Ming O Li

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer
    Ming O Li
    Yale University School of Medicine, New Haven, CT 06520 USA
    Expert Rev Clin Immunol 2:257-65. 2006
  2. ncbi request reprint Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
  3. ncbi request reprint JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response
    Jian Tao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8031, USA
    Eur J Immunol 37:818-29. 2007
  4. ncbi request reprint Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
  5. ncbi request reprint T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:579-91. 2007
  6. ncbi request reprint Transforming growth factor-beta: recent advances on its role in immune tolerance
    Martin A Kriegel
    Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520, USA
    Curr Rheumatol Rep 8:138-44. 2006
  7. pmc The stumpy gene is required for mammalian ciliogenesis
    Terrence Town
    Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
    Proc Natl Acad Sci U S A 105:2853-8. 2008
  8. pmc TGF-beta signaling is required for the function of insulin-reactive T regulatory cells
    Wei Du
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 066520, USA
    J Clin Invest 116:1360-70. 2006
  9. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
  10. pmc TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
    YuFeng Peng
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:4572-7. 2004

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer
    Ming O Li
    Yale University School of Medicine, New Haven, CT 06520 USA
    Expert Rev Clin Immunol 2:257-65. 2006
    ....
  2. ncbi request reprint Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  3. ncbi request reprint JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response
    Jian Tao
    Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8031, USA
    Eur J Immunol 37:818-29. 2007
    ..In summary, our results demonstrate that JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response...
  4. ncbi request reprint Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo...
  5. ncbi request reprint T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:579-91. 2007
    ..These findings reveal essential roles for T cell-produced TGF-beta1 in controlling differentiation of T helper cells and controlling inflammatory diseases...
  6. ncbi request reprint Transforming growth factor-beta: recent advances on its role in immune tolerance
    Martin A Kriegel
    Howard Hughes Medical Institute, Yale University School of Medicine, Section of Immunobiology, New Haven, CT 06520, USA
    Curr Rheumatol Rep 8:138-44. 2006
    ..We will also discuss recent advances on the role of TGF-beta in immune-mediated diabetes, inflammatory bowel disease, arthritis, and systemic lupus erythematosus...
  7. pmc The stumpy gene is required for mammalian ciliogenesis
    Terrence Town
    Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
    Proc Natl Acad Sci U S A 105:2853-8. 2008
    ..Therefore, stumpy is essential for ciliogenesis and may be involved in the pathogenesis of human congenital malformations such as HC and PKD...
  8. pmc TGF-beta signaling is required for the function of insulin-reactive T regulatory cells
    Wei Du
    Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 066520, USA
    J Clin Invest 116:1360-70. 2006
    ....
  9. pmc Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells
    Daniel H Kaplan
    Department of Dermatology, 2Department of Laboratory Medicine, 3Section of Immunobiology, and 4Section of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 204:2545-52. 2007
    ..Thus, TGFbeta1 derived from LCs acts directly on LCs through an autocrine/paracrine loop, and it is required for LC development and/or survival...
  10. pmc TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
    YuFeng Peng
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:4572-7. 2004
    ..Thus, these findings demonstrate a previously uncharacterized mechanism by which TGF-beta inhibits autoimmune diseases via regulation of the size of the CD4+CD25+ regulatory T cell pool in vivo...
  11. pmc Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    Robert M Samstein
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 151:153-66. 2012
    ..Thus, in a late cellular differentiation process, Foxp3 defines Treg cell functionality in an "opportunistic" manner by largely exploiting the preformed enhancer network instead of establishing a new enhancer landscape...
  12. ncbi request reprint JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:5783-9. 2005
    ..Taken together, our results demonstrate that JNK1 plays an important role in tumor immune surveillance through regulating the effector functions of CD8+ T cells...
  13. ncbi request reprint Phosphatidylserine receptor is required for clearance of apoptotic cells
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 302:1560-3. 2003
    ..These data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations...
  14. doi request reprint Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10
    Ming O Li
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 28:468-76. 2008
    ..The collective activity of TGF-beta and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues...
  15. ncbi request reprint Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression
    Xingyu Wang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 178:6770-6. 2007
    ..Our findings therefore indicate that NF-kappaB subunits p50, RelA, and cRel play a relatively minor role in virus-induced type 1 IFN expression...
  16. pmc TGF-beta: a master of all T cell trades
    Ming O Li
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 134:392-404. 2008
    ..The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells...

Research Grants1

  1. TGF-beta 1 Regulation of Peripheral T Cell Tolerance
    Ming Li; Fiscal Year: 2007
    ..TGF-beta1 is an important molecule for immune cell functions. My goal is to study the mechanism by which TGF-beta1 regulates T lymphocyte activity and the development of arthritis. ..