Insoo Kang

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Modulation of collagen-induced arthritis by IL-4 and dexamethasone: the synergistic effect of IL-4 and dexamethasone on the resolution of CIA
    I Kang
    Department of Internal Medicine, College of Medicine, Hallym University, South Korea
    Immunopharmacology 49:317-24. 2000
  2. ncbi request reprint Infectious complications in SLE after immunosuppressive therapies
    Insoo Kang
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Rheumatol 15:528-34. 2003
  3. ncbi request reprint Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
    Insoo Kang
    Section of Rheumatology, Yale University School of Medicine, PO Box 208031, 300 Cedar Street, Anlyan Center for Medical Research and Education, Rm 541C, New Haven, CT 06520, USA
    J Immunol 173:673-81. 2004
  4. pmc Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
    Hang Rae Kim
    Section of Rheumatology, Department of Internal Medicine, TAC S541C, Yale School of Medicine, PO Box 208031, New Haven, CT 06520
    Blood 107:2855-62. 2006
  5. ncbi request reprint Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies
    Insoo Kang
    Section of Rheumatology, S541C TAC, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    Clin Rheumatol 23:509-15. 2004
  6. pmc Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
    Kamini Shah
    Department of Internal Medicine, Yale University School of Medicine, S525C TAC, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Arthritis Res Ther 12:R53. 2010
  7. pmc Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-γ levels with aging
    Min Sun Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cytokine 61:485-90. 2013
  8. pmc Self double-stranded (ds)DNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies
    Min Sun Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 190:1407-15. 2013
  9. pmc Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling
    Naeun Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Immunol 152:101-10. 2014
  10. pmc Age-associated alteration in naive and memory Th17 cell response in humans
    Jin Soo Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Immunol 140:84-91. 2011

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Modulation of collagen-induced arthritis by IL-4 and dexamethasone: the synergistic effect of IL-4 and dexamethasone on the resolution of CIA
    I Kang
    Department of Internal Medicine, College of Medicine, Hallym University, South Korea
    Immunopharmacology 49:317-24. 2000
    ..These results suggest that the beneficial effects of high-dose DXM and the combination of IL-4 and DXM on CIA are independent of IL-10 and IFN-gamma...
  2. ncbi request reprint Infectious complications in SLE after immunosuppressive therapies
    Insoo Kang
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Rheumatol 15:528-34. 2003
    ..Careful monitoring of infectious complications is warranted in patients with systemic lupus erythematosus receiving immunosuppressive therapies, in particular those on high-dose glucocorticoids and cytotoxic drugs...
  3. ncbi request reprint Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine
    Insoo Kang
    Section of Rheumatology, Yale University School of Medicine, PO Box 208031, 300 Cedar Street, Anlyan Center for Medical Research and Education, Rm 541C, New Haven, CT 06520, USA
    J Immunol 173:673-81. 2004
    ..These findings raise an important clinical question about whether the vaccination strategy in the elderly should be modified to improve cellular immune responses...
  4. pmc Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
    Hang Rae Kim
    Section of Rheumatology, Department of Internal Medicine, TAC S541C, Yale School of Medicine, PO Box 208031, New Haven, CT 06520
    Blood 107:2855-62. 2006
    ....
  5. ncbi request reprint Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies
    Insoo Kang
    Section of Rheumatology, S541C TAC, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    Clin Rheumatol 23:509-15. 2004
    ..However, a test for anti-dsDNA Abs should be considered in samples with a homogeneous pattern at any titer including low titers...
  6. pmc Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
    Kamini Shah
    Department of Internal Medicine, Yale University School of Medicine, S525C TAC, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Arthritis Res Ther 12:R53. 2010
    ..Thus, this study analyzed the balance of CD4+ Th17 and Th1 cell responses in peripheral blood from patients with systemic lupus erythematosus (SLE) and healthy subjects...
  7. pmc Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-γ levels with aging
    Min Sun Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cytokine 61:485-90. 2013
    ....
  8. pmc Self double-stranded (ds)DNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies
    Min Sun Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 190:1407-15. 2013
    ....
  9. pmc Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling
    Naeun Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Immunol 152:101-10. 2014
    ....
  10. pmc Age-associated alteration in naive and memory Th17 cell response in humans
    Jin Soo Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Immunol 140:84-91. 2011
    ..These findings indicate that aging differentially affects naive and memory Th17 cell responses in humans...
  11. ncbi request reprint Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells
    Myung Sun Hong
    Section of Rheumatology, School of Medicine, Yale University, PO Box 208031, 300 Cedar Street, TAC Room 541C, New Haven, CT 06520, USA
    Mech Ageing Dev 125:615-8. 2004
    ..However, both groups had a similar frequency of CM cells. These findings suggest that age-associated changes in CD8+ T cell subsets occur, which could be a potential explanation for altered CD8+ T cell function in the elderly...
  12. ncbi request reprint Down-regulation of IL-7Ralpha expression in human T cells via DNA methylation
    Hang Rae Kim
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 178:5473-9. 2007
    ....
  13. ncbi request reprint Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
    Insoo Kang
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Immunol 172:1287-94. 2004
    ..These results demonstrate that patients with SLE have defective control of latent EBV infection that probably stems from altered T cell responses against EBV...
  14. pmc 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
    Seong Wook Kang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 188:5276-82. 2012
    ..These findings suggest that 1,25(OH)(2)VD(3) can affect human immune responses by regulating FOXP3 expression in CD4(+) T cells through direct VDR binding to the FOXP3 gene, which is essential for inhibitory function of VD-iTreg cells...
  15. ncbi request reprint IL-7 and IL-15: biology and roles in T-Cell immunity in health and disease
    Hang Rae Kim
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 USA
    Crit Rev Immunol 28:325-39. 2008
    ..Here, we review what is currently known about the roles of these cytokines in T-cell immunity, in general, as well as in RA, in particular, focusing on recent discoveries...
  16. ncbi request reprint Dual roles of IL-15 in maintaining IL-7RalphalowCCR7- memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway
    Hang Rae Kim
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:6734-40. 2007
    ..Moreover, IL-15 can be useful in reviving impaired proliferative function of such memory CD8(+) T cells with effector functions against infections and tumors via rescuing the PI3K/AKT pathway...
  17. pmc The relationship of cytomegalovirus (CMV) infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in human aging
    Won Woo Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cytokine 58:332-5. 2012
    ..Also, IFN-α could be associated with the expansion of IL-7Rα(low) CD45RA(+) EM CD8(+) T cells in the CMV-uninfected elderly...
  18. pmc Regulating human Th17 cells via differential expression of IL-1 receptor
    Won Woo Lee
    Department of Internal Medicine Yale University School of Medicine, New Haven, CT, USA
    Blood 115:530-40. 2010
    ..These results indicate that human Th17 cell differentiation is regulated via differential expression of IL-1RI, which is controlled by IL-7 and IL-15...
  19. ncbi request reprint Resistance to development of collagen-induced arthritis in C57BL/6 mice is due to a defect in secondary, but not in primary, immune response
    Meng Pan
    Section of Rheumatology, Yale School of Medicine, New Haven, Connecticut 06520 8031, USA
    J Clin Immunol 24:481-91. 2004
    ..Our results define for the first time that a defective secondary immune responses in B6 mice leads to the resistance of CIA...
  20. pmc Aging and human CD4(+) regulatory T cells
    Kyung A Hwang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Mech Ageing Dev 130:509-17. 2009
    ..Taken together, our observations suggest that aging may affect the capacity of CD4(+), FOXP3(+) T cells in regulating IL-10 production from target CD4(+) T cells in humans although their other cellular characteristics remain unchanged...
  21. pmc An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans
    Ki Soo Kang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Immunol 147:79-88. 2013
    ..These findings suggest that aging alters the association of influenza-vaccine specific IgG responses with HI antibody titers, cytokine-producing capacity and proportions of memory T cells in humans...
  22. pmc U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes
    Min Sun Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 188:4769-75. 2012
    ..Our findings indicate that endogenous RNA-containing U1-snRNP could be a signal that activates the NLRP3 inflammasome in autoimmune diseases like systemic lupus erythematosus where anti-U1-snRNP Abs are present...
  23. pmc T-cell biology in aging, with a focus on lung disease
    Naeun Lee
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, S525C TAC, 300 Cedar Street, New Haven, CT 06520, USA
    J Gerontol A Biol Sci Med Sci 67:254-63. 2012
    ..Here, we will review the recent advances in T-cell immunity and its alteration with aging and discuss the potential effects of such changes on the lung...
  24. pmc Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans
    Won Woo Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Immunol 275:19-23. 2012
    ..These finding provide new insight into how food supplements like AHCC could enhance human immunity by modulating monocytes and Th cells...
  25. pmc CD4+ T helper 1 cells facilitate regression of murine Lyme carditis
    L K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut 06520 8031, USA
    Infect Immun 69:5264-9. 2001
    ..These results show that alphabeta T cells can promote resolution of murine Lyme carditis and are the first demonstration of a beneficial role for CD4+ T helper 1 cells in this disease...
  26. pmc Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway
    M C Shanafelt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 66:266-71. 1998
    ..These studies may provide insight into the role of the B7/CD28 pathway in other infectious and autoimmune diseases in which deviation of Th cell immune responses occurs and antigen is persistently present...
  27. pmc Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells
    Min S Shin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Rheumatol 23:444-8. 2011
    ..We will review recent findings on effector T cells, in particular Th17 cells, in lupus...
  28. pmc Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies
    Xiao bo Zhong
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Nucleic Acids Res 33:e121. 2005
    ..We also present data supporting significant population stratification of the low- versus high-expression forms of MIF that may bear on the role of this gene in infectious diseases...

Research Grants8

  1. Pathogen-specific T cell responses in patients with SLE
    Insoo Kang; Fiscal Year: 2007
    ..abstract_text> ..
  2. Aging and IL-7-mediated CD8+ T Cell survival
    Insoo Kang; Fiscal Year: 2007
    ..The results of this study will advance our understanding about the effect of aging on the immune system, leading to better protection against infection and tumors. ..
  3. Investigating aging and membrane-associated T cell receptor signaling in human CD
    Insoo Kang; Fiscal Year: 2007
    ..The results of this study will provide important information on enhancing immune responses in the aged populations, leading to improved protection against infections and tumors. ..
  4. Aging and IL-7-mediated CD8+ T Cell survival
    Insoo Kang; Fiscal Year: 2009
    ..The results of this study will advance our understanding about the effect of aging on the immune system, leading to better protection against infection and tumors. ..
  5. Aging and IL-7-mediated CD8+ T Cell survival
    Insoo Kang; Fiscal Year: 2010
    ..The results of this study will advance our understanding about the effect of aging on the immune system, leading to better protection against infection and tumors. ..