Research Topics
| Jeffery KocsisSummaryAffiliation: Yale University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cellsKaren L Lankford
Department of Neurology, Yale University School of Medicine, PVA/EPVA Neuroscience Regeneration Research Center, VA Medical Center, West Haven, Connecticut, 06516, USA
J Comp Neurol 443:259-74. 2002..These results indicate that Schwann cells prepared under a variety of conditions are capable of eliciting remyelination, but that the density of remyelinated axons is much lower than the myelinated axon density in intact spinal cords...
Bone marrow stem cells in experimental strokeJeffery D Kocsis
Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
Prog Brain Res 201:79-98. 2012....
Pathology of blast-related brain injuryJeffery D Kocsis
Yale University School of Medicine, Neuroscience Research Center 127A, VA CT Healthcare System, West Haven, CT 06516, USA
J Rehabil Res Dev 46:667-72. 2009....- Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injuryJeffery D Kocsis
Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
Neurosci Lett 456:137-42. 2009..In this review we focus on several unique features of OECs when they are transplanted into the spinal cord... - Schwann cells and their precursors for repair of central nervous system myelinJeffery D Kocsis
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Brain 130:1978-80. 2007 - Restoration of function by glial cell transplantation into demyelinated spinal cordJ D Kocsis
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
J Neurotrauma 16:695-703. 1999..Moreover, conduction block can be overcome by remyelination, and no abnormal firing is observed. There is discussion of the challenges of a potential cell therapy approach in human demyelinating disease... - Cell transplantation of peripheral-myelin-forming cells to repair the injured spinal cordJeffery D Kocsis
Department of Neurology, Yale University School of Medicine, New Haven, CT 06516, USA
J Rehabil Res Dev 39:287-98. 2002..Better understanding of the repair potential of these cells in animal models may offer exciting opportunities to develop cells that may be used in future clinical studies... - Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cellsKaren L Lankford
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
Glia 56:1664-78. 2008..These results revealed a clear difference between the migratory properties of OECs and SCs in the X-irradiated spinal cord and demonstrated that engrafted OECs can participate in repair of subsequent lesions... - Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cellsMary A Dombrowski
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
Brain Res 1125:1-8. 2006.... - Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelinMasanori Sasaki
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 24:8485-93. 2004..Thus, transplanted OECs derived from the adult olfactory bulb can survive and orient longitudinally across a spinal cord transection site and form myelin. This pattern of repair is associated with improved locomotion... - Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repairChristine Radtke
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
Brain Res 1254:10-7. 2009..Even a modest improvement in nerve regeneration could have significant clinical implications for reconstructive nerve surgery... - Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axonsChristine Radtke
Department of Neurology, LCI 7, P.O. Box 208018, Yale University School of Medicine, New Haven, CT 06516, USA
Neurosci Lett 387:85-9. 2005..6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons... - Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cellsChristine Radtke
Department of Neurology, Yale University School of Medicine, New Haven, an Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
FASEB J 18:335-7. 2004..This is the first demonstration that xenotransplantation of characterized OECs into the primate spinal cord results in remyelination... - Impaired spinal cord remyelination by long-term cultured adult porcine olfactory ensheathing cells correlates with altered in vitro phenotypic propertiesChristine Radtke
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
Xenotransplantation 17:71-80. 2010..Here, we studied the impact of the culturing interval on the remyelinating capacity of adult porcine OECs... - Remyelination of the injured spinal cordMasanori Sasaki
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA, and Research Institute of Surgery, Daping Hospital, Chongqing, P R China
Prog Brain Res 161:419-33. 2007..The biology of the OEC, and recent experimental research and clinical studies using OECs as a potential cell therapy candidate are discussed... - Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cordMasanori Sasaki
Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 26:1803-12. 2006.... - Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesionsEleni A Markakis
Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 4:e7260. 2009..Multipotent cells from the progenitor fraction have been isolated from the adult olfactory bulb (OB) but their potential to remyelinate has not been studied... - BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injuryMasanori Sasaki
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 29:14932-41. 2009..These results indicate that transplantation of hMSCs hypersecreting BDNF results in structural changes in brain and spinal cord, which are associated with improved functional outcome in acute SCI... - Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cellsMasanori Sasaki
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, USA
Glia 53:352-9. 2006..The transplanted OECs associated longitudinally with axons at 4 weeks. Thus, OEC transplantation into the injured spinal cord has distant neuroprotective effects on descending cortical projection neurons... - Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cellsYukinori Akiyama
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
J Neurosci 22:6623-30. 2002..These findings indicate that cells contained within the stromal cell fraction of the mononuclear cell layer of bone marrow can form functional myelin during transplantation into demyelinated spinal cord... - Schwann cell engraftment into injured peripheral nerve prevents changes in action potential propertiesKewei Yu
Department of Neurology, Yale University School of Medicine, Neuroscience Research Center, West Haven, CT 06516, USA
J Neurophysiol 94:1519-27. 2005..Thus the engrafted SC procedure ameliorated the changes in action potential waveform of cutaneous primary afferents associated with target disconnection and neuroma formation... - A-fiber sprouting in spinal cord dorsal horn is attenuated by proximal nerve stump encapsulationFletcher A White
Department of Neurology, Yale University School of Medicine, Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
Exp Neurol 177:385-95. 2002.... - Neural precursors as a cell source to repair the demyelinated spinal cordJeffery D Kocsis
Department of Neurology, Yale University School of Medicine, New Haven, VA Medical Center, West Haven, Connecticut 06516, USA
J Neurotrauma 21:441-9. 2004..There is discussion on the challenges of cell type selection and preparation for a potential clinical cell therapy study in human demyelinating diseases... - Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injuryChristine Radtke
Neuroscience Research Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
J Rehabil Res Dev 45:141-51. 2008..This review provides information on these issues for spinal cord medicine clinicians... - Remyelination of the spinal cord following intravenous delivery of bone marrow cellsYukinori Akiyama
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Glia 39:229-36. 2002.... - Keratinocytes acting on injured afferents induce extreme neuronal hyperexcitability and chronic painChristine Radtke
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
Pain 148:94-102. 2010..These results have implications for persistent pain associated with burn and traumatic skin injuries... - Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nervesHajime A Tokuno
Department of Neurology, Yale University School of Medicine, VA Connecticut Healthcare Service, West Haven, CT 06516, USA
Brain Res 996:159-67. 2004..These studies provide a more complete understanding of the pharmaocology of potential agonist treatment candidates, and suggest a mechanism whereby cocaethylene produces a decreased euphoria in humans compared to cocaine... - Focal experimental autoimmune encephalomyelitis in the Lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factorMasanori Sasaki
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Glia 58:1523-31. 2010..This model may be useful for the study of transplanted myelin-forming cells in a discrete inflammatory demyelinating lesion... - A rat middle cerebral artery occlusion model and intravenous cellular deliveryMasanori Sasaki
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
Methods Mol Biol 549:187-95. 2009..One approach has been the intravenous delivery of bone marrow-derived mescenchymal stem cells at various times after MCAO. Histological and magnetic resonance imaging have been used to quantify infarction volume in this model system... - Noninactivating, tetrodotoxin-sensitive Na+ conductance in peripheral axonsHajime A Tokuno
Rehabilitation Research Center, VA Hospital, West Haven, Connecticut 06516, USA
Muscle Nerve 28:212-7. 2003..Tetrodotoxin-sensitive persistent inward Na(+) currents are present in both dorsal and ventral root axons at rest and may contribute to axonal excitability... - New avenues: exploring approaches for gene therapy in the injured spinal cordJeffery D Kocsis
Yale University School of Medicine, PVA-EPVA Center for Neuroscience and Regeneration, West Haven, CT, USA
J Spinal Cord Med 25:10. 2002 - Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRGChang-Ning Liu
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurophysiol 87:2009-17. 2002..Moreover, these observations indicate that both muscle and cutaneous afferents in the A(beta) size range give rise to injury-induced membrane oscillations, with muscle afferents being more prone to develop oscillations... - Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cordMichio Inoue
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
Glia 44:111-8. 2003.... - Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cordShinichi Oka
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan
Brain Res 1030:94-102. 2004.... - A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult ratsSatoshi Iihoshi
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, South-1st, West-16th, Chuo, Sapporo, Hokkaido 060-8543, Japan
Brain Res 1007:1-9. 2004..These findings suggest that early intervention with intravenous administration of autologous mononuclear cells from bone marrow can reduce lesion size in the MCAO model in the rat, and improve functional outcome... - Oscillatory mechanism in primary sensory neuronesRon Amir
Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
Brain 125:421-35. 2002..The oscillatory mechanism might be exploited in the search for novel analgesic drugs... - Magnetic resonance lactate and lipid signals in rat brain after middle cerebral artery occlusion modelKuniaki Harada
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060 8543, Japan
Brain Res 1134:206-13. 2007..Thus, adjustment of the echo time is essential to analyze the metabolites in acute cerebral infarction, which may be useful in both the clinic and laboratory... - Multiple interacting sites of ectopic spike electrogenesis in primary sensory neuronsRon Amir
Department of Cell and Animal Biology and the Center for Research on Pain, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Neurosci 25:2576-85. 2005..Correspondingly, discharge generated at these alternative sites may interact, explaining the sometimes-complex firing patterns observed in vivo... - Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult ratYoshifumi Horita
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
J Neurosci Res 84:1495-504. 2006.... - Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cellsSangnyon Kim
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan
Brain Res 1123:27-33. 2006..After withdrawal of the mitogens, these cells could differentiate into neurofilament-positive neurons or GFAP-positive glia. Thus, our findings suggest the potential use of PMSCs for a cell therapy in CNS diseases...
Research Grants
- Marrow stromal cell deliver to repair the spinal cordJeffery Kocsis; Fiscal Year: 2003....
- Marrow stromal cell deliver to repair the spinal cordJeffery Kocsis; Fiscal Year: 2006..abstract_text> ..
- Marrow stromal cell deliver to repair the spinal cordJeffery Kocsis; Fiscal Year: 2007..abstract_text> ..