Kenneth Kidd

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Intelligence, race, and genetics
    Robert J Sternberg
    PACE Center, Yale University, New Haven, CT 208358, USA
    Am Psychol 60:46-59. 2005
  2. pmc Genetic differences in human circadian clock genes among worldwide populations
    Christopher M Ciarleglio
    Department of Biological Sciences, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, USA
    J Biol Rhythms 23:330-40. 2008
  3. pmc Ethnic related selection for an ADH Class I variant within East Asia
    Hui Li
    Lab for Human Polymorphism Studies, Department of Genetics, School of Medicine, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 3:e1881. 2008
  4. doi Progress toward an efficient panel of SNPs for ancestry inference
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA Electronic address
    Forensic Sci Int Genet 10:23-32. 2014
  5. doi An historical perspective on "The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus"
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT, 06520 8005, USA
    Hum Genet 133:431-3. 2014
  6. pmc Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel
    Caroline M Nievergelt
    Department of Psychiatry, School of Medicine, University of San Diego California, La Jolla, CA, 92093, USA
    Investig Genet 4:13. 2013
  7. pmc High diversity and no significant selection signal of human ADH1B gene in Tibet
    Yan Lu
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Investig Genet 3:23. 2012
  8. pmc Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kb
    Haseena Rajeevan
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, P, O, Box 208005, New Haven, CT 06520 8005, USA
    Investig Genet 3:18. 2012
  9. doi Expanding data and resources for forensic use of SNPs in individual identification
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Forensic Sci Int Genet 6:646-52. 2012
  10. pmc A global view of the OCA2-HERC2 region and pigmentation
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Genet 131:683-96. 2012

Research Grants

  1. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 1999
  2. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 1993
  3. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009

Detail Information

Publications56

  1. ncbi Intelligence, race, and genetics
    Robert J Sternberg
    PACE Center, Yale University, New Haven, CT 208358, USA
    Am Psychol 60:46-59. 2005
    ..The authors also show that heritability, a behavior-genetic concept, is inadequate in regard to providing such a link...
  2. pmc Genetic differences in human circadian clock genes among worldwide populations
    Christopher M Ciarleglio
    Department of Biological Sciences, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN, USA
    J Biol Rhythms 23:330-40. 2008
    ..Population genetic analyses indicate that these differences are likely to arise from genetic drift rather than from natural selection...
  3. pmc Ethnic related selection for an ADH Class I variant within East Asia
    Hui Li
    Lab for Human Polymorphism Studies, Department of Genetics, School of Medicine, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 3:e1881. 2008
    ..As the frequency of ADH1B*47His is highest in East Asia, and very low in most of the rest of the world, we have undertaken more detailed investigation in this geographic region...
  4. doi Progress toward an efficient panel of SNPs for ancestry inference
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA Electronic address
    Forensic Sci Int Genet 10:23-32. 2014
    ..We have developed a panel of 55 SNPs analyzed on 73 populations from around the world. We present the details of the panel and discuss its strengths and limitations. ..
  5. doi An historical perspective on "The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus"
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT, 06520 8005, USA
    Hum Genet 133:431-3. 2014
    ....
  6. pmc Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel
    Caroline M Nievergelt
    Department of Psychiatry, School of Medicine, University of San Diego California, La Jolla, CA, 92093, USA
    Investig Genet 4:13. 2013
    ..Here we report on the development, application and limitations of a small, multiplexable ancestry informative marker (AIM) panel of SNPs (or AISNP) developed specifically for this purpose...
  7. pmc High diversity and no significant selection signal of human ADH1B gene in Tibet
    Yan Lu
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Investig Genet 3:23. 2012
    ..abstract:..
  8. pmc Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kb
    Haseena Rajeevan
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, P, O, Box 208005, New Haven, CT 06520 8005, USA
    Investig Genet 3:18. 2012
    ..abstract:..
  9. doi Expanding data and resources for forensic use of SNPs in individual identification
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Forensic Sci Int Genet 6:646-52. 2012
    ..We also describe initial developments of multiplex methods and various robustness analyses for our 45 marker IISNP panel...
  10. pmc A global view of the OCA2-HERC2 region and pigmentation
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Hum Genet 131:683-96. 2012
    ..Our data suggest that the haplotype restricted to Europe is the strongest marker for blue eyes globally and add further inferential evidence that the derived allele of rs1800414 is an East Asian skin pigmentation allele...
  11. pmc Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples
    Judith R Kidd
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Investig Genet 2:1. 2011
    ..abstract:..
  12. ncbi Developing a SNP panel for forensic identification of individuals
    Kenneth K Kidd
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Forensic Sci Int 164:20-32. 2006
    ..Expansion of this panel to approximately 50 comparable SNPs should give match probabilities of about 10(-15) with a small global range...
  13. ncbi Understanding human DNA sequence variation
    K K Kidd
    Department of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8005, USA
    J Hered 95:406-20. 2004
    ..We do not yet have a comprehensive understanding of the extensive variation in the human genome, but some of that understanding is coming from population genetics...
  14. ncbi On the use of DNA pooling to estimate haplotype frequencies
    Shuang Wang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Genet Epidemiol 24:74-82. 2003
    ..We find that the DNA pooling of two individuals can be more cost-effective than individual genotypings, especially when a large number of haplotype systems are studied...
  15. ncbi Global survey of haplotype frequencies and linkage disequilibrium at the RET locus
    Pratima Chattopadhyay
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Eur J Hum Genet 11:760-9. 2003
    ..Pairwise LD measures among the SNPs also show considerable variation among populations. Association of STRP alleles with the SNP-defined background haplotypes is generally higher outside of Africa than in Africa, but is highly variable...
  16. ncbi Haplotype block structures show significant variation among populations
    Nianjun Liu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genet Epidemiol 27:385-400. 2004
    ....
  17. ncbi HAPLOT: a graphical comparison of haplotype blocks, tagSNP sets and SNP variation for multiple populations
    Sheng Gu
    Department of Genetics, Yale University School of Medicine, New Haven, USA
    Bioinformatics 21:3938-9. 2005
    ..We present here a win32 system based Perl/Tk application for visual comparisons of these variations in different populations...
  18. pmc A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
    Michael V Osier
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Hum Genet 71:84-99. 2002
    ..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone...
  19. pmc Genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome
    Heping Zhang
    Department of Epidemiology and Public Health, Yale Child Study Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hum Genet 70:896-904. 2002
    ..000003. Although P values were not adjusted for multiple comparison, nearly all were much smaller than the customary significance level of.0001 for genomewide scans...
  20. ncbi Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003
    ..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...
  21. pmc Evidence of positive selection on a class I ADH locus
    Yi Han
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06510, USA
    Am J Hum Genet 80:441-56. 2007
    ....
  22. ncbi Considerable haplotype diversity within the 23kb encompassing the ADH7 gene
    Yi Han
    Department of Genetics, Yale University, School of Medicine, New Haven, CT 06520 8005, USA
    Alcohol Clin Exp Res 29:2091-100. 2005
    ..Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP...
  23. ncbi Candidate SNPs for a universal individual identification panel
    Andrew J Pakstis
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Genet 121:305-17. 2007
    ..The relative ease with which these markers could be identified also provides a cautionary lesson for investigations of possible balancing selection...
  24. pmc Global variation in CYP2C8-CYP2C9 functional haplotypes
    William C Speed
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Pharmacogenomics J 9:283-90. 2009
    ..This considerable geographic variation in haplotype frequencies impacts the interpretation of CYP2C8/CYP2C9 association studies, and has pharmacogenomic implications for drug interactions...
  25. doi SNPs for a universal individual identification panel
    Andrew J Pakstis
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, 208005, New Haven, CT 06520, USA
    Hum Genet 127:315-24. 2010
    ..The full set of 86 IISNPs that do not show LD can be used to provide even smaller genotype match probabilities in the range of 10(-31)-10(-35) based on the 44 population samples studied...
  26. pmc Population-specific variation in haplotype composition and heterozygosity at the POLB locus
    Jennifer Yamtich
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, United States
    DNA Repair (Amst) 8:579-84. 2009
    ..We have found a marked difference between haplotype frequencies in African populations and in non-African populations...
  27. ncbi Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome
    William C Speed
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Am J Med Genet B Neuropsychiatr Genet 147:463-6. 2008
    ..Although there is no evidence of selection, the haplotype frequency variation seen around the world will need to be considered in any future association studies of this locus with GTS or any other neuropsychiatric disorder...
  28. ncbi The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination
    Hiroki Oota
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT 06520 8005, USA
    Ann Hum Genet 68:93-109. 2004
    ..D. above the mean for a reference distribution of 117 autosomal biallelic markers. These high Fst values may indicate selection has operated at these or very tightly linked sites...
  29. pmc Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant
    Hui Li
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520 8005, USA
    Ann Hum Genet 73:335-45. 2009
    ..In general the study of fine scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures...
  30. ncbi Significant variation in haplotype block structure but conservation in tagSNP patterns among global populations
    Sheng Gu
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Eur J Hum Genet 15:302-12. 2007
    ..The analyses show an asymmetric pattern of tagSNP transferability coinciding with the subsetting of variation attributed to the spread of modern humans around the world...
  31. pmc A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
    Lena J Chin
    Department of Molecular, Yale University, New Haven, Connecticut 06520, USA
    Cancer Res 68:8535-40. 2008
    ..The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility...
  32. ncbi Possible epistatic role of ADH7 in the protection against alcoholism
    M V Osier
    Department of Genetics, SHM I 353, Yale University School of Medicine, 3334 Cedar Street, New Haven, CT 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 126:19-22. 2004
    ..The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD)...
  33. pmc Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia
    Hui Li
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Am J Hum Genet 81:842-6. 2007
    ..The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia...
  34. pmc Single-nucleotide polymorphism genotyping on optical thin-film biosensor chips
    Xiao bo Zhong
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:11559-64. 2003
    ..In studies of mutations associated with risk for venous thrombosis and genotyping/haplotyping of African-American samples, we document high-fidelity analysis with 0 misassignments in 500 assays performed in duplicate...
  35. ncbi A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans
    Michael V Osier
    Department of Genetics, Yale University, New Haven, Connecticut 06520, USA
    Alcohol Clin Exp Res 26:1759-63. 2002
    ....
  36. ncbi Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation
    Mellissa M C DeMille
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520 8005, USA
    Hum Genet 111:521-37. 2002
    ..Because other functional variation might exist, especially regulatory variation, these findings indicate that haplotypes would be more effective indicators of possible involvement of COMT in disease etiology...
  37. ncbi ALFRED: An allele frequency database for anthropology
    Michael V Osier
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 8005, USA
    Am J Phys Anthropol 119:77-83. 2002
    ..It is our hope that this database will be useful for research and teaching in a wide range of fields, and that colleagues from various fields will contribute to making ALFRED an important resource for many studies as yet unforeseen...
  38. pmc The distribution and most recent common ancestor of the 17q21 inversion in humans
    Michael P Donnelly
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Hum Genet 86:161-71. 2010
    ..This estimate range is much more recent than the 3 million year age estimated by Stefansson et al. in 2005...
  39. pmc Intra- and interpopulation genotype reconstruction from tagging SNPs
    Peristera Paschou
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
    Genome Res 17:96-107. 2007
    ..Finally, we show that reconstruction can be applied to retrieve significant SNP associations with disease, with important genotyping savings...
  40. ncbi Genetic structure of human populations
    Noah A Rosenberg
    Molecular and Computational Biology, 1042 West 36th Place DRB 289, University of Southern California, Los Angeles, CA 90089, USA
    Science 298:2381-5. 2002
    ..General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies...
  41. pmc The genetic structure of Pacific Islanders
    Jonathan S Friedlaender
    Anthropology Department, Temple University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 4:e19. 2008
    ..Our analysis indicates the ancestors of Polynesians moved through Melanesia relatively rapidly and only intermixed to a very modest degree with the indigenous populations there...
  42. pmc Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus
    Stephanie M Fullerton
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 70:1096-106. 2002
    ..These results suggest a history of positive natural selection at the locus, resulting in significant geographic differences in polymorphism frequencies. The relationship of these differences to disease risk is discussed...
  43. ncbi A human genome diversity cell line panel
    Howard M Cann
    Science 296:261-2. 2002
  44. ncbi Read all about it: The Lancet's Paper of the Year, 2003
    Richard Horton
    The Lancet, 32 Jamestown Road, London NW1 7BY, UK
    Lancet 362:2101-3. 2003
  45. ncbi Use of autosomal loci for clustering individuals and populations of East Asian origin
    Jong Jin Kim
    National Institute of Scientific Investigation, DNA Analysis Division, Seoul, Korea
    Hum Genet 117:511-9. 2005
    ..The majority of Koreans were difficult to distinguish from the Japanese. This study shows that a relatively few highly selected markers can, within limits, differentiate between closely related populations...
  46. pmc Evidence of positive selection acting at the human dopamine receptor D4 gene locus
    Yuan Chun Ding
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:309-14. 2002
    ....
  47. ncbi Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection
    David Fredman
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 27:173-86. 2006
    ..Four particularly striking clusters of these markers were apparent, and three of these coincide with genes/regions from among only several dozen such domains previously suggested by others to carry signatures of selection...
  48. ncbi Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles
    Paul Verdu
    CNRS FRE 2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
    Hum Mol Genet 15:2650-8. 2006
    ..The evolutionary neutrality of MBL2 strongly supports the notion that MBL2 variation does not have strong effects on population fitness, suggesting, therefore, that this lectin is largely redundant in host human defences...
  49. ncbi Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips
    Kaori Nakamoto
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Pharmacogenet Genomics 17:103-14. 2007
    ..The currently used restriction fragment length polymorphism-based method for genotyping CYP2C19*2 cannot distinguish between CYP2C19*2 and CYP2C19*10. We aim to develop a simple platform that can genotype all CYP2C19 functional alleles...
  50. ncbi Global diversity and evidence for coevolution of KIR and HLA
    Richard M Single
    The Department of Mathematics and Statistics, University of Vermont, Burlington, Vermont 05405, USA
    Nat Genet 39:1114-9. 2007
    ....
  51. ncbi Linkage disequilibrium patterns vary substantially among populations
    Sarah L Sawyer
    Center for Genomics and Bioinformatics, Karolinska Institute, Berzelius vag 35, Stockholm 17177, Sweden
    Eur J Hum Genet 13:677-86. 2005
    ....
  52. ncbi Implications of biogeography of human populations for 'race' and medicine
    Sarah A Tishkoff
    Department of Biology, Building 144, University of Maryland, College Park, Maryland 20742, USA
    Nat Genet 36:S21-7. 2004
    ..Identifiers based on race will often be insufficient...
  53. pmc Low nucleotide diversity in chimpanzees and bonobos
    Ning Yu
    Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA
    Genetics 164:1511-8. 2003
    ..Sequence data from this article have been deposited with the GenBank Data libraries under accession nos. AY 275957-AY 277244...
  54. pmc Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications G
    Hussam Al-Kateb
    Program in Genetics and Genome Biology, The Hospital for Sick Children, TMDT Building East Tower, Rm 15 707, 101 College St, Toronto, Ontario, Canada
    Diabetes 57:218-28. 2008
    ..Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes...
  55. ncbi Epidemiology. DNA identifications after the 9/11 World Trade Center attack
    Leslie G Biesecker
    Science 310:1122-3. 2005
    ....

Research Grants18

  1. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 1999
  2. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 1993
    ..Such other loci include the other known dopamine receptor genes (DRD1, DRD3, DRD4, DRD5) among many other possibilities...
  3. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009
    ..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..