Robert L Jakab

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, Yale University School of Medicine, 333 Cedar St, FMP 408, P O Box 208064, New Haven, CT 06520, USA
    Dig Dis Sci 57:2826-45. 2012
  2. pmc Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 303:G937-50. 2012
  3. pmc Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 300:G82-98. 2011
  4. pmc Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport
    Anne M Collaco
    Dept of Pediatrics Yale Univ School of Medicine, 333 Cedar St, LMP 3088b, P O Box 208064, New Haven, CT 06520
    Am J Physiol Gastrointest Liver Physiol 305:G258-75. 2013
  5. pmc Characterization of CFTR High Expresser cells in the intestine
    Robert L Jakab
    Dept of Pediatrics Gastroenterology and Hepatology, and Cellular and Molecular Physiology, Yale Univ School of Medicine, P O Box 208064, 333 Cedar St, FMP 408, New Haven, CT 06520
    Am J Physiol Gastrointest Liver Physiol 305:G453-65. 2013

Collaborators

  • Nadia A Ameen
  • Anne M Collaco
  • Nadia E Hoekstra
  • Amos Brooks
  • Kisha A Mitchell

Detail Information

Publications5

  1. pmc Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, Yale University School of Medicine, 333 Cedar St, FMP 408, P O Box 208064, New Haven, CT 06520, USA
    Dig Dis Sci 57:2826-45. 2012
    ..The aim of this study was to determine whether lubiprostone exerts secretory effects in the intestine by membrane trafficking of ion transporters and associated machinery...
  2. pmc Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 303:G937-50. 2012
    ..This is the first demonstration that physiologically relevant secretory stimuli exert their actions in villus enterocytes by membrane recruitment of CFTR and NBCe1 in tandem with NHE3 internalization...
  3. pmc Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine
    Robert L Jakab
    Department of Pediatrics Gastroenterology and Hepatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 300:G82-98. 2011
    ..Overall, the carbachol-induced membrane trafficking profile of the four ion transporters supports functional plasticity of the small intestinal villus epithelium that enables it to conduct both absorptive and secretory functions...
  4. pmc Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport
    Anne M Collaco
    Dept of Pediatrics Yale Univ School of Medicine, 333 Cedar St, LMP 3088b, P O Box 208064, New Haven, CT 06520
    Am J Physiol Gastrointest Liver Physiol 305:G258-75. 2013
    ..These data support functional transport of chloride, bicarbonate, water, and protons by second messenger-regulated traffic in mammalian Brunner's glands under physiological and pathophysiological conditions. ..
  5. pmc Characterization of CFTR High Expresser cells in the intestine
    Robert L Jakab
    Dept of Pediatrics Gastroenterology and Hepatology, and Cellular and Molecular Physiology, Yale Univ School of Medicine, P O Box 208064, 333 Cedar St, FMP 408, New Haven, CT 06520
    Am J Physiol Gastrointest Liver Physiol 305:G453-65. 2013
    ..These data strongly argue for a specialized role of CHE cells in Cl(-)-mediated "high-volume" fluid secretion on the villi of the proximal small intestine. ..