Dhanpat Jain

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Diagnosis of hepatocellular carcinoma: fine needle aspiration cytology or needle core biopsy
    Dhanpat Jain
    Department of Anatomic Pathology, Yale Univesity School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Clin Gastroenterol 35:S101-8. 2002
  2. ncbi request reprint Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejection
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Arch Pathol Lab Med 128:64-7. 2004
  3. ncbi request reprint Composite glandular and endocrine tumors of the stomach with pancreatic acinar differentiation
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Surg Pathol 29:1524-9. 2005
  4. ncbi request reprint Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis
    Jonathan A Dranoff
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, One Gilbert Street, New Haven, CT 06520, USA
    J Investig Med 52:475-82. 2004
  5. pmc Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage
    Pramod K Mistry
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06562, USA
    Proc Natl Acad Sci U S A 107:19473-8. 2010
  6. pmc Colchicine-associated ring mitosis in liver biopsy and their clinical implications
    Anitha Kamath
    Department of Anatomic Pathology, Yale University School of Medicine, New Haven, CTN 06520 8070, USA
    J Clin Gastroenterol 42:1060-2. 2008
  7. pmc Identification of lymphatics within the colonic lamina propria in inflammation and neoplasia using the monoclonal antibody D2-40
    Barton C Kenney
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Yale J Biol Med 81:103-13. 2008
  8. doi request reprint Molecular evidence for the neoplastic potential of hepatic Von-Meyenburg complexes
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Appl Immunohistochem Mol Morphol 18:166-71. 2010
  9. ncbi request reprint Adult nesidioblastosis. Clinicopathologic correlation between pre-operative selective arterial calcium stimulation studies and post-operative pathologic findings
    Barton Kenney
    Department of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    JOP 9:504-11. 2008
  10. doi request reprint Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma
    Imran Ahmad
    Department of Pathology, Yale School of Medicine, PO Box 208023 New Haven, CT 06520 8023, USA
    Hum Pathol 40:726-34. 2009

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Diagnosis of hepatocellular carcinoma: fine needle aspiration cytology or needle core biopsy
    Dhanpat Jain
    Department of Anatomic Pathology, Yale Univesity School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Clin Gastroenterol 35:S101-8. 2002
    ..However, the final choice of the diagnostic procedure should be decided on the basis of working clinical diagnosis and the institutional experience...
  2. ncbi request reprint Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejection
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Arch Pathol Lab Med 128:64-7. 2004
    ..Chronic hepatic allograft rejection is characterized by arteriopathy and bile duct loss. Pathology of the portal vein or its branches is not considered to play a major role in chronic rejection...
  3. ncbi request reprint Composite glandular and endocrine tumors of the stomach with pancreatic acinar differentiation
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Surg Pathol 29:1524-9. 2005
    ..In summary, these tumors represent another distinct type of composite glandular and endocrine gastric neoplasm with pancreatic acinar differentiation...
  4. ncbi request reprint Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis
    Jonathan A Dranoff
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, One Gilbert Street, New Haven, CT 06520, USA
    J Investig Med 52:475-82. 2004
    ..The ectonucleotidase* nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) is restricted to portal fibroblasts in the normal liver. However, the fate of NTPDase2 after bile duct ligation (BDL) is unknown...
  5. pmc Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage
    Pramod K Mistry
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06562, USA
    Proc Natl Acad Sci U S A 107:19473-8. 2010
    ..This study provides direct evidence for the involvement in GD1 of multiple cell lineages, suggesting that cells other than macrophages may be worthwhile therapeutic targets...
  6. pmc Colchicine-associated ring mitosis in liver biopsy and their clinical implications
    Anitha Kamath
    Department of Anatomic Pathology, Yale University School of Medicine, New Haven, CTN 06520 8070, USA
    J Clin Gastroenterol 42:1060-2. 2008
    ..Ring mitosis have been associated with colchicine-mediated tissue injury in various other sites, and their presence is felt to represent colchicine-induced liver injury in this case...
  7. pmc Identification of lymphatics within the colonic lamina propria in inflammation and neoplasia using the monoclonal antibody D2-40
    Barton C Kenney
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Yale J Biol Med 81:103-13. 2008
    ..However, in our experience, lymphatic vessels are sometimes identifiable within the lamina propria in the setting of inflammation and neoplasia...
  8. doi request reprint Molecular evidence for the neoplastic potential of hepatic Von-Meyenburg complexes
    Dhanpat Jain
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Appl Immunohistochem Mol Morphol 18:166-71. 2010
    ..The findings also support that VMCs are preneoplastic lesions that could progress to CC with time...
  9. ncbi request reprint Adult nesidioblastosis. Clinicopathologic correlation between pre-operative selective arterial calcium stimulation studies and post-operative pathologic findings
    Barton Kenney
    Department of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    JOP 9:504-11. 2008
    ..Overall, seventy-three cases of nesidioblastosis have been described in the English literature since the entity was first described by Laidlaw in 1938, and only a minute fraction of these have occurred in children...
  10. doi request reprint Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma
    Imran Ahmad
    Department of Pathology, Yale School of Medicine, PO Box 208023 New Haven, CT 06520 8023, USA
    Hum Pathol 40:726-34. 2009
    ..Prospective studies to evaluate use of these stains in challenging cases are needed to validate these findings...
  11. ncbi request reprint Increased T-cell sinusoidal lymphocytosis in liver biopsies in patients with chronic hepatitis C and mixed cryoglobulinemia
    Susanne Carmack
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Am J Gastroenterol 103:705-11. 2008
    ..This feature may be an important clue to predict the presence of MC, an HCV-associated phenomenon that has important implications for response to treatment and disease progression...
  12. ncbi request reprint Intraductal papillary cholangiocarcinoma associated with von Meyenberg complexes: a case report
    Antonio Galvao Neto
    Department of Pathology, Yale School of Medicine, PO Box 208070, New Haven, Connecticut 06520 8070, USA
    Dig Dis Sci 52:2643-5. 2007
    ..A possibility that the carcinoma may have originated in a VMC was considered. On follow-up after 12 months the patient is doing well and is without any disease or recurrence...
  13. pmc Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms
    Sanjay Kakar
    Department of Pathology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Histopathology 55:197-205. 2009
    ..To explore the utility of cytogenetic abnormalities in the distinction of hepatic adenoma (HA) and well-differentiated hepatocellular carcinoma (HCC)...
  14. ncbi request reprint Gastric siderosis: patterns and significance
    Esmeralda C Marginean
    Department of Anatomic Pathology, Program in Gastrointestinal Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Surg Pathol 30:514-20. 2006
    ....
  15. pmc Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
    Anita Iyer
    Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA
    Hum Pathol 39:1370-7. 2008
    ....
  16. pmc Expanding spectrum of the association between Type 1 Gaucher disease and cancers: a series of patients with up to 3 sequential cancers of multiple types--correlation with genotype and phenotype
    Sarah M Lo
    Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut 06520 8064, USA
    Am J Hematol 85:340-5. 2010
    ..We found an association between splenectomy and multiple cancers in GD1. It will be of interest to determine whether timely ERT and declining rates of splenectomy will translate into declining rates of multiple and single cancers...
  17. doi request reprint Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization
    Sanjay Kakar
    Department of Pathology, University of California, San Francisco, CA, USA
    Mod Pathol 22:134-41. 2009
    ..The favorable outcome in some fibrolamellar carcinomas may be due to absent or low number of cytogenetic aberrations...
  18. doi request reprint Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil
    Megan K Selbst
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Mod Pathol 22:737-43. 2009
    ..Increased awareness of the histologic spectrum of mycophenolate mofetil-induced changes is required by the pathologist to avoid diagnostic errors...
  19. ncbi request reprint Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis
    Satish Nagula
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Hepatol 44:111-7. 2006
    ..This study aimed to determine the relationship between specific histological parameters and HVPG in cirrhosis...
  20. ncbi request reprint Rapid progression of autoimmune hepatitis in the background of primary sclerosing cholangitis
    JoAnn Hong-Curtis
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Clin Gastroenterol 38:906-9. 2004
    ..By making the diagnosis of AIH in a patient with well-established PSC, appropriate treatment can be initiated, resulting in the patient's prompt recovery...
  21. ncbi request reprint Ileostomy adenocarcinomas in the setting of ulcerative colitis
    Hardean E Achneck
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    J Clin Gastroenterol 39:396-400. 2005
    ..The literature on adenocarcinoma arising in the 23 patients with ulcerative colitis who received a Brooke or Kock ileostomy and had no prior history of neoplasm is reviewed...
  22. ncbi request reprint Liver biopsy: evolving role in the new millennium
    Harinath Sheela
    Department of Internal Medicine, Section of Digestive Diseases and Liver Center, Yale University School of Medicine, New Haven, CT 06510, USA
    J Clin Gastroenterol 39:603-10. 2005
    ..This review discusses the technique, indications, contraindications, and the changing role of liver biopsy in some of the common disorders and the associated controversies...
  23. ncbi request reprint Target antigens determine graft-versus-host disease phenotype
    Daniel H Kaplan
    Departments of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:5467-75. 2004
    ..Thus, the selection of immunodominant Ags determines the target and character of GVHD, providing insight into the genetic basis for different forms of GVHD...
  24. ncbi request reprint Sampling error in the standard evaluation of endoscopic colonic biopsies
    Benjamin C Calhoun
    Department of Anatomic Pathology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Am J Surg Pathol 27:254-7. 2003
    ..Routine examination of at least two sides of randomly oriented biopsy material could provide additional diagnostic, and sometimes critical, information...
  25. ncbi request reprint Isolation of primary rat liver fibroblasts
    Emma A Kruglov
    Department of Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Conn 06520, USA
    J Investig Med 50:179-84. 2002
    ..Consequently, we developed a technique to isolate primary rat liver fibroblasts...
  26. doi request reprint Cadherin expression in gastrointestinal tract endometriosis: possible role in deep tissue invasion and development of malignancy
    Katy Van Patten
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Mod Pathol 23:38-44. 2010
    ....
  27. ncbi request reprint Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study
    Fatima Eslami-Varzaneh
    Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Surg Pathol 28:374-8. 2004
    ..In summary, these lesions represent a distinctive type of colonic mucosal polyp that should be distinguished from other stromal polyps of the gastrointestinal tract...
  28. pmc Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
    Abrahim I Orabi
    Department of Pediatrics, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 299:G196-204. 2010
    ..Blockade of Ca(2+) signals and particularly RYR-Ca(2+) may be useful as prophylactic treatment for this disease in high-risk settings for pancreatitis...
  29. pmc Protease activation during in vivo pancreatitis is dependent on calcineurin activation
    Ahsan U Shah
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Gastrointest Liver Physiol 297:G967-73. 2009
    ..05). These data suggest that PP2B is an important target of the aberrant acinar cell Ca(2+) rise associated with pathological protease activation and pancreatitis...
  30. doi request reprint To count and how to count, that is the question: interobserver and intraobserver variability among pathologists in lymph node counting
    Vinita Parkash
    Dept of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Clin Pathol 134:42-9. 2010
    ..6, which could be clinically significant when the count approaches the set minimum. Uniform criteria are necessary to allow for meaningful comparisons between studies on minimal nodal counts for cancer lymphadenectomies...
  31. pmc Hyperferritinemia and iron overload in type 1 Gaucher disease
    Philip Stein
    Department of Pediatrics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Am J Hematol 85:472-6. 2010
    ..There is a high prevalence of hyperferritinemia in Type 1 Gaucher disease that is associated with indicators of disease severity, reversed by ERT and is not related to HFE mutations...
  32. doi request reprint Mycophenolate mofetil-induced colitis in children
    Uma Padhye Phatak
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 43:967-9. 2009
    ..These cases underscore the importance of considering MMF-induced colitis in any patient who presents with diarrhea while on MMF therapy...
  33. ncbi request reprint Multiple angiomyolipomata of the liver: a case report
    Laura H Tang
    Department of Anatomic Pathology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Mod Pathol 15:167-71. 2002
    ..While the histologic diagnosis of AML in a surgical resection specimen is often straightforward, the radiographic, cytologic and intra-operative interpretation of a case with multiple lesions presents a considerable challenge...
  34. pmc CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL
    Catherine Matte-Martone
    Section of Medical Oncology, Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8032, USA
    Blood 111:3884-92. 2008
    ..Thus, CD4 cells use distinct effector mechanisms in GVHD and GVL: direct cytolytic action is required for GVL but not for GVHD. If these noncytolytic pathways can be inhibited, then GVHD might be ameliorated while preserving GVL...
  35. pmc HCV response in patients with end stage renal disease treated with combination pegylated interferon alpha-2a and ribavirin
    Wyel Hakim
    Department of Medicine, Yale University, New Haven, CT, USA
    J Clin Gastroenterol 43:477-81. 2009
    ..To determine the efficacy and safety of combination therapy in patients with hepatitis C virus (HCV) and end-stage renal disease (ESRD)...
  36. doi request reprint Lack of immunohistochemical detection of VEGF in prostate carcinoma
    Anitha Kamath
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Appl Immunohistochem Mol Morphol 17:227-32. 2009
    ..The objective of this study was to measure VEGF expression in PrCa specimens, using IHC analysis with antibodies from different manufacturers and different antigen retrieval techniques...
  37. ncbi request reprint Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
    Britt E Anderson
    Section of Immunobiology, The Department of Dermatology, Yale University School of Medicine, 333 Cedar St, Box 208035, New Haven, CT 06520 8035, USA
    Blood 105:2227-34. 2005
    ..These results identify differences in APC requirements between CD8-mediated aGVHD and CD4-mediated cGVHD. They further highlight donor APCs as additional targets for GVHD therapy...
  38. ncbi request reprint Diagnostic intraoperative imprint cytology of a solid pseudopapillary tumor of the pancreas
    M Rajan Mariappan
    Department of Surgical Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Diagn Cytopathol 32:351-2. 2005
  39. doi request reprint Nitric oxide and vascular remodeling modulate hepatic arterial vascular resistance in the isolated perfused cirrhotic rat liver
    Alexander Zipprich
    Digestive Disease Section, Yale University School of Medicine, New Haven, CT, USA
    J Hepatol 49:739-45. 2008
    ..Hepatic arterial resistance is modulated by the hepatic arterioles but the role of NO and vascular remodeling in hepatic arterial resistance in cirrhosis is unknown...
  40. doi request reprint Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience
    Jason N Rogart
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Gastrointest Endosc 68:1136-45. 2008
    ..There is no widely adopted, easily applied method for distinguishing between adenomatous and nonadenomatous polyps during real-time colonoscopy...
  41. pmc Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
    Hong Zheng
    Penn State Milton S Hershey Medical Center, Department of Medicine, Hershey, PA, USA
    Blood 111:2476-84. 2008
    ....
  42. ncbi request reprint Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis
    Sanjay Kakar
    Department of Anatomic Pathology, UCSF VA Medical Center, San Francisco, CA 94121, USA
    Mod Pathol 18:1417-23. 2005
    ..The better outcome in fibrolamellar carcinoma appears to be due to the absence of cirrhosis rather than its distinct clinicopathologic features...