Mark Kidd

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Global expression analysis of ECL cells in Mastomys natalensis gastric mucosa identifies alterations in the AP-1 pathway induced by gastrin-mediated transformation
    M Kidd
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Physiol Genomics 20:131-42. 2004
  2. ncbi request reprint Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 103:229-36. 2005
  3. pmc Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 244:52-60. 2006
  4. ncbi request reprint Utility of molecular genetic signatures in the delineation of gastric neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer 106:1480-8. 2006
  5. pmc Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 115:4934-45. 2009
  6. ncbi request reprint Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 109:2420-31. 2007
  7. doi request reprint Principal component analysis, hierarchical clustering, and decision tree assessment of plasma mRNA and hormone levels as an early detection strategy for small intestinal neuroendocrine (carcinoid) tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg Oncol 16:487-98. 2009
  8. pmc Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation
    Francesco Giovinazzo
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America Laboratory of Translational Surgery LURM, University of Verona, Verona, Italy
    PLoS ONE 8:e81111. 2013
  9. doi request reprint Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors
    Bernhard Svejda
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT, USA
    Cancer Sci 104:844-55. 2013
  10. pmc Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines
    Mark Kidd
    Gastrointestinal Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 113:690-700. 2008

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Global expression analysis of ECL cells in Mastomys natalensis gastric mucosa identifies alterations in the AP-1 pathway induced by gastrin-mediated transformation
    M Kidd
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Physiol Genomics 20:131-42. 2004
    ..These results suggest that expression of this receptor and an altered composition of AP-1 with a loss of inhibition play a role in ECL cell transformation...
  2. ncbi request reprint Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 103:229-36. 2005
    ..The authors postulated that a similar mechanism occurred during the malignant evolution of small bowel carcinoid tumors...
  3. pmc Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 244:52-60. 2006
    ..To use differential gene expression of candidate markers to discriminate benign appendiceal carcinoids (APCs) from malignant and mixed cell APCs...
  4. ncbi request reprint Utility of molecular genetic signatures in the delineation of gastric neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer 106:1480-8. 2006
    ..This strategy provides a molecular basis to define neuroendocrine gastric carcinoids (GCs), neuronal stromal tumors (GISTs), or epithelial cell (gastric adenocarcinomas [GCAs])-derived tumors...
  5. pmc Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 115:4934-45. 2009
    ..Given the expression of 5-HT receptors on NETs, the authors hypothesized that 5-HT autoregulated NET proliferation...
  6. ncbi request reprint Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 109:2420-31. 2007
    ..Whether this phenomenon is common to small intestinal carcinoid tumors was investigated...
  7. doi request reprint Principal component analysis, hierarchical clustering, and decision tree assessment of plasma mRNA and hormone levels as an early detection strategy for small intestinal neuroendocrine (carcinoid) tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg Oncol 16:487-98. 2009
    ..Including NET-related circulating hormones and growth factors in the algorithm increased the sensitivity of detection of SI-NETs from 58 to 82%...
  8. pmc Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation
    Francesco Giovinazzo
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America Laboratory of Translational Surgery LURM, University of Verona, Verona, Italy
    PLoS ONE 8:e81111. 2013
    ..We hypothesized that chromogranin A fragments were differentially expressed during NEN metastasis and played a role in the regulation of NEN proliferation...
  9. doi request reprint Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors
    Bernhard Svejda
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT, USA
    Cancer Sci 104:844-55. 2013
    ..Because IGF-1 regulates NEN proliferation, identification of a role for 5-HT₇ in the hepatic metastatic tumor microenvironment suggests the potential for novel therapeutic strategies for amine-producing mid-gut tumors...
  10. pmc Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines
    Mark Kidd
    Gastrointestinal Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 113:690-700. 2008
    ..Given the coexistence of somatostatin and dopamine regulatory receptors on NET cells, the antiproliferative efficacy as well as the signaling and transcriptional targets of their ligands were evaluated...
  11. pmc Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning
    Ignat Drozdov
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 115:1638-50. 2009
    ....
  12. doi request reprint The archaic distinction between functioning and nonfunctioning neuroendocrine neoplasms is no longer clinically relevant
    Irvin M Modlin
    Gastrointestinal Pathobiology Group, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, USA
    Langenbecks Arch Surg 396:1145-56. 2011
    ..Although the identification and treatment of clinical neuroendocrine syndromes are established, there is confusion when a NEN has no discernible clinical symptoms...
  13. ncbi request reprint Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Int J Oncol 33:1121-31. 2008
    ..We present an overview of the epidemiology of these uncommon cancers, and address their clinical behavior, and current diagnostic and therapeutic options...
  14. ncbi request reprint Evolution of the diffuse neuroendocrine system--clear cells and cloudy origins
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroendocrinology 84:69-82. 2006
    ..Their key role in the regulation of gastrointestinal function is, however, indubitable...
  15. doi request reprint Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT
    Bernhard Svejda
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 117:4141-54. 2011
    ..Because adenocarcinomas escape mTOR inhibition, we examined whether the escape phenomenon occurred in SINETs and whether usage of somatostatin analogs with mTOR inhibitors surmounted loss of inhibition...
  16. doi request reprint The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors
    Simon Schimmack
    Gastrointestinal Pathobiology Research Group, Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA
    Langenbecks Arch Surg 396:273-98. 2011
    ..Diagnosis is usually late since there is no biochemical screening test and symptoms are protean and overlooked. As a consequence, 60-80% exhibit metastases with a consequent suboptimal outcome...
  17. ncbi request reprint Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management
    Irvin M Modlin
    School of Medicine, Yale University, New Haven, Conn, USA
    Med J Aust 193:46-52. 2010
    ..The overarching requirement for best management of patients with NETs is to ensure that they have ready access to experienced multidisciplinary clinician groups located within centres of appropriate subspecialty expertise...
  18. ncbi request reprint GeneChip, geNorm, and gastrointestinal tumors: novel reference genes for real-time PCR
    Mark Kidd
    Gastrointestinal Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiol Genomics 30:363-70. 2007
    ....
  19. doi request reprint The epidemiology of gastroenteropancreatic neuroendocrine tumors
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520 8062, USA
    Endocrinol Metab Clin North Am 40:1-18, vii. 2011
    ..Overall, GEP-NET survival has improved over the past 3 decades, although the outcome for poorly differentiated tumors remains dismal...
  20. ncbi request reprint Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    Mark Kidd
    1Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 295:G260-72. 2008
    ..Luminal EC cell regulation is likely to be as important as G cell regulation in gastric acid secretion; development of agents to target EC cell function is therefore a critical therapeutic goal...
  21. ncbi request reprint Siegfried oberndorfer and the evolution of carcinoid disease
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Arch Surg 142:187-97. 2007
    ..This exploration of his life and times seeks to give Oberndorfer his well-deserved place in the pantheon of pathology and memorialize his unique observations that led to the discovery of the carcinoid tumor...
  22. pmc Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 208602, USA
    BMC Res Notes 5:318. 2012
    ..We hypothesized that detection of CgA mRNA transcripts would be a more sensitive method of detecting these metastases...
  23. doi request reprint A clinical perspective on gastric neuroendocrine neoplasia
    Ben Lawrence
    Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Gastroenterol Rep 13:101-9. 2011
    ..Elucidation of the precise biology of a gastric NET is critical to diagnosis and delineation of a type-specific management strategy...
  24. doi request reprint The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520 8062, USA
    Endocrinol Metab Clin North Am 40:111-34, viii. 2011
    ..Clinicians aware of the physiologic role of chromogranin A and its secretion in a variety of non-NET-related pathologic conditions can use this protein as a moderately effective tumor biomarker in the management of GEP-NETs...
  25. ncbi request reprint The role of genetic markers--NAP1L1, MAGE-D2, and MTA1--in defining small-intestinal carcinoid neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, Connecticut 06520 8062, USA
    Ann Surg Oncol 13:253-62. 2006
    ..We hypothesized that carcinoid malignancy could be defined by using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) and immunohistochemical approaches that evaluate potential marker genes...
  26. doi request reprint Neuroendocrine tumor epidemiology: contrasting Norway and North America
    Oyvind Hauso
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer 113:2655-64. 2008
    ..Norway also holds a robust and detailed cancer registry: the Norwegian Registry of Cancer (NRC)...
  27. pmc The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease
    Rikard Damen
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e62607. 2013
    ..Since hypoxia is associated with increased extracellular adenosine, we wanted to examine whether this nucleotide amplifies HIF-1α-mediated 5-HT secretion...
  28. ncbi request reprint A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 102:1464-73. 2007
    ..We examined patterns, incidence, prognosis, and outcomes of these tumors over a 30-yr period...
  29. ncbi request reprint Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and rapamycin
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, TMP202, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Mol Endocrinol 38:181-92. 2007
    ....
  30. doi request reprint Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors
    Mark Kidd
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 112:1404-14. 2008
    ....
  31. doi request reprint Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy
    Karim M Eltawil
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Clin Gastroenterol 44:687-95. 2010
    ..5% of all NETs, and little is known about their biological behavior. We sought to provide an overview of the current state of knowledge about GB-NETs and provide a recommendation for management...
  32. ncbi request reprint Gastrointestinal carcinoids: the evolution of diagnostic strategies
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Gastroenterol 40:572-82. 2006
    ....
  33. ncbi request reprint From the lumen to the laparoscope
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520, USA
    Arch Surg 139:1110-26. 2004
    ....
  34. ncbi request reprint Therapeutic options for gastrointestinal carcinoids
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Clin Gastroenterol Hepatol 4:526-47. 2006
    ..The keystone of current therapy remains the long-acting somatostatin analogues that alleviate symptomatology and substantially improve quality of life with minimal adverse effects...
  35. pmc Q RT-PCR detection of chromogranin A: a new standard in the identification of neuroendocrine tumor disease
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 243:273-80. 2006
    ..Message and protein expression of CgA was examined to evaluate the sensitivity of a PCR-based approach in the detection of covert neuroendocrine (NE) tissue...
  36. ncbi request reprint Biology and management of gastric carcinoid tumours: a review
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Eur J Surg 168:669-83. 2002
    ..Gastric carcinoids, however, can be managed initially by endoscopic excision of accessible tumours, followed by regular endoscopic surveillance...
  37. pmc The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms
    Simon Schimmack
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA
    Cancer 118:2763-75. 2012
    ..Given the role of internexin alpha (INA) in neuronal development, the authors assessed its function in neuroendocrine cell systems and the clinical implications of its expression as a GEP-NEN biomarker...
  38. doi request reprint KRJ-I and BON cell lines: defining an appropriate enterochromaffin cell neuroendocrine tumor model
    Zakiya Luna Siddique
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine New Haven, New Haven, CT 06520 8062, USA
    Neuroendocrinology 89:458-70. 2009
    ....
  39. ncbi request reprint Delineation of the chemomechanosensory regulation of gastrin secretion using pure rodent G cells
    Mark Kidd
    Gastrointestinal Pathobiology Research Group, Department of Gastroenterology, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 137:231-41, 241.e1-10. 2009
    ..Gastrin is a key regulator of gastric acid secretion. We aimed to isolate pure G cells to identify the mechanistic basis of luminal- and strain-mediated regulation...
  40. doi request reprint Bronchopulmonary neuroendocrine tumors
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Cancer 113:5-21. 2008
    ..This review provides a broad overview on BP-NETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options...
  41. ncbi request reprint Siegfried Oberndorfer: origins and perspectives of carcinoid tumors
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medinice, New Haven, CT 06520 8062, USA
    Hum Pathol 35:1440-51. 2004
    ..It also serves to memorialize the extraordinary accomplishments of Oberndorfer, whose vision exceeded his times...
  42. ncbi request reprint The molecular genetics of gastroenteropancreatic neuroendocrine tumors
    Michelle N Zikusoka
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 104:2292-309. 2005
    ..On the basis of the evolution of genetic information, enteric neuroendocrine lesions (carcinoids) and PETs may need to be classified as two distinct entities rather than grouped together as the single entity "GEP-NETs."..
  43. pmc The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e63364. 2013
    ..Application of this sensitive and specific PCR-based blood test to NENs will allow accurate detection of disease, and potentially define disease progress enabling monitoring of treatment efficacy...
  44. pmc Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors
    Martin Haugen
    Gastrointestinal Pathobiology Research Group, Yale Univ School of Medicine, New Haven, CT 06510, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1164-73. 2012
    ..This results in alterations in 5-HT production and secretion and identifies that the chemomechanosensory role of EC cells extends to oxygen sensing...
  45. ncbi request reprint A 50-year analysis of 562 gastric carcinoids: small tumor or larger problem?
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:23-32. 2004
    ..We sought to examine if there has been an increase in gastric carcinoid incidence time correlative with these parameters...
  46. doi request reprint From Leningrad to London: the saga of Kulchitsky and the legacy of the enterochromaffin cell
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Neuroendocrinology 89:1-12. 2009
    ....
  47. doi request reprint A nomogram to assess small-intestinal neuroendocrine tumor ('carcinoid') survival
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CN 06520 8062, USA
    Neuroendocrinology 92:143-57. 2010
    ..The development of a mathematically validated nomogram provides a platform for objective assessment of SI NET disease, a finite basis for precise prognostication and a tool to guide management strategy...
  48. doi request reprint Management of gastric carcinoids (neuroendocrine neoplasms)
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, PO Box 208602, New Haven, CT, USA
    Curr Gastroenterol Rep 14:467-72. 2012
    ..Infiltrating and metastasized tumors and type III lesions require a more aggressive approach with surgical resection and consideration of modalities such as somatostatin analogs, cytotoxics, and peptide receptor targeted treatment...
  49. doi request reprint Chromogranin A--biological function and clinical utility in neuro endocrine tumor disease
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT, USA
    Ann Surg Oncol 17:2427-43. 2010
    ..We review here the utility of CgA measurement in NETs and describe its biological role and the clinical value of its measurement...
  50. ncbi request reprint Gastroesophageal reflux disease: then and now
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Clin Gastroenterol 38:390-402. 2004
    ..In this respect, Barrett's esophagus still presents a major biologic and management conundrum for the physicians and scientists alike...
  51. doi request reprint Nikolai Konstantinovich Kulchitsky (1856-1925)
    Ignat Drozdov
    Yale University School of Medicine, USA
    J Med Biogr 17:47-54. 2009
    ..Kulchitsky's mysterious demise in a bizarre lift-shaft accident at UCL on his 69th birthday tragically terminated a life of service to science...
  52. ncbi request reprint Carcinoid tumors and fibrosis: an association with no explanation
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:2466-78. 2004
    ..In addition, we have provided more current mechanistic information in regard to the biological basis of fibrosis associated with small bowel carcinoid tumors...
  53. ncbi request reprint The functional characterization of normal and neoplastic human enterochromaffin cells
    Irvin M Modlin
    Department of Surgery, TMP202, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:2340-8. 2006
    ....
  54. doi request reprint Evolution of one-handed piano compositions
    Ignat Drozdov
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Hand Surg Am 33:780-6. 2008
    ....
  55. ncbi request reprint Friedrich Feyrter: a precise intellect in a diffuse system
    Manish C Champaneria
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Neuroendocrinology 83:394-404. 2006
    ..We describe the life and times of this gifted scientist, teacher, and pathologist, often referred to as the 'Father of Neuroendocrinology'...
  56. ncbi request reprint GERD 2004: issues from the past and a consensus for the future
    Irvin Modlin
    Department of Surgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8062, USA
    Best Pract Res Clin Gastroenterol 18:55-66. 2004
    ..A future consensus thus requires the identification of the appropriate tools to detect Barrett's early, identify the specific molecular markers associated with neoplastic transformation and establish a definitive therapeutic algorithm...
  57. ncbi request reprint Primary carcinoid tumor of the parotid gland: A case report and review of the literature
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Ear Nose Throat J 85:533-9. 2006
    ..In particular, it is important to differentiate them from metastatic tumors from other sites...
  58. ncbi request reprint Neuroendocrine tumors of the diffuse neuroendocrine system
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Curr Opin Oncol 20:1-12. 2008
    ..25% of all malignancies; their incidence is increasing by approximately 6% per year. The present review provides an overview on neuroendocrine tumors and focuses on general features and current diagnostic and therapeutic options...
  59. ncbi request reprint Current status of gastrointestinal carcinoids
    Irvin M Modlin
    Gastric Pathobiology Research Group, GI Surgical Division, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 128:1717-51. 2005
    ..Overall 5-year survival for carcinoids of the appendix is 98%, gastric (types I/II) is 81%, rectum is 87%, small intestinal is 60%, colonic carcinoids is 62%, and gastric type III/IV is 33%...
  60. ncbi request reprint GERD 2003: issues from the past and a consensus for the future
    Irvin Modlin
    Gastric Pathology Research Group, Department of Surgery, Yale University, School of Medicine, New Haven, CT 06520 8062, USA
    Drugs Today (Barc) 40:3-8. 2004
    ....
  61. ncbi request reprint Carcinoid tumors of the stomach
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Surg Oncol 12:153-72. 2003
    ..In addition, the clinical rationale of current diagnostic and therapeutic strategies will be examined, providing a logical basis for the formulation of appropriate management strategies for patient care...
  62. doi request reprint Small intestinal neuroendocrine cell pathobiology: 'carcinoid' tumors
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Curr Opin Oncol 23:45-52. 2011
    ..Despite these issues, approximately 350 studies were published in the last year...
  63. pmc Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellular Carcinoma
    Karim M Eltawil
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    World J Surg Oncol 8:43. 2010
    ..The purpose of this study was to compare the impact of the type of resection (anatomic versus non-anatomic) on early intra-hepatic HCC recurrence in patients with solitary HCC and preserved liver function...
  64. ncbi request reprint Gastric stem cells: an update
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Keio J Med 52:134-7. 2003
    ..Ultimately, the identification of these pathways will play an important role in identifying new molecular targets for the treatment of gastric disease...
  65. ncbi request reprint An analysis of rare carcinoid tumors: clarifying these clinical conundrums
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, CT 06520 8062, USA
    World J Surg 29:92-101. 2005
    ..Familiarity with such unusual sites of origin will facilitate appropriate recognition and characterization of such tumors, allowing for timely intervention...
  66. ncbi request reprint Surgical treatment of achalasia: current status and controversies
    Farshad Abir
    Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Dig Surg 21:165-76. 2004
    ..To review the current management of achalasia, and the controversies regarding the different treatment options...
  67. ncbi request reprint Historical perspectives on the treatment of gastroesophageal reflux disease
    Irvin M Modlin
    Yale University School of Medicine, Department of Surgery, TMP 202, 333 Cedar Street, New Haven, CT 06520, USA
    Gastrointest Endosc Clin N Am 13:19-55, vii-viii. 2003
    ..Similarly, a specific pharmacotherapeutic probe targeting the lower esophageal sphincter, while long fantasized, remains to be identified...
  68. ncbi request reprint Multiple gastrointestinal stromal tumors and synchronous ileal carcinoids
    Michele Buragas
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Clin Pract Oncol 2:166-70; quiz 1 p following 170. 2005
    ..A gastric-wedge resection revealed an ulcerated 4.5 cm mass in the stomach, and exploration of the abdomen revealed two ileal carcinoid tumors, jejunal diverticula and reactive mesenteric lymphadenopathy...
  69. ncbi request reprint A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
    ....
  70. ncbi request reprint Traces of human migrations in Helicobacter pylori populations
    Daniel Falush
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, 10117 Berlin, Germany
    Science 299:1582-5. 2003
    ..Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the slave trade...
  71. ncbi request reprint Gastric and duodenal mucosal protein fractional synthesis and growth factor expression in patients with H. pylori-associated gastritis before and after eradication of the organism
    Trevor A Winter
    Gastrointestinal Clinic, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    Dig Dis Sci 49:925-30. 2004
    ..Eradication of HP results in reduction of gastric, but not duodenal, MPFS and has no effect on the growth factors measured. Increased MPFS associated with HP gastritis may relate to the potential for neoplastic transformation...
  72. ncbi request reprint Investigation of the biological relevance of Helicobacter pylori cagE locus diversity, presence of CagA tyrosine phosphorylation motifs and vacuolating cytotoxin genotype on IL-8 induction in gastric epithelial cells
    Robert J Owen
    Laboratory of Enteric Pathogens, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK
    FEMS Immunol Med Microbiol 36:135-40. 2003
    ....
  73. ncbi request reprint The relationship of a Helicobacter heilmannii infection to the mucosal changes in abattoir and laboratory pig stomach
    Anwar S Mall
    Department of Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Surg Today 34:943-9. 2004
    ..The infection with Hh and its relationship to ulceration and mucus integrity was examined...
  74. ncbi request reprint Investigation of HLA-DPA1 genotypes as predictors of inflammatory bowel disease in the German, South African, and South Korean populations
    Annette Lantermann
    Department of General Internal Medicine, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Int J Colorectal Dis 17:238-44. 2002
    ..The HLA-DP genes play an important role in antigen presentation and are located within the chromosome 6p linkage region...
  75. ncbi request reprint Multiple gastric carcinoids
    Irvin M Modlin
    J Am Coll Surg 198:174. 2004