Hui Li

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Gene fusions and RNA trans-splicing in normal and neoplastic human cells
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cell Cycle 8:218-22. 2009
  2. doi request reprint A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 321:1357-61. 2008
  3. pmc Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20001-6. 2007
  4. doi request reprint Selection on the human bitter taste gene, TAS2R16, in Eurasian populations
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Biol 83:363-77. 2011
  5. doi request reprint Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation
    Yanmei Zhang
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Discov 2:598-607. 2012
  6. pmc A global view of the OCA2-HERC2 region and pigmentation
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Genet 131:683-96. 2012
  7. pmc Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
    Ann Hum Genet 73:335-45. 2009
  8. pmc Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
    Vinita Takiar
    Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:2462-7. 2011
  9. pmc Diversification of the ADH1B gene during expansion of modern humans
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
    Ann Hum Genet 75:497-507. 2011

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Gene fusions and RNA trans-splicing in normal and neoplastic human cells
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cell Cycle 8:218-22. 2009
    ..Furthermore, it may be possible that other means for abnormal production of chimeric gene products, such as hyperactive transsplicing of RNA, may be another mechanism underlying the neoplastic properties of tumor cells...
  2. doi request reprint A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 321:1357-61. 2008
    ..These observations suggest that certain gene fusions may be pro-neoplastic owing to constitutive expression of chimeric gene products normally generated by trans-splicing of RNAs in developing tissues...
  3. pmc Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20001-6. 2007
    ..Furthermore, these results indicate the likely functional importance of allelic exclusion of genes disrupted by chromosomal translocations, as seen in a variety of other cancers...
  4. doi request reprint Selection on the human bitter taste gene, TAS2R16, in Eurasian populations
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Biol 83:363-77. 2011
    ..Alternatively, the promoter region variant may be a marker for altered function beyond what the derived amino acid allele conferred...
  5. doi request reprint Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation
    Yanmei Zhang
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Discov 2:598-607. 2012
    ..Our results suggest that gene fusions can arise from cis-splicing of adjacent genes without corresponding DNA changes...
  6. pmc A global view of the OCA2-HERC2 region and pigmentation
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Genet 131:683-96. 2012
    ..Our data suggest that the haplotype restricted to Europe is the strongest marker for blue eyes globally and add further inferential evidence that the derived allele of rs1800414 is an East Asian skin pigmentation allele...
  7. pmc Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
    Ann Hum Genet 73:335-45. 2009
    ..In general the study of fine scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures...
  8. pmc Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
    Vinita Takiar
    Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:2462-7. 2011
    ..Our results suggest a possible role for AMPK activation in slowing renal cystogenesis as well as the potential for therapeutic application of metformin in the context of ADPKD...
  9. pmc Diversification of the ADH1B gene during expansion of modern humans
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
    Ann Hum Genet 75:497-507. 2011
    ..H7 is estimated to have expanded recently, around 2,800 years ago, and ancient DNA samples from North China confirm its presence about that time. The dating of the H7 expansion may help understand the selective force on the ADH1B gene...