Rossitza Lazova

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Imaging mass spectrometry--a new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine and the Yale Cancer Center, New Haven, CT 06520, USA
    Am J Dermatopathol 34:82-90. 2012
  2. doi request reprint Promontory sign--present in patch and plaque stage of angiosarcoma!
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Am J Dermatopathol 31:132-6. 2009
  3. doi request reprint Leukocyte-cancer cell fusion: initiator of the warburg effect in malignancy?
    Rossitza Lazova
    Department of Dermatology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, 06520 8059, USA
    Adv Exp Med Biol 714:151-72. 2011
  4. doi request reprint P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Am Acad Dermatol 63:852-8. 2010
  5. ncbi request reprint The characteristic histopathologic features of nevi on and around the ear
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:40-4. 2005
  6. ncbi request reprint CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both?
    Jennifer M McNiff
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:541-5. 2005
  7. doi request reprint Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    Rossitza Lazova
    Departments of Dermatology and Pathology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 18:370-9. 2012
  8. doi request reprint Why do melanomas get so dark?
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Exp Dermatol 18:934-8. 2009
  9. doi request reprint Neuropilin-2 as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus
    Jade Wititsuwannakul
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Am Acad Dermatol 68:129-37. 2013
  10. doi request reprint P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin
    Alicia C Sigal
    Department of Dermatology, Yale University School of Medicine, 15 York Street, New Haven, CT 06520, USA
    Am J Dermatopathol 34:145-50. 2012

Collaborators

Detail Information

Publications33

  1. pmc Imaging mass spectrometry--a new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine and the Yale Cancer Center, New Haven, CT 06520, USA
    Am J Dermatopathol 34:82-90. 2012
    ..Differentiating Spitz nevus (SN) from Spitzoid malignant melanoma (SMM) is one the most difficult problems in dermatopathology...
  2. doi request reprint Promontory sign--present in patch and plaque stage of angiosarcoma!
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Am J Dermatopathol 31:132-6. 2009
    ..The presence of promontory sign has not been emphasized in lesions other than Kaposi sarcoma, but seems to be a feature that is not uncommon in patch/plaque stage AS...
  3. doi request reprint Leukocyte-cancer cell fusion: initiator of the warburg effect in malignancy?
    Rossitza Lazova
    Department of Dermatology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, 06520 8059, USA
    Adv Exp Med Biol 714:151-72. 2011
    ....
  4. doi request reprint P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Am Acad Dermatol 63:852-8. 2010
    ..Conventional melanocytic markers in SCM are usually negative...
  5. ncbi request reprint The characteristic histopathologic features of nevi on and around the ear
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:40-4. 2005
    ..The purpose of this study was to characterize the distinctive features of nevi with a junctional component located on and around the ear...
  6. ncbi request reprint CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both?
    Jennifer M McNiff
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:541-5. 2005
    ..In MCC altered by crush artifact or obscured by lymphocytes, the histologic features coupled with CD56 positivity can lead to an erroneous impression of NK-cell lymphoma...
  7. doi request reprint Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    Rossitza Lazova
    Departments of Dermatology and Pathology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 18:370-9. 2012
    ..Accordingly, we investigated LC3B as an autophagosome marker by analyzing nearly 1,400 tumors from 20 types of cancer, focusing on correlations with clinical outcomes in melanoma and breast cancer...
  8. doi request reprint Why do melanomas get so dark?
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Exp Dermatol 18:934-8. 2009
    ..In any event, pigmentation in melanoma, long considered as a secondary aspect of the malignancy, may be a visible warning that the cells have gained competence for invasion and metastasis...
  9. doi request reprint Neuropilin-2 as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus
    Jade Wititsuwannakul
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Am Acad Dermatol 68:129-37. 2013
    ..The distinction between SMM and SN remains one of the most difficult diagnostic problems in dermatopathology. Neuropilin-2 (NRP2) is a cytoplasmic/cell surface protein that is a mediator of melanoma-endothelial cell interaction...
  10. doi request reprint P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin
    Alicia C Sigal
    Department of Dermatology, Yale University School of Medicine, 15 York Street, New Haven, CT 06520, USA
    Am J Dermatopathol 34:145-50. 2012
    ..This marker exhibits greater sensitivity than S100 in identifying SCM and may be a useful diagnostic and ancillary stain especially in the setting of an S100 negative spindle cell neoplasm...
  11. ncbi request reprint Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans
    Jennifer M McNiff
    Departments of Dermatology and Pathology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 32:413-8. 2005
    ..Digital fibromas are common benign acral tumors typically reported as angiofibromas (AFs) or acquired digital fibrokeratomas (ADFs). Cellular variants are not well recognized...
  12. doi request reprint Fatal HHV6 infection in an immunocompromised patient presenting with skin involvement
    Anjela Galan
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 37:277-81. 2010
    ..Although rare, HHV6 virus may be an important pathogen in immunocompromised patients, and may present initially in the skin. Awareness of this infection is critical to diagnosis in acute settings...
  13. doi request reprint Multiple Spitz nevi: a clinicopathologic study of 9 patients
    Maya Zayour
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Acad Dermatol 67:451-8, 458.e1-2. 2012
    ..Whether agminated, within a speckled lentiginous nevus/nevus spilus, or randomly scattered, multiple Spitz nevi (SN), defined as two or more SN, is a rare entity...
  14. doi request reprint Dilated lymphatic vessels in tufted angioma: a potential source of diagnostic confusion
    Mona Sadeghpour
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Dermatopathol 34:400-3. 2012
    ..Accurate diagnosis of TA has important clinical implications given its occasional association with Kasabach-Merritt phenomenon, and the presence of lymphangioma-like vessels in biopsies of vascular lesions is entirely compatible with TA...
  15. doi request reprint The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA rossitza lazoraoyale edu
    Am J Dermatopathol 31:177-81. 2009
    ..Our data show a significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma...
  16. doi request reprint Pseudoepitheliomatous hyperplasia: a review
    Maya Zayour
    Dermatology and Pathology, Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Dermatopathol 33:112-22; quiz 123-6. 2011
    ..Herein, we review different inflammatory, infectious, and neoplastic skin diseases, in which florid epidermal hyperplasia is a prominent histopathologic feature, and introduce a systematic approach in the interpretation of PEH...
  17. doi request reprint Congenital melanocytic nevi
    Maya Zayour
    Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Lab Med 31:267-80. 2011
    ..The risk for development of malignant melanoma in association with a congenital melanocytic nevus and variable causes for changing mole are discussed...
  18. pmc Expression of tumor necrosis factor--related apoptosis-inducing ligand receptors 1 and 2 in melanoma
    Mary M McCarthy
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin Cancer Res 12:3856-63. 2006
    ..We assessed TRAIL-R1 and TRAIL-R2 expression patterns in a large cohort of melanomas and benign nevi...
  19. doi request reprint Autophagy in cutaneous malignant melanoma
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 37:256-68. 2010
    ..The results suggest that therapies inhibiting autophagy may be effective for the treatment of malignant melanoma by depriving cells of an important energy source...
  20. doi request reprint Expression of p16 alone does not differentiate between Spitz nevi and Spitzoid melanoma
    Ashley Mason
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 39:1062-74. 2012
    ..Spitz nevi and Spitzoid melanomas show overlapping histopathologic features, often making the diagnosis challenging. The p16 protein functions as a tumor suppressor and loss of its expression may be seen in some melanomas...
  21. doi request reprint The perichondrium in auricular melanomas: implications for surgical management
    E Stirling Craig
    Department of Plastic and Reconstructive Surgery, Yale School of Medicine, New Haven, Connecticut 06520 8062, USA
    Otolaryngol Head Neck Surg 148:431-5. 2013
    ..Given the paucity of cases, no standardized recommendations exist for tumor resection. In this study, we provide a pathologic basis in support of conservative tumor resection along the perichondrial plane...
  22. doi request reprint A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution
    Maya Zayour
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    Am J Dermatopathol 31:37-43. 2009
    ..Because most of these cases follow a relatively benign clinical course, we recommend a more conservative approach in the clinical management of these patients...
  23. ncbi request reprint Urticarial vasculitis in an infant
    Phoebe E Koch
    Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8059, USA
    Cutis 81:49-52. 2008
    ..His lesions appeared as erythematous wheals followed by the development of purpuric papules and resolving with ecchymoses and postinflammatory hyperpigmentation. Laboratory studies and skin biopsy results were consistent with UV...
  24. ncbi request reprint Bazex syndrome (acrokeratosis paraneoplastica)
    Brian Poligone
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Lancet 369:530. 2007
  25. ncbi request reprint Calciphylaxis associated with acute, reversible renal failure in the setting of alcoholic cirrhosis
    Severine M Chavel
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Am Acad Dermatol 50:S125-8. 2004
    ....
  26. ncbi request reprint Fatal childhood calciphylaxis in a 10-year-old and literature review
    Jing Feng
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Pediatr Dermatol 23:266-72. 2006
    ..Parathyroidectomy in combination with supportive medical management may be the best treatment option in stopping the progression of disease in the pediatric population...
  27. ncbi request reprint Minocycline hyperpigmentation isolated to the subcutaneous fat
    Zakia Rahman
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:516-9. 2005
    ..Special stain for iron was negative. This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron...
  28. pmc Iron in skin of mice with three etiologies of systemic iron overload
    Brian D Adams
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Invest Dermatol 125:1200-5. 2005
    ..It appears that neither Hfe deletion nor elevated skin iron alone can account for cutaneous manifestations reportedly seen in humans with hereditary hemochromatosis...
  29. ncbi request reprint Calcinosis cutis: a complication of intravenous administration of calcium glucanate
    Jeremy Moss
    Department of Dermatology, Yale University, New Haven, CT 06890, USA
    J Cutan Pathol 33:60-2. 2006
    ..While iatrogenic calcinosis cutis is generally a benign entity, it is important to recognize its unique clinical and histopathologic presentation to avoid complications from misdiagnosis...
  30. ncbi request reprint Cutaneous natural killer/T-cell lymphoma
    Michael A Radonich
    Department of Dermatology, Yale Dermatopathology Laboratory, Yale University School of Medicine, 15 York Street, New Haven, CT 06520 8059, USA
    J Am Acad Dermatol 46:451-6. 2002
    ..We report a case of aggressive NK-cell leukemia/lymphoma with numerous secondary cutaneous lesions and review the clinical and histopathologic spectrum of non-nasal CD56(+) lymphomas, with an emphasis on the dermatologic findings...
  31. ncbi request reprint Subcutaneous fat necrosis of the newborn presenting as a large plaque with lobulated cystic areas
    Erika Balfour
    Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Cutis 70:169-73. 2002
    ..Most cases are related to some form of fetal distress, including obstetric trauma. Some cases are associated with hypercalcemia. We report a case of SFN with an unusual clinical presentation, complicated by hypercalcemia...
  32. ncbi request reprint Cutaneous larva migrans with parts of the larva in the epidermis
    Erika Balfour
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cutis 69:368-70. 2002
    ..We report a case with parts of the larva migrans in the epidermis on histologic examination...
  33. ncbi request reprint Histopathologic misdiagnoses and their clinical consequences
    Ingrid H Olhoffer
    Arch Dermatol 138:1381-3. 2002