in the central nervous system
    Angeliki Louvi
    Department of Neurosurgery, Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 504:550-69. 2007
  5. pmc L-histidine decarboxylase and Tourette's syndrome
    A Gulhan Ercan-Sencicek
    Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 362:1901-8. 2010
  6. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
  7. pmc Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome
    Althea A Stillman
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 513:21-37. 2009
  8. pmc WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
    Jesse Rinehart
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 286:30171-80. 2011
  9. pmc Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
    Kaya Bilguvar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 467:207-10. 2010
  10. pmc Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration
    Kaya Bilguvar
    Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 110:3489-94. 2013

Research Grants

Collaborators

Detail Information

Publications22

  1. doi request reprint Notch and disease: a growing field
    Angeliki Louvi
    Department of Neurosurgery and Neurobiology, Program on Neurogenetics, Yale School of Medicine, New Haven, CT, United States
    Semin Cell Dev Biol 23:473-80. 2012
    ....
  2. pmc Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology
    Angeliki Louvi
    Department of Neurosurgery, Yale Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:3737-42. 2011
    ..Our findings implicate neural cells in the pathogenesis of CCMs, showing the importance of this pathway in neural/vascular interactions within the neurovascular unit...
  3. ncbi request reprint Presenilin 1 in migration and morphogenesis in the central nervous system
    Angeliki Louvi
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 E 58th Street, Chicago, IL 60637, USA
    Development 131:3093-105. 2004
    ..Our results demonstrate that presenilin 1 plays a much more important role in brain development than has been assumed, consistent with a pleiotropic involvement of this molecule in cellular signaling...
  4. ncbi request reprint The derivatives of the Wnt3a lineage in the central nervous system
    Angeliki Louvi
    Department of Neurosurgery, Program on Neurogenetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 504:550-69. 2007
    ....
  5. pmc L-histidine decarboxylase and Tourette's syndrome
    A Gulhan Ercan-Sencicek
    Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 362:1901-8. 2010
    ..Our findings, together with previously published data from model systems, point to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics...
  6. pmc Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
    Betul Bakkaloglu
    Program on Neurogenetics, Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 82:165-73. 2008
    ....
  7. pmc Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome
    Althea A Stillman
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 513:21-37. 2009
    ....
  8. pmc WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters
    Jesse Rinehart
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 286:30171-80. 2011
    ..These findings suggest a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling...
  9. pmc Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
    Kaya Bilguvar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 467:207-10. 2010
    ..These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging...
  10. pmc Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration
    Kaya Bilguvar
    Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 110:3489-94. 2013
    ..These findings demonstrate a broad requirement of UCHL1 in the maintenance of the nervous system...
  11. ncbi request reprint CCM2 expression parallels that of CCM1
    Askin Seker
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Stroke 37:518-23. 2006
    ..Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive...
  12. pmc Apoptotic functions of PDCD10/CCM3, the gene mutated in cerebral cavernous malformation 3
    Leiling Chen
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Conn 06510, USA
    Stroke 40:1474-81. 2009
    ..Mutations in the Programmed Cell Death 10 (PDCD10) gene cause autosomal dominant familial cerebral cavernous malformations (CCM3). To date, little is known about the function of this gene and its role in disease pathogenesis...
  13. pmc Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration
    Angeliki Louvi
    Departments of Neurosurgery and Neurobiology, Yale Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06520, USA
    Development 141:1404-15. 2014
    ..Thus, we identify a novel cytoplasmic regulator of neuronal migration and demonstrate that its inactivation in radial glia progenitors and nascent neurons produces severe malformations of cortical development. ..
  14. pmc Recessive LAMC3 mutations cause malformations of occipital cortical development
    Tanyeri Barak
    Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, USA
    Nat Genet 43:590-4. 2011
    ..The discovery of the molecular basis of this unusual occipital malformation furthers our understanding of the complex biology underlying the formation of cortical gyrations...
  15. ncbi request reprint CADASIL: a critical look at a Notch disease
    Angeliki Louvi
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
    Dev Neurosci 28:5-12. 2006
    ....
  16. ncbi request reprint Notch signalling in vertebrate neural development
    Angeliki Louvi
    Department of Neurosurgery, Yale University School of Medicine, P O Box 208082, New Haven, Connecticut 06520 8082, USA
    Nat Rev Neurosci 7:93-102. 2006
    ....
  17. pmc Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
    Sekiya Shibazaki
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 17:1505-16. 2008
    ..Cysts in ADPKD exhibit both increased proliferation and activation of MAPK/ERK, but cyst growth is not prevented by inhibition of ERK1/2 activation...
  18. pmc Cilia in the CNS: the quiet organelle claims center stage
    Angeliki Louvi
    Departments of Neurosurgery and Neurobiology, Yale School of Medicine, New Haven, CT 06520, USA
    Neuron 69:1046-60. 2011
    ..We review a fast expanding literature to determine what we now know about the primary cilium in the developing and adult CNS and what new directions should lead to further clarity...
  19. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
    ..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...
  20. pmc WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16783-8. 2005
    ..They suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission...
  21. doi request reprint PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit
    Gamze Tanriover
    Department of Histology and Embryology, Akdeniz University, Antalya, Turkey
    Neurosurgery 62:930-8; discussion 938. 2008
    ..Mutations in the programmed cell death 10 gene, PDCD10, cause the autosomal-dominant familial cerebral cavernous malformation 3 (CCM3). Little is known about the function of this gene in disease pathogenesis...
  22. ncbi request reprint The isthmic neuroepithelium is essential for cerebellar midline fusion
    Angeliki Louvi
    R├ęgionalisation Nerveuse CNRS ENS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Development 130:5319-30. 2003
    ....

Research Grants1

  1. Development of Choroid Plexus and the Blood-CSF Barrier
    Angeliki Louvi; Fiscal Year: 2006
    ....