Jeffery Kocsis

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, PVA EPVA Neuroscience Regeneration Research Center, VA Medical Center, West Haven, Connecticut, 06516, USA
    J Comp Neurol 443:259-74. 2002
  2. doi request reprint Bone marrow stem cells in experimental stroke
    Jeffery D Kocsis
    Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
    Prog Brain Res 201:79-98. 2012
  3. ncbi request reprint Pathology of blast-related brain injury
    Jeffery D Kocsis
    Yale University School of Medicine, Neuroscience Research Center 127A, VA CT Healthcare System, West Haven, CT 06516, USA
    J Rehabil Res Dev 46:667-72. 2009
  4. pmc Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
    Neurosci Lett 456:137-42. 2009
  5. ncbi request reprint Schwann cells and their precursors for repair of central nervous system myelin
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Brain 130:1978-80. 2007
  6. ncbi request reprint Restoration of function by glial cell transplantation into demyelinated spinal cord
    J D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Neurotrauma 16:695-703. 1999
  7. ncbi request reprint Cell transplantation of peripheral-myelin-forming cells to repair the injured spinal cord
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06516, USA
    J Rehabil Res Dev 39:287-98. 2002
  8. doi request reprint Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 56:1664-78. 2008
  9. pmc Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
    Mary A Dombrowski
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1125:1-8. 2006
  10. pmc Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:8485-93. 2004

Research Grants

Collaborators

Detail Information

Publications40

  1. pmc A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, PVA EPVA Neuroscience Regeneration Research Center, VA Medical Center, West Haven, Connecticut, 06516, USA
    J Comp Neurol 443:259-74. 2002
    ..These results indicate that Schwann cells prepared under a variety of conditions are capable of eliciting remyelination, but that the density of remyelinated axons is much lower than the myelinated axon density in intact spinal cords...
  2. doi request reprint Bone marrow stem cells in experimental stroke
    Jeffery D Kocsis
    Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
    Prog Brain Res 201:79-98. 2012
    ....
  3. ncbi request reprint Pathology of blast-related brain injury
    Jeffery D Kocsis
    Yale University School of Medicine, Neuroscience Research Center 127A, VA CT Healthcare System, West Haven, CT 06516, USA
    J Rehabil Res Dev 46:667-72. 2009
    ....
  4. pmc Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
    Neurosci Lett 456:137-42. 2009
    ..In this review we focus on several unique features of OECs when they are transplanted into the spinal cord...
  5. ncbi request reprint Schwann cells and their precursors for repair of central nervous system myelin
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Brain 130:1978-80. 2007
  6. ncbi request reprint Restoration of function by glial cell transplantation into demyelinated spinal cord
    J D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Neurotrauma 16:695-703. 1999
    ..Moreover, conduction block can be overcome by remyelination, and no abnormal firing is observed. There is discussion of the challenges of a potential cell therapy approach in human demyelinating disease...
  7. ncbi request reprint Cell transplantation of peripheral-myelin-forming cells to repair the injured spinal cord
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06516, USA
    J Rehabil Res Dev 39:287-98. 2002
    ..Better understanding of the repair potential of these cells in animal models may offer exciting opportunities to develop cells that may be used in future clinical studies...
  8. doi request reprint Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 56:1664-78. 2008
    ..These results revealed a clear difference between the migratory properties of OECs and SCs in the X-irradiated spinal cord and demonstrated that engrafted OECs can participate in repair of subsequent lesions...
  9. pmc Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
    Mary A Dombrowski
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1125:1-8. 2006
    ....
  10. pmc Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:8485-93. 2004
    ..Thus, transplanted OECs derived from the adult olfactory bulb can survive and orient longitudinally across a spinal cord transection site and form myelin. This pattern of repair is associated with improved locomotion...
  11. doi request reprint Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1254:10-7. 2009
    ..Even a modest improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery...
  12. pmc Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons
    Christine Radtke
    Department of Neurology, LCI 7, P O Box 208018, Yale University School of Medicine, New Haven, CT 06516, USA
    Neurosci Lett 387:85-9. 2005
    ..6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons...
  13. pmc Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells
    Christine Radtke
    Department of Neurology, Yale University School of Medicine, New Haven, an Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
    FASEB J 18:335-7. 2004
    ..This is the first demonstration that xenotransplantation of characterized OECs into the primate spinal cord results in remyelination...
  14. doi request reprint Impaired spinal cord remyelination by long-term cultured adult porcine olfactory ensheathing cells correlates with altered in vitro phenotypic properties
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Xenotransplantation 17:71-80. 2010
    ..Here, we studied the impact of the culturing interval on the remyelinating capacity of adult porcine OECs...
  15. pmc Remyelination of the injured spinal cord
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA, and Research Institute of Surgery, Daping Hospital, Chongqing, P R China
    Prog Brain Res 161:419-33. 2007
    ..The biology of the OEC, and recent experimental research and clinical studies using OECs as a potential cell therapy candidate are discussed...
  16. pmc Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord
    Masanori Sasaki
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:1803-12. 2006
    ....
  17. pmc Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions
    Eleni A Markakis
    Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 4:e7260. 2009
    ..Multipotent cells from the progenitor fraction have been isolated from the adult olfactory bulb (OB) but their potential to remyelinate has not been studied...
  18. pmc BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 29:14932-41. 2009
    ..These results indicate that transplantation of hMSCs hypersecreting BDNF results in structural changes in brain and spinal cord, which are associated with improved functional outcome in acute SCI...
  19. pmc Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 53:352-9. 2006
    ..The transplanted OECs associated longitudinally with axons at 4 weeks. Thus, OEC transplantation into the injured spinal cord has distant neuroprotective effects on descending cortical projection neurons...
  20. pmc Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells
    Yukinori Akiyama
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    J Neurosci 22:6623-30. 2002
    ..These findings indicate that cells contained within the stromal cell fraction of the mononuclear cell layer of bone marrow can form functional myelin during transplantation into demyelinated spinal cord...
  21. pmc Schwann cell engraftment into injured peripheral nerve prevents changes in action potential properties
    Kewei Yu
    Department of Neurology, Yale University School of Medicine, Neuroscience Research Center, West Haven, CT 06516, USA
    J Neurophysiol 94:1519-27. 2005
    ..Thus the engrafted SC procedure ameliorated the changes in action potential waveform of cutaneous primary afferents associated with target disconnection and neuroma formation...
  22. ncbi request reprint A-fiber sprouting in spinal cord dorsal horn is attenuated by proximal nerve stump encapsulation
    Fletcher A White
    Department of Neurology, Yale University School of Medicine, Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
    Exp Neurol 177:385-95. 2002
    ....
  23. ncbi request reprint Neural precursors as a cell source to repair the demyelinated spinal cord
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, VA Medical Center, West Haven, Connecticut 06516, USA
    J Neurotrauma 21:441-9. 2004
    ..There is discussion on the challenges of cell type selection and preparation for a potential clinical cell therapy study in human demyelinating diseases...
  24. ncbi request reprint Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury
    Christine Radtke
    Neuroscience Research Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    J Rehabil Res Dev 45:141-51. 2008
    ..This review provides information on these issues for spinal cord medicine clinicians...
  25. pmc Remyelination of the spinal cord following intravenous delivery of bone marrow cells
    Yukinori Akiyama
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Glia 39:229-36. 2002
    ....
  26. doi request reprint Keratinocytes acting on injured afferents induce extreme neuronal hyperexcitability and chronic pain
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Pain 148:94-102. 2010
    ..These results have implications for persistent pain associated with burn and traumatic skin injuries...
  27. ncbi request reprint Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
    Hajime A Tokuno
    Department of Neurology, Yale University School of Medicine, VA Connecticut Healthcare Service, West Haven, CT 06516, USA
    Brain Res 996:159-67. 2004
    ..These studies provide a more complete understanding of the pharmaocology of potential agonist treatment candidates, and suggest a mechanism whereby cocaethylene produces a decreased euphoria in humans compared to cocaine...
  28. doi request reprint Focal experimental autoimmune encephalomyelitis in the Lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Glia 58:1523-31. 2010
    ..This model may be useful for the study of transplanted myelin-forming cells in a discrete inflammatory demyelinating lesion...
  29. doi request reprint A rat middle cerebral artery occlusion model and intravenous cellular delivery
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 549:187-95. 2009
    ..One approach has been the intravenous delivery of bone marrow-derived mescenchymal stem cells at various times after MCAO. Histological and magnetic resonance imaging have been used to quantify infarction volume in this model system...
  30. ncbi request reprint Noninactivating, tetrodotoxin-sensitive Na+ conductance in peripheral axons
    Hajime A Tokuno
    Rehabilitation Research Center, VA Hospital, West Haven, Connecticut 06516, USA
    Muscle Nerve 28:212-7. 2003
    ..Tetrodotoxin-sensitive persistent inward Na(+) currents are present in both dorsal and ventral root axons at rest and may contribute to axonal excitability...
  31. ncbi request reprint New avenues: exploring approaches for gene therapy in the injured spinal cord
    Jeffery D Kocsis
    Yale University School of Medicine, PVA EPVA Center for Neuroscience and Regeneration, West Haven, CT, USA
    J Spinal Cord Med 25:10. 2002
  32. pmc Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRG
    Chang Ning Liu
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 87:2009-17. 2002
    ..Moreover, these observations indicate that both muscle and cutaneous afferents in the A(beta) size range give rise to injury-induced membrane oscillations, with muscle afferents being more prone to develop oscillations...
  33. pmc Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord
    Michio Inoue
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    Glia 44:111-8. 2003
    ....
  34. ncbi request reprint Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord
    Shinichi Oka
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1030:94-102. 2004
    ....
  35. ncbi request reprint A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats
    Satoshi Iihoshi
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, South 1st, West 16th, Chuo, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1007:1-9. 2004
    ..These findings suggest that early intervention with intravenous administration of autologous mononuclear cells from bone marrow can reduce lesion size in the MCAO model in the rat, and improve functional outcome...
  36. ncbi request reprint Oscillatory mechanism in primary sensory neurones
    Ron Amir
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Brain 125:421-35. 2002
    ..The oscillatory mechanism might be exploited in the search for novel analgesic drugs...
  37. pmc Magnetic resonance lactate and lipid signals in rat brain after middle cerebral artery occlusion model
    Kuniaki Harada
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1134:206-13. 2007
    ..Thus, adjustment of the echo time is essential to analyze the metabolites in acute cerebral infarction, which may be useful in both the clinic and laboratory...
  38. pmc Multiple interacting sites of ectopic spike electrogenesis in primary sensory neurons
    Ron Amir
    Department of Cell and Animal Biology and the Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Neurosci 25:2576-85. 2005
    ..Correspondingly, discharge generated at these alternative sites may interact, explaining the sometimes-complex firing patterns observed in vivo...
  39. pmc Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat
    Yoshifumi Horita
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 84:1495-504. 2006
    ....
  40. pmc Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells
    Sangnyon Kim
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
    Brain Res 1123:27-33. 2006
    ..After withdrawal of the mitogens, these cells could differentiate into neurofilament-positive neurons or GFAP-positive glia. Thus, our findings suggest the potential use of PMSCs for a cell therapy in CNS diseases...

Research Grants5

  1. Marrow stromal cell deliver to repair the spinal cord
    Jeffery Kocsis; Fiscal Year: 2003
    ....
  2. Marrow stromal cell deliver to repair the spinal cord
    Jeffery Kocsis; Fiscal Year: 2006
    ..abstract_text> ..
  3. Marrow stromal cell deliver to repair the spinal cord
    Jeffery Kocsis; Fiscal Year: 2007
    ..abstract_text> ..