M L Landry

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Comparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Clinical Virology Laboratory, Yale New Haven Hospital, New Haven, Connecticut, USA
    J Clin Microbiol 52:3057-9. 2014
  2. ncbi request reprint Comparison of Binax NOW and Directigen for rapid detection of influenza A and B
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Virol 31:113-5. 2004
  3. pmc Cytospin-enhanced immunofluorescence and impact of sample quality on detection of novel swine origin (H1N1) influenza virus
    Marie L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    J Clin Microbiol 48:957-9. 2010
  4. doi request reprint Developments in immunologic assays for respiratory viruses
    Marie Louise Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Clin Lab Med 29:635-47. 2009
  5. pmc Detection of human metapneumovirus in clinical samples by immunofluorescence staining of shell vial centrifugation cultures prepared from three different cell lines
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, P O Box 208035, New Haven, CT 06520 8035, USA
    J Clin Microbiol 43:1950-2. 2005
  6. ncbi request reprint Herpes simplex virus type 2 acute retinal necrosis 9 years after neonatal herpes
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conneticut 06520 8035, USA
    J Pediatr 146:836-8. 2005
  7. pmc Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens
    Marie L Landry
    Department of Laboratory Medicine, P O Box 208035, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Microbiol 43:3136-9. 2005
  8. ncbi request reprint Herpes simplex type-2 meningitis: presentation and lack of standardized therapy
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Am J Med 122:688-91. 2009
  9. pmc Adenovirus type 3 outbreak in connecticut associated with a novel variant
    Marie L Landry
    Department of Laboratory Medicine, Yale New Haven Hospital, Yale University School of Medicine, Connecticut 06520 8035, USA
    J Med Virol 81:1380-4. 2009
  10. pmc False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing
    Marie L Landry
    Department of Laboratory Medicine, 333 Cedar Street, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Virol 43:247-9. 2008

Detail Information

Publications40

  1. ncbi request reprint Comparison of Simplexa Flu A/B & RSV PCR with Cytospin-Immunofluorescence and Laboratory-Developed TaqMan PCR in Predominantly Adult Hospitalized Patients
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Clinical Virology Laboratory, Yale New Haven Hospital, New Haven, Connecticut, USA
    J Clin Microbiol 52:3057-9. 2014
    ..The specificities were 99.6%, 100%, 100%, and 100%, respectively. The two Simplexa methods were more sensitive than the DFA (P = 0.0001) but less sensitive than the TaqMan reverse transcriptase PCR (P = 0.0001). ..
  2. ncbi request reprint Comparison of Binax NOW and Directigen for rapid detection of influenza A and B
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Virol 31:113-5. 2004
    ..9%) and 31 (52.5%) of 59 influenza-positive samples, respectively. In children under 2 years of age, sensitivity increased to 75% for both tests. Three samples tested falsely-positive for influenza B using Binax NOW...
  3. pmc Cytospin-enhanced immunofluorescence and impact of sample quality on detection of novel swine origin (H1N1) influenza virus
    Marie L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    J Clin Microbiol 48:957-9. 2010
    ..6%) of 272 swine influenza A PCR-positive results overall but 25 (92.6%) of 27 positive results in patients less than 5 years old and 208 (96.7%) of 215 positive samples with cycle threshold values of <26...
  4. doi request reprint Developments in immunologic assays for respiratory viruses
    Marie Louise Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Clin Lab Med 29:635-47. 2009
    ..This article discusses the major immunologic methods employed for respiratory virus diagnosis, recent developments in immunoassays and sample collection, and current test algorithms...
  5. pmc Detection of human metapneumovirus in clinical samples by immunofluorescence staining of shell vial centrifugation cultures prepared from three different cell lines
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, P O Box 208035, New Haven, CT 06520 8035, USA
    J Clin Microbiol 43:1950-2. 2005
    ..Detection of HMPV was similar in A549, HEp-2, and LLC-MK2 SVCC, and MAb-8 staining was optimal on day 2 postinoculation. Availability of SVCC for HMPV will be of significant benefit to clinical laboratories...
  6. ncbi request reprint Herpes simplex virus type 2 acute retinal necrosis 9 years after neonatal herpes
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conneticut 06520 8035, USA
    J Pediatr 146:836-8. 2005
    ..Pediatricians should be aware of this entity and alert to recurrences that may be delayed by years...
  7. pmc Real-time nucleic acid sequence-based amplification using molecular beacons for detection of enterovirus RNA in clinical specimens
    Marie L Landry
    Department of Laboratory Medicine, P O Box 208035, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Microbiol 43:3136-9. 2005
    ..5 h, hands-on time was reduced by 25 min, and the assay was much simpler for technologists to learn and perform...
  8. ncbi request reprint Herpes simplex type-2 meningitis: presentation and lack of standardized therapy
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Am J Med 122:688-91. 2009
    ..Herpes simplex type-2 (HSV-2) causes both primary and recurrent lymphocytic meningitis, but optimal patient management is not well defined...
  9. pmc Adenovirus type 3 outbreak in connecticut associated with a novel variant
    Marie L Landry
    Department of Laboratory Medicine, Yale New Haven Hospital, Yale University School of Medicine, Connecticut 06520 8035, USA
    J Med Virol 81:1380-4. 2009
    ..This outbreak represents the first detection of Ad3a51 in the United States. While most infections were mild, children under 3 were at increased risk for severe disease and one patient with underlying disease died...
  10. pmc False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testing
    Marie L Landry
    Department of Laboratory Medicine, 333 Cedar Street, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Virol 43:247-9. 2008
    ..Ultimately, brain biopsy established the diagnosis of progressive multifocal leukoencephalopathy (PML). Repeat PCR testing of the same CSF targeting a different region of the genome yielded a high positive result...
  11. doi request reprint Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, P O Box 208035, New Haven, CT, United States
    J Clin Virol 43:148-51. 2008
    ..Rapid tests have had a significant impact on influenza diagnosis, but more accurate tests are needed for hospitalized patients who test negative by rapid methods...
  12. doi request reprint Diagnostic tests for influenza infection
    Marie Louise Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Pediatr 23:91-7. 2011
    ..The 2009 H1N1 pandemic focused attention on the speed and accuracy of influenza diagnostic methods. This review provides an update on current tests and new developments...
  13. pmc Prospective study of human metapneumovirus detection in clinical samples by use of light diagnostics direct immunofluorescence reagent and real-time PCR
    Marie L Landry
    Department of Laboratory Medicine, Yale New Haven Hospital, and Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Microbiol 46:1098-100. 2008
    ..Of the 202 samples tested, 48 were positive by RT-PCR, and 41 (85.4%) of these were positive by DFA (P = 0.0771). The commercial availability of an HMPV DFA reagent will be of significant benefit to clinical laboratories...
  14. pmc 2-Hour cytomegalovirus pp65 antigenemia assay for rapid quantitation of cytomegalovirus in blood samples
    M L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Microbiol 38:427-8. 2000
    ..There was no significant difference in the number of positive cells detected per sample. The seven discrepant samples contained a median of only one positive cell...
  15. pmc Impact of sample type on rapid detection of influenza virus A by cytospin-enhanced immunofluorescence and membrane enzyme-linked immunosorbent assay
    M L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, New Haven, Connecticut 06520, USA
    J Clin Microbiol 38:429-30. 2000
    ..All 15 positive nasopharyngeal aspirates from children were detected by both tests. In contrast, 34 of 38 (89.5%) positive swabs from adults were detected by DFA, but only 25 (66%) were detected by ELISA...
  16. pmc SimulFluor respiratory screen for rapid detection of multiple respiratory viruses in clinical specimens by immunofluorescence staining
    M L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Microbiol 38:708-11. 2000
    ..The availability of a rapid DFA screening reagent for detection of multiple common respiratory viruses within 1 to 2 h of sample collection should be of great benefit in terms of patient management and infection control...
  17. pmc A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates
    M L Landry
    Yale University, New Haven, Connecticut, USA
    Antimicrob Agents Chemother 44:688-92. 2000
    ..This collaborative effort, by addressing these problems, represents a significant step toward the development of a standardized assay...
  18. pmc Use of plastic vacutainer tubes for quantification of human immunodeficiency virus type 1 in blood specimens
    M L Landry
    Clinical Virology Laboratory, Yale New Haven Hospital, New Haven, Connecticut 06520, USA
    J Clin Microbiol 39:354-6. 2001
    ..The results showed a strong correlation (P < 0.0001), and plastic tubes can be substituted for glass tubes...
  19. pmc Evaluation of biosite triage Clostridium difficile panel for rapid detection of Clostridium difficile in stool samples
    M L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, P O Box 208035, New Haven, CT 06520, USA
    J Clin Microbiol 39:1855-8. 2001
    ..difficile-negative patients. However, with Triage Panel common antigen-positive patients, a sensitive cytotoxin assay should be used to distinguish true cytotoxin-positive patients from C. difficile carriers...
  20. pmc Rapid enterovirus RNA detection in clinical specimens by using nucleic acid sequence-based amplification
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Microbiol 41:346-50. 2003
    ..The NucliSens Basic kit (bioMerieux) was utilized for RNA detection. For virus isolation, samples were inoculated into MRC-5, primary rhesus monkey kidney, A549, rhabdomyosarcoma, and/or Buffalo green monkey kidney cells...
  21. pmc Suboptimal detection of influenza virus in adults by the Directigen Flu A+B enzyme immunoassay and correlation of results with the number of antigen-positive cells detected by cytospin immunofluorescence
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, and Clinical Virology Laboratory, Yale New Haven Hospital, New Haven, Connecticut 06504, USA
    J Clin Microbiol 41:3407-9. 2003
    ..A positive EIA result usually correlated with 50 or more influenza virus cells positive by DFA...
  22. pmc Comparison of the NucliSens Basic kit (Nucleic Acid Sequence-Based Amplification) and the Argene Biosoft Enterovirus Consensus Reverse Transcription-PCR assays for rapid detection of enterovirus RNA in clinical specimens
    Marie L Landry
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Microbiol 41:5006-10. 2003
    ..5% of positive samples. NASBA could be completed in 6.5 h versus 9 h for the Argene Biosoft RT-PCR kit...
  23. pmc Comparison of SmartCycler real-time reverse transcription-PCR assay in a public health laboratory with direct immunofluorescence and cell culture assays in a medical center for detection of influenza A virus
    Nadia F Habib-Bein
    Yale University School of Medicine Yale New Haven Hospital, New Haven, Connecticut 06520 8035, USA
    J Clin Microbiol 41:3597-601. 2003
    ..7% sensitive and 100% specific compared to the results of culture and provided results within 2 h throughout operating hours, helping with bed allocation on admission and patient management...
  24. ncbi request reprint A 1-year experience with human metapneumovirus in children aged <5 years
    Frank Esper
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Infect Dis 189:1388-96. 2004
    ..Of hMPV-positive children, 60.4% were aged <12 months. hMPV accounted for a small but significant proportion of respiratory-tract disease in infants and children...
  25. pmc Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use
    Thuy Le
    Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 4:e6079. 2009
    ..Further, the clinical implications of low-abundance drug-resistant variants at time of virologic failure are unknown...
  26. ncbi request reprint Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease
    Richard A Martinello
    Department of Internal Medicine, Infectious Diseases Section, Yale University School of Medicine, New Haven, CT 06520, USA
    J Infect 53:248-54. 2006
    ..Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD...
  27. doi request reprint An outbreak of concurrent echovirus 30 and coxsackievirus A1 infections associated with sea swimming among a group of travelers to Mexico
    Elizabeth M Begier
    Infectious Diseases Division, Connecticut Department of Public Health, Hartford, Connecticut, USA
    Clin Infect Dis 47:616-23. 2008
    ..Enteroviruses are shed in human stool and can cause a wide spectrum of illness. They are the leading cause of aseptic meningitis...
  28. ncbi request reprint Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children
    Frank Esper
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Infect Dis 191:492-8. 2005
    ..We sought to determine whether novel human coronaviruses (HCoVs) are circulating in New Haven, Connecticut, and, if so, whether they are associated with respiratory tract disease in infants and young children...
  29. doi request reprint Rhinoviruses are a major cause of wheezing and hospitalization in children less than 2 years of age
    Zofia Piotrowska
    Division of Infectious Diseases, Yale University School of Medicine, New Haven, CT
    Pediatr Infect Dis J 28:25-9. 2009
    ..Human rhinoviruses (HRV) are now considered major respiratory pathogens. We sought to determine whether HRV are a cause of wheezing and/or hospitalization in children <2 years old...
  30. pmc In vitro amplification techniques for the detection of nucleic acids: new tools for the diagnostic laboratory
    D H Persing
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
    Yale J Biol Med 62:159-71. 1989
    ..The hope of these new technologies is to simplify yet improve on the sensitivity of nucleic acid-based tests to enable them to attain a more prominent place in the diagnostic repertoire of the clinical laboratory...
  31. pmc Comparison of BD GeneOhm Cdiff real-time PCR assay with a two-step algorithm and a toxin A/B enzyme-linked immunosorbent assay for diagnosis of toxigenic Clostridium difficile infection
    Elizabeth J Kvach
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    J Clin Microbiol 48:109-14. 2010
    ..1237). Enhanced sensitivity and rapid turnaround time make the BD GeneOhm Cdiff assay an important advance in the diagnosis of toxigenic C. difficile infection...
  32. ncbi request reprint Serum IgA antibodies to Epstein-Barr virus (EBV) early lytic antigens are present in primary EBV infection
    Sumita Bhaduri-McIntosh
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Infect Dis 195:483-92. 2007
    ..Detection of IgA antibodies to EA may be developed into a diagnostic tool for primary EBV infection...
  33. pmc Human metapneumovirus and severity of respiratory syncytial virus disease
    Isaac Lazar
    Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Emerg Infect Dis 10:1318-20. 2004
    ..Although HMPV was circulating in Connecticut, none of the 46 RSV-infected patients tested positive for HMPV. In our study population, HMPV did not contribute to the severity of RSV disease...
  34. ncbi request reprint Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus
    Deniz Kesebir
    Division of Respiratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Infect Dis 194:1276-82. 2006
    ..To further investigate the epidemiological profile and clinical characteristics of HBoV infection, we screened infants and children <2 years of age (hereafter referred to as "children") for HBoV...
  35. pmc WU polyomavirus in patients infected with HIV or hepatitis C virus, Connecticut, USA, 2007
    Michael A Miller
    Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Emerg Infect Dis 15:1095-7. 2009
    ..5%) of 79 hepatitis C virus (HCV)-positive serum specimens. KI polyomavirus was not detected in HIV-positive plasma or HCV-positive serum specimens. HIV-infected persons may be susceptible to systemic WUPyV infection...
  36. doi request reprint Educating medical students in laboratory medicine: a proposed curriculum
    Brian R Smith
    Dept of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Am J Clin Pathol 133:533-42. 2010
    ..This curriculum is presented as a potentially helpful outline for use by medical school faculty and curriculum committees...
  37. ncbi request reprint Association between a novel human coronavirus and Kawasaki disease
    Frank Esper
    Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Infect Dis 191:499-502. 2005
    ..0 [95% confidence interval, 3.4-74.4]; P=.0015). These data suggest that HCoV-NH infection is associated with Kawasaki disease...
  38. pmc Role of human polyomaviruses in respiratory tract disease in young children
    Rachel L Wattier
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Emerg Infect Dis 14:1766-8. 2008
    ..215). WU virus was detected in 26/367 (7.1%) symptomatic and 6/96 (6.3%) asymptomatic children (p = 1.00). These human polyomaviruses may not independently cause respiratory tract disease in young children...
  39. ncbi request reprint Frequency of normal cerebrospinal fluid protein level and leukocyte count in enterovirus meningitis
    Marie L Landry
    J Clin Virol 32:73-4. 2005
  40. pmc Coronavirus HKU1 infection in the United States
    Frank Esper
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Emerg Infect Dis 12:775-9. 2006
    ..Sequence analyses suggest that a single strain was circulating. HCoV-HKU1 is therefore likely circulating in the United States and is associated with upper and lower respiratory tract disease...