Akiko Iwasaki

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques
    Brian Jameson
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 76:1866-75. 2002
  2. pmc A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide
    Hong Shen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 116:2237-43. 2006
  3. pmc Innate immune recognition of HIV-1
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 37:389-98. 2012
  4. pmc A virological view of innate immune recognition
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Microbiol 66:177-96. 2012
  5. ncbi request reprint Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
  6. ncbi request reprint Role of autophagy in innate viral recognition
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Autophagy 3:354-6. 2007
  7. ncbi request reprint Mucosal dendritic cells
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 25:381-418. 2007
  8. ncbi request reprint Division of labor by dendritic cells
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 128:435-6. 2007
  9. pmc Antiviral immune responses in the genital tract: clues for vaccines
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 10:699-711. 2010
  10. pmc Regulation of adaptive immunity by the innate immune system
    Akiko Iwasaki
    Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
    Science 327:291-5. 2010

Research Grants

  1. Antiviral CTL mobilization to the genital mucosa
    Akiko Iwasaki; Fiscal Year: 2009
  2. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2010
  3. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2009
  4. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2009
  5. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2010
  6. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2010
  7. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2009
  8. Antiviral CTL mobilization to the genital mucosa
    Akiko Iwasaki; Fiscal Year: 2011
  9. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2007
  10. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2007

Collaborators

Detail Information

Publications75

  1. pmc Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques
    Brian Jameson
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 76:1866-75. 2002
    ..Finally, we identified a MAb that blocked simian immunodeficiency virus interactions with rhesus macaque DC-SIGN. This and other specific MAbs may be used to assess the relevance of DC-SIGN in virus transmission in vivo...
  2. pmc A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide
    Hong Shen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 116:2237-43. 2006
    ..Our results imply that temporally and spatially controlled targeting of CpG ODN to pDCs and epithelial cells can potentially maximize their effectiveness as microbicides while minimizing the associated inflammatory responses...
  3. pmc Innate immune recognition of HIV-1
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 37:389-98. 2012
    ....
  4. pmc A virological view of innate immune recognition
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Microbiol 66:177-96. 2012
    ..On the basis of other unique features common to viral infections, undiscovered areas of virus detection are discussed...
  5. ncbi request reprint Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  6. ncbi request reprint Role of autophagy in innate viral recognition
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Autophagy 3:354-6. 2007
    ..These results indicated that autophagy plays a key role in mediating virus detection and IFNalpha secretion in pDCs, and suggest that cytosolic replication intermediates of ssRNA viruses serve as pathogen signatures recognized by TLR7...
  7. ncbi request reprint Mucosal dendritic cells
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 25:381-418. 2007
    ....
  8. ncbi request reprint Division of labor by dendritic cells
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 128:435-6. 2007
    ..In a recent Science paper, Dudziak et al. (2007) reveal that these tasks are handled by distinct populations of dendritic cells in vivo...
  9. pmc Antiviral immune responses in the genital tract: clues for vaccines
    Akiko Iwasaki
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 10:699-711. 2010
    ....
  10. pmc Regulation of adaptive immunity by the innate immune system
    Akiko Iwasaki
    Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
    Science 327:291-5. 2010
    ....
  11. ncbi request reprint The role of dendritic cells in immune responses against vaginal infection by herpes simplex virus type 2
    Akiko Iwasaki
    Department of Epidemiology and Public Health and Immunobiology, Yale University School of Medicine, 60 College Street, LEPH 716, New Haven, CT 06510, USA
    Microbes Infect 5:1221-30. 2003
    ....
  12. pmc The importance of CD11b+ dendritic cells in CD4+ T cell activation in vivo: with help from interleukin 1
    Akiko Iwasaki
    Department of Epidemiology and Public Health, 60 College St, LEPH 716, New Haven, CT 06510, USA
    J Exp Med 198:185-90. 2003
  13. pmc Influenza virus activates inflammasomes via its intracellular M2 ion channel
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 11:404-10. 2010
    ..Our results show a mechanism by which influenza virus infection activates inflammasomes and identify the sensing of disturbances in intracellular ionic concentrations as a previously unknown pathogen-recognition pathway...
  14. pmc Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
    Ayuko Sato
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:16274-9. 2004
    ....
  15. pmc Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
    Norifumi Iijima
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:3041-52. 2008
    ..Thus, these results revealed a distinct mechanism by which memory Th1 cells mediate noncytolytic IFN-gamma-dependent antiviral protection after recognition of processed viral antigens by local DCs and B cells...
  16. ncbi request reprint Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 177:7510-4. 2006
    ..Thus, by way of migrating directly into the peripheral mucosa, pDCs act strictly as innate antiviral effector cells against mucosal viral infection in situ...
  17. pmc Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:359-70. 2009
    ..Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo...
  18. pmc IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus
    Iris K Pang
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 14:246-53. 2013
    ..Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus...
  19. pmc Recognition of single-stranded RNA viruses by Toll-like receptor 7
    Jennifer M Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:5598-603. 2004
    ..These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens...
  20. pmc Inflammasome recognition of influenza virus is essential for adaptive immune responses
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:79-87. 2009
    ..These results demonstrate that in addition to the TLR pathways, ASC inflammasomes play a central role in adaptive immunity to influenza virus...
  21. ncbi request reprint Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Science 315:1398-401. 2007
    ..These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7...
  22. pmc In vivo requirement for Atg5 in antigen presentation by dendritic cells
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 32:227-39. 2010
    ..Thus, our study revealed that DCs utilize autophagic machinery to optimally process and present extracellular microbial antigens for MHC II presentation...
  23. pmc Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I
    Iris K Pang
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 110:13910-5. 2013
    ..Our data suggest that IAV uses physiological levels of inflammatory responses for its replicative advantage and highlight the complex interplay between viruses and the host innate-immune responses. ..
  24. ncbi request reprint MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection
    Kelly A Soderberg
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:1908-13. 2004
    ..Therefore, an LT beta-independent pathway exists for the development of a lymph node associated with the genital mucosa, and such a lymph node serves to generate potent immune responses against viral challenge...
  25. pmc Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3
    Miwa Sasai
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 329:1530-4. 2010
    ..Our results reveal an intracellular mechanism for bifurcation of TLR9 signals by selective receptor trafficking within the endosomal system...
  26. pmc Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2
    Xinyan Zhao
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Exp Med 197:153-62. 2003
    ....
  27. pmc CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help
    Yusuke Nakanishi
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 462:510-3. 2009
    ..Our results reveal a previously unappreciated role of CD4 help in mobilizing effector CTL to the peripheral sites of infection where they help to eliminate infected cells...
  28. pmc Vaginal epithelial dendritic cells renew from bone marrow precursors
    Norifumi Iijima
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:19061-6. 2007
    ..Collectively, our results revealed mucosa-specific features of the VEDCs with respect to their phenotype, activation status, and homeostatic renewal potential...
  29. ncbi request reprint [Inflammasomes in viral infection]
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, TAC S655B New Haven, Connecticut 06520, USA
    Uirusu 59:13-21. 2009
    ..Here, we review our current understanding of the mechanism by which various stimuli activate inflammasomes. Further, we discuss the role of inflammasomes in the induction of adaptive immunity against influenza virus infection...
  30. pmc Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts
    Lisa M Mattei
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Virology 442:20-7. 2013
    ..Together, these data suggest that the MVMp efficiently evades antiviral immune mechanisms imposed by type I IFNs, which may in part explain their efficient transmission between mice...
  31. pmc Autophagy and selective deployment of Atg proteins in antiviral defense
    Brian Yordy
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int Immunol 25:1-10. 2013
    ....
  32. pmc Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue
    Norifumi Iijima
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:284-9. 2011
    ....
  33. pmc CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input
    Yosuke Kumamoto
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:8749-54. 2011
    ..Our results reveal a previously unappreciated mode of CD4(+) T-cell help, whereby they increase the input of naïve lymphocytes to the relevant LN for efficient screening of cognate CD8(+) T cells...
  34. pmc Innate control of adaptive immunity via remodeling of lymph node feed arteriole
    Kelly A Soderberg
    Section of Immunobiology, John B Pierce Laboratory and Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:16315-20. 2005
    ..Our data reveal a mechanism of innate control of adaptive immunity: by increasing the pool of naïve lymphocytes for detection of foreign antigens via regulation of vascular input to the local lymph node...
  35. pmc Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
    Ayuko Sato
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:17343-8. 2006
    ....
  36. pmc CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity
    Yosuke Kumamoto
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 39:733-43. 2013
    ..These results reveal CD301b⁺ DDCs as the key mediators of Th2 immunity...
  37. pmc A vaccine strategy that protects against genital herpes by establishing local memory T cells
    Haina Shin
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nature 491:463-7. 2012
    ..These results reveal a promising vaccination strategy against herpes simplex virus 2, and potentially against other sexually transmitted infections such as human immunodeficiency virus...
  38. pmc Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    Jennifer Lund
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 198:513-20. 2003
    ..Therefore, these results demonstrate a novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-alpha by pDCs...
  39. pmc A neuron-specific role for autophagy in antiviral defense against herpes simplex virus
    Brian Yordy
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 12:334-45. 2012
    ..These findings reveal a fundamental difference in the innate antiviral strategies employed by neurons and mitotic cells to control HSV-1 infection...
  40. ncbi request reprint CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells
    Xinyan Zhao
    Department of Epidemiology and Public Health and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:2797-803. 2003
    ..Taken together, these results demonstrate an important role of CCL9 in CD11b(+) DC recruitment to the dome regions of mouse Peyer's patches...
  41. pmc In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa
    Melissa M Linehan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 78:2530-6. 2004
    ..Together, these results suggest the importance of nectin-1 in mediating viral entry for both HSV-1 and HSV-2 in the genital mucosa in female hosts...
  42. pmc Autophagy and antiviral immunity
    Heung Kyu Lee
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    Curr Opin Immunol 20:23-9. 2008
    ..In this review, we describe recent advances in the field of autophagy as it relates to innate and adaptive antiviral immune responses...
  43. pmc Autophagic control of RLR signaling
    Michal Caspi Tal
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Autophagy 5:749-50. 2009
    ..Our study provides the first link between ROS and cytosolic signaling mediated by the RLRs, and suggests the importance of autophagy in the regulation of signaling emanating from mitochondria...
  44. pmc Microbiota regulates immune defense against respiratory tract influenza A virus infection
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:5354-9. 2011
    ..Our results reveal the importance of commensal microbiota in regulating immunity in the respiratory mucosa through the proper activation of inflammasomes...
  45. pmc High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells
    Norifumi Iijima
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA
    Virology 444:257-62. 2013
    ..Our results suggest that cells infected by high-risk HPV evade immune surveillance by blocking the differentiation of monocytes into competent antigen presenting cells. ..
  46. pmc Cell type-dependent requirement of autophagy in HSV-1 antiviral defense
    Brian Yordy
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Autophagy 9:236-8. 2013
    ..Our findings reveal a cell type-specific requirement for autophagy in defense against HSV-1, and offer insight into the cell-appropriate antiviral defense mechanism employed by neurons...
  47. pmc MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    Namiko Hoshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Commun 3:1120. 2012
    ..Thus, gut bacterial sensing through MyD88 in mononuclear phagocytes drives inflammatory bowel disease when unopposed by interleukin-10...
  48. pmc Unique features of antiviral immune system of the vaginal mucosa
    Yosuke Kumamoto
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, United States
    Curr Opin Immunol 24:411-6. 2012
    ..In this review, we provide an overview of our current understanding of a wide spectrum of immune responses in vagina--from innate viral sensing to memory development...
  49. pmc Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5
    Zhenglong Wang
    Program for Vascular Biology and Therapeutics and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 284:28599-606. 2009
    ..In addition, Arhgef5 deficiency attenuated allergic airway inflammation. Therefore, this study provides new insights into signaling mechanisms for DC migration regulation...
  50. ncbi request reprint Innate control of adaptive immunity: dendritic cells and beyond
    Heung Kyu Lee
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Immunol 19:48-55. 2007
    ..This review focuses on recent understanding of the contributions of several key cell types, which regulate, and are regulated by DCs, in the generation of adaptive immune responses...
  51. pmc Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling
    Michal Caspi Tal
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunol Rev 243:215-34. 2011
    ....
  52. pmc Generating protective immunity against genital herpes
    Haina Shin
    Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Immunol 34:487-94. 2013
    ..In this review we outline recent studies that improve our understanding of host responses against HSV infection, discuss past clinical vaccine trials, and highlight new strategies for vaccine design against genital herpes. ..
  53. pmc Autophagy in the control and pathogenesis of viral infection
    Brian Yordy
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Virol 1:196-203. 2011
    ..Herein, we aim to summarize these recent findings as well as to highlight key unanswered questions of the field...
  54. pmc Toll-like receptors regulation of viral infection and disease
    Joseph M Thompson
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Adv Drug Deliv Rev 60:786-94. 2008
    ..In this report we describe the interactions of viruses with both the TLR system and the intracellular recognition system and highlight the role of TLRs in shaping the outcome of virus infection in both a positive and negative manner...
  55. ncbi request reprint Involvement of dendritic cell subsets in the induction of oral tolerance and immunity
    Marina Fleeton
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1029:60-5. 2004
    ....
  56. pmc Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    Michal Caspi Tal
    Department of Immunobiology, Pathology, and Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:2770-5. 2009
    ....
  57. doi request reprint ELF4 is critical for induction of type I interferon and the host antiviral response
    Fuping You
    Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 14:1237-46. 2013
    ..Thus, in addition to identifying a regulator of innate immune signaling, we uncovered a role for EICE elements in interferon transactivation. ..
  58. pmc Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses
    Lisa M Mattei
    Department of Immunobiology, Yale University, New Haven, CT, USA
    J Virol 87:3605-8. 2013
    ..Here we have shown that despite the ability of purified genomic DNA to stimulate TLR9 and despite the ability to enter TLR9 endosomes, ssDNA viruses of the Parvoviridae family failed to elicit an interferon (IFN) response in pDCs...
  59. pmc Control of antiviral immunity by pattern recognition and the microbiome
    Iris K Pang
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    Immunol Rev 245:209-26. 2012
    ..Furthermore, we discuss the possible roles of microbiome in chronic viral infection and pathogenesis of autoimmune disease and speculate on the benefit for probiotic therapies against such diseases...
  60. ncbi request reprint The use of bone marrow-chimeric mice in elucidating immune mechanisms
    Akiko Iwasaki
    Section of Immunobiology, Yale University, New Haven, CT, USA
    Methods Mol Med 127:281-92. 2006
    ..This chapter provides practical guide in making irradiation-induced bone marrow chimeric mice, which can be used to dissect a variety of aspects of antigen presentation by the hematopoietic vs nonhematopoietic compartments...
  61. pmc Innate sensors of influenza virus: clues to developing better intranasal vaccines
    Takeshi Ichinohe
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    Expert Rev Vaccines 7:1435-45. 2008
    ..Further, we discuss the potential roles of these receptors in developing intranasal influenza vaccines...
  62. pmc Genome-virome interactions: examining the role of common viral infections in complex disease
    Ellen F Foxman
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Rev Microbiol 9:254-64. 2011
    ....
  63. doi request reprint Autophagy and innate recognition systems
    Michal Caspi Tal
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    Curr Top Microbiol Immunol 335:107-21. 2009
    ..In this chapter, we will highlight key findings relevant to the role of the autophagic machinery in the innate immune system...
  64. pmc Inflammasomes as mediators of immunity against influenza virus
    Iris K Pang
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Immunol 32:34-41. 2011
    ..Here, we review the cellular and molecular mechanisms by which influenza virus infection leads to inflammasome activation, and discuss the consequences of such activation in innate and adaptive immune defense against influenza viruses...
  65. pmc Different routes to the same destination
    Kachiko Hayashi
    is at the Department of Immunobiology, Yale University School of Medicine, New Haven, United States
    elife 2:e00572. 2013
    ..The toll-like receptors that detect viral DNA and viral RNA in cells take different paths from the endoplasmic reticulum to the endosome...
  66. pmc Skin T(RM) mediates distributed border patrol
    Haina Shin
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Res 22:1325-7. 2012
    ..A recent study by Jiang et al. sheds light on the migration behavior of TRM in both infected and unifected skin, and their ability to provide protection against re-infection even within a previously uninfected skin tissue...
  67. pmc A new shield for a cytokine storm
    Akiko Iwasaki
    Department of Immunobiology, School of Medicine, Yale University New Haven, CT 06520, USA
    Cell 146:861-2. 2011
    ..Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network...
  68. ncbi request reprint Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection
    Akiko Iwasaki
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, Connecticut, USA
    J Infect Dis 186:585-92. 2002
    ..This suggests that productive poliovirus infection of the gut is dependent on the expression of CD155 within the FAE, including the M cells, and on cells within Peyer's patches, most likely within germinal centers...
  69. pmc Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction
    Miwa Sasai
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 35:3-5. 2011
    ..In this issue of Immunity, Fukui et al. (2011) revealed that Unc93B1 regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity...
  70. pmc Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node
    Joseph M Thompson
    Department of Microbiology and Immunology, Carolina Vaccine Institute, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 181:574-85. 2008
    ..A further understanding of the critical immunological and viral components of this pathway may significantly improve both our knowledge of viral-induced immunity and the efficacy of viral-based vaccines...
  71. ncbi request reprint Dendritic cells at the host-pathogen interface
    Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 7:117-20. 2006
    ..How DCs integrate information from pathogens, tissues, and innate leukocytes for the induction of immune responses was presented at the second International Conference on Dendritic Cells at the Host-Pathogen Interface...
  72. ncbi request reprint CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells
    Ayuko Sato
    Department of Applied Biological Chemistry, University of Tokyo, Tokyo, Japan
    J Immunol 171:3684-90. 2003
    ..These results suggest a unique role of PP CD11b(+) DCs in enhancing IgA production from B cells via secretion of IL-6...
  73. ncbi request reprint The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo
    Matthew K Park
    Inflammation Biology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1433-43. 2002
    ....
  74. ncbi request reprint The autophagy gene ATG5 plays an essential role in B lymphocyte development
    Brian C Miller
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Autophagy 4:309-14. 2008
    ..In addition, B-1a B cells require ATG5 for their maintenance in the periphery. We conclude that ATG5 is differentially required at discrete stages of development in distinct, but closely related, cell lineages...
  75. doi request reprint Securing mucosal borders--migrant monocytes to the rescue
    George S Yap
    Center for Immunity and Inflammation, Department of Medicine, UMDNJ New Jersey Medical School, Newark, NJ 07101, USA
    Cell Host Microbe 4:192-4. 2008
    ..In a recent issue of Immunity, Dunay et al. (2008) report a surprisingly crucial role for inflammatory monocytes in mucosal resistance to the parasitic agent Toxoplasma gondii...

Research Grants22

  1. Antiviral CTL mobilization to the genital mucosa
    Akiko Iwasaki; Fiscal Year: 2009
    ....
  2. Autophagy in Antiviral Immunity
    Akiko Iwasaki; Fiscal Year: 2010
    ....
  3. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2009
    ..Through basic understanding of the biology of pDCs, these studies will help to provide important foundation with which to design immunological interventions against viral diseases. ..
  4. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2009
    ....
  5. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2010
    ..Through basic understanding of the biology of pDCs, these studies will help to provide important foundation with which to design immunological interventions against viral diseases. ..
  6. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2010
    ....
  7. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2009
    ....
  8. Antiviral CTL mobilization to the genital mucosa
    Akiko Iwasaki; Fiscal Year: 2011
    ....
  9. Viral recognition by plasmacytoid dendritic cell
    Akiko Iwasaki; Fiscal Year: 2007
    ..Through basic understanding of the biology of pDCs, these studies will help to provide important foundation with which to design immunological interventions against viral diseases. ..
  10. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2007
    ....
  11. Antiviral CTL mobilization to the genital mucosa
    Akiko Iwasaki; Fiscal Year: 2007
    ....
  12. Immune Induction to Genital Herpes Simplex Virus 2
    Akiko Iwasaki; Fiscal Year: 2010
    ....