Farren J Isaacs

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 333:348-53. 2011
  2. pmc Rational optimization of tolC as a powerful dual selectable marker for genome engineering
    Christopher J Gregg
    Department of Genetics and Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA, Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA, Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA and Molecular, Cellular, Developmental and Systems Biology Institute, Yale University, New Haven, CT 06516, USA
    Nucleic Acids Res 42:4779-90. 2014
  3. ncbi request reprint Genomically recoded organisms expand biological functions
    Marc J Lajoie
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 342:357-60. 2013
  4. ncbi request reprint RNA synthetic biology
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:545-54. 2006
  5. ncbi request reprint Programming cells by multiplex genome engineering and accelerated evolution
    Harris H Wang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:894-8. 2009
  6. ncbi request reprint Molecular biology. Signal processing in single cells
    Farren J Isaacs
    Lipper Center for Computational Genetics and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 307:1886-8. 2005
  7. ncbi request reprint Engineered riboregulators enable post-transcriptional control of gene expression
    Farren J Isaacs
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Biotechnol 22:841-7. 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Precise manipulation of chromosomes in vivo enables genome-wide codon replacement
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 333:348-53. 2011
    ..Our methods treat the chromosome as both an editable and an evolvable template, permitting the exploration of vast genetic landscapes...
  2. pmc Rational optimization of tolC as a powerful dual selectable marker for genome engineering
    Christopher J Gregg
    Department of Genetics and Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA, Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA, Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA and Molecular, Cellular, Developmental and Systems Biology Institute, Yale University, New Haven, CT 06516, USA
    Nucleic Acids Res 42:4779-90. 2014
    ..Finally, we combined these advances to create an optimized E. coli strain for genome engineering that is ∼10-fold more efficient at achieving allelic diversity than previous best practices. ..
  3. ncbi request reprint Genomically recoded organisms expand biological functions
    Marc J Lajoie
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 342:357-60. 2013
    ..The GRO also exhibited increased resistance to T7 bacteriophage, demonstrating that new genetic codes could enable increased viral resistance. ..
  4. ncbi request reprint RNA synthetic biology
    Farren J Isaacs
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 24:545-54. 2006
    ..Further challenges include designing RNA molecules to be sensors of intracellular and environmental stimuli, probes to explore the behavior of biological networks and components of engineered cellular control systems...
  5. ncbi request reprint Programming cells by multiplex genome engineering and accelerated evolution
    Harris H Wang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:894-8. 2009
    ..Our multiplex approach embraces engineering in the context of evolution by expediting the design and evolution of organisms with new and improved properties...
  6. ncbi request reprint Molecular biology. Signal processing in single cells
    Farren J Isaacs
    Lipper Center for Computational Genetics and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 307:1886-8. 2005
  7. ncbi request reprint Engineered riboregulators enable post-transcriptional control of gene expression
    Farren J Isaacs
    Center for BioDynamics and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Biotechnol 22:841-7. 2004
    ....