James Leckman

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Biol Psychiatry 57:667-73. 2005
  2. ncbi request reprint Annotation: Tourette syndrome: a relentless drumbeat--driven by misguided brain oscillations
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Child Psychol Psychiatry 47:537-50. 2006
  3. pmc Symptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective
    James F Leckman
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    Dialogues Clin Neurosci 11:21-33. 2009
  4. ncbi request reprint Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Children s Clinical Research Center, and Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Brain Dev 25:S24-8. 2003
  5. ncbi request reprint Primary parental preoccupation: circuits, genes, and the crucial role of the environment
    J F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Neural Transm 111:753-71. 2004
  6. pmc Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study
    James F Leckman
    Child Study Center and the Yale Center for Clinical Investigation, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 50:108-118.e3. 2011
  7. pmc An evolutionary and developmental perspective
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    Biol Psychiatry 62:831-2. 2007
  8. ncbi request reprint Tourette syndrome: the self under siege
    James F Leckman
    Yale Child Study Center, New Haven, CT 06510, USA
    J Child Neurol 21:642-9. 2006
  9. ncbi request reprint Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-V
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    CNS Spectr 12:376-87, 400. 2007
  10. ncbi request reprint Development of the Yale Children's Global Stress Index (YCGSI) and its application in children and adolescents ith Tourette's syndrome and obsessive-compulsive disorder
    Diane B Findley
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 42:450-7. 2003

Detail Information

Publications89

  1. ncbi request reprint Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Biol Psychiatry 57:667-73. 2005
    ..This study was carried out to investigate whether cytokines associated with the innate immune response or T cell activation were altered under baseline conditions and during periods of symptom exacerbation...
  2. ncbi request reprint Annotation: Tourette syndrome: a relentless drumbeat--driven by misguided brain oscillations
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Child Psychol Psychiatry 47:537-50. 2006
    ..This annotation reviews recent evidence that points to the likely role of aberrant neural oscillations in the pathogenesis of Tourette syndrome (TS)...
  3. pmc Symptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective
    James F Leckman
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    Dialogues Clin Neurosci 11:21-33. 2009
    ....
  4. ncbi request reprint Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Children s Clinical Research Center, and Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Brain Dev 25:S24-8. 2003
    ..Future progress may also be expected as endophenotypes, and possibly genetic markers, are identified that are associated with specific comorbid conditions and etiologically distinct forms of TS...
  5. ncbi request reprint Primary parental preoccupation: circuits, genes, and the crucial role of the environment
    J F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Neural Transm 111:753-71. 2004
    ....
  6. pmc Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study
    James F Leckman
    Child Study Center and the Yale Center for Clinical Investigation, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 50:108-118.e3. 2011
    ..A group of children with Tourette syndrome and/or OC disorder without a PANDAS history served as the comparison (non-PANDAS) group...
  7. pmc An evolutionary and developmental perspective
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    Biol Psychiatry 62:831-2. 2007
  8. ncbi request reprint Tourette syndrome: the self under siege
    James F Leckman
    Yale Child Study Center, New Haven, CT 06510, USA
    J Child Neurol 21:642-9. 2006
    ....
  9. ncbi request reprint Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-V
    James F Leckman
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    CNS Spectr 12:376-87, 400. 2007
    ..Finally, existing assessment methods are inadequate and new dimensional scales are needed to take full advantage of a dimensional approach in clinical and population-based studies...
  10. ncbi request reprint Development of the Yale Children's Global Stress Index (YCGSI) and its application in children and adolescents ith Tourette's syndrome and obsessive-compulsive disorder
    Diane B Findley
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 42:450-7. 2003
    ..This study was designed to evaluate the psychometric properties of the YCGSI...
  11. ncbi request reprint Tic disorders: when habit forming neural systems form habits of their own?
    J F Leckman
    Child Study Center, Department of Pediatrics, Yale University, New Haven, CT 06520 7900, USA
    Zhonghua Yi Xue Za Zhi (Taipei) 64:669-92. 2001
    ..It is likely that the research paradigms utilized in these studies and many of the empirical findings resulting from them, will be relevant to other disorders of childhood onset and to our understanding of normal development...
  12. ncbi request reprint Preoccupations and behaviors associated with romantic and parental love. Perspectives on the origin of obsessive-compulsive disorder
    J F Leckman
    Child Adolesc Psychiatr Clin N Am 8:635-65. 1999
    ..Third, the authors evaluate the hypothesis that these highly conserved behavioral and neural systems and the genetic messages that guide their development are intimately involved in the pathogenesis of OCD...
  13. ncbi request reprint Tourette's syndrome
    James F Leckman
    Child Study Center and Departments of Paediatrics, Psychiatry, and Psychology, Yale University, New Haven, CT 06520 7900, USA
    Lancet 360:1577-86. 2002
    ..This seminar focuses on these changing views and offers a new perspective on our understanding of the pathogenesis of Tourette's syndrome and on principles for treatment of patients with this disorder...
  14. pmc Neurobiological substrates of Tourette's disorder
    James F Leckman
    Child Study Center, Yale University, New Haven, Connecticut 06520 7900, USA
    J Child Adolesc Psychopharmacol 20:237-47. 2010
    ..This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD)...
  15. ncbi request reprint Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003
    ..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...
  16. doi request reprint Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V
    James F Leckman
    Departments of Pediatrics and Psychology, Yale University, Child Study Center, New Haven, Connecticut, USA
    Depress Anxiety 27:507-27. 2010
    ..It is timely to reconsider the nosology of this disorder, assessing whether changes to diagnostic criteria as well as subtypes and specifiers may improve diagnostic validity and clinical utility...
  17. pmc Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Arch Pediatr Adolesc Med 160:65-9. 2006
    ..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
  18. pmc Streptococcal upper respiratory tract infections and psychosocial stress predict future tic and obsessive-compulsive symptom severity in children and adolescents with Tourette syndrome and obsessive-compulsive disorder
    Haiqun Lin
    Department of Epidemiology and Public Health, Yale Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut 06520 7900, USA
    Biol Psychiatry 67:684-91. 2010
    ..We then examined the power of GABHS infections and measures of psychosocial stress to predict future tic, obsessive-compulsive (OC), and depressive symptom severity...
  19. ncbi request reprint Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
    Michael H Bloch
    Yale Child Study Center, CT 06510, USA
    J Child Psychol Psychiatry 47:551-9. 2006
    ..Patients with TS have deficits on neuropsychological tests involving fine-motor coordination and visual-motor integration. We seek to determine if these neuropsychological tests are useful in predicting future symptom severity...
  20. pmc Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    Neurology 65:1253-8. 2005
    ..Currently no clinical measures can predict whose tic symptoms will persist into adulthood. Previous cross-sectional imaging studies have identified reduced caudate nucleus volumes in subjects with TS...
  21. ncbi request reprint A family study of early-onset obsessive-compulsive disorder
    Maria Conceição do Rosario-Campos
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 136:92-7. 2005
    ..Childhood onset OCD is a highly familial disorder. Some early-onset cases may represent a valid subgroup, with higher genetic loading and shared vulnerability with chronic tic disorders...
  22. ncbi request reprint Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment
    Denis G Sukhodolsky
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 42:98-105. 2003
    ..To examine the association of disruptive behavior with social, adaptive, and family functioning in Tourette's syndrome (TS) with and without comorbid attention-deficit/hyperactivity disorder (ADHD)...
  23. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
    ..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...
  24. doi request reprint Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder
    Angeli Landeros-Weisenberger
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Affect Disord 121:175-9. 2010
    ..Our objective was to replicate these results in OCD patients who participated in one of four randomized, placebo-controlled, clinical trials (RCT)...
  25. pmc Neuropsychological functioning in children with Tourette syndrome with and without attention-deficit/hyperactivity disorder
    Denis G Sukhodolsky
    Yale Child Study Center, 230 South Frontage Road, PO Box 207900, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 49:1155-64. 2010
    ..We examined neuropsychological functioning in relatively large and well-characterized samples of children categorized as TS, TS-plus-ADHD, ADHD, and unaffected controls...
  26. doi request reprint Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, PO Box 2070900, New Haven, CT 06520, USA
    Pediatrics 124:1085-93. 2009
    ....
  27. doi request reprint The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
    Denis G Sukhodolsky
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT, 06520, USA
    Eur Child Adolesc Psychiatry 16:51-9. 2007
    ..To examine the role of aberrant neural oscillatory activity in the pathophysiology of co-occurring Tourette Syndrome (TS) and Attention-Deficit/Hyperactivity Disorder (ADHD)...
  28. ncbi request reprint Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study
    Ivana Kawikova
    Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 61:273-8. 2007
    ..We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE])...
  29. ncbi request reprint Systematic review: pharmacological and behavioral treatment for trichotillomania
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 62:839-46. 2007
    ..Future therapy and pharmacotherapy studies in trichotillomania should employ larger sample sizes and intention-to-treat analysis and seek to validate clinical rating scales of trichotillomania severity...
  30. pmc Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder
    Haiqun Lin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Child Psychol Psychiatry 48:157-66. 2007
    ....
  31. doi request reprint Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 147:850-8. 2008
    ..Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD...
  32. doi request reprint Perfectionism and sensory phenomena: phenotypic components of obsessive-compulsive disorder
    Jennifer C Lee
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Compr Psychiatry 50:431-6. 2009
    ..The aim of the study was to investigate how perfectionism and sensory phenomena (SP) interact as possible phenotypic components of obsessive-compulsive disorder (OCD)...
  33. doi request reprint Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:884-93. 2009
    ..We sought to determine the relative efficacy of different medications in treating ADHD and tic symptoms in children with both Tourette's syndrome and ADHD...
  34. doi request reprint Randomized trial of anger control training for adolescents with Tourette's syndrome and disruptive behavior
    Denis G Sukhodolsky
    Yale Child Study Center, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 48:413-21. 2009
    ..To evaluate the efficacy of a 10-session individually administered anger control training (ACT) for adolescents with Tourette's syndrome (TS) and disruptive behavior...
  35. doi request reprint Clinical course of Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Psychosom Res 67:497-501. 2009
    ..The goal of this article was to review the long-term clinical course of tics and comorbid conditions in children with TS...
  36. doi request reprint Risk and resilience: early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes
    Hanna E Stevens
    230 S Frontage Rd, Yale Child Study Center, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:114-27. 2009
    ..To review the contributions of research on nonhuman primates, specifically macaque monkeys, to the understanding of early social stress and its effects on behavior and neurophysiology...
  37. doi request reprint Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report
    Ivana Kawikova
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 67:679-83. 2010
    ..We hypothesized that antineuronal antibodies may be elevated in patients (reflecting autoimmune processes), and levels of total immunoglobulins (Igs) may be decreased (reflecting immune deficiency)...
  38. doi request reprint Model curriculum for academic child and adolescent psychiatry training
    Dorothy Stubbe
    Department of Child and Adolescent Psychiatry, Yale Child Study Center, New Haven, CT 06520 7900, USA
    Acad Psychiatry 32:366-76. 2008
    ..The United States is facing a severe shortage of academic child and adolescent psychiatrists. This article reviews a model integrated pathway to improve recruitment...
  39. doi request reprint Meta-analysis of the symptom structure of obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, USA
    Am J Psychiatry 165:1532-42. 2008
    ..The authors conducted a meta-analysis to determine the factor structure of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist...
  40. doi request reprint Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome
    Maria G Motlagh
    Child Study Center, Yale University School of Medicine, I 383 SHM, 230 South Frontage Road, New Haven, CT 06520 7920, USA
    Eur Child Adolesc Psychiatry 19:755-64. 2010
    ..Efforts are needed to reduce the frequency of these risk factors in high-risk populations. Future studies, using genetically sensitive designs, are also needed to sort out the causal pathways...
  41. pmc Maternal brain response to own baby-cry is affected by cesarean section delivery
    James E Swain
    Yale Child Study Center, Program for Risk, Resilience and Recovery, USA
    J Child Psychol Psychiatry 49:1042-52. 2008
    ..Second, independent of mode of delivery, parental worries and mood are related to specific brain activations in response to own baby-cry...
  42. pmc Brain areas coactivating with motor cortex during chronic motor tics and intentional movements
    Michelle Hampson
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    Biol Psychiatry 65:594-9. 2009
    ....
  43. ncbi request reprint From too little too late to early and often: child psychiatry education during medical school (and before and after)
    Andres Martin
    Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    Child Adolesc Psychiatr Clin N Am 16:17-43, vii-viii. 2007
    ..We view our different programs as seamlessly interconnected with one another but present them as separate entities to facilitate the incorporation of different components into local realities...
  44. ncbi request reprint Maternal behavior and developmental psychopathology
    James F Leckman
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    Biol Psychiatry 51:27-43. 2002
    ..Future studies of genetic and environmental influences on maternal behavior have the potential to inform models of disease pathogenesis...
  45. pmc Adaptive, emotional, and family functioning of children with obsessive-compulsive disorder and comorbid attention deficit hyperactivity disorder
    Denis G Sukhodolsky
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Am J Psychiatry 162:1125-32. 2005
    ....
  46. ncbi request reprint Sudden death in a patient with Tourette syndrome during a clinical trial of ziprasidone
    Lawrence Scahill
    Child Study Center, School of Medicine and School of Nursing, Yale University, New Haven, CT 06520, USA
    J Psychopharmacol 19:205-6. 2005
  47. ncbi request reprint Age effects on antidepressant-induced manic conversion
    Andres Martin
    Child Study Center, The Department of Psychiatry, Yale University School of Medicine, New Haven, CN 06520 7900, USA
    Arch Pediatr Adolesc Med 158:773-80. 2004
    ..Antidepressant drug therapy can precipitate mania in vulnerable individuals, but little is known about the effects of age on this phenomenon...
  48. ncbi request reprint Expression of BEN, a member of TFII-I family of transcription factors, during mouse pre- and postimplantation development
    Dashzeveg Bayarsaihan
    Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Gene Expr Patterns 3:579-89. 2003
    ..5, during early gastrulation stage, BEN is localized in the cytoplasm. At later stages, BEN retains an extensive expression pattern in a variety of developing systems implicating its involvement in tissue development and organogenesis...
  49. pmc Homez, a homeobox leucine zipper gene specific to the vertebrate lineage
    Dashzeveg Bayarsaihan
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:10358-63. 2003
    ..We apply a duplication-degeneration-complementation model to explain how this family of genes has evolved...
  50. ncbi request reprint Influence of age and tic disorders on obsessive-compulsive disorder in a pediatric sample
    Larry Scahill
    Yale Child Study Center, and Yale School of Nursing, New Haven, Connecticut 06520, USA
    J Child Adolesc Psychopharmacol 13:S7-17. 2003
    ..Obsessive-compulsive disorder (OCD) is a heterogeneous disorder with emerging data suggesting that age of onset and/or the presence of tics may define clinically important subgroups...
  51. pmc Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
    Matthew W State
    Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4684-9. 2003
    ....
  52. ncbi request reprint Assessment of symptom exacerbations in a longitudinal study of children with Tourette's syndrome or obsessive-compulsive disorder
    Haiqun Lin
    Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 41:1070-7. 2002
    ..A second major aim was to assess whether fluctuations in tic and OC symptom severity covaried with one another...
  53. pmc Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome
    Heping Zhang
    Department of Epidemiology and Public Health, Yale Child Study Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hum Genet 70:896-904. 2002
    ..000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of.0001 for genomewide scans...
  54. pmc Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
    Paul S A Kalanithi
    Child Study Center and Department of Neurobiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 102:13307-12. 2005
    ..The imbalance in striatal and GPi inhibitory neuron distribution suggests that the functional dynamics of cortico-striato-thalamic circuitry are fundamentally altered in severe, persistent TS...
  55. ncbi request reprint Tourette syndrome and tic disorders: a decade of progress
    James E Swain
    Child Study Center of Yale University, New Haven, CT, USA
    J Am Acad Child Adolesc Psychiatry 46:947-68. 2007
    ..This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment...
  56. ncbi request reprint Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections
    Feng Luo
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
    Pediatrics 113:e578-85. 2004
    ..It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms...
  57. doi request reprint The human immune response to streptococcal extracellular antigens: clinical, diagnostic, and potential pathogenetic implications
    Dwight R Johnson
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Clin Infect Dis 50:481-90. 2010
    ..Although the importance of immunologic confirmation of infection is widely accepted, the immediate and long-term immunokinetics of the human antibody response are incompletely documented and poorly understood...
  58. pmc Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
    Yuko Kataoka
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:277-91. 2010
    ..The selective deficit of PV+ and cholinergic striatal interneurons in TS subjects may result in an impaired cortico/thalamic control of striatal neuron firing in TS...
  59. doi request reprint Consanguineous Iranian kindreds with severe Tourette syndrome
    Maria G Motlagh
    Child Study Center Yale University School of Medicine, New Haven, Connecticut 06520 7920, USA
    Mov Disord 23:2079-83. 2008
    ..Genotyping the affected and unaffected members of these pedigrees has the potential to identify rare recessive contributions to this disorder...
  60. pmc Genes controlling affiliative behavior as candidate genes for autism
    Carolyn M Yrigollen
    Department of Statistics, Department of Epidemiology and PublicHealth, Yale University, Newhaven, CT 06519 1124, USA
    Biol Psychiatry 63:911-6. 2008
    ..Autism spectrum disorders (ASD) are neurodevelopmental disorders of complex etiology, with a recognized substantial contribution of heterogeneous genetic factors; one of the core features of ASD is a lack of affiliative behaviors...
  61. ncbi request reprint Public health significance of tic disorders in children and adolescents
    Lawrence Scahill
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 96:240-8. 2005
    ..Community samples and recent investigations in clinical samples confirm that the presence of ADHD predicts greater disability than that associated with tic disorders alone...
  62. ncbi request reprint Antidepressant-induced manic conversion: a developmentally informed synthesis of the literature
    Christine J Lim
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Int Rev Neurobiol 65:25-52. 2005
  63. ncbi request reprint Disruptive behavior problems in a community sample of children with tic disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:184-90. 2006
  64. ncbi request reprint Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Sterling Hall of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:1-16. 2006
  65. ncbi request reprint The normalcy of neurosis: evolutionary origins of obsessive-compulsive disorder and related behaviors
    Diana L Feygin
    Child Study Center, Yale University, P O Box 207900, New Haven, CT 06520 7900, United States
    Prog Neuropsychopharmacol Biol Psychiatry 30:854-64. 2006
    ..These neural systems are also likely to underlie aspects of religious experience and ritual as well as the wonders of romantic and early parental love...
  66. doi request reprint Perceived quality of maternal care in childhood and structure and function of mothers' brain
    Pilyoung Kim
    Yale Program for Risk, Resilience and Recovery, Child Study Center, Yale University School of Medicine, USA
    Dev Sci 13:662-73. 2010
    ..These findings suggest that maternal care in childhood may be associated with anatomy and functions in brain regions implicated in appropriate responsivity to infant stimuli in human mothers...
  67. ncbi request reprint An animal model of Tourette's syndrome
    Jane R Taylor
    Child Study Center, Children s Clinical Research Center, School of Nursing, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Psychiatry 159:657-60. 2002
    ..An animal model was used to investigate an autoimmune etiology for some cases of Tourette's syndrome...
  68. ncbi request reprint Basal Ganglia volumes in patients with Gilles de la Tourette syndrome
    Bradley S Peterson
    Division of Child and Adolescent Psychiatry, The Department of Psychiatry, New York State Psychiatric Institute and Columbia University College of Physicians and Surgeons, New York 10032, USA
    Arch Gen Psychiatry 60:415-24. 2003
    ....
  69. ncbi request reprint Nurturing resilient children
    James F Leckman
    The Child Study Center, and the Departments of Psychiatry, Pediatrics and Psychology, Yale University
    J Child Psychol Psychiatry 48:221-3. 2007
  70. ncbi request reprint Principal components analysis of obsessive-compulsive disorder symptoms in children and adolescents
    S Evelyn Stewart
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 61:285-91. 2007
    ..The purpose of this study was to conduct an exploratory principal components analysis of obsessive-compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies...
  71. ncbi request reprint A controlled family study of attention-deficit/hyperactivity disorder and Tourette's disorder
    S Evelyn Stewart
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Am Acad Child Adolesc Psychiatry 45:1354-62. 2006
    ..Familial relationships between DSM-IV ADHD and TD are studied in TD+ADHD, TD-only (TD-ADHD), ADHD-only (ADHD-TD), and control groups...
  72. ncbi request reprint A primary candidate gene for obsessive-compulsive disorder
    James F Leckman
    Arch Gen Psychiatry 63:717-20. 2006
  73. ncbi request reprint Issues for DSM-V: how should obsessive-compulsive and related disorders be classified?
    David Mataix-Cols
    Am J Psychiatry 164:1313-4. 2007
  74. ncbi request reprint Obsessive-compulsive disorder: an open-label pilot trial of escitalopram
    Amanda Galvão-de Almeida
    Department of Psychiatry, Federal University of Bahia, Brazil
    CNS Spectr 12:519-24. 2007
    ..However, approximately 40% of patients do not have a significant improvement, suggesting that new medications are needed. This study was designed to investigate the treatment response to escitalopram in OCD patients...
  75. doi request reprint Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatment
    Aribert Rothenberger
    Eur Child Adolesc Psychiatry 16:1-4. 2007
    ....
  76. ncbi request reprint A developmental perspective on the controversy surrounding the use of SSRIs to treat pediatric depression
    James F Leckman
    Am J Psychiatry 164:1304-6. 2007
  77. doi request reprint Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults
    S Evelyn Stewart
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:763-72. 2008
    ..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
  78. ncbi request reprint Repetitive Transcranial Magnetic Stimulation of the Supplementary Motor Area in the treatment of Tourette Syndrome: report of two cases
    Antonio Mantovani
    Clin Neurophysiol 118:2314-5. 2007
  79. pmc Identification of pyruvate kinase as an antigen associated with Tourette syndrome
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Neuroimmunol 181:165-76. 2006
    ..These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders...
  80. ncbi request reprint A developmental and evolutionary perspective on obsessive-compulsive disorder: whence and whither compulsive hoarding?
    James F Leckman
    Am J Psychiatry 165:1229-33. 2008
  81. ncbi request reprint Obsessions and compulsions in anorexia nervosa subtypes
    Katherine A Halmi
    New York Presbyterian Hospital Westchester Division, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Int J Eat Disord 33:308-19. 2003
    ..We examined the type and frequency of characteristic OCD obsessions and compulsions in a large sample of AN patients...
  82. ncbi request reprint Altered interhemispheric connectivity in individuals with Tourette's disorder
    Kerstin J Plessen
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 74, New York, NY 10032, USA
    Am J Psychiatry 161:2028-37. 2004
    ..The authors assessed corpus callosum size and anatomical connectivity across the cerebral hemispheres in persons with Tourette's disorder...
  83. ncbi request reprint Obsessive-compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands
    Yukiko Kano
    Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan
    Psychiatry Clin Neurosci 58:348-52. 2004
    ..No significant relationship was observed between OCS in TS or ASD probands and OCS of their parents. Further studies on OCD and OCS including a dimensional approach within ASD families are needed...
  84. ncbi request reprint A multidimensional model of obsessive-compulsive disorder
    David Mataix-Cols
    Institute of Psychiatry, London
    Am J Psychiatry 162:228-38. 2005
    ..This heterogeneity can reduce the power and obscure the findings from natural history studies to genome scans, neuroimaging, and clinical trials. The authors review the evidence supporting a multidimensional model of OCD...
  85. ncbi request reprint Clinical characteristics of Tourette syndrome probands and relatives' risks
    Yukiko Kano
    J Am Acad Child Adolesc Psychiatry 41:1148-9. 2002
  86. ncbi request reprint Antineural antibody in patients with Tourette's syndrome and their family members
    Chin Bin Yeh
    Department of Psychiatry, Tri Service General Hospital, Taipei, Taiwan
    J Biomed Sci 13:101-12. 2006
    ..Future studies should investigate the interactions of genetics, environment, infectious agents, and immunity on symptom expression in families with tic disorders...
  87. ncbi request reprint Nurturing resilient children
    James F Leckman
    Rev Bras Psiquiatr 29:5-6. 2007
  88. doi request reprint Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections
    Harvey S Singer
    Division of Pediatric Neurology, Johns Hopkins Hospital, Rubenstein Child Health Building, Suite 2158, 200 N Wolfe St, Baltimore, MD 21287, USA
    Pediatrics 121:1198-205. 2008
    ....
  89. ncbi request reprint Development and natural history of mood disorders
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    Biol Psychiatry 52:529-42. 2002
    ..A diverse program of multidisciplinary research is recommended to reduce the burden on children and families affected with these conditions...

Research Grants12

  1. Research Education for Future Physician-Scientists in Child Psychiatry
    James Leckman; Fiscal Year: 2007
    ..Funds are also requested to support the national independent evaluation of both the KGT Foundation Medical Student Fellowship (at six sites) and the Integrated Research Pathway Program (at two sites). ..
  2. TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERS
    James Leckman; Fiscal Year: 2007
    ....
  3. Treatment of Tourette's Syndrome & Obsessive-Compulsive Disorder
    James Leckman; Fiscal Year: 2007
    ....
  4. A Prospective Longitudinal Study of PANDAS
    James Leckman; Fiscal Year: 2005
    ..These insights may be relevant to our understanding of other diseases including AIDS. ..