Research Topics
Species | Jeansok J KimSummaryAffiliation: Yale University Country: USA Publications
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Publications
Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical reviewJeansok J Kim
Department of Psychology and Program in Neurobiology and Behavior, University of Washington, Guthrie Hall, Seattle, WA 98195 1525, USA
Neurosci Biobehav Rev 30:188-202. 2006..The purpose of this review is to critically evaluate the strengths and weaknesses of evidence indicating that fear conditioning depend crucially upon the amygdalar circuit and plasticity...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient miceJ J Kim
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
Proc Natl Acad Sci U S A 94:5929-33. 1997..These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior...- Inhibitory cerebello-olivary projections and blocking effect in classical conditioningJ J Kim
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
Science 279:570-3. 1998..These results suggest that the inferior olive becomes functionally inhibited by the cerebellum during conditioning, and that this negative feedback process might be the neural mechanism mediating blocking... - Amygdala is critical for stress-induced modulation of hippocampal long-term potentiation and learningJ J Kim
Department of Psychology, Yale University, New Haven, Connecticut 06520 8205, USA
J Neurosci 21:5222-8. 2001..These results indicate that an intact amygdala is necessary for the expression of the modulatory effects of stress on hippocampal LTP and memory... - The stressed hippocampus, synaptic plasticity and lost memoriesJeansok J Kim
Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520 8205, USA
Nat Rev Neurosci 3:453-62. 2002..Here, we provide an overview of the neurobiology of stress memory interactions, and present a neural endocrine model to explain how stress modifies hippocampal functioning... - Amygdalar stimulation produces alterations on firing properties of hippocampal place cellsEun Joo Kim
Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
J Neurosci 32:11424-34. 2012.... - Stress effects in the hippocampus: synaptic plasticity and memoryJeansok J Kim
Department of Psychology, University of Washington, Seattle, WA 98195 1520, USA
Stress 9:1-11. 2006..This review focuses on endocrine-system-level mechanisms of stress effects in the hippocampus, and how stress, by altering the property of hippocampal plasticity, can subsequently influence hippocampal memory... - Cerebellar cortical inhibition and classical eyeblink conditioningShaowen Bao
Neuroscience Program, University of Southern California, Los Angeles, CA 90089-2520, USA
Proc Natl Acad Sci U S A 99:1592-7. 2002..Together, these results suggest that different aspects of the memories for eyeblink CRs are encoded in the cerebellar cortex and the cerebellar deep nuclei... 
Discriminative conditioning with different CS-US intervals produces temporally differentiated conditioned responses in the two eyes of the rabbit (Oryctolagus cuniculus)Taekwan Lee
Department of Psychology, Yale University, USA
Behav Neurosci 123:1085-94. 2009..The results indicate that the neuronal substrates subserving CRs of the two eyes involve not only a dominant lateralization but also some avenue of bilaterality...- Prefrontal cortex and hippocampus subserve different components of working memory in ratsTaejib Yoon
Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
Learn Mem 15:97-105. 2008..These results suggest that while both the mPFC and hippocampus are necessarily involved in DAT, they seem to process different informational components associated with the memory task... - Bilateral nature of the conditioned eyeblink response in the rabbit: behavioral characteristics and potential mechanismsTaekwan Lee
Department of Psychology, Yale University, USA
Behav Neurosci 122:1306-17. 2008..The observed differences in the IET suggest that the effect depends largely on the specific development of eyeblink CRs rather than the CER. The neurobiological implications of this apparent bilaterality of the eyeblink CR are discussed... - Stress-induced alterations in hippocampal plasticity, place cells, and spatial memoryJeansok J Kim
Department of Psychology, University of Washington, Seattle, WA 98195 1520, USA
Proc Natl Acad Sci U S A 104:18297-302. 2007.... - Biologically predisposed learning and selective associations in amygdalar neuronsAin Chung
Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
Learn Mem 18:371-4. 2011..Results indicate coincident Arc mRNA activation within BLA neurons after CS-US combinations that yield rapid, efficient learning, but not after CS-US combinations that do not... - Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging studyTaekwan Lee
Department of Psychology, Garland Hall, University of Wisconsin, Milwaukee, Wisconsin, USA
Neuroreport 20:1554-8. 2009..This longitudinal, within-subjects design study provides direct evidence that the hippocampus is differentially vulnerable and sensitive to chronic stress... - Selective neurotoxic lesions of basolateral and central nuclei of the amygdala produce differential effects on fear conditioningJa Wook Koo
Department of Psychology, Yale University, New Haven, Connecticut 06520-8205, USA
J Neurosci 24:7654-62. 2004..Instead, the expression of conditioned fear appears to primarily involve BLA projections that course through the CeA en route to downstream fear response structures... - Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivityTherese A Kosten
Yale University, New Haven, CT 06516, USA
Behav Brain Res 157:235-44. 2005..The sex-specific effect of ISO on context fear may reflect neuronal reorganization in stress responsive areas and/or sex differences in some unconditioned responses... - Stress impairs optimal behavior in a water foraging choice task in ratsLauren K Graham
Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
Learn Mem 17:1-4. 2010..Temporary inactivation of the amygdala during stress, however, blocked impairing effects on decision making... - Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in ratsKevin B Baker
Department of Psychology, Yale University, New Haven, Connecticut 06520-8205, USA
Learn Mem 9:58-65. 2002..Together, these results suggest that stress and intrahippocampal administration of APV affect recognition memory by influencing synaptic plasticity in the hippocampus... - Differential effects of cerebellar, amygdalar, and hippocampal lesions on classical eyeblink conditioning in ratsTaekwan Lee
Department of Psychology, Yale University, New Haven, Connecticut 06520-8205, USA
J Neurosci 24:3242-50. 2004.... - A thalamo-cortico-amygdala pathway mediates auditory fear conditioning in the intact brainJeffrey A Boatman
Department of Psychology, 335 Guthrie Hall, University of Washington, Seattle, WA 98195-1525, USA
Eur J Neurosci 24:894-900. 2006..These results suggest that the thalamo-cortico-amygdala pathway is the principal auditory CS pathway when the brain is intact... - Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdalaKevin B Baker
Department of Psychology, Yale University, New Haven, CT, USA
Behav Neurosci 118:15-23. 2004..These results indicate that fear conditioning is partially disrupted with unilateral amygdalar lesions, but that the right amygdala has greater involvement than the left amygdala when conditioning occurs under a normal brain state... - Early life stress impairs fear conditioning in adult male and female ratsTherese A Kosten
Department of Psychiatry, Yale University School of Medicine, VA CT Hospital System, 950 Campbell Ave, Building 5, 3rd Floor, West Haven, CT 06516, USA
Brain Res 1087:142-50. 2006..These opposing effects may reflect developmental differences on stress-induced alterations on hippocampal regulation of the hypothalamic-pituitary-adrenal axis... - Auditory Cortex is Important in the Extinction of Two Different Tone-Based Conditioned Fear Memories in RatsEun Young Song
Department of Psychology, University of Washington Seattle, WA, USA
Front Behav Neurosci 4:24. 2010..These findings indicate that the auditory cortex contributes to extinction of wide-ranging auditory fear memories, as evidenced by deficits in both tone-on CS and tone-off CS extinction training... - Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learningKaryn M Frick
Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
Hippocampus 14:244-54. 2004..The failure of BF cholinergic lesions to impair contextual fear conditioning indicates that scopolamine-induced impairments in fear conditioning may not be mediated by affecting cholinergic input to the hippocampus and neocortex... - A computer vision-based automated Figure-8 maze for working memory test in rodentsSamuel F Pedigo
Department of Psychology, University of Washington, Seattle, WA 98195-1520, USA
J Neurosci Methods 156:10-6. 2006..Thus, our automated Figure-8 maze is effective at assessing working memory and provides novel behavioral measures in rodents... - Amygdalar inactivation blocks stress-induced impairments in hippocampal long-term potentiation and spatial memoryJeansok J Kim
Department of Psychology and Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195 1525, USA
J Neurosci 25:1532-9. 2005..Together, these results suggest that the amygdalar neuronal activity during stress, but not shortly after stress, is essential for the emergence of stress-induced alterations in hippocampal LTP and memory... - Serotonin, stress, and conditioningJeansok J Kim
Department of Psychology and Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195-1525, USA
Biol Psychiatry 63:819-20. 2008 - Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experienceTherese A Kosten
Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Research Service Line 151, 2002 Holcombe Blvd, Houston, TX 77030, USA
Neurobiol Learn Mem 88:167-76. 2007.... - Neonatal handling alters learning in adult male and female rats in a task-specific mannerTherese A Kosten
Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
Brain Res 1154:144-53. 2007..These data suggest that neonatal handling alters learning and memory in a task-specific manner that may reflect alterations in emotional reactivity or differential effects of the manipulation on unknown neurohormonal mechanisms... - Immediate shock deficit in fear conditioning: effects of shock manipulationsJ Landeira-Fernandez
Departamento de Psicologia, Pontificia Universidade Catolico do Rio de Janeiro, Rio de Janeiro, Brazil
Behav Neurosci 120:873-9. 2006..However, immediate shock seems to sensitize subsequent context conditioning (Experiment 3). These findings suggest that the associative deficit produced by immediate shock is not related to the rat's ability to process the footshock US... - Learning-induced enduring changes in functional connectivity among prefrontal cortical neuronsEun H Baeg
Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443 721, Korea
J Neurosci 27:909-18. 2007..The present finding of negatively accelerated changes in FC confirms associative learning theories and provides crucial neurophysiological evidence for Hebb's hypothesis...