Paul Lombroso

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders
    Susan M Goebel-Goody
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacol Rev 64:65-87. 2012
  2. ncbi request reprint [Learning and memory]
    Paul Lombroso
    Yale Child Study Center, USA
    Rev Bras Psiquiatr 26:207-10. 2004
  3. ncbi request reprint Genetics of childhood disorders: XLVIII. Learning and memory, Part 1: Fragile X syndrome update
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    J Am Acad Child Adolesc Psychiatry 42:372-5. 2003
  4. ncbi request reprint Genetics of childhood disorders: LV. Prenatal drug exposure
    Linda C Mayes
    Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 42:1258-61. 2003
  5. pmc Tourette syndrome and obsessive-compulsive disorder
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, United States
    Brain Dev 30:231-7. 2008
  6. doi request reprint Fragile X syndrome: keys to the molecular genetics of synaptic plasticity
    Paul J Lombroso
    Yale Child Study Center, CT, USA
    J Am Acad Child Adolesc Psychiatry 47:736-9. 2008
  7. ncbi request reprint Genetics of childhood disorders: XXXVII. News flash: a gene for expressive language
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 41:482-5. 2002
  8. ncbi request reprint Development of the cerebral cortex: III. The reeler mutation
    P J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 37:333-4. 1998
  9. ncbi request reprint Receptor and nonreceptor protein tyrosine phosphatases in the nervous system
    S Paul
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, Connecticut 06520, USA
    Cell Mol Life Sci 60:2465-82. 2003
  10. ncbi request reprint A neuronal protein tyrosine phosphatase induced by nerve growth factor
    E Sharma
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    J Biol Chem 270:49-53. 1995

Research Grants

Detail Information

Publications36

  1. pmc Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders
    Susan M Goebel-Goody
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacol Rev 64:65-87. 2012
    ..This comprehensive review discusses STEP expression and regulation and highlights how disrupted STEP function contributes to the pathophysiology of diverse neuropsychiatric disorders...
  2. ncbi request reprint [Learning and memory]
    Paul Lombroso
    Yale Child Study Center, USA
    Rev Bras Psiquiatr 26:207-10. 2004
    ..Neurofibromatosis, Coffin-Lowry syndrome and Rubinstein-Taybi syndrome are three examples of developmental disorders that have mutations in key components of the MAP kinase signaling pathway...
  3. ncbi request reprint Genetics of childhood disorders: XLVIII. Learning and memory, Part 1: Fragile X syndrome update
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    J Am Acad Child Adolesc Psychiatry 42:372-5. 2003
  4. ncbi request reprint Genetics of childhood disorders: LV. Prenatal drug exposure
    Linda C Mayes
    Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 42:1258-61. 2003
  5. pmc Tourette syndrome and obsessive-compulsive disorder
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, United States
    Brain Dev 30:231-7. 2008
    ..Recent advances in research models are also reviewed in an attempt to clarify some of the molecular etiologies that lead to these disorders...
  6. doi request reprint Fragile X syndrome: keys to the molecular genetics of synaptic plasticity
    Paul J Lombroso
    Yale Child Study Center, CT, USA
    J Am Acad Child Adolesc Psychiatry 47:736-9. 2008
  7. ncbi request reprint Genetics of childhood disorders: XXXVII. News flash: a gene for expressive language
    Paul J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 41:482-5. 2002
  8. ncbi request reprint Development of the cerebral cortex: III. The reeler mutation
    P J Lombroso
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 37:333-4. 1998
  9. ncbi request reprint Receptor and nonreceptor protein tyrosine phosphatases in the nervous system
    S Paul
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, Connecticut 06520, USA
    Cell Mol Life Sci 60:2465-82. 2003
    ..Evidence gathered to date provides some insight into the physiological function of these PTPs in the nervous system. In this review, we outline what is currently known about the functional role of PTPs expressed in the brain...
  10. ncbi request reprint A neuronal protein tyrosine phosphatase induced by nerve growth factor
    E Sharma
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    J Biol Chem 270:49-53. 1995
    ..The data presented suggest that NGF regulates the expression of PC12-PTP1 during periods of neuronal growth and differentiation...
  11. ncbi request reprint Child mental health consultation with families of medically compromised infants
    Linda C Mayes
    Yale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA
    Child Adolesc Psychiatr Clin N Am 12:401-21. 2003
    ..For such families, child mental health professionals are uniquely suited to play a further role in research and treatment...
  12. ncbi request reprint Predicting which children benefit most from parental presence during induction of anesthesia
    Zeev N Kain
    Department of Anesthesiology, Center for the Advancement of Perioperative Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Paediatr Anaesth 16:627-34. 2006
    ..The purpose of this large-scale prospective cohort study (n = 426) was to identify child and parent characteristics that are associated with low anxiety and good compliance during induction of anesthesia when parents are present...
  13. ncbi request reprint Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery
    Zeev N Kain
    Center for the Advancement of Perioperative Health, Department of Anesthesiology, Yale University School of Medicine, PO Box 208051, 333 Cedar St, New Haven, Connecticut 06521, USA
    Pediatrics 118:651-8. 2006
    ..To date, no similar investigation has ever been conducted in young children...
  14. ncbi request reprint Family-centered preparation for surgery improves perioperative outcomes in children: a randomized controlled trial
    Zeev N Kain
    Center for the Advancement of Perioperative Health and the Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Anesthesiology 106:65-74. 2007
    ....
  15. ncbi request reprint Arousal regulation, emotional flexibility, medial amygdala function, and the impact of early experience: comments on the paper of Lewis et al
    Linda C Mayes
    Yale University, Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1094:178-92. 2006
    ..An important interface between Drs. Lewis and Davis's work is how early experience, especially through early parenting, may set the threshold of responsiveness for these arousal regulatory neural systems...
  16. ncbi request reprint Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children
    Zeev N Kain
    Center for the Advancement of Perioperative Health, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Anesthesiology 107:545-52. 2007
    ..Multiple studies document the beneficial effect of midazolam on preoperative anxiety in children. Many clinicians report, however, that some children may in fact not benefit from the administration of this drug...
  17. pmc Individual differences in EEG theta and alpha dynamics during working memory correlate with fMRI responses across subjects
    Jed A Meltzer
    Yale University, Interdepartmental Neuroscience Program, PO Box 208043, TAC N134, New Haven, CT 06520 8043, USA
    Clin Neurophysiol 118:2419-36. 2007
    ..We explored individual differences in EEG reactivity to determine whether it is positively or negatively correlated with BOLD across subjects...
  18. ncbi request reprint Sleeping characteristics of children undergoing outpatient elective surgery
    Zeev N Kain
    Department of Anesthesiology, The Children s Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Anesthesiology 97:1093-101. 2002
    ..The aim of this longitudinal cohort study was to expand previous research in this area by using a new objective technology...
  19. ncbi request reprint The enduring impact of perceptual memories
    Linda C Mayes
    Yale Child Study Center, New Haven, Connecticut 06520, USA
    Biol Psychiatry 62:1067-9. 2007
  20. doi request reprint An examination of the construct validity and factor structure of the Groton Maze Learning Test, a new measure of spatial working memory, learning efficiency, and error monitoring
    Robert H Pietrzak
    Department of Psychology, Clinical Division, University of Connecticut, Storrs, CT 06269 1020, USA
    Arch Clin Neuropsychol 23:433-45. 2008
    ..Exploratory factor analysis yielded a two-factor solution of error monitoring and learning efficiency, which was stable across repeated assessments...
  21. ncbi request reprint A behavioral teratogenic model of the impact of prenatal cocaine exposure on arousal regulatory systems
    Linda C Mayes
    Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    Neurotoxicol Teratol 24:385-95. 2002
    ..A theoretical model of interactive arousal systems is presented as one possibility for integrating the profile of apparent cocaine-related neurobehavioral impairments in infants and young children prenatally exposed to cocaine...
  22. pmc Substance-abusing mothers and disruptions in child custody: an attachment perspective
    Nancy E Suchman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Subst Abuse Treat 30:197-204. 2006
    ..g., children nested within families). Findings are consistent with an attachment perspective on parenting suggesting that the internal psychological processes of a parent play a critical role in the continuity of parenting...
  23. ncbi request reprint Predicting which child-parent pair will benefit from parental presence during induction of anesthesia: a decision-making approach
    Zeev N Kain
    Center for the Advancement of Perioperative Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Anesth Analg 102:81-4. 2006
    ..49). We conclude that the presence of a calm parent does benefit an anxious child during induction of anesthesia and the presence of an overly anxious parent has no benefit...
  24. ncbi request reprint Behavioral interactions in the perioperative environment: a new conceptual framework and the development of the perioperative child-adult medical procedure interaction scale
    Alison A Caldwell-Andrews
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Anesthesiology 103:1130-5. 2005
    ..As a first step, the authors aimed to develop a behavioral coding system that would measure child and adult interactions in the perioperative environment...
  25. ncbi request reprint Developmental trajectories of cocaine-and-other-drug-exposed and non-cocaine-exposed children
    Linda C Mayes
    Yale Child Study Center, New Haven, CT 06520, USA
    J Dev Behav Pediatr 24:323-35. 2003
    ..Results suggest that prenatally cocaine-exposed children show delayed developmental indices, particularly in their mental performance, but their trajectories across time are similar to those from impoverished, non-cocaine-exposed groups...
  26. ncbi request reprint Emotion regulation behavior during a separation procedure in 18-month-old children of mothers using cocaine and other drugs
    Adriana Molitor
    Department of Psychology, University of San Diego, CA 92110 2492, USA
    Dev Psychopathol 15:39-54. 2003
    ..Results suggest a possible impairment or restriction of emotional expression and regulation in the face of stress and/or maternal disengagement that is more common among cocaine-exposed children with their mothers...
  27. ncbi request reprint Center differences and outcomes of extremely low birth weight infants
    Betty R Vohr
    Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Pediatrics 113:781-9. 2004
    ....
  28. ncbi request reprint Subcortical discrimination of unperceived objects during binocular rivalry
    Brian N Pasley
    Developmental Neuroimaging Laboratory, Child Study Center, Yale University, New Haven, CT 06520, USA
    Neuron 42:163-72. 2004
    ..These findings indicate that, for certain behaviorally relevant stimuli, a high-level cortical representation in IT is not required for object discrimination in the amygdala...
  29. ncbi request reprint Interactive music therapy as a treatment for preoperative anxiety in children: a randomized controlled trial
    Zeev N Kain
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Anesth Analg 98:1260-6, table of contents. 2004
    ..IMPLICATIONS: Depending on the music therapist, interactive music therapy may relieve anxiety on separation and entrance to the operating room but appears less effective during the induction of anesthesia...
  30. ncbi request reprint Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors
    Zeev N Kain
    Department of Anesthesiology, Yale University School of Medicine 333 Cedar Street, New Haven, CT 06510, USA
    Anesth Analg 99:1648-54, table of contents. 2004
    ....
  31. ncbi request reprint Parental intervention choices for children undergoing repeated surgeries
    Zeev N Kain
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Anesth Analg 96:970-5, table of contents. 2003
    ..Also, parents' intervention preferences at the subsequent surgery were influenced by children's anxiety at the initial surgery...
  32. ncbi request reprint Parental presence during induction of anesthesia: physiological effects on parents
    Zeev N Kain
    Departments of Anesthesiology, Pediatrics, and Child and Adolescent Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Anesthesiology 98:58-64. 2003
    ..The authors conducted a randomized controlled trial to determine whether parental presence during induction of anesthesia (PPIA) is associated with parental physiologic and behavioral manifestations of stress...
  33. ncbi request reprint Motivation and maternal presence during induction of anesthesia
    Alison A Caldwell-Andrews
    Department of Anesthesiology, Center for the Advancement of Perioperative Health, New Haven, CT 06510, USA
    Anesthesiology 103:478-83. 2005
    ..The authors developed a measure to determine whether maternal motivation to be present during induction (Motivation for Parental Presence during Induction of Anesthesia [MPPIA]) is related to children's anxiety during the induction process...
  34. ncbi request reprint Something is different but what or why is unclear: commentary on the Boston Change Process Study Group
    Linda C Mayes
    Yale Child Study Center, New Haven, CT 06520, USA
    J Am Psychoanal Assoc 53:745-50; discussion 761-9. 2005
  35. ncbi request reprint Sevoflurane versus halothane: postoperative maladaptive behavioral changes: a randomized, controlled trial
    Zeev N Kain
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Anesthesiology 102:720-6. 2005
    ....
  36. ncbi request reprint Nurturing resilient children
    James F Leckman
    The Child Study Center, and the Departments of Psychiatry, Pediatrics and Psychology, Yale University
    J Child Psychol Psychiatry 48:221-3. 2007

Research Grants18

  1. The PTP, STEP, Regulates Amphetamine Actions
    Paul Lombroso; Fiscal Year: 2007
    ..We show preliminary feasibility data on this approach. A complementary set of experiments will study the STEP knock-out mouse that we predict is hypersensitive to stimulant treatment. ..
  2. MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPS
    Paul Lombroso; Fiscal Year: 2007
    ..abstract_text> ..
  3. STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPS
    Paul Lombroso; Fiscal Year: 2007
    ..STEP knock-out mice will also be characterized. The proposed investigations will be done in the supportive environment of the Child Study Center with its commitment to cliniclaly informed basic science research. ..
  4. MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPS
    Paul Lombroso; Fiscal Year: 2003
    ..We will identify the physiological substrates of STEP, one of which is proposed to be the NMDA receptor. We will these these hypotheses using biochemical, molecular, and electrophysiological techniques. ..
  5. Molecular and Cellular Analysis of Brain Enriched PTP's
    Paul J Lombroso; Fiscal Year: 2010
    ..The proposed studies examine the molecular mechanisms that regulate STEP activity and will clarify how this important family of regulatory proteins are involved in synaptic plasticity, cell death, and human disease. ..