Haifan Lin


Affiliation: Yale University
Country: USA


  1. Juliano C, Wang J, Lin H. Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. Annu Rev Genet. 2011;45:447-69 pubmed publisher
  2. Lin H. Capturing the cloud: UAP56 in nuage assembly and function. Cell. 2012;151:699-701 pubmed publisher
    ..The nuage is a hazy electron-dense structure unique to germ cells and is enriched in components of the piRNA pathway. Although the nuage is cytoplasmic, Zhang et al. now show that it is organized by an intranuclear protein, UAP56. ..
  3. Park A, Liu N, Neuenkirchen N, Guo Q, Lin H. The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production. Genetics. 2018;: pubmed publisher
    ..Our study reveals the earliest contribution of HP1a during oogenesis in regulating the production of maternal transcripts that drive early Drosophila embryogenesis. ..
  4. Lin H. Cell biology of stem cells: an enigma of asymmetry and self-renewal. J Cell Biol. 2008;180:257-60 pubmed publisher
    ..Further investigations of these questions in diverse types of stem cells will significantly advance our knowledge of cell biology and allow us to effectively harness stem cells for therapeutic applications. ..
  5. Watanabe T, Lin H. Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Mol Cell. 2014;56:18-27 pubmed publisher
  6. Lin H, Chen M, Kundaje A, Valouev A, Yin H, Liu N, et al. Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution. Dev Cell. 2015;32:772-4 pubmed publisher
    ..claim that Piwi influences RNA polymerase II distribution in the genome. This Matters Arising Response addresses the Marinov et al. (2015) Matters Arising, published concurrently in this issue of Developmental Cell. ..
  7. Ge X, Han J, Cheng E, Yamaguchi S, Shima N, Thomas J, et al. Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress. Stem Cell Reports. 2015;5:185-94 pubmed publisher
    ..Furthermore, mice with reduced DOs show abnormal neurogenesis and semi-embryonic lethality. Our results reveal that ESCs are equipped with more DOs to better protect against replicative stress than tissue-specific stem/progenitor cells. ..
  8. Parikh R, Lin H, Gangaraju V. A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila. J Biol Chem. 2018;293:9140-9147 pubmed publisher
    ..Our results point to a critical role for Nup358 in the piRNA pathway, laying the foundation for future studies to fully elucidate the mechanisms by which Nup358 contributes to piRNA biogenesis and transposon silencing. ..
  9. Gonzalez J, Qi H, Liu N, Lin H. Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis. Cell Rep. 2015;12:150-161 pubmed publisher
    ..Our work reveals the cell-autonomous function of Piwi in both somatic and germline stem cell types, with somatic function possibly via its epigenetic mechanism. ..

More Information


  1. Wang Z, Liu N, Shi S, Liu S, Lin H. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. J Biol Chem. 2016;291:10646-58 pubmed publisher
    ..These findings suggest that PIWIL4 may serve as a potential therapeutic target for breast cancer. ..
  2. request reprint
    Lin H. piRNAs in the germ line. Science. 2007;316:397 pubmed
    ..Recently, a class of small RNAs that interact with Piwi proteins has been discovered in the mammalian germ line and Drosophila. These Piwi-interacting RNAs (piRNAs) represent a distinct small RNA pathway. ..
  3. Mak W, Fang C, Holden T, Dratver M, Lin H. An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod. 2016;94:134 pubmed publisher
    ..Our study reveals an important role of translational regulation in mammalian female germ cell development. ..