Diane Krause

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Lack of a fusion requirement for development of bone marrow-derived epithelia
    Robert G Harris
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 305:90-3. 2004
  2. ncbi request reprint Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
  3. pmc Bone marrow-derived lung epithelial cells
    Diane S Krause
    Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA
    Proc Am Thorac Soc 5:699-702. 2008
  4. pmc Bone marrow-derived cells and stem cells in lung repair
    Diane S Krause
    Department of Laboratory Medicine, Yale University, 333 Cedar St, Stem Cell Program, PO Box 208073, New Haven, CT 06520 8073, USA
    Proc Am Thorac Soc 5:323-7. 2008
  5. ncbi request reprint Engraftment of bone marrow-derived epithelial cells
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1044:117-24. 2005
  6. pmc Detection of bone marrow-derived lung epithelial cells
    Susannah H Kassmer
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06509, USA
    Exp Hematol 38:564-73. 2010
  7. ncbi request reprint The importance of National Blood Foundation funding
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    Transfusion 45:67S-71S. 2005
  8. ncbi request reprint Regulation of hematopoietic stem cell fate
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, CT 06520 8035, USA
    Oncogene 21:3262-9. 2002
  9. pmc Bone marrow-derived cells contribute to epithelial engraftment during wound healing
    Xenia Borue
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Am J Pathol 165:1767-72. 2004
  10. pmc Role for MKL1 in megakaryocytic maturation
    Ee Chun Cheng
    Department of Laboratory Medicine, Yale University, New Haven, CT 06520 8073, USA
    Blood 113:2826-34. 2009

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Lack of a fusion requirement for development of bone marrow-derived epithelia
    Robert G Harris
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 305:90-3. 2004
    ..We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion...
  2. ncbi request reprint Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
    ..This finding may contribute to clinical treatment of genetic disease or tissue repair...
  3. pmc Bone marrow-derived lung epithelial cells
    Diane S Krause
    Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA
    Proc Am Thorac Soc 5:699-702. 2008
    ..Once these important concerns are addressed, further studies on the function(s) of these cells will need to be performed to determine whether this engraftment has any clinical significance-either beneficial or detrimental...
  4. pmc Bone marrow-derived cells and stem cells in lung repair
    Diane S Krause
    Department of Laboratory Medicine, Yale University, 333 Cedar St, Stem Cell Program, PO Box 208073, New Haven, CT 06520 8073, USA
    Proc Am Thorac Soc 5:323-7. 2008
    ..Potential mechanisms underlying the appearance of marrow-derived epithelial cells, and the role of tissue damage are discussed...
  5. ncbi request reprint Engraftment of bone marrow-derived epithelial cells
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1044:117-24. 2005
    ..This frequency is likely to be too low to be of therapeutic relevance. Therefore, future efforts will need to be focused on enhancing levels of engraftment...
  6. pmc Detection of bone marrow-derived lung epithelial cells
    Susannah H Kassmer
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06509, USA
    Exp Hematol 38:564-73. 2010
    ....
  7. ncbi request reprint The importance of National Blood Foundation funding
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    Transfusion 45:67S-71S. 2005
    ..The work that was funded by the NBF has led my laboratory down many new avenues of research, all of which have been exciting and rewarding...
  8. ncbi request reprint Regulation of hematopoietic stem cell fate
    Diane S Krause
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, CT 06520 8035, USA
    Oncogene 21:3262-9. 2002
  9. pmc Bone marrow-derived cells contribute to epithelial engraftment during wound healing
    Xenia Borue
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Am J Pathol 165:1767-72. 2004
    ....
  10. pmc Role for MKL1 in megakaryocytic maturation
    Ee Chun Cheng
    Department of Laboratory Medicine, Yale University, New Haven, CT 06520 8073, USA
    Blood 113:2826-34. 2009
    ..In conclusion, MKL1 promotes physiologic maturation of human and murine megakaryocytes...
  11. ncbi request reprint Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
    J Dawn Abbott
    Department of Cardiology, Yale University Medical School, New Haven, Conn, USA
    Circulation 110:3300-5. 2004
    ..The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1alpha (SDF-1) in this process...
  12. ncbi request reprint Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice
    Emanuela M Bruscia
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, Connecticut 06520 8035, USA
    Stem Cells 24:2299-308. 2006
    ..However, BMT into newborn mice, regardless of the myeloablative regimen used, did not increase the number of bone marrow-derived epithelial cells over that which occurs after BMT into lethally irradiated adult mice...
  13. ncbi request reprint Plasticity of marrow-derived stem cells
    Erica L Herzog
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Blood 102:3483-93. 2003
    ..Only after we have a better understanding of the mechanisms involved and of the cells required for this differentiation will we be able to fully harness adult stem cell plasticity for clinical purposes...
  14. pmc C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx
    Stephanie Halene
    Section of Hematology, Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8073, USA
    Exp Hematol 38:90-103. 2010
    ..Although the specific granule deficiency phenotype has been replicated in C/EBPepsilon(-/-) (knockout [KO]) mice, the mechanisms by which C/EBPepsilon mutations act to decrease neutrophil function are not entirely clear...
  15. pmc Engraftment of marrow-derived epithelial cells: the role of fusion
    Erica L Herzog
    Department of Laboratory Medicine, 333 Cedar Street, P O Box 208035, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Proc Am Thorac Soc 3:691-5. 2006
    ..This article discusses the processes leading to the appearance of marrow-derived pneumocytes and highlights the therapeutic potential of bone marrow to fuse with or differentiate into epithelial cells of the lung...
  16. ncbi request reprint Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium
    Joanna E Grove
    Department of Laboratory Medicine, Yale University, New Haven, Connecticut, USA
    Am J Respir Cell Mol Biol 27:645-51. 2002
    ....
  17. pmc Hepatocyte nuclear factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice
    E Scott Swenson
    Section of Digestive Diseases, Yale University School of Medicine, LMP 1080, New Haven, Connecticut 06520 8019, USA
    Stem Cells 26:1768-77. 2008
    ..The use of a nuclear marker of mature hepatocytes or cholangiocytes, such as HNF1, improves discrimination of marrow-derived epithelial cells in tissue sections...
  18. ncbi request reprint Circulating stem cells in extremely preterm neonates
    Matthew J Bizzarro
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Acta Paediatr 96:521-5. 2007
    ..To measure circulating CD34+ cell levels in premature neonates and to correlate the initial CD34+ counts with measures of pulmonary function and neonatal morbidity...
  19. pmc Serum response factor is an essential transcription factor in megakaryocytic maturation
    Stephanie Halene
    Department of Internal Medicine and Yale Cancer Center, Section of Hematology, 333 Cedar Street, New Haven, CT 06520, USA
    Blood 116:1942-50. 2010
    ..Critical actin cytoskeletal genes are down-regulated in KO megakaryocytes. Thus, Srf is required for normal megakaryocyte maturation and platelet production partly because of regulation of cytoskeletal genes...
  20. ncbi request reprint Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation
    Erica L Herzog
    Yale University School of Medicine, Internal Medicine Pulmonary and Critical Care Division, 333 Cedar St, TAC 441 S, New Haven CT 06511, USA
    FASEB J 21:2592-601. 2007
    ..This process does not reverse inflammation caused by Sp-C deficiency; nevertheless, further investigation may identify phenotypes benefiting from such an approach...
  21. ncbi request reprint The commonly used beta-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis
    Jian Kan Guo
    Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, 333 Cedar St, P O Box 208029, New Haven, CT 06520, USA
    Transgenic Res 16:829-34. 2007
    ..Moreover, experiments using this strain of GFP mouse should be hereafter carefully planned because its renal pathology may interfere with data interpretation...
  22. pmc Chimeric mice reveal clonal development of pancreatic acini, but not islets
    E Scott Swenson
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 330 Cedar St, LMP 1080, New Haven, CT 06520 8019, USA
    Biochem Biophys Res Commun 379:526-31. 2009
    ..Male-female chimeric mice demonstrate that the adult mouse exocrine pancreatic acinus is patterned from a single stem/progenitor cell, while the endocrine pancreas arises from multiple progenitors...
  23. ncbi request reprint Limitations of green fluorescent protein as a cell lineage marker
    E Scott Swenson
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Stem Cells 25:2593-600. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  24. pmc Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration
    E Scott Swenson
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    Liver Int 28:308-18. 2008
    ..Stem cell factor (SCF) and stromal-derived factor-1 (SDF-1) regulate the regenerative response to liver injury, possibly through activation of liver progenitor 'oval' cells and recruitment of circulating, marrow-derived progenitors...
  25. ncbi request reprint Threshold of lung injury required for the appearance of marrow-derived lung epithelia
    Erica L Herzog
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Stem Cells 24:1986-92. 2006
    ..2%) were present at 28 days. These data indicate a critical relationship between lung injury and the phenotypic change from BMDCs to lung epithelial cells...
  26. ncbi request reprint Plasticity of bone marrow-derived stem cells
    Joanna E Grove
    Department of Laboratory Medicine, Yale University School of Medicine, P O Box 8035, 333 Cedar Street, New Haven, CT 06520 8035, USA
    Stem Cells 22:487-500. 2004
    ..Also reviewed is the possibility that adult BMCs can change their gene expression profile after fusion with a mature cell, which has brought into question whether this stem cell plasticity is real...
  27. ncbi request reprint Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library
    Xianyong Ma
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Blood 100:833-44. 2002
    ..med.yale.edu/, allows for retrieval of information regarding these genes. Our microarray allows for genomewide expression analysis of myeloid stem cells, which will help in defining the regulatory mechanisms of stem cell differentiation...
  28. pmc SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis
    Luyang Yu
    Interdepartmental Program in Vascular Biology and Therapeutics, Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 207:1183-95. 2010
    ..Collectively, we conclude that SENP1 promotes GATA1 activation and subsequent erythropoiesis by deSUMOylating GATA1...
  29. pmc Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons
    Christine Radtke
    Department of Neurology, LCI 7, P O Box 208018, Yale University School of Medicine, New Haven, CT 06516, USA
    Neurosci Lett 387:85-9. 2005
    ..6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons...
  30. pmc Bone marrow stem cells contribute to repair of the ischemically injured renal tubule
    Sujata Kale
    Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06437, USA
    J Clin Invest 112:42-9. 2003
    ..Thus, therapies aimed at enhancing the mobilization, propagation, and/or delivery of bone marrow stem cells to the kidney hold potential as entirely new approaches for the treatment of acute tubular necrosis...
  31. ncbi request reprint A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment
    Maria K Angelopoulou
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Transfusion 44:555-66. 2004
    ..Delayed megakaryocytic engraftment occurs in approximately 8 percent of patients undergoing autologous transplantation with PBPCs, and a reliable assay to predict engraftment is not yet available...
  32. ncbi request reprint Engraftment of bone marrow-derived epithelial cells
    John S Van Arnam
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Stem Cell Rev 1:21-7. 2005
    ....
  33. pmc Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?
    Diane Krause
    Department of Laboratory Medicine and Department of Internal Medicine, Yale University, New Haven, CT 06520, USA
    J Clin Invest 115:1705-8. 2005
    ..Importantly, both groups conclude that the majority of tubule repair occurs via proliferation of endogenous renal cells rather than incorporation of bone marrow-derived cells...
  34. pmc Influence of culture medium on smooth muscle cell differentiation from human bone marrow-derived mesenchymal stem cells
    Zhaodi Gong
    Department of Anesthesiology and Biomedical Engineering, Vascular Biology and Transplantation VBT Program, Yale University School of Medicine, New Haven, Connecticut 06520 8089, USA
    Tissue Eng Part A 15:319-30. 2009
    ..Finally, the mechanism underlying SMC differentiation from hMSCs grown in FBS-containing medium was explored by following the expression changes of serum response factor during the establishment of hMSC culture...
  35. pmc Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells
    Mehdi Mohamadnejad
    Yale University, School of Medicine, Department of Internal Medicine, Section of Digestive Diseases, New Haven, CT, USA
    Hepatology 51:963-73. 2010
    ..We speculate that adenosine might initiate the process of differentiation of MSCs into hepatocyte-like cells...
  36. ncbi request reprint Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
    Maria Angelopoulou
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Exp Hematol 31:413-20. 2003
    ..Because cotransplantation of marrow-derived stromal cells has been shown to enhance engraftment of human hematopoietic stem cells, we hypothesized that cotransplantation of MSC could enhance platelet and myeloid cell development...
  37. ncbi request reprint Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models
    Scott A Weiner
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510, USA
    Pediatr Res 63:73-8. 2008
    ..The data suggest that the in vivo RPD assay is a reliable assay of functional CFTR expression in CF mouse models...
  38. pmc Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice
    Emanuela M Bruscia
    Yale University School of Medicine, Department of Pediatrics, 333 Cedar Street, PO Box 208064, New Haven, CT 06520 8035, USA
    Am J Respir Cell Mol Biol 40:295-304. 2009
    ....
  39. pmc Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture
    Milind C Mahajan
    Department of Genetics, The Anlyan Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Hematol 37:1143-1156.e3. 2009
    ....
  40. pmc Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids
    Joanna Y Chin
    Departments of Therapeutic Radiology and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:13514-9. 2008
    ..This work suggests that PNAs can be effective tools to induce heritable, site-specific modification of disease-related genes in human cells...
  41. pmc Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation
    Xianyong Ma
    Yale University School of Medicine, Department of Laboratory Medicine, P O Box 208035, 333 Cedar Street, New Haven, CT 06520 8035, USA
    Mol Cell Biol 27:3056-64. 2007
    ..Thus, Rbm15 is differentially expressed during hematopoiesis and may act to inhibit myeloid differentiation in hematopoietic cells via a mechanism that is mediated by stimulation of Notch signaling via RBPJkappa...
  42. ncbi request reprint Bone marrow transplantation can attenuate the progression of mesangial sclerosis
    Jian Kan Guo
    Department of Laboratory Medicine, Yale School of Medicine, M D 333 Cedar Street, P O Box 208035, New Haven, Connecticut 06520, USA
    Stem Cells 24:406-15. 2006
    ....
  43. pmc Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation
    Emanuela M Bruscia
    Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2965-70. 2006
    ..Detection of CFTR mRNA and protein in tissues of transplanted CFTR-/- mice supports these data...
  44. ncbi request reprint Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow
    Neil D Theise
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Exp Hematol 30:1333-8. 2002
    ..To better understand the process by which pneumocytes can be derived from bone marrow cells, we investigated the in vivo kinetics of such engraftment following lethal irradiation...
  45. ncbi request reprint Bone marrow to liver: the blood of Prometheus
    Neil D Theise
    Department of Pathology, New York University School of Medicine, Room 461, 560 First Avenue, New York, NY 10016, USA
    Semin Cell Dev Biol 13:411-7. 2002
    ..Moreover, the physiological importance and therapeutic utility of this phenomenon remains controversial...
  46. ncbi request reprint Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry
    Christopher R Cogle
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida, ARB R4 216B, Gainesville, FL 32610 0277, USA
    Stem Cells 25:1881-7. 2007
    ..Disclosure of Potential Conflicts of Interest is found at the end of this article...
  47. ncbi request reprint Comment on "Little evidence for developmental plasticity of adult hematopoietic stem cells"
    Neil D Theise
    Science 299:1317; author reply 1317. 2003
  48. pmc Lineage specificity of gene expression patterns
    Yuval Kluger
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:6508-13. 2004
    ..Thus, the mRNA expression data implicitly contained information about developmental relationships among cell types...
  49. pmc SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
    Yupo Ma
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Blood 108:2726-35. 2006
    ..Our murine model provides a useful platform to study human MDS/AML transformation, as well as the Wnt/beta-catenin pathway's role in the pathogenesis of leukemia stem cells...

Research Grants24

  1. Epithelial differentiation of bone marrow stem cells
    Diane Krause; Fiscal Year: 2004
    ..Finally, using viral vectors to infect bone marrow stem cells, I will use an autologous/syngeneic transplantation model to obtain liver specific gene expression in vivo. ..
  2. Type II pneumocyte engraftment of bone marrow stem cells
    Diane Krause; Fiscal Year: 2006
    ..abstract_text> ..
  3. Epithelial engraftment of bone marrow derived stem cells
    Diane Krause; Fiscal Year: 2007
    ..Engraftment of BMDC as functional epithelial cells could facilitate healing in response to tissue injury. The data obtained will lead us to design novel therapeutic strategies tissue injury and disease. ..
  4. Type II pneumocyte engraftment of bone marrow stem cells
    Diane S Krause; Fiscal Year: 2010
    ..Further, the cells could be used vehicles for gene therapy to treat pediatric lung diseases such as surfactant protein deficiency or alpha-1 anti-trypsin deficiency. ..
  5. STAGE SPECIFIC EXPRESSION OF CD34 IN EARLY HEMATOPOIESIS
    Diane Krause; Fiscal Year: 2001
    ..Also, a better understanding of the molecular control for early hematopoiesis will improve our ability to combat selective cytopenias and aplastic anemia. ..
  6. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2010
    ..The results of these studies will provide new insights into the role of MKL1 in normal as well as malignant cells.) ..