Hugo Y K Lam

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc MOTIPS: automated motif analysis for predicting targets of modular protein domains
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 11:243. 2010
  2. pmc AlzPharm: integration of neurodegeneration data using RDF
    Hugo Y K Lam
    Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA
    BMC Bioinformatics 8:S4. 2007
  3. pmc Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project
    Xinmeng Jasmine Mu
    Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, W M Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 39:7058-76. 2011
  4. pmc Segmental duplications in the human genome reveal details of pseudogene formation
    Ekta Khurana
    Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Nucleic Acids Res 38:6997-7007. 2010
  5. pmc Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA
    Nat Biotechnol 28:47-55. 2010
  6. pmc Measuring the evolutionary rewiring of biological networks
    Chong Shou
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America
    PLoS Comput Biol 7:e1001050. 2011
  7. pmc Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history
    Philip M Kim
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Genome Res 18:1865-74. 2008
  8. pmc Pseudofam: the pseudogene families database
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 37:D738-43. 2009
  9. pmc Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
    Janine Mok
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Sci Signal 3:ra12. 2010
  10. pmc Tilescope: online analysis pipeline for high-density tiling microarray data
    Zhengdong D Zhang
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Genome Biol 8:R81. 2007

Collaborators

Detail Information

Publications12

  1. pmc MOTIPS: automated motif analysis for predicting targets of modular protein domains
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 11:243. 2010
    ..However, predicting domain targets by motif sequence alone without considering other genomic and structural information has been shown to be lacking in accuracy...
  2. pmc AlzPharm: integration of neurodegeneration data using RDF
    Hugo Y K Lam
    Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA
    BMC Bioinformatics 8:S4. 2007
    ....
  3. pmc Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project
    Xinmeng Jasmine Mu
    Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, W M Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 39:7058-76. 2011
    ....
  4. pmc Segmental duplications in the human genome reveal details of pseudogene formation
    Ekta Khurana
    Program in Computational Biology and Bioinformatics, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Nucleic Acids Res 38:6997-7007. 2010
    ....
  5. pmc Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA
    Nat Biotechnol 28:47-55. 2010
    ..As new data become available, we expect our BreakSeq approach will become more sensitive and facilitate rapid SV genotyping of personal genomes...
  6. pmc Measuring the evolutionary rewiring of biological networks
    Chong Shou
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America
    PLoS Comput Biol 7:e1001050. 2011
    ....
  7. pmc Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history
    Philip M Kim
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Genome Res 18:1865-74. 2008
    ..In addition to a coarse-grained analysis, we performed targeted sequencing of 67 CNVs and then analyzed a combined set of 270 CNVs (540 breakpoints) to verify our conclusions...
  8. pmc Pseudofam: the pseudogene families database
    Hugo Y K Lam
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    Nucleic Acids Res 37:D738-43. 2009
    ..The statistics also show how the number of genes and pseudogenes in families correlates across different species. Overall, they highlight the fact that housekeeping families tend to be enriched with a large number of pseudogenes...
  9. pmc Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
    Janine Mok
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Sci Signal 3:ra12. 2010
    ..Together, these results elucidate how kinase catalytic domains recognize their phosphorylation targets and suggest general avenues for the identification of previously unknown kinase substrates across eukaryotes...
  10. pmc Tilescope: online analysis pipeline for high-density tiling microarray data
    Zhengdong D Zhang
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Genome Biol 8:R81. 2007
    ..The program is designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page, downloadable for further analysis...
  11. pmc Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response
    Mei Zhong
    Department of Molecular Cellular Developmental Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS Genet 6:e1000848. 2010
    ..These results indicate distinct roles for this regulator in two different biological processes and demonstrate the versatility of transcription factors in mediating diverse biological roles...
  12. pmc SenseLab: new developments in disseminating neuroscience information
    Chiquito J Crasto
    Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Brief Bioinform 8:150-62. 2007
    ..We describe here: the new features for each database, the evolution of SenseLab's unifying database architecture and instances of SenseLab database interoperation with other neuroscience online resources...