Akiko Iwasaki

Summary

Affiliation: Yale University
Country: USA

Publications

  1. Fink S, Jayewickreme T, Molony R, Iwawaki T, Landis C, Lindenbach B, et al. IRE1α promotes viral infection by conferring resistance to apoptosis. Sci Signal. 2017;10: pubmed publisher
    ..Our results reveal a prosurvival role for IRE1α in virally infected cells and suggest a possible target for IFN-independent antiviral therapy. ..
  2. Treger R, Pope S, Kong Y, Tokuyama M, Taura M, Iwasaki A. The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Immunity. 2019;50:334-347.e9 pubmed publisher
    ..Increased ERV expression in lupus patients inversely correlated with three putative ERV-suppressing KRAB-ZFPs, suggesting that loss of KRAB-ZFP-mediated ERV control may contribute to human lupus pathogenesis. ..
  3. Taura M, Song E, Ho Y, Iwasaki A. Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat. Proc Natl Acad Sci U S A. 2019;116:2282-2289 pubmed publisher
    ..We show that knockdown of A3A in latently infected human primary CD4 T cells enhanced HIV-1 reactivation. Collectively, we provide evidence and a mechanism by which A3A reinforces HIV-1 latency in infected CD4 T cells. ..
  4. Tokuyama M, Kong Y, Song E, Jayewickreme T, Kang I, Iwasaki A. ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses. Proc Natl Acad Sci U S A. 2018;115:12565-12572 pubmed publisher
    ..Use of ERVmap across a range of diseases and experimental conditions has the potential to uncover novel disease-associated antigens and effectors involved in human health that is currently missed by focusing on protein-coding sequences. ..
  5. Iwasaki A. The importance of CD11b+ dendritic cells in CD4+ T cell activation in vivo: with help from interleukin 1. J Exp Med. 2003;198:185-90 pubmed
  6. Yockey L, Iwasaki A. Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development. Immunity. 2018;49:397-412 pubmed publisher
    ..Understanding the contributions of the immune system in pregnancy and fetal development provides important insights into the pathogenesis underlying maternal and fetal diseases and sheds insights on possible targets for therapy. ..
  7. Iijima N, Iwasaki A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science. 2014;346:93-8 pubmed publisher
    ..Our results highlight the need for vaccine strategies that enable establishment of T(RM) cells for protection from a sexually transmitted virus and provide insights as to how such a pool might be established. ..
  8. Hayashi K, Taura M, Iwasaki A. The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome. Sci Signal. 2018;11: pubmed publisher
    ..Together, these data suggest a direct link between LAP formation and IKKα recruitment downstream of TLR9 activation that is necessary to facilitate type I IFN production. ..
  9. Gopinath S, Iwasaki A. Cervicovaginal microbiota: simple is better. Immunity. 2015;42:790-1 pubmed publisher
    ..Anahtar et al. (2015) identify a specific vaginal cervicotype commonly found in healthy South African women that causes localized inflammation including activation of antigen-presenting cells and vaginal recruitment of HIV target cells. ..

More Information

Publications30

  1. Gopinath S, Kim M, Rakib T, Wong P, Van Zandt M, Barry N, et al. Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner. Nat Microbiol. 2018;3:611-621 pubmed publisher
    ..These results highlight an unexpected ability of aminoglycoside antibiotics to confer broad antiviral resistance in vivo. ..
  2. Foxman E, Storer J, Fitzgerald M, Wasik B, Hou L, Zhao H, et al. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci U S A. 2015;112:827-32 pubmed publisher
    ..These findings demonstrate that in mouse airway cells, rhinovirus replicates preferentially at nasal cavity temperature due, in part, to a less efficient antiviral defense response of infected cells at cool temperature. ..
  3. Iijima N, Iwasaki A. Tissue instruction for migration and retention of TRM cells. Trends Immunol. 2015;36:556-64 pubmed publisher
  4. Khoury Hanold W, Iwasaki A. Autophagy Snuffs a Macrophage's Inner Fire. Cell Host Microbe. 2016;19:9-11 pubmed publisher
    ..2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance. ..
  5. Iwasaki A. Immune Regulation of Antibody Access to Neuronal Tissues. Trends Mol Med. 2017;23:227-245 pubmed publisher
  6. Foxman E, Storer J, Vanaja K, Levchenko A, Iwasaki A. Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature. Proc Natl Acad Sci U S A. 2016;113:8496-501 pubmed publisher
  7. Iwasaki A. A virological view of innate immune recognition. Annu Rev Microbiol. 2012;66:177-96 pubmed publisher
    ..On the basis of other unique features common to viral infections, undiscovered areas of virus detection are discussed. ..
  8. Khoury Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti Buck K, et al. Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. Cell Host Microbe. 2016;19:788-99 pubmed publisher
    ..Laxative treatment rescued mice from lethality following genital HSV-1 infection. These results reveal an unexpected pathogenesis of HSV associated with ENS infection. ..
  9. Iwasaki A. Exploiting Mucosal Immunity for Antiviral Vaccines. Annu Rev Immunol. 2016;34:575-608 pubmed publisher
  10. Yockey L, Jurado K, Arora N, Millet A, Rakib T, Milano K, et al. Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol. 2018;3: pubmed publisher
    ..Our results implicate type I IFNs as a possible mediator of pregnancy complications, including spontaneous abortions and growth restriction, in the context of congenital viral infections. ..
  11. Yockey L, Varela L, Rakib T, Khoury Hanold W, Fink S, Stutz B, et al. Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell. 2016;166:1247-1256.e4 pubmed publisher
    ..This was exacerbated in mice deficient in IFN pathways, leading to abortion. Our study highlights the vaginal tract as a highly susceptible site of ZIKV replication and illustrates the dire disease consequences during pregnancy. ..
  12. Molony R, Nguyen J, Kong Y, Montgomery R, Shaw A, Iwasaki A. Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes. Sci Signal. 2017;10: pubmed publisher
    ..Aging thus compromises both the primary and secondary RIG-I signaling pathways that govern expression of type I IFN genes, thereby impairing antiviral resistance to IAV. ..
  13. Wong P, Iwasaki A. RAB15 empowers dendritic cells to drive antiviral immunity. Sci Immunol. 2017;2: pubmed publisher
    ..CD1c+ and CD141+ dendritic cells cooperate to sustain antiviral T cell responses. ..
  14. Hastings A, Yockey L, Jagger B, Hwang J, Uraki R, Gaitsch H, et al. TAM Receptors Are Not Required for Zika Virus Infection in Mice. Cell Rep. 2017;19:558-568 pubmed publisher
    ..These findings indicate that, in mice, TAM receptors are not required for ZIKV entry and infection. ..
  15. Kumamoto Y, Camporez J, Jurczak M, Shanabrough M, Horvath T, Shulman G, et al. CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. 2016;45:583-596 pubmed publisher
    ..Reconstituting RELM? in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance. ..
  16. Hayashi K, Sasai M, Iwasaki A. Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity. Int Immunol. 2015;27:435-45 pubmed publisher
    ..Further, AP-3 recruitment to TLR9 endosomes was impaired by PIKfyve inhibition. These data indicate that PIKfyve provides critical PIs necessary for the formation of endosome from which TLR9 signals to induce type I IFNs. ..
  17. Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nat Rev Immunol. 2010;10:699-711 pubmed publisher
  18. request reprint
    Iwasaki A. Role of autophagy in innate viral recognition. Autophagy. 2007;3:354-6 pubmed
    ..These results indicated that autophagy plays a key role in mediating virus detection and IFNalpha secretion in pDCs, and suggest that cytosolic replication intermediates of ssRNA viruses serve as pathogen signatures recognized by TLR7. ..
  19. Jurado K, Yockey L, Wong P, Lee S, Huttner A, Iwasaki A. Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice. Nat Microbiol. 2018;3:141-147 pubmed publisher
  20. Pillai P, Molony R, Martinod K, Dong H, Pang I, Tal M, et al. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science. 2016;352:463-6 pubmed publisher
    ..Therefore, in the context of weakened antiviral resistance, vulnerability to IAV disease is a function of caspase-dependent pathology. ..
  21. Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010;327:291-5 pubmed publisher