Affiliation: Yale University
Katrancha S, Shaw J, Zhao A, Myers S, Cocco A, Jeng A, et al
. Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell Rep. 2019;26:2805-2817.e9 pubmed publisher
..Elevation of PDE4A5 and drug-based attenuation of PKA signaling rescue Trio haploinsufficiency-related dendritic spine defects, suggesting an avenue for therapeutic intervention for TRIO-related neurodevelopmental disorders. ..
Gifford S, Liu W, Mader C, Halo T, Machida K, Boggon T, et al
. Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. J Biol Chem. 2014;289:19704-13 pubmed publisher
..Together, these observations indicate that these two amino acid positions confer different binding affinities and cellular functions on the distinct Abl family kinases. ..
Scherer A, Anand N, Koleske A. Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state. J Biol Chem. 2018;293:13022-13032 pubmed publisher
Levy A, Xiao X, Shaw J, Sudarsana Devi S, Katrancha S, Bennett A, et al
. Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function. Cell Rep. 2018;24:1523-1535 pubmed publisher
..These results establish SHP2 and Nck2 as NMDAR regulatory proteins and strongly suggest that NMDAR dysfunction contributes to NS cognitive deficits. ..
Kerrisk M, Cingolani L, Koleske A. ECM receptors in neuronal structure, synaptic plasticity, and behavior. Prog Brain Res. 2014;214:101-31 pubmed publisher
..This chapter highlights a number of ECM receptors, their roles in the control of synapse structure and function, and the impact of these receptors on synaptic plasticity and animal behavior. ..
Courtemanche N, Gifford S, Simpson M, Pollard T, Koleske A. Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin. J Biol Chem. 2015;290:4038-46 pubmed publisher
..These activities likely underlie important roles that Arg plays in the formation, dynamics, and stability of actin-based cellular structures. ..
Simpson M, Bradley W, Harburger D, Parsons M, Calderwood D, Koleske A. Direct interactions with the integrin Î²1 cytoplasmic tail activate the Abl2/Arg kinase. J Biol Chem. 2015;290:8360-72 pubmed publisher
..These findings provide a model for understanding how Î²1-containing integrins interact with and activate Abl family kinases. ..
Koleske A. Molecular mechanisms of dendrite stability. Nat Rev Neurosci. 2013;14:536-50 pubmed publisher
..Recent findings have provided insights into the molecular mechanisms that underlie long-term dendrite stabilization, how these mechanisms differ from those used to mediate structural plasticity and how they are disrupted in disease. ..
Rosenberg B, Gil Henn H, Mader C, Halo T, Yin T, Condeelis J, et al
. Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells. Mol Biol Cell. 2017;28:1347-1360 pubmed publisher
..Together these data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells. ..