Leslie Jacobsen

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1134-40. 2000
  2. ncbi request reprint Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Neurosci 27:13491-8. 2007
  3. ncbi request reprint Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 207, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 193:557-66. 2007
  4. ncbi request reprint Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 32:2453-64. 2007
  5. ncbi request reprint C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 188:530-40. 2006
  6. ncbi request reprint Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, Connecticut 06519, USA
    Biol Psychiatry 61:31-40. 2007
  7. ncbi request reprint Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 31:1550-61. 2006
  8. ncbi request reprint Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 100 York Street 2B, New Haven, CT 06511, USA
    Biol Psychiatry 57:56-66. 2005
  9. ncbi request reprint Impact of cannabis use on brain function in adolescents
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Ann N Y Acad Sci 1021:384-90. 2004
  10. ncbi request reprint Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06511, USA
    Psychopharmacology (Berl) 173:383-90. 2004

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1134-40. 2000
    ..The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk for relapse in cocaine dependence...
  2. ncbi request reprint Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Neurosci 27:13491-8. 2007
    ....
  3. ncbi request reprint Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 207, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 193:557-66. 2007
    ..Work in rodents has shown that exposure to nicotine during adolescence leads to nicotine withdrawal emergent alterations in cortical and subcortical dopamine neurotransmission...
  4. ncbi request reprint Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 32:2453-64. 2007
    ....
  5. ncbi request reprint C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 188:530-40. 2006
    ....
  6. ncbi request reprint Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, Connecticut 06519, USA
    Biol Psychiatry 61:31-40. 2007
    ..Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development...
  7. ncbi request reprint Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 31:1550-61. 2006
    ....
  8. ncbi request reprint Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 100 York Street 2B, New Haven, CT 06511, USA
    Biol Psychiatry 57:56-66. 2005
    ..We tested for evidence of acute and chronic effects of tobacco smoking on cognition in adolescents who smoked tobacco daily and were compared with adolescent nonsmokers...
  9. ncbi request reprint Impact of cannabis use on brain function in adolescents
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Ann N Y Acad Sci 1021:384-90. 2004
    ..This paper reports results of a pilot study using fMRI and a working memory task to compare brain function of adolescent cannabis users to that of two control groups, one matched for tobacco use and the other for nonsmokers...
  10. ncbi request reprint Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06511, USA
    Psychopharmacology (Berl) 173:383-90. 2004
    ..Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence...
  11. ncbi request reprint Impact of intravenous nicotine on BOLD signal response to photic stimulation
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Magn Reson Imaging 20:141-5. 2002
    ..This observation suggests that nicotine does not alter the coupling between BOLD signal and neuronal activity in the visual cortex...
  12. ncbi request reprint Substance use disorders in patients with posttraumatic stress disorder: a review of the literature
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Psychiatry 158:1184-90. 2001
    ..This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of comorbid PTSD and substance use disorders...
  13. ncbi request reprint Prediction of dopamine transporter binding availability by genotype: a preliminary report
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1700-3. 2000
    ..Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes...
  14. ncbi request reprint Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine and the VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Drug Alcohol Depend 62:49-56. 2001
    ..No evidence for decreased hippocampal or total brain volume in cocaine dependence was observed. Similarly, basal and oCRH stimulated ACTH and cortisol levels in cocaine dependent patients did not differ from those in healthy subjects...
  15. ncbi request reprint Quantitative morphology of the caudate and putamen in patients with cocaine dependence
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 158:486-9. 2001
    ....
  16. pmc Early and late talkers: school-age language, literacy and neurolinguistic differences
    Jonathan L Preston
    Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, USA
    Brain 133:2185-95. 2010
    ....
  17. ncbi request reprint Nicotine effects on brain function and functional connectivity in schizophrenia
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 100 York Street 28, West Haven, CT 06511, USA
    Biol Psychiatry 55:850-8. 2004
    ..Our primary aim was to determine whether nicotine improves cognitive function by facilitating activation of brain regions mediating task performance or by facilitating functional connectivity...
  18. pmc Phonological awareness predicts activation patterns for print and speech
    Stephen J Frost
    Haskins Laboratories, 300 George Street, New Haven, CT 06511, USA
    Ann Dyslexia 59:78-97. 2009
    ....
  19. doi request reprint Glutamate and choline levels predict individual differences in reading ability in emergent readers
    Kenneth R Pugh
    Haskins Laboratories, New Haven, Connecticut 06511, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, Department of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, Department of Psychiatry, University of California San Francisco, San Francisco, California 94143 0984, Yale University Child Study Center, New Haven, Connecticut 06520, Department of Communication Disorders, Southern Connecticut State University, New Haven, Connecticut 06515, and Department of Psychology, University of Wisconsin Madison, Madison, Wisconsin 53706 1611
    J Neurosci 34:4082-9. 2014
    ..These findings point to new directions for research on gene-brain-behavior pathways in human studies of reading disability. ..
  20. pmc Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06320, USA
    Biol Psychiatry 65:671-9. 2009
    ..The present study tested for evidence that genetic variation may contribute to individual differences in vulnerability to the effects of developmental exposure to tobacco smoke on memory and medial temporal lobe function in adolescents...
  21. ncbi request reprint Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, One Church Street, New Haven, CT 06510, USA
    J Nucl Med 46:745-51. 2005
    ..Previous investigations of the effects of the SLC6A3 polymorphism on DAT availability in smaller samples of humans have yielded divergent results...
  22. ncbi request reprint Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:525-31. 2004
    ..In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear...
  23. ncbi request reprint Smoking and structural brain deficits: a volumetric MR investigation
    Jurgen Gallinat
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, St Hedwig Krankenhaus, Turmstrasse 21, 10559 Berlin, Germany
    Eur J Neurosci 24:1744-50. 2006
    ..The present findings may explain in part the frequently reported cognitive dysfunctions in chronic cigarette consumers...
  24. ncbi request reprint Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T
    Jurgen Gallinat
    Klinik fur Psychiatrie und Psychotherapie, Charite Universitatsmedizin, Campus Mitte PUK Charité SHK, Berlin, Germany
    J Clin Psychopharmacol 27:80-4. 2007
    ..In this study, proton magnetic resonance spectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC)...

Research Grants11

  1. Prenatal Cocaine Exposure: Studies of Brain Function
    Leslie Jacobsen; Fiscal Year: 2007
    ..C. Mayes). ..
  2. Brain Functional Correlates of MDMA Use in Adolescence
    Leslie Jacobsen; Fiscal Year: 2007
    ..abstract_text> ..
  3. Smoking, Brain Function and Outcome in Adolescents
    Leslie Jacobsen; Fiscal Year: 2004
    ..The relationship between the degree of change cognitive performance (assessed prior to and during scanning) in response to recent tobacco use and tobacco use at one-year follow-up will also be examined. ..