Research Topics
| CHARLES JANEWAYSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient miceG Das
Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510, USA
J Exp Med 190:881-4. 1999..In beta2-microglobulin (beta2m)-deficient mice, all of the TCR-alpha/beta CD8alpha/alpha and CD8alpha/beta T cells disappear, but TCR-gamma/delta cells are unaffected by the absence of beta2m...- Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2J M Blander
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
J Exp Med 191:2065-74. 2000..We conclude from these data that a mutation in the TCR at a key position that contacts major histocompatibility complex-bound peptide is associated with a shift in T cell differentiation from Th1 to Th2... 
The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discoveryC A Janeway
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Immunol Cell Biol 77:177-9. 1999..All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology...- Innate immune recognitionCharles A Janeway
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
Annu Rev Immunol 20:197-216. 2002..Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens... - A trip through my life with an immunological themeCharles A Janeway
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 310 Cedar Street, New Haven, Connecticut 06520 8011, USA
Annu Rev Immunol 20:1-28. 2002..These cells recognize antigen as do all T cells, but they secrete the immunoregulatory cytokines IL-10 and TGF beta... - How the immune system protects the host from infectionC A Janeway
Section of Immunobiology, LH 416, PO Box 208011, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
Microbes Infect 3:1167-71. 2001..This in turn leads to B-cell-derived antibody responses. The entire response is controlled by suppressor T cells, as predicted many years ago by Richard Gershon... - The role of self-recognition in receptor repertoire development. Members of the Janeway LaboratoryC A Janeway
Section of Immunobiology, Yale University School of Medicine, and the Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
Immunol Res 19:107-18. 1999..Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses... - Obituary: Charles A. Janeway Jr (1943-2003)William E Paul
Nature 423:237. 2003 - Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitisMargaret S Bynoe
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 19:317-28. 2003..There was no CD4 T cell infiltration in the brain of protected mice. Finally, ECi with autoantigenic peptides protected two nontransgenic models from relapsing-remitting EAE in an antigen-specific and antigen dose-dependent manner... - A pool of central memory-like CD4 T cells contains effector memory precursorsJ Magarian Blander
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520, USA
J Immunol 170:2940-8. 2003..Having these properties, the L51S TCR transgenic memory CD4 T cells cannot be classified as either strict central memory or effector memory, but, rather, as a pool of memory T cells containing effector memory precursors... - MHC specificity of iIELsGobardhan Das
Room #3335, Bld-JR2, Aventis Pharmaceuticals, 202-206 North, Bridgewater, NJ 08807, USA
Trends Immunol 24:88-93. 2003..Here, we focus systematically on recent developments in innate immunity and in TCR recognition of different subtypes of iIELs by various MHC molecules... - Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activityChristophe Viret
Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520-8011, USA
J Immunol 170:201-9. 2003..Finally, the margin created by the absence of CD4 coreceptor was substantial because it could accommodate various amounts of the deleting ligand on thymic stromal cells... - The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activationHilda Holcombe
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 169:4982-9. 2002.... - In memoriam. Charles A. Janeway, Jr. February 5, 1943-April 12, 2003Richard W Dutton
AAI Past President Trudeau Institute. AAI Executive Director
J Immunol 171:6314-5. 2003 - Investigation of the role of B-cells in type 1 diabetes in the NOD mouseF Susan Wong
Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
Diabetes 53:2581-7. 2004..This may relate to reduced ability to activate an islet-specific T-cell repertoire, presumably due to the reduced islet-specific B-cell repertoire. Our results implicate a specific antigen-presenting function for B-cells... - T cells from epicutaneously immunized mice are prone to T cell receptor revisionMargaret S Bynoe
Section of Immunobiology, Howard Hughes Medical Institute and Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:2898-903. 2005..The emergence of these cells did not depend on the thymic compartment. We conclude that in mice epicutaneously immunized with an autoantigen, peripheral specific T cells are susceptible to multiple mechanisms of tolerance... - IRAK-M is a negative regulator of Toll-like receptor signalingKoichi Kobayashi
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 110:191-202. 2002..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis... - Negative selection of thymocytes expressing the D10 TCRDEREK B SANT'ANGELO
Section of Immunobiology, Yale University School of Medicine and the Howard Hughes Medical Institute, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 99:6931-6. 2002..Finally, we show that the self-peptide repertoire plays a significant role in selection because alteration of the self-peptide repertoire by disruption of the H2-Ma gene drastically alters selection of D10 TCR-expressing thymocytes... - Decoding the patterns of self and nonself by the innate immune systemRuslan Medzhitov
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Science 296:298-300. 2002..These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals... - Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitusF Susan Wong
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
Proc Natl Acad Sci U S A 99:5551-6. 2002.... - RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsKoichi Kobayashi
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 416:194-9. 2002..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems... - Dual receptor T cells extend the immune repertoire for foreign antigensXin He
Section of Immunobiology, Yale University School of Medicine, 310 Cedar St, New Haven, CT 06520 8011, USA
Nat Immunol 3:127-34. 2002..Thus, dual TCR cells can extend the TCR repertoire for foreign antigens by rescuing functional TCRs that cannot be selected on single TCR cells; they can, therefore, benefit the immune system... - A goodbye to Charlie Janeway: Charles A. Janeway Jr (1943-2003)Alexander Sasha I Rudensky
HHMI and Department of immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Trends Immunol 24:403. 2003 - Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selectionChristophe Viret
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 100:5354-9. 2003..1 T cells. The data support the notion that the integration of distinct signals generated by the simultaneous recognition of multiple self-peptide/MHC complexes directs intrathymic selection of T cells... - Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanismIqbal S Grewal
Millennium Pharmaceuticals, Inc Cambridge, MA 02139, USA
J Autoimmun 19:9-22. 2002..TUNEL assays revealed increased apoptosis of invading cells when compared to non-transgenic NOD mice. Taken together, these results suggest that TGF-beta protects islets by a local event... - Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the ruleXin He
Trends Immunol 23:467-9. 2002..Therefore, the KB TCR beta chain transgenic mice offer a unique opportunity for addressing this issue... - Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptorDEREK B SANT'ANGELO
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Eur J Immunol 32:2510-20. 2002..However, using an HLA-DM-mediated technique to measure peptide binding to MHC class II molecules, we found that the peptide flanking residues contribute substantially to MHC binding... - Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's HospitalRaif S Geha
Division of Immunology, Children's Hospital, Department of Paediatrics, Harvard Medical School, Boston, MA, USA
J Allergy Clin Immunol 116:937-40. 2005
Research Grants
- INFLUENCE OF H-2 ANTIGENS ON MOUSE T CELL RESPONSESCHARLES JANEWAY; Fiscal Year: 1980..The ability of these products to bind to antigen and to MHC antigens will be determined to find out if the T cell has one or two types of receptor on its surface. ..
- INFLUENCE OF H-2 ANTIGENS ON T CELL RESPONSESCHARLES JANEWAY; Fiscal Year: 1990..The applicants will also analyze the antibody they have to determine the exact nature of its ligand, the process by which this ligand is generated, and the molecular details of the interaction of the antibody with its ligand...
- H2 ANTIGENS AND MOUSE CELL RESPONSESCHARLES JANEWAY; Fiscal Year: 2002..We will test these hypotheses in a variety of ways to determine their correctness. ..