CHARLES JANEWAY

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice
    G Das
    Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510, USA
    J Exp Med 190:881-4. 1999
  2. pmc Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2
    J M Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    J Exp Med 191:2065-74. 2000
  3. ncbi The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Immunol Cell Biol 77:177-9. 1999
  4. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
  5. ncbi A trip through my life with an immunological theme
    Charles A Janeway
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 310 Cedar Street, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:1-28. 2002
  6. ncbi How the immune system protects the host from infection
    C A Janeway
    Section of Immunobiology, LH 416, PO Box 208011, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
    Microbes Infect 3:1167-71. 2001
  7. ncbi The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, and the Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
    Immunol Res 19:107-18. 1999
  8. ncbi Obituary: Charles A. Janeway Jr (1943-2003)
    William E Paul
    Nature 423:237. 2003
  9. ncbi Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis
    Margaret S Bynoe
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 19:317-28. 2003
  10. ncbi A pool of central memory-like CD4 T cells contains effector memory precursors
    J Magarian Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520, USA
    J Immunol 170:2940-8. 2003

Research Grants

  1. INFLUENCE OF H-2 ANTIGENS ON MOUSE T CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 1980
  2. INFLUENCE OF H-2 ANTIGENS ON T CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 1990
  3. H2 ANTIGENS AND MOUSE CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 2002

Collaborators

Detail Information

Publications28

  1. pmc Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice
    G Das
    Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510, USA
    J Exp Med 190:881-4. 1999
    ..In beta2-microglobulin (beta2m)-deficient mice, all of the TCR-alpha/beta CD8alpha/alpha and CD8alpha/beta T cells disappear, but TCR-gamma/delta cells are unaffected by the absence of beta2m...
  2. pmc Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2
    J M Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    J Exp Med 191:2065-74. 2000
    ..We conclude from these data that a mutation in the TCR at a key position that contacts major histocompatibility complex-bound peptide is associated with a shift in T cell differentiation from Th1 to Th2...
  3. ncbi The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Immunol Cell Biol 77:177-9. 1999
    ..All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology...
  4. ncbi Innate immune recognition
    Charles A Janeway
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:197-216. 2002
    ..Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens...
  5. ncbi A trip through my life with an immunological theme
    Charles A Janeway
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, 310 Cedar Street, New Haven, Connecticut 06520 8011, USA
    Annu Rev Immunol 20:1-28. 2002
    ..These cells recognize antigen as do all T cells, but they secrete the immunoregulatory cytokines IL-10 and TGF beta...
  6. ncbi How the immune system protects the host from infection
    C A Janeway
    Section of Immunobiology, LH 416, PO Box 208011, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
    Microbes Infect 3:1167-71. 2001
    ..This in turn leads to B-cell-derived antibody responses. The entire response is controlled by suppressor T cells, as predicted many years ago by Richard Gershon...
  7. ncbi The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, and the Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
    Immunol Res 19:107-18. 1999
    ..Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses...
  8. ncbi Obituary: Charles A. Janeway Jr (1943-2003)
    William E Paul
    Nature 423:237. 2003
  9. ncbi Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis
    Margaret S Bynoe
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 19:317-28. 2003
    ..There was no CD4 T cell infiltration in the brain of protected mice. Finally, ECi with autoantigenic peptides protected two nontransgenic models from relapsing-remitting EAE in an antigen-specific and antigen dose-dependent manner...
  10. ncbi A pool of central memory-like CD4 T cells contains effector memory precursors
    J Magarian Blander
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520, USA
    J Immunol 170:2940-8. 2003
    ..Having these properties, the L51S TCR transgenic memory CD4 T cells cannot be classified as either strict central memory or effector memory, but, rather, as a pool of memory T cells containing effector memory precursors...
  11. ncbi MHC specificity of iIELs
    Gobardhan Das
    Room 3335, Bld JR2, Aventis Pharmaceuticals, 202 206 North, Bridgewater, NJ 08807, USA
    Trends Immunol 24:88-93. 2003
    ..Here, we focus systematically on recent developments in innate immunity and in TCR recognition of different subtypes of iIELs by various MHC molecules...
  12. ncbi Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity
    Christophe Viret
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, CT 06520 8011, USA
    J Immunol 170:201-9. 2003
    ..Finally, the margin created by the absence of CD4 coreceptor was substantial because it could accommodate various amounts of the deleting ligand on thymic stromal cells...
  13. ncbi The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation
    Hilda Holcombe
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 169:4982-9. 2002
    ....
  14. ncbi In memoriam. Charles A. Janeway, Jr. February 5, 1943-April 12, 2003
    Richard W Dutton
    AAI Past President Trudeau Institute AAI Executive Director
    J Immunol 171:6314-5. 2003
  15. ncbi Investigation of the role of B-cells in type 1 diabetes in the NOD mouse
    F Susan Wong
    Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Diabetes 53:2581-7. 2004
    ..This may relate to reduced ability to activate an islet-specific T-cell repertoire, presumably due to the reduced islet-specific B-cell repertoire. Our results implicate a specific antigen-presenting function for B-cells...
  16. pmc T cells from epicutaneously immunized mice are prone to T cell receptor revision
    Margaret S Bynoe
    Section of Immunobiology, Howard Hughes Medical Institute and Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:2898-903. 2005
    ..The emergence of these cells did not depend on the thymic compartment. We conclude that in mice epicutaneously immunized with an autoantigen, peripheral specific T cells are susceptible to multiple mechanisms of tolerance...
  17. ncbi IRAK-M is a negative regulator of Toll-like receptor signaling
    Koichi Kobayashi
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 110:191-202. 2002
    ..Endotoxin tolerance, a protection mechanism against endotoxin shock, was significantly reduced in IRAK-M(-/-) cells. Thus, IRAK-M regulates TLR signaling and innate immune homeostasis...
  18. pmc Negative selection of thymocytes expressing the D10 TCR
    DEREK B SANT'ANGELO
    Section of Immunobiology, Yale University School of Medicine and the Howard Hughes Medical Institute, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:6931-6. 2002
    ..Finally, we show that the self-peptide repertoire plays a significant role in selection because alteration of the self-peptide repertoire by disruption of the H2-Ma gene drastically alters selection of D10 TCR-expressing thymocytes...
  19. ncbi Decoding the patterns of self and nonself by the innate immune system
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 296:298-300. 2002
    ..These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals...
  20. pmc Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus
    F Susan Wong
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 99:5551-6. 2002
    ....
  21. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...
  22. ncbi Dual receptor T cells extend the immune repertoire for foreign antigens
    Xin He
    Section of Immunobiology, Yale University School of Medicine, 310 Cedar St, New Haven, CT 06520 8011, USA
    Nat Immunol 3:127-34. 2002
    ..Thus, dual TCR cells can extend the TCR repertoire for foreign antigens by rescuing functional TCRs that cannot be selected on single TCR cells; they can, therefore, benefit the immune system...
  23. ncbi A goodbye to Charlie Janeway: Charles A. Janeway Jr (1943-2003)
    Alexander Sasha I Rudensky
    HHMI and Department of immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Trends Immunol 24:403. 2003
  24. pmc Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection
    Christophe Viret
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:5354-9. 2003
    ..1 T cells. The data support the notion that the integration of distinct signals generated by the simultaneous recognition of multiple self-peptide/MHC complexes directs intrathymic selection of T cells...
  25. ncbi Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism
    Iqbal S Grewal
    Millennium Pharmaceuticals, Inc Cambridge, MA 02139, USA
    J Autoimmun 19:9-22. 2002
    ..TUNEL assays revealed increased apoptosis of invading cells when compared to non-transgenic NOD mice. Taken together, these results suggest that TGF-beta protects islets by a local event...
  26. ncbi Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the rule
    Xin He
    Trends Immunol 23:467-9. 2002
    ..Therefore, the KB TCR beta chain transgenic mice offer a unique opportunity for addressing this issue...
  27. ncbi Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor
    DEREK B SANT'ANGELO
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur J Immunol 32:2510-20. 2002
    ..However, using an HLA-DM-mediated technique to measure peptide binding to MHC class II molecules, we found that the peptide flanking residues contribute substantially to MHC binding...
  28. ncbi Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's Hospital
    Raif S Geha
    Division of Immunology, Children s Hospital, Department of Paediatrics, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 116:937-40. 2005

Research Grants17

  1. INFLUENCE OF H-2 ANTIGENS ON MOUSE T CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 1980
    ..The ability of these products to bind to antigen and to MHC antigens will be determined to find out if the T cell has one or two types of receptor on its surface. ..
  2. INFLUENCE OF H-2 ANTIGENS ON T CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 1990
    ..The applicants will also analyze the antibody they have to determine the exact nature of its ligand, the process by which this ligand is generated, and the molecular details of the interaction of the antibody with its ligand...
  3. H2 ANTIGENS AND MOUSE CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 2002
    ..We will test these hypotheses in a variety of ways to determine their correctness. ..