J H Krystal

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Psychiatric disorders: diagnosis to therapy
    John H Krystal
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516, USA Electronic address
    Cell 157:201-14. 2014
  2. pmc Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 73:1133-41. 2013
  3. ncbi request reprint Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
    John H Krystal
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 63:957-68. 2006
  4. ncbi request reprint Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    CNS Drugs 24:669-93. 2010
  5. ncbi request reprint Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology
    John H Krystal
    Yale University School of Medicine, 950 Campbell Ave, West Haven, CT 06519, USA
    Isr J Psychiatry Relat Sci 39:89-91. 2002
  6. ncbi request reprint NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 169:215-33. 2003
  7. ncbi request reprint Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1793-800. 2006
  8. ncbi request reprint N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
    John H Krystal
    NIAAA Center for the Translational Neuroscience of Alcoholism, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Pharmacol Ther 99:79-94. 2003
  9. ncbi request reprint Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients
    John H Krystal
    Department of Veterans Affairs Alcohol Research Center, VA Connecticut Healthcare System 116 A, West Haven, CT, USA
    Neuropsychopharmacology 28:2020-8. 2003
  10. ncbi request reprint Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism"
    John H Krystal
    Alcohol Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:85-91. 2008

Research Grants

  1. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John H Krystal; Fiscal Year: 2010
  2. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2001
  3. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2003
  4. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2009
  5. CTR FOR TRANSLATIONAL NEUROSCIENCE OF ALCOHOL
    John Krystal; Fiscal Year: 2007
  6. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2007
  7. AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2007
  8. Novel Glutamatergic Detoxification Strategies
    John Krystal; Fiscal Year: 2006
  9. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2000
  10. NALTREXONE BLOCKADE OF NMDA
    John Krystal; Fiscal Year: 2002

Detail Information

Publications113 found, 100 shown here

  1. pmc Psychiatric disorders: diagnosis to therapy
    John H Krystal
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516, USA Electronic address
    Cell 157:201-14. 2014
    ....
  2. pmc Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 73:1133-41. 2013
    ..This article presents the path that led to the testing of ketamine, considers its promise as an antidepressant, and reviews novel treatment mechanisms that are emerging from this line of research...
  3. ncbi request reprint Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
    John H Krystal
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 63:957-68. 2006
    ..Advances in molecular neuroscience, genetics, and neuroimaging provide new insights into the role of brain GABA systems in short- and long-term alcohol effects...
  4. ncbi request reprint Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    CNS Drugs 24:669-93. 2010
    ..This review also links growing insights into the role of glutamate in the pathophysiology of these disorders to hypothesized mGluR-related treatment mechanisms...
  5. ncbi request reprint Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology
    John H Krystal
    Yale University School of Medicine, 950 Campbell Ave, West Haven, CT 06519, USA
    Isr J Psychiatry Relat Sci 39:89-91. 2002
  6. ncbi request reprint NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 169:215-33. 2003
    ..The purpose of this review is to consider the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia...
  7. ncbi request reprint Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1793-800. 2006
    ..However, these data suggest that at levels of NMDA receptor antagonism associated with heavy drinking, this protective effect of naltrexone on drinking is no longer present...
  8. ncbi request reprint N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
    John H Krystal
    NIAAA Center for the Translational Neuroscience of Alcoholism, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Pharmacol Ther 99:79-94. 2003
    ....
  9. ncbi request reprint Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients
    John H Krystal
    Department of Veterans Affairs Alcohol Research Center, VA Connecticut Healthcare System 116 A, West Haven, CT, USA
    Neuropsychopharmacology 28:2020-8. 2003
    ..The alterations in NMDA receptor function observed in recovering ethanol-dependent patients may have important implications for ethanol tolerance, ethanol dependence, and the treatment of alcoholism...
  10. ncbi request reprint Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism"
    John H Krystal
    Alcohol Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:85-91. 2008
    ..It is not clear whether naltrexone is effective in reducing alcohol consumption among patients with clinically significant mood symptoms and whether naltrexone favorably interacts with antidepressant medications when they are co-prescribed...
  11. ncbi request reprint The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neurotox Res 10:235-52. 2006
    ..The focus on distinctions between motivation and reward with respect to substance abuse risk by schizophrenic patients suggests a need for a reconsideration of the construct of "negative symptoms" for this dually-diagnosed patient group...
  12. ncbi request reprint Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function
    John H Krystal
    Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
    Arch Gen Psychiatry 62:985-94. 2005
    ..Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition...
  13. ncbi request reprint NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 1003:176-84. 2003
    ....
  14. ncbi request reprint What's missing in posttraumatic stress disorder research? Studies of human postmortem tissue
    John H Krystal
    Clinical Neurosciences Division, National Center for PTSD 116 A, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Psychiatry 67:398-403. 2004
  15. ncbi request reprint Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 179:303-9. 2005
    ..Some of the behavioral consequences of deficits in N-methyl-D-aspartate (NMDA) glutamate receptor function are thought to arise from the disinhibition of cortical glutamatergic circuitry...
  16. doi request reprint Capitalizing on extrasynaptic glutamate neurotransmission to treat antipsychotic-resistant symptoms in schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, Connecticut, USA
    Biol Psychiatry 64:358-60. 2008
  17. doi request reprint It is time to take a stand for medical research and against terrorism targeting medical scientists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 63:725-7. 2008
  18. ncbi request reprint Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
    J H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 7:S71-80. 2002
    ..Future research will be needed to develop and evaluate new agents with specific glutamate and GABA receptor targets in the treatment of mood disorders...
  19. pmc Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence
    John H Krystal
    Department of Psychiatry, NIAAA Center for the Translational Neuroscience of Alcoholism, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 36:701-10. 2011
    ..Thus, this study provided evidence that raising glycine levels accentuated the NMDA receptor antagonist-like effects of DCS and that alcohol-dependent patients showed tolerance to these DCS effects...
  20. ncbi request reprint Neuroplasticity as a target for the pharmacotherapy of psychiatric disorders: new opportunities for synergy with psychotherapy
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 62:833-4. 2007
  21. ncbi request reprint Interactive effects of subanesthetic ketamine and haloperidol in healthy humans
    J H Krystal
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Psychopharmacology (Berl) 145:193-204. 1999
    ..These data outline an important, but functionally delineated modulation of ketamine effects by dopamine2 receptors and other sites of haloperidol action...
  22. doi request reprint Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial
    John H Krystal
    Clinical Neuroscience Division, Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, USA
    JAMA 306:493-502. 2011
    ..Serotonin reuptake-inhibiting (SRI) antidepressants are the only FDA-approved pharmacotherapies for the treatment of posttraumatic stress disorder (PTSD)...
  23. ncbi request reprint Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders
    J H Krystal
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Med Clin North Am 85:559-77. 2001
    ..The current era is an exciting one for psychiatric research and the rapidity with which advances are being made is a source of hope to patients with these disorders and for society...
  24. ncbi request reprint Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients
    J H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Res 35:S35-49. 1999
    ..The relationship between these hypotheses and possible pharmacotherapeutic approaches for substance-abusing schizophrenic patients will be considered...
  25. pmc Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States
    Drug Discov Today 14:690-7. 2009
    ..In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia...
  26. ncbi request reprint Naltrexone in the treatment of alcohol dependence
    J H Krystal
    Department of Veterans Affairs Alcohol Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Conn
    N Engl J Med 345:1734-9. 2001
    ..Although naltrexone, an opiate-receptor antagonist, has been approved by the Food and Drug Administration for the treatment of alcohol dependence, its efficacy is uncertain...
  27. ncbi request reprint Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists
    A Anand
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Gen Psychiatry 57:270-6. 2000
    ..In this study, we tested the hypothesis that lamotrigine, a drug reported to inhibit glutamate release, will reduce the neuropsychiatric effects of ketamine in humans...
  28. ncbi request reprint Nicotine effects on brain function and functional connectivity in schizophrenia
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 100 York Street 28, West Haven, CT 06511, USA
    Biol Psychiatry 55:850-8. 2004
    ..Our primary aim was to determine whether nicotine improves cognitive function by facilitating activation of brain regions mediating task performance or by facilitating functional connectivity...
  29. ncbi request reprint Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy
    G Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 56:1043-7. 1999
    ..In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression...
  30. ncbi request reprint Greater vulnerability to the amnestic effects of ketamine in males
    Celia J A Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 187:405-14. 2006
    ....
  31. ncbi request reprint Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil
    A Abi-Dargham
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:1550-5. 1998
    ..The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [123I]iomazenil...
  32. ncbi request reprint Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients
    K L Behar
    Department of Neurology, Yale University, New Haven, CT 06520 8043, USA
    Am J Psychiatry 156:952-4. 1999
    ..The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy...
  33. pmc Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission
    Todd D Watson
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Neuropsychopharmacol 12:357-70. 2009
    ..Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing...
  34. ncbi request reprint Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients
    I L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 25:1151-5. 2001
    ..This study evaluated whether attenuation of serotonin synthesis via depletion of its precursor tryptophan reduces the magnitude of cue-induced craving for alcohol in recently abstinent alcoholic individuals...
  35. ncbi request reprint Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists
    E M Krupitsky
    Alcohol Research Center (116-A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Neuropsychopharmacology 25:936-47. 2001
    ..They also suggest that drugs, such as ethanol, that combine NMDA and L-type VSCC antagonism may have enhanced tolerability without attenuation of their stimulant effects...
  36. ncbi request reprint Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors
    Louis Trevisan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 32:36-42. 2008
    ....
  37. ncbi request reprint Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms
    Walid Abi-Saab
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    Psychopharmacology (Berl) 162:55-62. 2002
    ..Objectives: In order to test this hypothesis this study evaluated the capacity of pretreatment with the 5-HT(2) receptor antagonist ritanserin to attenuate the effects of the 5-HT agonist, m-chlorophenylpiperazine (mCPP)...
  38. pmc A neurobiological basis for substance abuse comorbidity in schizophrenia
    R A Chambers
    Ribicoff Research Facilities, West Haven Veterans Administration Hospital, Connecticut, USA
    Biol Psychiatry 50:71-83. 2001
    ..Thus, schizophrenic patients may have a predilection for addictive behavior as a primary disease symptom in parallel to, and in many, cases independent from, their other symptoms...
  39. ncbi request reprint Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans
    M Fujita
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Eur J Pharmacol 368:161-72. 1999
    ..Clinical effects showed corresponding changes 1-2 weeks after the changes in the receptor. Thus, the decrease of benzodiazepine receptor densities may be one of the major mechanisms for tolerance development in humans...
  40. ncbi request reprint Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy
    A W Goddard
    Yale Anxiety Clinic, Yale Department of Psychiatry, 100 York St, Room 2J, New Haven, CT 06511, USA
    Arch Gen Psychiatry 58:556-61. 2001
    ..The purpose of the present work was to determine whether cortical GABA levels are abnormally low in patients with panic disorder...
  41. doi request reprint beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
    Christoph Czermak
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Int J Neuropsychopharmacol 11:419-24. 2008
    ..66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development...
  42. pmc A prospective cohort study investigating factors associated with depression during medical internship
    Srijan Sen
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Gen Psychiatry 67:557-65. 2010
    ....
  43. pmc The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation
    Lingjun Zuo
    Departments of Psychiatry, West Haven Campus, Connecticut, USA
    Pharmacogenet Genomics 19:437-46. 2009
    ..We hypothesized that DTNBP1 might also influence the response to antipsychotic treatments. This study aimed to investigate the relationship between the DTNBP1 and the effects of clozapine and haloperidol on refractory schizophrenia...
  44. pmc Serotonin 1B receptor imaging in alcohol dependence
    Jian Hu
    Molecular Imaging Program, Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 67:800-3. 2010
    ..Because of its central role in AD, we were particularly interested in ventral striatal 5-HT(1B)R BP(ND) values...
  45. ncbi request reprint GABA and glutamate systems as therapeutic targets in depression and mood disorders
    Steven F Kendell
    Yale University School of Medicine, Department of Psychiatry, 333 Cedar Street, New Haven, CT 06510, USA
    Expert Opin Ther Targets 9:153-68. 2005
    ....
  46. ncbi request reprint The NMDA receptor as a therapeutic target in major depressive disorder
    Christopher Pittenger
    Department of Psychiatry, Yale University, USA
    CNS Neurol Disord Drug Targets 6:101-15. 2007
    ..Nevertheless, other effects of such medications, including both cognitive side effects and their psychotomimetic properties, complicate such an application and represent a challenge to the development of clinically useful agents...
  47. ncbi request reprint Psychiatric safety of ketamine in psychopharmacology research
    Edward B Perry
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 192:253-60. 2007
    ..Therefore, it is timely to revisit the safety of subanesthetic doses of ketamine in experimental psychopharmacology studies...
  48. ncbi request reprint NMDA receptor regulation of memory and behavior in humans
    J W Newcomer
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Hippocampus 11:529-42. 2001
    ....
  49. pmc Toward a neurobiology of delusions
    P R Corlett
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Centre, Abraham Ribicoff Research Facility, 34 Park Street, New Haven, CT 06519, USA
    Prog Neurobiol 92:345-69. 2010
    ..The present model attempts to provide a framework through which we can build a mechanistic and translational understanding of these puzzling symptoms...
  50. pmc Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence
    Naomi R Driesen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 64:1026-34. 2008
    ..This study featured a spatial working memory task, similar to that used in nonhuman primates, that was designed to facilitate separating brain activation into encoding, maintenance, and response phases...
  51. pmc Glutamatergic model psychoses: prediction error, learning, and inference
    Philip R Corlett
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 36:294-315. 2011
    ....
  52. pmc Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
    Synapse 64:729-32. 2010
    ..The decrease in beta(2)*-nAChR availability is influenced by alcohol consumption, suggesting the chronicity and severity of alcohol consumption may underlie persistent changes in beta(2)*-nAChR availability...
  53. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  54. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers...
  55. pmc New insights into the efficacy of naltrexone based on trajectory-based reanalyses of two negative clinical trials
    Ralitza Gueorguieva
    Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:1290-5. 2007
    ..The objective of this study was to identify distinct trajectories of daily drinking over time in two negative clinical trials and to determine whether naltrexone affected the probability to follow a particular trajectory...
  56. ncbi request reprint Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking
    Suchitra Krishnan-Sarin
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Biol Psychiatry 62:694-7. 2007
    ..The purpose of this study was to examine the interactive effects of family history of alcoholism (FH+, FH-) and naltrexone dose (0, 50, 100 mg/day) on alcohol drinking...
  57. ncbi request reprint Multidimensionality of the Alcohol Withdrawal Symptom Checklist: a factor analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar
    Brian Pittman
    NIAAA Center for the Translational Neuroscience of Alcoholism, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 31:612-8. 2007
    ....
  58. ncbi request reprint Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI
    Hilary P Blumberg
    Department of Psychiatry and Diagnostic Radiology and the Yale Child Study Center, Yale University School of Medicine, New Haven, Conn, 06516, USA
    Am J Psychiatry 160:1345-7. 2003
    ..This study investigated whether the functional abnormalities in prefrontal systems observed in adult bipolar disorder are manifested in adolescents with this illness...
  59. doi request reprint Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2218-26. 2009
    ..Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol...
  60. pmc Neural synchrony in schizophrenia: from networks to new treatments
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 33:848-52. 2007
    ..Based on this, we argue that we can begin to use oscillations, across frequencies, to do translational studies to understand the neural basis of schizophrenia...
  61. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  62. pmc Practitioner review: adolescent alcohol use disorders: assessment and treatment issues
    Francheska Perepletchikova
    Department of Psychiatry, Child and Adolescent Research and Education CARE Program, Yale University, UniversityTowers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    J Child Psychol Psychiatry 49:1131-54. 2008
    ..Alcohol use disorders in adolescents are associated with significant morbidity and mortality. Over the past decade, there has been a burgeoning of research on adolescent alcohol use disorders...
  63. ncbi request reprint Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 186:425-33. 2006
    ..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)...
  64. ncbi request reprint Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
    Joan Kaufman
    Child and Adolescent Research and Education Program, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 59:673-80. 2006
    ..Child abuse and genotype interact to contribute to risk for depression in children. This study examined gene-by-gene and gene-by-environment interactions...
  65. ncbi request reprint Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
    ..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men...
  66. pmc Abnormal hemodynamics in schizophrenia during an auditory oddball task
    Kent A Kiehl
    Clinical Cognitive Neuroscience Laboratory, Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, Connecticut 06106, USA
    Biol Psychiatry 57:1029-40. 2005
    ..This deficit in the processing of salience stimuli might be related to abnormalities in orienting, attention, and memory processes...
  67. ncbi request reprint gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA
    Biol Psychiatry 59:128-37. 2006
    ....
  68. ncbi request reprint Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 159:663-5. 2002
    ..The goal of this study was to determine whether these occipital cortex GABA concentrations are altered after administration of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression...
  69. ncbi request reprint Fore-period effect and stop-signal reaction time
    Chiang Shan Ray Li
    Connecticut Mental Health Center, S103 Department of Psychiatry, Yale University, 34 Park Street, New Haven, 06519, USA
    Exp Brain Res 167:305-9. 2005
    ..This finding suggests that response readiness needs to be accounted for in examining response inhibition in a stop-signal task...
  70. ncbi request reprint Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, VA Depression Research Center REAP, VA Connecticut Healthcare System 116 A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Ann N Y Acad Sci 1021:376-83. 2004
    ..This potential neurodevelopmental model for BD could have important implications for the recognition of early signs of the disorder and for age-specific treatment strategies...
  71. pmc Social supports and serotonin transporter gene moderate depression in maltreated children
    Joan Kaufman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 101:17316-21. 2004
    ....
  72. ncbi request reprint Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder
    Hilary P Blumberg
    Mood Disorders Research Program, Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 183:308-13. 2005
    ..Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets...
  73. ncbi request reprint Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking
    Graeme F Mason
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
    Biol Psychiatry 59:85-93. 2006
    ..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
  74. ncbi request reprint Extracellular metabolites in the cortex and hippocampus of epileptic patients
    Idil Cavus
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Ann Neurol 57:226-35. 2005
    ..Our data suggest that a different neurometabolic process underlies the neocortical epilepsies...
  75. ncbi request reprint The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 26:969-75. 2002
    ....
  76. ncbi request reprint Increased cortical GABA concentrations in depressed patients receiving ECT
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:577-9. 2003
    ..The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT...
  77. ncbi request reprint Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Psychopharmacology (Berl) 172:291-7. 2004
    ..The purpose of this study was to evaluate the efficacy of naltrexone in alcohol-abusing schizophrenic patients...
  78. ncbi request reprint Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 59:611-8. 2006
    ..However, the developmental trajectory of VPFC morphological abnormalities in BD is unknown. This study investigated potential age-dependent volume abnormalities in VPFC in BD...
  79. ncbi request reprint Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Arch Gen Psychiatry 60:1201-8. 2003
    ..Appreciation of whether volumetric abnormalities are early features of BD or whether the abnormalities represent neurodegenerative changes associated with illness duration is limited by the paucity of data in juvenile samples...
  80. ncbi request reprint Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 20 York St LV108, New Haven, CT 06504, USA
    Arch Gen Psychiatry 60:49-56. 2003
    ..We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication...
  81. ncbi request reprint Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    Ismene L Petrakis
    West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:1776-82. 2004
    ....
  82. ncbi request reprint Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06511, USA
    Psychopharmacology (Berl) 173:383-90. 2004
    ..Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence...
  83. ncbi request reprint Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial
    Vladimir Coric
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Biol Psychiatry 58:424-8. 2005
    ..Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD...
  84. ncbi request reprint Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 61:705-13. 2004
    ..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects...
  85. pmc Working memory overload: fronto-limbic interactions and effects on subsequent working memory function
    Richard J Yun
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Brain Imaging Behav 4:96-108. 2010
    ..These findings suggest that vulnerability to overload effects in cognitive functioning may be mediated by reduced amygdala suppression and subsequent amygdala-prefrontal interaction...
  86. ncbi request reprint Clinical studies implementing glutamate neurotransmission in mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06519, USA
    Ann N Y Acad Sci 1003:292-308. 2003
    ..Here we review the available literature in the field and suggest a possible pathophysiological model that may account for the many of the findings...
  87. pmc Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    Biol Psychiatry 57:44-8. 2005
    ..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers...
  88. ncbi request reprint Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 100 York Street 2B, New Haven, CT 06511, USA
    Biol Psychiatry 57:56-66. 2005
    ..We tested for evidence of acute and chronic effects of tobacco smoking on cognition in adolescents who smoked tobacco daily and were compared with adolescent nonsmokers...
  89. ncbi request reprint The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Psychopharmacol 21:414-20. 2007
    ..While preliminary, the results suggest that serotonin may be less critical to the pathogenesis of depression during the menopause...
  90. pmc Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Bipolar Disord 7:570-6. 2005
    ..Here we use a within-subject longitudinal design to investigate whether amygdala volume abnormalities persist in adolescents and young adults with BD over a time interval of approximately 2 years...
  91. doi request reprint Sex-related differences in amygdala activity influences immediate memory
    Deane E Aikins
    Department of Psychiatry, Yale University, USA
    Neuroreport 21:273-6. 2010
    ..Our results indicate that increased amygdala activation while viewing unpleasant pictures may preferentially facilitate immediate recognition memory in men relative to women...
  92. ncbi request reprint A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices
    Hilary P Blumberg
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 60:601-9. 2003
    ..We sought to characterize state- and trait-related functional impairment in frontal systems in bipolar disorder...
  93. ncbi request reprint Cerebral metabolic effects of intravenous glycine in healthy human subjects
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    J Clin Psychopharmacol 26:595-9. 2006
    ....
  94. pmc Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation
    Ralph E Hoffman
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Cereb Cortex 17:2733-43. 2007
    ..These findings suggest that dominant hemisphere temporoparietal areas are involved in expressing AVHs, with higher levels of coactivation and/or coupling involving inferior frontal regions reinforcing underlying pathophysiology...
  95. ncbi request reprint MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases
    Graeme F Mason
    Department of Diagnostic Radiology, Yale University, School of Medicine, 300 Cedar St, New Haven, CT 06520 8043, USA
    NMR Biomed 19:690-701. 2006
    ..The third major direction of this article is the discussion of where MRS techniques are headed and how those new techniques can contribute to studies of mechanisms of psychiatric disease and drug discovery...
  96. ncbi request reprint CSF monoamine metabolite and beta endorphin levels in recently detoxified alcoholics and healthy controls: prediction of alcohol cue-induced craving?
    I L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 23:1336-41. 1999
    ..It also evaluated whether these CSF measures levels predicted the degree of craving experienced in response to an alcohol cue...
  97. ncbi request reprint Quantitative morphology of the caudate and putamen in patients with cocaine dependence
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 158:486-9. 2001
    ....
  98. pmc Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans
    N R Driesen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 18:1199-204. 2013
    ..This study supports the hypothesis that pathological increases in resting brain functional connectivity contribute to the emergence of positive and negative symptoms associated with schizophrenia. ..
  99. ncbi request reprint Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation
    N N Boutros
    Yale University School of Medicine and VA-Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 49:369-73. 2001
    ..We hypothesize that this observation reflects adaptation to those effects of cocaine intoxication that promote cortical excitability and seizures...
  100. ncbi request reprint Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus
    J Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 9:312-9. 2004
    ..16 cM on chromosome 1. In addition, these results provide independent confirmation of the linkage finding regarding the identification of at least one gene in this region increasing the risk for alcohol dependence...
  101. ncbi request reprint Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI
    A Belger
    Cognitive Neuroscience Laboratory, VA Medical Center, West Haven, Connecticut 06516, USA
    Hum Brain Mapp 6:14-32. 1998
    ..The results also affirm the distinction between spatial and object perceptual processing in dorsal and ventral visual pathways...

Research Grants20

  1. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John H Krystal; Fiscal Year: 2010
    ....
  2. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2001
    ..Thus, this proposal would provide a multi-dimensional evaluation of GABA disturbances that may help to clarify both the pharmacologic and neurotoxic consequences of alcoholism. ..
  3. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2003
    ..Thus, this proposal would provide a multi-dimensional evaluation of GABA disturbances that may help to clarify both the pharmacologic and neurotoxic consequences of alcoholism. ..
  4. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2009
    ....
  5. CTR FOR TRANSLATIONAL NEUROSCIENCE OF ALCOHOL
    John Krystal; Fiscal Year: 2007
    ..Further it will continue to promote translational research through sponsorship of educational programs, such as the NIAAA-supported International Conference on the Applications of Neuroimaging to Alcoholism. ..
  6. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2007
    ....
  7. AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2007
    ..abstract_text> ..
  8. Novel Glutamatergic Detoxification Strategies
    John Krystal; Fiscal Year: 2006
    ..abstract_text> ..
  9. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2000
    ..Thus, this proposal would provide a multi-dimensional evaluation of GABA disturbances that may help to clarify both the pharmacologic and neurotoxic consequences of alcoholism. ..
  10. NALTREXONE BLOCKADE OF NMDA
    John Krystal; Fiscal Year: 2002
    ..Thus, the blockade of the rewarding effects of ketamine by naltrexone may provide insight into an important mechanism underlying the psychopharmacology of ethanol and the treatment of alcoholism. ..
  11. NALTREXONE BLOCKADE OF NMDA
    John Krystal; Fiscal Year: 2001
    ..Thus, the blockade of the rewarding effects of ketamine by naltrexone may provide insight into an important mechanism underlying the psychopharmacology of ethanol and the treatment of alcoholism. ..
  12. NALTREXONE BLOCKADE OF NMDA
    John Krystal; Fiscal Year: 2000
    ..Thus, the blockade of the rewarding effects of ketamine by naltrexone may provide insight into an important mechanism underlying the psychopharmacology of ethanol and the treatment of alcoholism. ..
  13. Symposium on Neuroimaging in Alcoholism
    John Krystal; Fiscal Year: 2007
    ....
  14. Symposium on Neuroimaging in Alcoholism
    John Krystal; Fiscal Year: 2003
    ..A call for abstracts also will bring forward names and ideas from other groups that might be added to the main program. Young Investigator travel scholarships will be considered. ..
  15. AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2003
    ..In summary, this K02 award would foster my academic development and enable me to better contribute to the building of pathophysiologic models of alcoholism that can guide medications development for this disorder. ..
  16. CORTICAL GABA FUNCTION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2002
    ..Thus, this proposal would provide a multi-dimensional evaluation of GABA disturbances that may help to clarify both the pharmacologic and neurotoxic consequences of alcoholism. ..