M L Irwin

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study
    Sara B Jones
    Yale School of Public Health, New Haven, CT 06520, USA
    Cancer Prev Res (Phila) 6:109-18. 2013
  2. pmc Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res 13:R56. 2011
  3. ncbi request reprint Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Prev Med 39:1080-6. 2004
  4. pmc Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, PO Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 23:774-82. 2005
  5. doi request reprint Impact of nutrition and exercise on cancer survival
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520 8034, USA
    Cancer J 14:435-41. 2008
  6. doi request reprint Physical activity interventions for cancer survivors
    M L Irwin
    Yale School of Public Health, 60 College St, New Haven, CT 06520 8034, USA
    Br J Sports Med 43:32-8. 2009
  7. pmc Pre-diagnosis physical activity and mammographic density in breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 95:171-8. 2006
  8. pmc Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 14:2881-8. 2005
  9. pmc Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 26:3958-64. 2008
  10. ncbi request reprint Randomized controlled trials of physical activity and breast cancer prevention
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
    Exerc Sport Sci Rev 34:182-93. 2006

Detail Information

Publications39

  1. pmc Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study
    Sara B Jones
    Yale School of Public Health, New Haven, CT 06520, USA
    Cancer Prev Res (Phila) 6:109-18. 2013
    ..Future studies should examine the effect of different types and doses of exercise and weight loss on inflammatory markers in large-scale trials of women diagnosed with breast cancer...
  2. pmc Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res 13:R56. 2011
    ..This study aimed to investigate the role of telomere length and telomerase activity in breast cancer prognosis...
  3. ncbi request reprint Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Prev Med 39:1080-6. 2004
    ..We examined the patterns of adherence to a yearlong exercise intervention and the influence of demographic, physiologic, and psychosocial variables on patterns of adherence among 173 sedentary, overweight, postmenopausal women...
  4. pmc Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, PO Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 23:774-82. 2005
    ....
  5. doi request reprint Impact of nutrition and exercise on cancer survival
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520 8034, USA
    Cancer J 14:435-41. 2008
    ....
  6. doi request reprint Physical activity interventions for cancer survivors
    M L Irwin
    Yale School of Public Health, 60 College St, New Haven, CT 06520 8034, USA
    Br J Sports Med 43:32-8. 2009
    ....
  7. pmc Pre-diagnosis physical activity and mammographic density in breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res Treat 95:171-8. 2006
    ....
  8. pmc Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 14:2881-8. 2005
    ..Few studies have examined the associations between obesity, physical activity, and these hormones/peptides among breast cancer survivors...
  9. pmc Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 26:3958-64. 2008
    ..To investigate the association between pre- and postdiagnosis physical activity (as well as change in prediagnosis to postdiagnosis physical activity) and mortality among women with breast cancer...
  10. ncbi request reprint Randomized controlled trials of physical activity and breast cancer prevention
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
    Exerc Sport Sci Rev 34:182-93. 2006
    ..This review presents a rationale for randomized controlled exercise trials for breast cancer prevention and proposes a construct for designing such trials...
  11. pmc Physical activity, body mass index, and mammographic density in postmenopausal breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Oncol 25:1061-6. 2007
    ....
  12. pmc Physical activity levels among breast cancer survivors
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    Med Sci Sports Exerc 36:1484-91. 2004
    ....
  13. pmc Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 18:306-13. 2009
    ....
  14. ncbi request reprint Physical activity and the metabolic syndrome in a tri-ethnic sample of women
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Obes Res 10:1030-7. 2002
    ....
  15. pmc Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 97:1746-57. 2003
    ....
  16. ncbi request reprint Physical activity interventions following cancer diagnosis: methodologic challenges to delivery and assessment
    Melinda L Irwin
    Department of Epidemiology and Public Health, School of Medicine, Yale University, 60 College St, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Invest 22:30-50. 2004
    ..Future studies are needed that use a randomized controlled design with process, short-term impact, and long-term outcome measures to identify a dose-response effect of increased PA and physical fitness on cancer recurrence and survival...
  17. pmc Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative
    Melinda L Irwin
    Division of Chronic Disease Epidemiology, Yale School of Public Health, PO Box 208034, New Haven, CT 06520 8034, USA
    Cancer Prev Res (Phila) 4:522-9. 2011
    ..Women diagnosed with breast cancer should be encouraged to initiate and maintain a program of physical activity...
  18. pmc Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle study
    Melinda L Irwin
    Yale School of Public Health, P O Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 29:47-53. 2011
    ..To examine the association between serum C-peptide, a marker of insulin secretion, measured 3 years after a breast cancer diagnosis, and death resulting from all causes and breast cancer...
  19. pmc Exercise improves body fat, lean mass, and bone mass in breast cancer survivors
    Melinda L Irwin
    Yale School of Medicine, New Haven, Connecticut, USA
    Obesity (Silver Spring) 17:1534-41. 2009
    ..043). In summary, moderate-intensity aerobic exercise, such as brisk walking, produces favorable changes in body composition that may improve breast cancer prognosis...
  20. doi request reprint Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial: the Yale Exercise and Survivorship Study
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut, USA
    Cancer 112:2593-606. 2008
    ....
  21. ncbi request reprint Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  22. doi request reprint Adherence to a randomized controlled trial of aerobic exercise in breast cancer survivors: the Yale exercise and survivorship study
    Rebecca N Latka
    Yale School of Public Health, New Haven, CT 06520 8034, USA
    J Cancer Surviv 3:148-57. 2009
    ..To examine predictors of exercise adherence in breast cancer survivors...
  23. pmc Obesity and endometrial cancer survival: a systematic review
    H Arem
    Department of Chronic Disease Epidemiology, Yale University, School of Public Health, New Haven, CT 06520, USA
    Int J Obes (Lond) 37:634-9. 2013
    ..Future studies are needed to understand disease-specific mortality, the importance of obesity-onset timing and whether mechanisms of obesity-related mortality in this population of women differ from those of the general population...
  24. pmc Physical activity, long-term symptoms, and physical health-related quality of life among breast cancer survivors: a prospective analysis
    Catherine M Alfano
    Comprehensive Cancer Center and School of Public Health, The Ohio State University, Columbus, OH, USA
    J Cancer Surviv 1:116-28. 2007
    ..This prospective study investigated physical activity (PA), occurrence of physical symptoms, and HRQOL in a large, ethnically-diverse cohort of breast cancer survivors...
  25. ncbi request reprint Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004
    ..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones...
  26. ncbi request reprint The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women
    Shelley S Tworoger
    Channing Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obes Res 12:972-81. 2004
    ..These genes metabolize estrogens and androgens, which are important in body fat regulation...
  27. ncbi request reprint Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal women
    Erin J Aiello
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Menopause 11:382-8. 2004
    ..To evaluate the effect of moderate-intensity exercise on the occurrence and severity of menopause symptoms...
  28. ncbi request reprint Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:2923-8. 2004
    ..The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens...
  29. ncbi request reprint No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial
    Anne McTiernan
    Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 14:1020-1. 2005
  30. ncbi request reprint Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial
    Laura Lewis Frank
    Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109 1024, USA
    Obes Res 13:615-25. 2005
    ..This study examined the effects of exercise on metabolic risk variables insulin, leptin, glucose, and triglycerides in overweight/obese postmenopausal women...
  31. ncbi request reprint Comparison of energy expenditure estimates from doubly labeled water, a physical activity questionnaire, and physical activity records
    Joan M Conway
    US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet and Human Performance Laboratory, Beltsville, MD 20705, USA
    Am J Clin Nutr 75:519-25. 2002
    ..However, there is limited validation of these methods against the doubly labeled water technique for determining energy expenditure (EE)...
  32. ncbi request reprint Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, Wash 98109 1024, USA
    Sleep 26:830-6. 2003
    ....
  33. ncbi request reprint Exercise effect on weight and body fat in men and women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Obesity (Silver Spring) 15:1496-512. 2007
    ..The effect of national exercise recommendations on adiposity is unknown and may differ by sex. We examined long-term effects of aerobic exercise on adiposity in women and men...
  34. ncbi request reprint Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women
    Charlotte Atkinson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:868-74. 2004
    ..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women...
  35. ncbi request reprint Estimating energy expenditure from the Minnesota Leisure Time Physical Activity and Tecumseh Occupational Activity questionnaires - a doubly labeled water validation
    Joan M Conway
    USDA, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet and Human Performance Laboratory, Beltsville, MD 20705, USA
    J Clin Epidemiol 55:392-9. 2002
    ..This investigation demonstrates that a combination of previously validated physical activity questionnaires can be used to accurately determine the mean energy expenditure of a population of employed males...
  36. ncbi request reprint Effect of a 12-month exercise intervention on the apoptotic regulating proteins Bax and Bcl-2 in colon crypts: a randomized controlled trial
    Kristin L Campbell
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:1767-74. 2007
    ..The objective of this study is to examine the effects of a 12-month aerobic exercise program on expression of proteins that promote (Bax) or inhibit (Bcl-2) apoptosis in colon crypts...
  37. ncbi request reprint Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1588-97. 2006
    ..A hypothesized mechanism for exercise-induced colon cancer risk reduction might be through alterations in colon crypt cell architecture and proliferation...
  38. ncbi request reprint No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial
    Page E Abrahamson
    Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2351-6. 2007
    ..We hypothesized that an exercise intervention would decrease prostaglandin E(2) concentrations and increase prostaglandin F(2alpha) in colon biopsies compared with controls...
  39. ncbi request reprint Effect of exercise on bone mineral density and lean mass in postmenopausal women
    Jessica Chubak
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, and University of Washington, School of Public Health and Community Medicine, Department of Epidemiology, Seattle, WA 98109 1024, USA
    Med Sci Sports Exerc 38:1236-44. 2006
    ..To evaluate the effects of physical activity on bone mineral density, bone mineral content, and lean mass in postmenopausal, overweight/obese women...

Research Grants4

  1. Impact of exercise on ovarian cancer prognosis
    Melinda Irwin; Fiscal Year: 2009
    ..Our study, the largest exercise trial in ovarian cancer survivors, could be a "proof of principal" and will also help shape post-treatment physical activity guidelines for millions of cancer survivors. ..
  2. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda Irwin; Fiscal Year: 2009
    ....
  3. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2010
    ..Our study, the largest exercise trial in ovarian cancer survivors, could be a "proof of principal" and will also help shape post-treatment physical activity guidelines for millions of cancer survivors. ..
  4. RCT of exercise on aromatase inhibitor side effects in breast cancer survivors
    Melinda L Irwin; Fiscal Year: 2010
    ....