Charles Lockwood

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 196:382.e1-8. 2007
  2. pmc Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
    Seth Guller
    Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Lab Invest 88:1057-67. 2008
  3. pmc Intercellular adhesion molecule-1 expression in human endometrium: implications for long term progestin only contraception
    Frederick Schatz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Reprod Biol Endocrinol 4:2. 2006
  4. pmc Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06510, USA
    J Angiogenes Res 2:8. 2010
  5. pmc Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin-enhanced interleukin-8 expression in term decidua
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, PO Box 208063, Room 334FMB, New Haven, CT 06520 8063, USA
    Am J Pathol 167:1443-9. 2005
  6. ncbi request reprint The initiation of parturition at term
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Obstet Gynecol Clin North Am 31:935-47, xii. 2004
  7. ncbi request reprint Pregnancy-associated changes in the hemostatic system
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Clin Obstet Gynecol 49:836-43. 2006
  8. ncbi request reprint Testing for risk of preterm delivery
    Charles J Lockwood
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8055, USA
    Clin Lab Med 23:345-60. 2003
  9. pmc Thrombin and interleukin-1beta decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
    Jennifer Sarno
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Hum Reprod 15:451-7. 2009
  10. doi request reprint Long-term progestin-only contraception in humans versus animal models
    Graciela Krikun
    Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1221:119-23. 2011

Research Grants

  1. Decidual-Endothelial Tissue Factor and IUGR
    Charles Lockwood; Fiscal Year: 2006
  2. Progestin Effects on Uterine Hemostasis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2006
  3. The Yale WRHR Career Development Center
    Charles Lockwood; Fiscal Year: 2007
  4. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2007
  5. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2009
  6. SGI Meeting: Training and Development Plan
    Charles Lockwood; Fiscal Year: 2005
  7. PROGESTIN EFFECTS ON UTERINE HEMOSTASIS AND ANGIOGENESIS
    Charles Lockwood; Fiscal Year: 1999
  8. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2010

Detail Information

Publications63

  1. ncbi request reprint Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 196:382.e1-8. 2007
    ..This study investigates the separate and interactive effects of steroid hormones and thrombin on PAI-1, uPA, and tPA expression by term decidual cells (DCs)...
  2. pmc Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
    Seth Guller
    Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Lab Invest 88:1057-67. 2008
    ....
  3. pmc Intercellular adhesion molecule-1 expression in human endometrium: implications for long term progestin only contraception
    Frederick Schatz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Reprod Biol Endocrinol 4:2. 2006
    ....
  4. pmc Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06510, USA
    J Angiogenes Res 2:8. 2010
    ..However, obtaining sufficient, good quality tissues have precluded elucidation of the mechanisms underlying these morphological and functional vascular changes...
  5. pmc Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin-enhanced interleukin-8 expression in term decidua
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, PO Box 208063, Room 334FMB, New Haven, CT 06520 8063, USA
    Am J Pathol 167:1443-9. 2005
    ..In summary, thrombin-enhanced IL-8 expression in term decidual cells may explain how abruption-associated PPROM promotes decidual neutrophil infiltration...
  6. ncbi request reprint The initiation of parturition at term
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Obstet Gynecol Clin North Am 31:935-47, xii. 2004
    ..This article discusses the initiation of parturition at term...
  7. ncbi request reprint Pregnancy-associated changes in the hemostatic system
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Clin Obstet Gynecol 49:836-43. 2006
    ..Unfortunately, they also lead to an increase in the prevalence of venous thromboembolism, which is otherwise uncommon in reproductive age women...
  8. ncbi request reprint Testing for risk of preterm delivery
    Charles J Lockwood
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8055, USA
    Clin Lab Med 23:345-60. 2003
    ..Use of multiple markers (eg, serum CRH, salivary E3, cervical IL-6, TAT, and fFN) holds promise for implementing targeted interventions to prevent PTD...
  9. pmc Thrombin and interleukin-1beta decrease HOX gene expression in human first trimester decidual cells: implications for pregnancy loss
    Jennifer Sarno
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Hum Reprod 15:451-7. 2009
    ..Since HOXA10 and HOXA11 are known to be necessary for successful pregnancy, these findings suggest a molecular mechanism by which bleeding or inflammation may affect pregnancy outcome...
  10. doi request reprint Long-term progestin-only contraception in humans versus animal models
    Graciela Krikun
    Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1221:119-23. 2011
    ..In this review, we describe these models including the guinea pig, an animal model we have previously investigated, to assess the mechanisms involved in abnormal uterine bleeding following long-term progestin-only contraception...
  11. pmc The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists
    Kimberly A Yonkers
    Department of Psychiatry, Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
    Gen Hosp Psychiatry 31:403-13. 2009
    ..To address the maternal and neonatal risks of both depression and antidepressant exposure and develop algorithms for periconceptional and antenatal management...
  12. pmc The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists
    Kimberly A Yonkers
    Department of Psychiatry, Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
    Obstet Gynecol 114:703-13. 2009
    ..To address the maternal and neonatal risks of both depression and antidepressant exposure and develop algorithms for periconceptional and antenatal management...
  13. ncbi request reprint A novel three-dimensional in vitro system to study trophoblast-endothelium cell interactions
    Paulomi B Aldo
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 58:98-110. 2007
    ..We describe a novel in vitro model to evaluate endothelial-trophoblast interaction and signaling in a three-dimensional system...
  14. ncbi request reprint Differential cell-specific modulation of HOXA10 by estrogen and specificity protein 1 response elements
    Ryan Martin
    Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    J Clin Endocrinol Metab 92:1920-6. 2007
    ..HOX genes are highly evolutionarily conserved regulators of embryonic development. HOXA10 also regulates differentiation of the adult reproductive tract and mammary gland in response to sex steroids...
  15. ncbi request reprint Thrombin activation of endometrial endothelial cells: a possible role in intrauterine growth restriction
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, School of Medicine, New Haven, CT 06520 8063, USA
    Thromb Haemost 97:245-53. 2007
    ..Thus, we postulate that reductions in uteroplacental flow initiate a cascade of molecular effects leading to hypoxia, thrombosis, inflammation, and endothelial cell dysfunction resulting in untoward pregnancy outcomes...
  16. ncbi request reprint The role of decidualization in regulating endometrial hemostasis during the menstrual cycle, gestation, and in pathological states
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA
    Semin Thromb Hemost 33:111-7. 2007
    ..In association with long-term progestin-only contraception, overexpression of decidual cell-derived thrombin promotes aberrant angiogenesis and vessel maintenance to contribute to abnormal uterine bleeding...
  17. ncbi request reprint Tibolone exerts progestational inhibition of matrix metalloproteinase expression in human endometrial stromal cells
    Frederick Schatz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street Room 334 FMB, PO Box 208063, New Haven, CT 06520 8063, USA
    Steroids 71:768-75. 2006
    ..These observations help to explain the paradox that the endometrium becomes atrophic after tibolone administration despite the persistence in the circulation of 3alpha-OH and 3beta-OH tibolone, but not tibolone or Delta-4 tibolone...
  18. pmc Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Med 4:e18. 2007
    ..Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score...
  19. ncbi request reprint Differential regulation of colony stimulating factor 1 and macrophage migration inhibitory factor expression by inflammatory cytokines in term human decidua: implications for macrophage trafficking at the fetal-maternal interface
    Felice Arcuri
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Biol Reprod 76:433-9. 2007
    ....
  20. pmc Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells: implications for the genesis of chorioamnionitis
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB P O Box 208063 New Haven, CT
    Am J Pathol 169:1294-302. 2006
    ....
  21. ncbi request reprint Thrombin regulates monocyte chemoattractant protein-1 expression in human first trimester and term decidual cells
    Paul Matta
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 196:268.e1-8. 2007
    ..Therefore, the current study evaluated whether thrombin affects monocyte chemoattractant protein-1 (MCP-1) expression in stromal cells that are derived from cycling and gestational endometrium...
  22. pmc Thrombin regulates soluble fms-like tyrosine kinase-1 (sFlt-1) expression in first trimester decidua: implications for preeclampsia
    Charles J Lockwood
    The Anita O Keefe Young Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT, USA
    Am J Pathol 170:1398-405. 2007
    ..In early pregnancy, thrombin may act as an autocrine/paracrine enhancer of sFlt-1 expression by decidual cells to promote pre-eclampsia by interfering with local vascular transformation...
  23. pmc Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia
    Michael Cackovic
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Obstet Gynecol 112:93-100. 2008
    ..We sought to estimate the fractional excretion of tumor necrosis factor (TNF)-alpha in relationship to proteinuria in women with severe preeclampsia...
  24. pmc Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Pathol 172:1571-9. 2008
    ....
  25. pmc Endometriosis and tissue factor
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine 333 Cedar St, P O Box 208063, New Haven, CT, 06520 8063, USA
    Ann N Y Acad Sci 1127:101-5. 2008
    ..Thus, our studies suggest that TF might be an ideal target for therapeutic intervention in endometriosis...
  26. doi request reprint Decidual cell-expressed tissue factor in human pregnancy and its involvement in hemostasis and preeclampsia-related angiogenesis
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT, 06510, USA
    Ann N Y Acad Sci 1127:67-72. 2008
    ....
  27. ncbi request reprint Antithrombotic prophylaxis in multiparous women with preeclampsia or intrauterine growth retardation in an antecedent pregnancy
    Gabriele Urban
    University of Milano Bicocca, Department of Obstetrics and Gynecology, Italy
    Int J Fertil Womens Med 52:59-67. 2007
    ..To determine whether prophylactic low dose aspirin (LDA) alone or in combination with low-molecular-weight-heparin (LMWH) reduces the recurrence of adverse pregnancy outcome (APO)...
  28. doi request reprint Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth
    - Guoyang Luo
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Reprod Sci 15:147-55. 2008
    ..5 kg/m(2) (relative risk, 10.8; 95% confidence interval, 1.4-82.6; P = .02). Maternal carriage of minor alleles of +331(G>A), +770(C>T), and +660(G> T) SNPs in the PR gene is not associated with spontaneous preterm birth...
  29. pmc Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells
    Charles J Lockwood
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Reprod 78:1064-72. 2008
    ..At the implantation site, inflammatory cytokine-enhanced MMP9 may promote preeclampsia by disrupting the decidual ECM to interfere with normal stepwise EVT invasion...
  30. ncbi request reprint Thromboembolism in pregnancy
    Victor A Rosenberg
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Obstet Gynecol Clin North Am 34:481-500, xi. 2007
    ..Therapy involves supportive care and anticoagulation with unfractionated or low molecular weight heparin, depending on the clinical scenario...
  31. pmc Progestin-inflammatory cytokine interactions affect matrix metalloproteinase-1 and -3 expression in term decidual cells: implications for treatment of chorioamnionitis-induced preterm delivery
    Ceyda Oner
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 93:252-9. 2008
    ..We hypothesized that IL-1beta and TNF-alpha may induce matrix metalloproteinase (MMP)-1 and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix...
  32. ncbi request reprint Elevated first trimester maternal levels of soluble fibrin polymer are associated with lower birthweight in twin gestation
    Gabriele Urban
    Department of Obstetrics and Gynecology, Milano Bicocca University, Monza, Italy
    Blood Coagul Fibrinolysis 17:343-6. 2006
    ..Current studies are underway to determine the utility of soluble fibrin polymer in assessing fetal growth abnormalities...
  33. ncbi request reprint Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: analysis of U.S. perinatal mortality data, 1995-1997
    Mert O Bahtiyar
    Department of Obstetrics and Gynecology, Yale University, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 195:1373-8. 2006
    ..This study investigated the association between prior cesarean delivery and unexplained intrauterine fetal demise at term in the United States...
  34. ncbi request reprint Keeping medicine and science together
    Frederick Naftolin
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Exp Biol Med (Maywood) 229:437-8. 2004
  35. ncbi request reprint Effects of thrombin, hypoxia, and steroids on interleukin-8 expression in decidualized human endometrial stromal cells: implications for long-term progestin-only contraceptive-induced bleeding
    Charles J Lockwood
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 89:1467-75. 2004
    ..However, LTPOC-induced hypoxia and excess thrombin generation enhance IL-8 expression in decidualized HESCs, thereby eliciting aberrant angiogenesis and inflammation that promote the onset of abnormal uterine bleeding...
  36. ncbi request reprint Maternal thrombophilias are not associated with early pregnancy loss
    Henry Roque
    Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
    Thromb Haemost 91:290-5. 2004
    ..60, 95%CI: 1.43-9.09) and preeclampsia (OR:3.21, 95%CI:1.20-8.58). In conclusion, these data indicate maternal thrombophilias are not associated with pregnancy wastage prior to 10 weeks of gestation...
  37. ncbi request reprint A novel immortalized human endometrial stromal cell line with normal progestational response
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Endocrinology 145:2291-6. 2004
    ..In summary, an immortalized HESC line has been developed that is karyotypically, morphologically, and phenotypically similar to the primary parent cells, and it is a powerful and consistent resource for in vitro work...
  38. ncbi request reprint Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis
    Frederick Schatz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
    Steroids 68:849-60. 2003
    ..Since thrombin and VEGF induce angiogenesis via separate endothelial cell receptors, they may synergize to elicit aberrant angiogenesis, and ultimately lead to focal bleeding...
  39. ncbi request reprint Circulating levels of inflammatory cytokines (IL-1 beta and TNF-alpha), resistance to activated protein C, thrombin and fibrin generation in uncomplicated pregnancies
    De Hui W Ku
    The Center for Thrombosis in Women Health, Obstetrics and Gynecology Department, Yale University, New Haven, CT, USA
    Thromb Haemost 90:1074-9. 2003
    ..A sub-group of pregnancies with APC resistance had increased levels of TNF-alpha and may be important in the risk for adverse pregnancy outcomes...
  40. ncbi request reprint Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in the patient with cervical cerclage
    Ashley S Roman
    Departments of Obstetrics and Gynecology, New York University School of Medicine, Bellevue Hospital Center, First Avenue and 27th Street, Room 9E2, New York, NY 10016, USA
    Am J Obstet Gynecol 189:1368-73. 2003
    ..The purpose of this study was to assess the validity of vaginal fetal fibronectin as a screening test for spontaneous preterm birth in patients with cervical cerclage...
  41. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
    ..Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells...
  42. ncbi request reprint Steroid hormones, endometrial gene regulation and the Sp1 family of proteins
    Graciela Krikun
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA
    J Soc Gynecol Investig 9:329-34. 2002
    ....
  43. ncbi request reprint Differential effects of thrombin and hypoxia on endometrial stromal and glandular epithelial cell vascular endothelial growth factor expression
    Charles J Lockwood
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
    J Clin Endocrinol Metab 87:4280-6. 2002
    ..Because angiogenesis occurs in a matrix of decidualized HESCs, these in vitro results provide a novel mechanism to account for both the peak in VEGF and angiogenesis in luteal phase human endometrium...
  44. pmc Abnormal uterine bleeding during progestin-only contraception may result from free radical-induced alterations in angiopoietin expression
    Graciela Krikun
    Department of Obstetrics and Gynecology, New York University Medical Center, New York, USA
    Am J Pathol 161:979-86. 2002
    ....
  45. ncbi request reprint Mechanisms of abruption-induced premature rupture of the fetal membranes: Thrombin enhanced decidual matrix metalloproteinase-3 (stromelysin-1) expression
    Andrew P Mackenzie
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
    Am J Obstet Gynecol 191:1996-2001. 2004
    ..The aim of the study was to evaluate thrombin and progestin effects on matrix metalloproteinase-3 expression in term decidual cells as a mechanism of abruption-related preterm delivery...
  46. pmc Endometrial angiopoietin expression and modulation by thrombin and steroid hormones: a mechanism for abnormal angiogenesis following long-term progestin-only contraception
    Graciela Krikun
    Department of Obstetrics, Yale University, School of Medicine, New Haven, Connecticut 06520 8063, USA
    Am J Pathol 164:2101-7. 2004
    ....
  47. ncbi request reprint A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 194:309-16. 2006
    ....
  48. ncbi request reprint Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects
    Frederick Schatz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8063, USA
    Steroids 70:840-5. 2005
    ..Since TF and PAI-1 promote hemostasis by complementary mechanisms, our findings account for the reduced occurrence of abnormal uterine bleeding associated with tibolone therapy...
  49. ncbi request reprint Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor
    Jennifer L Sarno
    Division of Reproductive Endocrinology and Fertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:2366-72. 2006
    ..The uteri of Hoxa10(-/-) mice demonstrate progesterone resistance; several genes, including prostaglandin receptors, are inappropriately regulated in response to progesterone...
  50. ncbi request reprint Progestin suppresses thrombin- and interleukin-1beta-induced interleukin-11 production in term decidual cells: implications for preterm delivery
    Hakan Cakmak
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 334, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 90:5279-86. 2005
    ..Paradoxically, it enhances the synthesis of prostaglandins, which induce labor...
  51. ncbi request reprint Inflammatory cytokine and thrombin regulation of interleukin-8 and intercellular adhesion molecule-1 expression in first trimester human decidua
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB P O Box 208063, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 90:4710-5. 2005
    ..Transendothelial neutrophil migration into inflamed tissues involves IL-8-mediated chemoattraction, then neutrophil attachment to endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1)...
  52. ncbi request reprint Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 192:734-41. 2005
    ..We sought to identify whether similar alterations in urinary levels of these proteins cluster hypertensive disorders in pregnancy, and identify women with severe preeclampsia (sPE)...
  53. ncbi request reprint Fractional excretion of angiogenic factors in women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, Connecticut 06520, USA
    Obstet Gynecol 107:1103-13. 2006
    ..We estimated the fractional excretions of soluble fms-like tyrosine kinase 1 (sFlt-1), vascular endothelial growth factor, and placental growth factor of severely preeclamptic women at the time of disease clinical manifestation...
  54. ncbi request reprint Endometrial endothelial cell steroid receptor expression and steroid effects on gene expression
    Graciela Krikun
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 90:1812-8. 2005
    ..Thus, quantitative RT-PCR and microarray analyses demonstrate that HEECs express ER-beta and PR mRNA and that gene expression by HEECs is differentially regulated by treatment with estrogen or progestin...
  55. pmc Regulation of monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha and interleukin-1beta in first trimester human decidual cells: implications for preeclampsia
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Pathol 168:445-52. 2006
    ..This finding suggests a mechanism by which recruitment of excess macrophages to the decidua impairs endovascular trophoblast invasion, the primary placental defect of preeclampsia...
  56. ncbi request reprint The term, singleton, vaginal breech delivery controversy
    Charles J Lockwood
    J Matern Fetal Neonatal Med 12:75-7. 2002
  57. ncbi request reprint Inherited thrombophilias in pregnant patients: detection and treatment paradigm
    Charles J Lockwood
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
    Obstet Gynecol 99:333-41. 2002
    ....
  58. ncbi request reprint Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses
    Jacob H Rand
    Division of Clinical Pathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Obstet Gynecol 194:182-8. 2006
    ..We investigated whether levels of annexin A5, evidence for resistance to annexin A5 activity, and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses...
  59. ncbi request reprint Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes
    Courtney D Stephenson
    Carolinas Medical Center, Charlotte, North Carolina, USA
    J Matern Fetal Neonatal Med 18:17-22. 2005
    ..Bleeding is a major risk factor for PPROM. Since such hemorrhage into the tissue factor-enriched decidua induces intense thrombin formation, we determined whether thrombin stimulates MMP levels in amniochorionic membranes...
  60. doi request reprint Preface: novel features of the physiology and pathology of human reproduction
    Carlo Bulletti
    Ann N Y Acad Sci 1127:xi. 2008
  61. ncbi request reprint Predicting premature delivery--no easy task
    Charles J Lockwood
    N Engl J Med 346:282-4. 2002
  62. ncbi request reprint Chorionic villus sampling significantly affects fetal cardiovascular function
    Nebojsa Radunovic
    Institute of Obstetrics and Gynecology, University of Belgrade, Belgrade, Serbia
    J Matern Fetal Neonatal Med 20:285-8. 2007
    ..To assess the effects of chorionic villus sampling (CVS) on fetal heart rate (FHR)...
  63. ncbi request reprint The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface
    Paola Vigano
    II Department of Obstetrics and Gynecology, University of Milan and Istituto Auxologico Italiano, 20100 Milan, Italy
    Semin Immunopathol 29:135-50. 2007
    ..The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal-maternal interface...

Research Grants23

  1. Decidual-Endothelial Tissue Factor and IUGR
    Charles Lockwood; Fiscal Year: 2006
    ..Additionally, we will correlate maternal plasma levels of two sensitive thrombin markers with the presence of acquired or inherited thrombophilias in the selected patient population. ..
  2. Progestin Effects on Uterine Hemostasis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2006
    ..abstract_text> ..
  3. The Yale WRHR Career Development Center
    Charles Lockwood; Fiscal Year: 2007
    ..Yale shall seek to retain as faculty Scholars who successfully complete an individualized training program at Yale and who have made significant progress toward independent funding. ..
  4. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2007
    ..Moreover, a model will be established to test innovative LTPOC formulations that minimize uterine and endometrial vasoconstriction and ROS-generation, thus preventing abnormal bleeding to improve the acceptability of LTPOC therapies. ..
  5. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2009
    ..Moreover, a model will be established to test innovative LTPOC formulations that minimize uterine and endometrial vasoconstriction and ROS-generation, thus preventing abnormal bleeding to improve the acceptability of LTPOC therapies. ..
  6. SGI Meeting: Training and Development Plan
    Charles Lockwood; Fiscal Year: 2005
    ..It is hoped that this initiative will stimulate greater interest in Ob/Gyn research by those early in their careers, and will enhance the scientific exchange and collaboration of more senior investigators. ..
  7. PROGESTIN EFFECTS ON UTERINE HEMOSTASIS AND ANGIOGENESIS
    Charles Lockwood; Fiscal Year: 1999
    ..Such a reduction would be expected to reduce the occurrence of unplanned pregnancies. ..
  8. Progestin Effects on Uterine Hemostatis & Angiogenesis
    Charles Lockwood; Fiscal Year: 2010
    ..Moreover, a model will be established to test innovative LTPOC formulations that minimize uterine and endometrial vasoconstriction and ROS-generation, thus preventing abnormal bleeding to improve the acceptability of LTPOC therapies. ..