ANTHONY KOLESKE

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders
    Yu Chih Lin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    Annu Rev Neurosci 33:349-78. 2010
  2. pmc Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion
    Stefanie Lapetina
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Biol 185:503-19. 2009
  3. pmc The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion
    Ann L Miller
    Department of Molecular Biophysics and Biochemistry, Yale University, SHMC E31, 333 Cedar St, New Haven, CT 06520, USA
    J Cell Biol 165:407-19. 2004
  4. pmc Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp
    Matthew M Miller
    Department of Cell Biology, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 49:2227-34. 2010
  5. pmc Molecular mechanisms of dendrite stability
    Anthony J Koleske
    Departments of Molecular Biophysics and Biochemistry and Neurobiology, Yale University, 333 Cedar Street SHMC E31, New Haven, Connecticut 06520 8024, USA
    Nat Rev Neurosci 14:536-50. 2013
  6. ncbi request reprint Essential roles for the Abl and Arg tyrosine kinases in neurulation
    A J Koleske
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 21:1259-72. 1998
  7. ncbi request reprint Do filopodia enable the growth cone to find its way?
    Anthony J Koleske
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Box 208024, 333 Cedar Street, New Haven, CT 06520 8024, USA
    Sci STKE 2003:pe20. 2003
  8. ncbi request reprint Regulation of neuronal morphogenesis and synaptic function by Abl family kinases
    Eva M Y Moresco
    Department of Genetics, Yale School of Medicine, PO Box 208024, New Haven, CT 06520 8204, USA
    Curr Opin Neurobiol 13:535-44. 2003
  9. pmc Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts
    William D Bradley
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Sci 122:3441-54. 2009
  10. ncbi request reprint How do Abl family kinases regulate cell shape and movement?
    Samuel E Hernandez
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA
    Trends Cell Biol 14:36-44. 2004

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders
    Yu Chih Lin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    Annu Rev Neurosci 33:349-78. 2010
    ..We also discuss how synapse and dendrite maintenance mechanisms are compromised in psychiatric and neurodegenerative disorders...
  2. pmc Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion
    Stefanie Lapetina
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Biol 185:503-19. 2009
    ..These results demonstrate that interactions between Arg, cortactin, and Nck1 are critical to promote adhesion-dependent cell edge protrusions...
  3. pmc The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion
    Ann L Miller
    Department of Molecular Biophysics and Biochemistry, Yale University, SHMC E31, 333 Cedar St, New Haven, CT 06520, USA
    J Cell Biol 165:407-19. 2004
    ..These findings demonstrate that Arg can mediate physical contact between F-actin and MTs at the cell periphery and that this cross-linking activity is required for Arg to regulate lamellipodial dynamics in fibroblasts...
  4. pmc Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp
    Matthew M Miller
    Department of Cell Biology, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 49:2227-34. 2010
    ..These results suggest that Arg promotes actin-based protrusions in response to extracellular stimuli through phosphorylation of and physical interactions with N-WASp...
  5. pmc Molecular mechanisms of dendrite stability
    Anthony J Koleske
    Departments of Molecular Biophysics and Biochemistry and Neurobiology, Yale University, 333 Cedar Street SHMC E31, New Haven, Connecticut 06520 8024, USA
    Nat Rev Neurosci 14:536-50. 2013
    ..Recent findings have provided insights into the molecular mechanisms that underlie long-term dendrite stabilization, how these mechanisms differ from those used to mediate structural plasticity and how they are disrupted in disease. ..
  6. ncbi request reprint Essential roles for the Abl and Arg tyrosine kinases in neurulation
    A J Koleske
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 21:1259-72. 1998
    ..Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin cytoskeleton...
  7. ncbi request reprint Do filopodia enable the growth cone to find its way?
    Anthony J Koleske
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Box 208024, 333 Cedar Street, New Haven, CT 06520 8024, USA
    Sci STKE 2003:pe20. 2003
    ..Together, these studies suggest that Ena/VASP proteins regulate axon guidance by controlling the formation or rearrangement of growth cone filopodia...
  8. ncbi request reprint Regulation of neuronal morphogenesis and synaptic function by Abl family kinases
    Eva M Y Moresco
    Department of Genetics, Yale School of Medicine, PO Box 208024, New Haven, CT 06520 8204, USA
    Curr Opin Neurobiol 13:535-44. 2003
    ..Abelson non-receptor tyrosine kinases are also found in mature synapses, where their activities are required for optimal synaptic function...
  9. pmc Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts
    William D Bradley
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Sci 122:3441-54. 2009
    ..Elucidating how Abl-family kinases are regulated, and where and when they coordinate cytoskeletal changes, is essential for garnering a better understanding of these complex processes...
  10. ncbi request reprint How do Abl family kinases regulate cell shape and movement?
    Samuel E Hernandez
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA
    Trends Cell Biol 14:36-44. 2004
    ..Emerging evidence suggests that Abl family kinases can use these domains to directly organize cytoskeletal structure in vivo...
  11. ncbi request reprint Adhesion-dependent regulation of p190RhoGAP in the developing brain by the Abl-related gene tyrosine kinase
    Samuel E Hernandez
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA
    Curr Biol 14:691-6. 2004
    ..Our results demonstrate that p190RhoGAP is an Arg substrate in the developing brain and suggest that Arg mediates the adhesion-dependent regulation of neuronal morphogenesis in the postnatal brain by phosphorylating p190RhoGAP...
  12. pmc The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin
    Justin G Peacock
    Department of Molecular Biophysics and Biochemistry, Department of Neurobiology, and Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06511, USA
    Mol Biol Cell 18:3860-72. 2007
    ..Together, our data strongly suggest that Arg inhibits cell migration by restricting actomyosin contractility and regulating its coupling to the substrate through focal adhesions...
  13. pmc Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
    Keith Q Tanis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell Biol 23:3884-96. 2003
    ..The autoactivation pathway may allow Abl family kinases to integrate or amplify cues relayed by Src family kinases from cell surface receptors...
  14. ncbi request reprint Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity
    Eva Marie Yang Moresco
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurophysiol 89:1678-87. 2003
    ..These results indicate that an important function of Abl and Arg is to modulate synaptic efficacy via a presynaptic mechanism during repetitive activation...
  15. pmc Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration
    Brian A Couch
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Alzheimers Dis 20:1003-8. 2010
    ..We report that increased dendrite branching occurs in AbetaPP/PS1 mice and that fasudil promotes lengthening of the dendrite arbors of CA1 pyramidal neurons...
  16. ncbi request reprint Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior
    Mindan K Sfakianos
    Department of Molecular Biophysics and Biochemistry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:10982-92. 2007
    ..Together, these data indicate that signaling through Arg and p190RhoGAP acts late during synaptic refinement to promote dendritic spine maturation and synapse/dendrite stability by attenuating synaptic Rho activity...
  17. ncbi request reprint Dissecting kinase signaling pathways
    Scott N Boyle
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, United States
    Drug Discov Today 12:717-24. 2007
    ..Once putative substrates are identified, their validation as physiological substrates remains a major challenge. We propose three criteria for confirming the physiological relevance of a putative substrate's interaction with a kinase...
  18. pmc Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane
    William D Bradley
    Department of Molecular Biophysics and Biochemistry, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA
    Mol Biol Cell 17:4827-36. 2006
    ..Our results demonstrate that integrin signaling through Arg activates p190 by promoting its association with p120, resulting in recruitment of p190 to the cell periphery where it inhibits Rho...
  19. ncbi request reprint Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases
    Eva Marie Yang Moresco
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 8024, USA
    J Neurosci 25:6105-18. 2005
    ..These data suggest that integrin signaling through Abl and Arg support cortical dendrite branch maintenance by promoting dendrite branch dynamics in response to adhesive cues...
  20. ncbi request reprint Defective T cell development and function in the absence of Abelson kinases
    Jing Jin Gu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:7334-43. 2007
    ..Together these findings reveal cell-autonomous roles for the Abl family kinases in both T cell development and mature T cell function, and show that loss of these kinases specifically in T cells results in compromised immunity...
  21. pmc The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse
    Yanping Huang
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 112:111-9. 2008
    ..In addition, c-Abl is required for normal localization of WAVE2 to the immune synapse (IS). These studies identify c-Abl as a key player in the signaling cascade, leading to actin reorganization during T-cell activation...
  22. pmc Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor
    Rina Plattner
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:2573-83. 2004
    ..These data show that, although both kinases are activated and form complexes with proteins in the PDGFR signaling pathway, only c-Abl functions downstream of PLC-gamma1 to mediate chemotaxis...
  23. ncbi request reprint Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation
    Patrizia Sini
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milan, Italy
    Nat Cell Biol 6:268-74. 2004
    ..Thus, our data identify the molecular connections of a pathway RTKs-Abl-Sos-1-Rac that is involved in signal transduction and actin remodelling...
  24. ncbi request reprint The Arg non-receptor tyrosine kinase modifies F-actin structure
    Vitold E Galkin
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA 22908 0733, USA
    J Mol Biol 346:565-75. 2005
    ..The conformational changes in the filament introduced by Arg can explain the cooperative binding of Arg to F-actin and might prevent other actin binding proteins from binding to actin filaments...
  25. ncbi request reprint Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase
    Scott N Boyle
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Biochemistry 46:11614-20. 2007
    ..Our results indicate that the bump-hole technique can be used to identify Abl family kinase substrates and suggests that myosin IIB may be regulated by tyrosine phosphorylation...
  26. ncbi request reprint A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation
    Scott N Boyle
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Curr Biol 17:445-51. 2007
    ..Our results reveal that Abl-family kinases target cortactin as an effector of cytoskeletal rearrangements in response to PDGF...

Research Grants14

  1. ROLES FOR ABL AND ARG IN NEURONAL DEVELOPMENT
    ANTHONY KOLESKE; Fiscal Year: 2000
    ..The information gained from these studies will allow us to pose sharper mechanistic questions aimed at understanding the biochemistry of signal transduction by Abl and Arg. ..
  2. Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2010
    ..We will use live cell imaging and RNAi-mediated protein knockdown to examine whether the cortactin-P-binding proteins localize to invadopodia and regulate their formation. ..
  3. Regulation of invadopodia formation in breast cancer cells
    ANTHONY KOLESKE; Fiscal Year: 2009
    ..We will use live cell imaging and RNAi-mediated protein knockdown to examine whether the cortactin-P-binding proteins localize to invadopodia and regulate their formation. ..
  4. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    ANTHONY KOLESKE; Fiscal Year: 2009
    ..We will study a biochemical pathway that regulates synapse morphogenesis and function and protects against degeneration of neural circuits in the brain. ..
  5. A biochemical screen for novel regulators of neuronal morphogenesis
    ANTHONY KOLESKE; Fiscal Year: 2007
    ..Identifying these substrate will expand the "toolkit" available to dissect the molecular mechanisms of axon and dendrite morphogenesis. ..
  6. Roles of Abl and Arg Neuronal Development
    ANTHONY KOLESKE; Fiscal Year: 2007
    ..We will determine whether these receptors regulate Abl and Arg kinase activity and examine whether Abl and Arg mediate migratory or morphogenetic signals from these receptors. ..
  7. Roles of Abl and Arg Neuronal Development
    ANTHONY KOLESKE; Fiscal Year: 2006
    ..We will determine whether these receptors regulate Abl and Arg kinase activity and examine whether Abl and Arg mediate migratory or morphogenetic signals from these receptors. ..
  8. Roles of Abl and Arg Neuronal Development
    ANTHONY KOLESKE; Fiscal Year: 2005
    ..We will determine whether these receptors regulate Abl and Arg kinase activity and examine whether Abl and Arg mediate migratory or morphogenetic signals from these receptors. ..
  9. ROLES FOR ABL AND ARG IN NEURONAL DEVELOPMENT
    ANTHONY KOLESKE; Fiscal Year: 2004
    ..We will determine whether these receptors regulate Abl and Arg kinase activity and examine whether Abl and Arg mediate migratory or morphogenetic signals from these receptors. ..
  10. ROLES FOR ABL AND ARG IN NEURONAL DEVELOPMENT
    ANTHONY KOLESKE; Fiscal Year: 2003
    ..The information gained from these studies will allow us to pose sharper mechanistic questions aimed at understanding the biochemistry of signal transduction by Abl and Arg. ..
  11. ROLES FOR ABL AND ARG IN NEURONAL DEVELOPMENT
    ANTHONY KOLESKE; Fiscal Year: 2002
    ..The information gained from these studies will allow us to pose sharper mechanistic questions aimed at understanding the biochemistry of signal transduction by Abl and Arg. ..
  12. ROLES FOR ABL AND ARG IN NEURONAL DEVELOPMENT
    ANTHONY KOLESKE; Fiscal Year: 2001
    ..The information gained from these studies will allow us to pose sharper mechanistic questions aimed at understanding the biochemistry of signal transduction by Abl and Arg. ..
  13. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    Anthony J Koleske; Fiscal Year: 2010
    ..We will study a biochemical pathway that regulates synapse morphogenesis and function and protects against degeneration of neural circuits in the brain. ..