Research Topics
| Kenneth KiddSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Intelligence, race, and geneticsRobert J Sternberg
PACE Center, Yale University, New Haven, CT 208358, USA
Am Psychol 60:46-59. 2005..The authors also show that heritability, a behavior-genetic concept, is inadequate in regard to providing such a link...
Genetic differences in human circadian clock genes among worldwide populationsChristopher M Ciarleglio
Department of Biological Sciences, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, USA
J Biol Rhythms 23:330-40. 2008..Population genetic analyses indicate that these differences are likely to arise from genetic drift rather than from natural selection...- Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kbHaseena Rajeevan
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, P, O, Box 208005, New Haven, CT 06520 8005, USA
Investig Genet 3:18. 2012..abstract:.. 
Expanding data and resources for forensic use of SNPs in individual identificationKenneth K Kidd
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Forensic Sci Int Genet 6:646-52. 2012..We also describe initial developments of multiplex methods and various robustness analyses for our 45 marker IISNP panel...- A global view of the OCA2-HERC2 region and pigmentationMichael P Donnelly
Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
Hum Genet 131:683-96. 2012..Our data suggest that the haplotype restricted to Europe is the strongest marker for blue eyes globally and add further inferential evidence that the derived allele of rs1800414 is an East Asian skin pigmentation allele... - Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samplesJudith R Kidd
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Investig Genet 2:1. 2011..abstract:.. - Developing a SNP panel for forensic identification of individualsKenneth K Kidd
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Forensic Sci Int 164:20-32. 2006..Expansion of this panel to approximately 50 comparable SNPs should give match probabilities of about 10(-15) with a small global range... - Understanding human DNA sequence variationK K Kidd
Department of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8005, USA
J Hered 95:406-20. 2004..We do not yet have a comprehensive understanding of the extensive variation in the human genome, but some of that understanding is coming from population genetics... - Haplotype block structures show significant variation among populationsNianjun Liu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Genet Epidemiol 27:385-400. 2004.... - Global survey of haplotype frequencies and linkage disequilibrium at the RET locusPratima Chattopadhyay
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA
Eur J Hum Genet 11:760-9. 2003..Pairwise LD measures among the SNPs also show considerable variation among populations. Association of STRP alleles with the SNP-defined background haplotypes is generally higher outside of Africa than in Africa, but is highly variable... - On the use of DNA pooling to estimate haplotype frequenciesShuang Wang
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034, USA
Genet Epidemiol 24:74-82. 2003..We find that the DNA pooling of two individuals can be more cost-effective than individual genotypings, especially when a large number of haplotype systems are studied... - Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndromeJames F Leckman
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental... - HAPLOT: a graphical comparison of haplotype blocks, tagSNP sets and SNP variation for multiple populationsSheng Gu
Department of Genetics, Yale University School of Medicine, New Haven, USA
Bioinformatics 21:3938-9. 2005..AVAILABILITY: The application package is available at http://info.med.yale.edu/genetics/kkidd/programs.html CONTACT: sheng.gu@yale.edu... - Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndromeHeping Zhang
Department of Epidemiology and Public Health, Yale Child Study Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
Am J Hum Genet 70:896-904. 2002..000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of.0001 for genomewide scans... - A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversityMichael V Osier
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Hum Genet 71:84-99. 2002..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone... - Population-specific variation in haplotype composition and heterozygosity at the POLB locusJennifer Yamtich
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, United States
DNA Repair (Amst) 8:579-84. 2009..We have found a marked difference between haplotype frequencies in African populations and in non-African populations... - Considerable haplotype diversity within the 23kb encompassing the ADH7 geneYi Han
Department of Genetics, Yale University, School of Medicine, New Haven, CT 06520-8005, USA
Alcohol Clin Exp Res 29:2091-100. 2005..Thus, the previously observed epistatic effect of ADH7 cannot be explained by its linkage disequilibrium with a causative factor in ADH1B... - SNPs for a universal individual identification panelAndrew J Pakstis
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, 208005, New Haven, CT 06520, USA
Hum Genet 127:315-24. 2010..The full set of 86 IISNPs that do not show LD can be used to provide even smaller genotype match probabilities in the range of 10(-31)-10(-35) based on the 44 population samples studied... - Evidence of positive selection on a class I ADH locusYi Han
Department of Genetics, School of Medicine, Yale University, New Haven, CT 06510, USA
Am J Hum Genet 80:441-56. 2007.... - Candidate SNPs for a universal individual identification panelAndrew J Pakstis
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Hum Genet 121:305-17. 2007..The relative ease with which these markers could be identified also provides a cautionary lesson for investigations of possible balancing selection... - The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombinationHiroki Oota
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT 06520 8005, USA
Ann Hum Genet 68:93-109. 2004..D. above the mean for a reference distribution of 117 autosomal biallelic markers. These high Fst values may indicate selection has operated at these or very tightly linked sites... - Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndromeWilliam C Speed
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
Am J Med Genet B Neuropsychiatr Genet 147:463-6. 2008..Although there is no evidence of selection, the haplotype frequency variation seen around the world will need to be considered in any future association studies of this locus with GTS or any other neuropsychiatric disorder... - Global variation in CYP2C8-CYP2C9 functional haplotypesWilliam C Speed
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
Pharmacogenomics J 9:283-90. 2009..This considerable geographic variation in haplotype frequencies impacts the interpretation of CYP2C8/CYP2C9 association studies, and has pharmacogenomic implications for drug interactions... - Significant variation in haplotype block structure but conservation in tagSNP patterns among global populationsSheng Gu
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
Eur J Hum Genet 15:302-12. 2007..The analyses show an asymmetric pattern of tagSNP transferability coinciding with the subsetting of variation attributed to the spread of modern humans around the world... - Ethnic related selection for an ADH Class I variant within East AsiaHui Li
Lab for Human Polymorphism Studies, Department of Genetics, School of Medicine, Yale University, New Haven, Connecticut, United States of America
PLoS ONE 3:e1881. 2008..As the frequency of ADH1B*47His is highest in East Asia, and very low in most of the rest of the world, we have undertaken more detailed investigation in this geographic region... - Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variantHui Li
Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
Ann Hum Genet 73:335-45. 2009..In general the study of fine scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures... - A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer riskLena J Chin
Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
Cancer Res 68:8535-40. 2008..The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility... - Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western AsiaHui Li
Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
Am J Hum Genet 81:842-6. 2007..The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia... - Possible epistatic role of ADH7 in the protection against alcoholismM V Osier
Department of Genetics, SHM I-353, Yale University School of Medicine, 3334 Cedar Street, New Haven, CT 06520, USA
Am J Med Genet B Neuropsychiatr Genet 126:19-22. 2004..The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD)... - Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variationMellissa M C DeMille
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA
Hum Genet 111:521-37. 2002..Because other functional variation might exist, especially regulatory variation, these findings indicate that haplotypes would be more effective indicators of possible involvement of COMT in disease etiology... - Single-nucleotide polymorphism genotyping on optical thin-film biosensor chipsXiao-Bo Zhong
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 100:11559-64. 2003..In studies of mutations associated with risk for venous thrombosis and genotyping/haplotyping of African-American samples, we document high-fidelity analysis with 0 misassignments in 500 assays performed in duplicate... - A proline-threonine substitution in codon 351 of ADH1C is common in Native AmericansMichael V Osier
Department of Genetics, Yale University, New Haven, Connecticut 06520, USA
Alcohol Clin Exp Res 26:1759-63. 2002.... - Intra- and interpopulation genotype reconstruction from tagging SNPsPeristera Paschou
Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
Genome Res 17:96-107. 2007..Finally, we show that reconstruction can be applied to retrieve significant SNP associations with disease, with important genotyping savings... - The distribution and most recent common ancestor of the 17q21 inversion in humansMichael P Donnelly
Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
Am J Hum Genet 86:161-71. 2010..This estimate range is much more recent than the 3 million year age estimated by Stefansson et al. in 2005... - ALFRED: An allele frequency database for anthropologyMichael V Osier
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520-8005, USA
Am J Phys Anthropol 119:77-83. 2002..It is our hope that this database will be useful for research and teaching in a wide range of fields, and that colleagues from various fields will contribute to making ALFRED an important resource for many studies as yet unforeseen... - Genetic structure of human populationsNoah A Rosenberg
Molecular and Computational Biology, 1042 West 36th Place DRB 289, University of Southern California, Los Angeles, CA 90089, USA
Science 298:2381-5. 2002..General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies... - The genetic structure of Pacific IslandersJonathan S Friedlaender
Anthropology Department, Temple University, Philadelphia, Pennsylvania, United States of America
PLoS Genet 4:e19. 2008..Our analysis indicates the ancestors of Polynesians moved through Melanesia relatively rapidly and only intermixed to a very modest degree with the indigenous populations there... - A human genome diversity cell line panelHoward M Cann
Science 296:261-2. 2002 - Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locusStephanie M Fullerton
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 70:1096-106. 2002..These results suggest a history of positive natural selection at the locus, resulting in significant geographic differences in polymorphism frequencies. The relationship of these differences to disease risk is discussed... - Evidence of positive selection acting at the human dopamine receptor D4 gene locusYuan Chun Ding
Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 99:309-14. 2002.... - Read all about it: The Lancet's Paper of the Year, 2003Richard Horton
The Lancet, 32 Jamestown Road, London NW1 7BY, UK
Lancet 362:2101-3. 2003 - Use of autosomal loci for clustering individuals and populations of East Asian originJong-Jin Kim
National Institute of Scientific Investigation, DNA Analysis Division, Seoul, Korea
Hum Genet 117:511-9. 2005..The majority of Koreans were difficult to distinguish from the Japanese. This study shows that a relatively few highly selected markers can, within limits, differentiate between closely related populations... - Global diversity and evidence for coevolution of KIR and HLARichard M Single
The Department of Mathematics and Statistics, University of Vermont, Burlington, Vermont 05405, USA
Nat Genet 39:1114-9. 2007.... - Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chipsKaori Nakamoto
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
Pharmacogenet Genomics 17:103-14. 2007..The currently used restriction fragment length polymorphism-based method for genotyping CYP2C19*2 cannot distinguish between CYP2C19*2 and CYP2C19*10. We aim to develop a simple platform that can genotype all CYP2C19 functional alleles... - Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selectionDavid Fredman
Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
Hum Mutat 27:173-86. 2006..Four particularly striking clusters of these markers were apparent, and three of these coincide with genes/regions from among only several dozen such domains previously suggested by others to carry signatures of selection... - Linkage disequilibrium patterns vary substantially among populationsSarah L Sawyer
Center for Genomics and Bioinformatics, Karolinska Institute, , Stockholm 17177, Sweden
Eur J Hum Genet 13:677-86. 2005.... - Evolutionary insights into the high worldwide prevalence of MBL2 deficiency allelesPaul Verdu
CNRS FRE 2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
Hum Mol Genet 15:2650-8. 2006..The evolutionary neutrality of MBL2 strongly supports the notion that MBL2 variation does not have strong effects on population fitness, suggesting, therefore, that this lectin is largely redundant in host human defences... - Low nucleotide diversity in chimpanzees and bonobosNing Yu
Department of Ecology and Evolution, University of Chicago, 1101 E. 57th Street, Chicago, IL 60637, USA
Genetics 164:1511-8. 2003..Sequence data from this article have been deposited with the GenBank Data libraries under accession nos. AY 275957-AY 277244... - Implications of biogeography of human populations for 'race' and medicineSarah A Tishkoff
Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
Nat Genet 36:S21-7. 2004..Identifiers based on race will often be insufficient... - Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications GHussam Al-Kateb
Program in Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building East Tower, Rm 15 707, 101 College St, Toronto, Ontario, Canada
Diabetes 57:218-28. 2008..Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes... - Epidemiology. DNA identifications after the 9/11 World Trade Center attackLeslie G Biesecker
Science 310:1122-3. 2005....
Research Grants
- CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISMKenneth Kidd; Fiscal Year: 1993..Such other loci include the other known dopamine receptor genes (DRD1, DRD3, DRD4, DRD5) among many other possibilities...
- CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISMKenneth Kidd; Fiscal Year: 1999
- CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISMKenneth Kidd; Fiscal Year: 2009..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..