Affiliation: Yale University
Xicola R, Bontu S, Doyle B, Rawson J, Garre P, Lee E, et al
. Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis. 2016;37:751-8 pubmed publisher
..Thus, rs868 potentially is a CRC risk-causing allele. Our results support the concept that rs868 is associated with lower TGFBR1 expression thereby increasing CRC risk. ..
Xicola R, Clark J, Carroll T, Alvikas J, Marwaha P, Regan M, et al
. Implication of DNA repair genes in Lynch-like syndrome. Fam Cancer. 2019;: pubmed publisher
..The possibility of hereditary factors in LLS warrants further studies so counseling can be properly informed. ..
Hulur I, Gamazon E, Skol A, Xicola R, Llor X, Onel K, et al
. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics. 2015;16:138 pubmed publisher
..Moreover, bioinformatic characterization of colon eQTL provides a tissue-specific tool to improve understanding of biological differences in diseases between different ethnic groups. ..