E K Lambe
Affiliation: Yale University
- Dyslexia, gender, and brain imagingE K Lambe
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
Neuropsychologia 37:521-36. 1999..Well-controlled studies, with large numbers of male and female dyslexics, may produce more sensitive and accurate identification of the neurological substrates of dyslexia...
- Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the ratE K Lambe
Interdepartmental Neuroscience Program, Section of Neurobiology, and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Cereb Cortex 10:974-80. 2000..The specific induction of EPSCs in layer V neurons suggests that 5-HT preferentially modulates the output neurons of the frontal cortex...
- The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortexE K Lambe
Interdepartmental Neuroscience Program and Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven Connecticut 06508, USA
J Neurosci 21:9955-63. 2001..These results indicate that blockade of Kv1.2-containing potassium channels is part of the mechanism underlying 5-HT-induced glutamate release from thalamocortical terminals...
- Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal sliceEvelyn K Lambe
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
Neuron 40:139-50. 2003..By this mechanism, the hypocretin projection to prefrontal cortex may play a larger role in prefrontal or "executive" aspects of alertness and attention than previously anticipated...
- Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in ratEvelyn K Lambe
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
J Neurosci 25:5225-9. 2005..We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex...
- Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptorsEvelyn K Lambe
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06508, USA
Neuropsychopharmacology 31:1682-9. 2006..Such recruitment could account for certain cognitive, affective, and sensory perturbations generated by psychedelic hallucinogens...
- Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkeyE K Lambe
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 20:8780-7. 2000..By contrast, 5-HT innervation of both types of neurons remains relatively constant over the age range studied...
- Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activationE K Lambe
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
Neuroscience 145:900-10. 2007..The tempering of network UP states by D1/D5 receptor activation may have implications for the proposed use of D1/D5 agonists in the treatment of schizophrenia...
- Schizophrenia, hypocretin (orexin), and the thalamocortical activating systemEvelyn K Lambe
Department of Physiology, University of Toronto, Toronto, Canada
Schizophr Bull 33:1284-90. 2007....
- Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant miceMaribel Rios
Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurobiol 66:408-20. 2006....
- Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinasesRong Jian Liu
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Eur J Neurosci 21:945-58. 2005..Increased calcium influx at higher firing rates, by activating tryptophan hydroxylase via CaMKII and PKA, can work together with tryptophan to enhance negative feedback control of the output of the serotonergic system...
- Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortexEvelyn K Lambe
Departments of Psychiatry and Pharmacology, Yale School of Medicine, New Haven, CT, USA
Neuropsychopharmacology 28:216-25. 2003..These findings give new insight into the mechanism by which nicotine affects excitatory neurotransmission to the output neurons of the cerebral cortex in a pathway that is critical for cognitive function and reward expectation...
- Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptorsSameera M Kassam
Departments of Physiology and Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada
J Neurosci 28:8756-64. 2008..In summary, we show that layer VI corticothalamic neurons can be strongly excited during development by an unusual subtype of nicotinic receptor...