Research Topics
| Sharon K InouyeSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment methodSharon K Inouye
Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520, USA
J Am Geriatr Soc 53:312-8. 2005..To validate a chart-based method for identification of delirium and compare it with direct interviewer assessment using the Confusion Assessment Method (CAM)...
Patterns of diffusion of evidence-based clinical programmes: a case study of the Hospital Elder Life ProgramElizabeth H Bradley
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
Qual Saf Health Care 15:334-8. 2006..The effective translation of scientific evidence into clinical practice is paramount to improving the quality and safety of patient care. However, little is known about the patterns of diffusion of evidence-based programmes in healthcare...- Depressive symptoms and the risk of incident delirium in older hospitalized adultsGail J McAvay
Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA
J Am Geriatr Soc 55:684-91. 2007..To determine whether specific subsets of symptoms from the Geriatric Depression Scale (GDS), assessed at hospital admission, were associated with the incidence of delirium... - Premature death associated with delirium at 1-year follow-upDouglas L Leslie
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Arch Intern Med 165:1657-62. 2005..The objective of this study is to estimate the fraction of a year of life lost associated with delirium at 1-year follow-up... - Consequences of preventing delirium in hospitalized older adults on nursing home costsDouglas L Leslie
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
J Am Geriatr Soc 53:405-9. 2005..To determine whether costs of long-term nursing home (NH) care for patients who received a multicomponent targeted intervention (MTI) to prevent delirium while hospitalized were less than for those who did not receive the intervention... - Older adults discharged from the hospital with delirium: 1-year outcomesGail J McAvay
Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
J Am Geriatr Soc 54:1245-50. 2006..To compare 1-year institutionalization and mortality rates of patients who were delirious at discharge, patients whose delirium resolved by discharge, and patients who were never delirious in the hospital... - After adoption: sustaining the innovation. A case study of disseminating the hospital elder life programElizabeth H Bradley
Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520, USA
J Am Geriatr Soc 53:1455-61. 2005..To examine key factors that influence sustainability in the diffusion of the Hospital Elder Life Program (HELP) as an example of an evidence-based, multifaceted, innovative program to improve care for hospitalized older adults... 
A research algorithm to improve detection of delirium in the intensive care unitMargaret A Pisani
Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, New Haven, CT 06520 8057, USA
Crit Care 10:R121. 2006..The purpose of this study was to develop a research algorithm to enhance detection of delirium in critically ill ICU patients using chart review to complement a validated clinical delirium instrument...- The role of adherence on the effectiveness of nonpharmacologic interventions: evidence from the delirium prevention trialSharon K Inouye
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06504, USA
Arch Intern Med 163:958-64. 2003..Thus, adherence must be ensured in nonpharmacologic interventions to optimize effectiveness... - Underrecognition of preexisting cognitive impairment by physicians in older ICU patientsMargaret A Pisani
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520 8057, USA
Chest 124:2267-74. 2003..Little is known, however, about physician recognition of preexisting cognitive impairment in the ICU and which patient factors may play a role in physician recognition... - Detection of delirium in the intensive care unit: comparison of confusion assessment method for the intensive care unit with confusion assessment method ratingsLynn McNicoll
Department of Internal Medicine, School of Medicine, Brown University, Providence, Rhode Island, USA
J Am Geriatr Soc 53:495-500. 2005..To compare the Confusion Assessment Method (CAM) and CAM for the Intensive Care Unit (CAM-ICU) methods for detecting delirium in alert, nonintubated older ICU patients... - Short-term outcomes in older intensive care unit patients with dementiaMargaret A Pisani
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
Crit Care Med 33:1371-6. 2005..To determine the impact of dementia on the outcomes of intensive care unit (ICU) care and use of ICU interventions among older patients... - Cognitive impairment in the intensive care unitMargaret A Pisani
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8057, USA
Clin Chest Med 24:727-37. 2003..Moreover, studies that examine the impact of delirium prevention in the ICU on rates of delirium, duration and persistence of delirium, and long-term cognitive and functional outcomes post-ICU stay are greatly needed... - Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older populationMargaret A Pisani
Department of Internal Medicine, Pulmonary and Critical Care Section, and the Program on Aging, Yale University School of Medicine, USA
Crit Care Med 37:177-83. 2009..The objective of this study was to examine the impact of benzodiazepine or opioid use on the duration of ICU delirium in an older medical population... - The roles of senior management in improving hospital experiences for frail older adultsElizabeth H Bradley
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut, USA
J Healthc Manag 51:323-36; discussion 336-7. 2006..Our findings can be used by hospital management teams as they identify ways to influence and benefit from efforts to improve clinical quality, safety, and the experiences of older adults treated in their hospitals... - Evaluation of a guided protocol for quality improvement in identifying common geriatric problemsSidney T Bogardus
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06504, USA
J Am Geriatr Soc 50:328-35. 2002..The objective of this study was to evaluate a standardized, semistructured quality-improvement protocol (the guided geriatric care protocol) for the assessment of common geriatric problems... - The effects of a targeted multicomponent delirium intervention on postdischarge outcomes for hospitalized older adultsSidney T Bogardus
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06504, USA
Am J Med 114:383-90. 2003..We sought to determine whether a multicomponent hospital-based intervention targeted toward risk factors for delirium had any effect on patient outcomes 6 months later... - Characteristics associated with delirium in older patients in a medical intensive care unitMargaret A Pisani
Pulmonary and Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
Arch Intern Med 167:1629-34. 2007..Delirium is a highly prevalent disorder among older patients in the intensive care unit... - Screening for preexisting cognitive impairment in older intensive care unit patients: use of proxy assessmentMargaret A Pisani
Department of Internal Medicine, Yale University School ofMedicine, New Haven, Connecticut 06520, USA
J Am Geriatr Soc 51:689-93. 2003..To determine the prevalence of preexisting cognitive impairment (CI) in patients admitted to the medical intensive care unit (ICU) and compare two different proxy measures of preexisting CI in ICU patients... - Dissemination of the hospital elder life program: implementation, adaptation, and successesSharon K Inouye
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02131, USA
J Am Geriatr Soc 54:1492-9. 2006..To describe the Hospital Elder Life Program (HELP) across dissemination sites, to detail adaptations, and to summarize advantages across sites... - Improving sedative-hypnotic prescribing in older hospitalized patients: provider-perceived benefits and barriers of a computer-based reminderJoseph V Agostini
Clinical Epidemiology Research Center 151B, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
J Gen Intern Med 23:32-6. 2008..Older adults are commonly prescribed sedative-hypnotic (SH) medications when hospitalized, yet these drugs are associated with important adverse effects such as falls and delirium... - Suburban leptospirosis: atypical lymphocytosis and gamma-delta T cell responseMichele Barry
Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
Clin Infect Dis 43:1304-7. 2006..Atypical lymphocytosis corresponded to an expansion of gamma-delta T cells in peripheral blood... - Use of a computer-based reminder to improve sedative-hypnotic prescribing in older hospitalized patientsJoseph V Agostini
Clinical Epidemiology Research Center, VA Connecticut Healthcare Center, West Haven, CT 06516, USA
J Am Geriatr Soc 55:43-8. 2007..To develop a feasible, inexpensive, point-of-care computerized reminder to improve sedative-hypnotic prescribing in hospitalized older people... - Achieving goals in geriatric assessment: role of caregiver agreement and adherence to recommendationsSidney T Bogardus
Departments ofInternal Medicine Epidemiology and Public Health, Yale University School of Medicine, New Haven Connecticut 06504, USA
J Am Geriatr Soc 52:99-105. 2004..To determine predictors of recommendation adherence and goal attainment of family caregivers of patients at a geriatric assessment center... - Delirium in the intensive care unit: occurrence and clinical course in older patientsLynn McNicoll
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
J Am Geriatr Soc 51:591-8. 2003..To describe the occurrence of delirium in a cohort of older medical intensive care unit (ICU) patients and its short-term duration in the hospital and to determine the association between preexisting dementia and the occurrence of delirium... - Translating research into clinical practice: making change happenElizabeth H Bradley
Department of Epidemiology and Public Health, Yale School of Medicine, 60 College Street, New Haven, CT 06520, USA
J Am Geriatr Soc 52:1875-82. 2004..This study examined common challenges faced by hospitals implementing the Hospital Elder Life Program (HELP) and strategies used to address these challenges... - Clinical yield of computed tomography brain scans in older general medical patientsLianne A Hirano
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
J Am Geriatr Soc 54:587-92. 2006..Targeting scans toward patients with new focal neurological deficits will help to improve clinical yield... - Burden of illness score for elderly persons: risk adjustment incorporating the cumulative impact of diseases, physiologic abnormalities, and functional impairmentsSharon K Inouye
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06504, USA
Med Care 41:70-83. 2003..Although index performance using different data sources has been evaluated, the full BISEP model, incorporating disease, laboratory, and functional impairment information, demonstrates the best performance... - A practical program for preventing delirium in hospitalized elderly patientsSharon K Inouye
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Cleve Clin J Med 71:890-6. 2004..A systematic program can improve the rate of recognition of this problem and decrease its incidence, and is cost-effective... - An evidence-based guide to writing grant proposals for clinical researchSharon K Inouye
Yale University School of Medicine, New Haven, Connecticut 06520-8025, USA
Ann Intern Med 142:274-82. 2005..We also provide specific recommendations to help grant writers improve the quality of areas commonly cited as deficient. Application of this systematic approach will make the task more manageable for anyone who writes grants... - Development and validation of a risk-adjustment index for older patients: the high-risk diagnoses for the elderly scaleMayur M Desai
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06504, USA
J Am Geriatr Soc 50:474-81. 2002..Future studies are needed to test this index in other settings and populations... 
One-year health care costs associated with delirium in the elderly populationDouglas L Leslie
Department of Health Administration and Policy, Medical University of South Carolina, 151 Rutledge Ave, Bldg B, PO Box 250961, Charleston, SC 29425, USA
Arch Intern Med 168:27-32. 2008..While delirium has been increasingly recognized as a serious and potentially preventable condition, its long-term implications are not well understood. This study determined the total 1-year health care costs associated with delirium...- Recognizing delirium superimposed on dementia: assessing nurses' knowledge using case vignettesDonna M Fick
School of Nursing, Pennsylvania State University, University Park 16802 6508, USA
J Gerontol Nurs 33:40-7; quiz 48-9. 2007..Interventions and educational programs designed to increase nursing awareness of DSD symptoms could help to decrease this gap in nursing knowledge... - Delirium superimposed on dementia in a community-dwelling managed care population: a 3-year retrospective study of occurrence, costs, and utilizationDonna M Fick
Medical College of Georgia School of Medicine, Center for Healthcare Improvement, and Office of Biostatistics and Bioinformatics, Augusta, GA, USA
J Gerontol A Biol Sci Med Sci 60:748-53. 2005..The purpose of this study was to examine the 3-year occurrence, healthcare utilization, and costs associated with delirium superimposed on dementia in community-dwelling persons... - Geriatric syndromes: clinical, research, and policy implications of a core geriatric conceptSharon K Inouye
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Am Geriatr Soc 55:780-91. 2007..National strategic initiatives are required to overcome barriers and to achieve clinical, research, and policy advances that will improve quality of life for older persons... - Risk factors for delirium at discharge: development and validation of a predictive modelSharon K Inouye
Aging Brain Center, Hebrew SeniorLife, 1200 Centre St, Boston, MA 02131, USA
Arch Intern Med 167:1406-13. 2007..Persistent delirium at the time of hospital discharge is associated with poor outcomes. The objectives of this study were to develop and validate a predictive model for persistent delirium at hospital discharge... - Delirium superimposed on dementia: a systematic reviewDonna M Fick
Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
J Am Geriatr Soc 50:1723-32. 2002..This paper highlights the dearth of research on delirium superimposed on dementia and stresses the importance of early recognition and prevention of delirium in persons with dementia... - Independent vascular and cognitive risk factors for postoperative deliriumJames L Rudolph
Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, Mass 02130, USA lt
Am J Med 120:807-13. 2007..We hypothesized that vascular risk factors and mildly impaired cognitive performance would independently predispose nondemented patients to develop delirium after noncardiac surgery... - The Confusion Assessment Method: a systematic review of current usageLeslie A Wei
Medical School, Brown University, Providence, Rhode Island, USA
J Am Geriatr Soc 56:823-30. 2008..To examine the psychometric properties, adaptations, translations, and applications of the Confusion Assessment Method (CAM), a widely used instrument and diagnostic algorithm for identification of delirium... - Participation in activity and risk for incident deliriumFrances M Yang
Department of Psychiatry, Brigham and Woman s Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 56:1479-84. 2008..To examine the mediating role between educational attainment and risk for incidence delirium of activity participation and to examine the contribution of participation in specific activities to the development of delirium... - Risk factors for hospitalization among community-dwelling primary care older patients: development and validation of a predictive modelSharon K Inouye
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Med Care 46:726-31. 2008..Unplanned hospitalization often represents a costly and hazardous event for the older population... - Hospital at home: feasibility and outcomes of a program to provide hospital-level care at home for acutely ill older patientsBruce Leff
Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, and The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21224, USA
Ann Intern Med 143:798-808. 2005..Acutely ill older persons often experience adverse events when cared for in the acute care hospital... - Delirium in older personsSharon K Inouye
Department of Medicine, Harvard Medical School, Boston, USA
N Engl J Med 354:1157-65. 2006 - Replicating the Hospital Elder Life Program in a community hospital and demonstrating effectiveness using quality improvement methodologyFred H Rubin
Department of Medicine, School of Medicine, University of Pittsburgh, UPMC Shadyside, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
J Am Geriatr Soc 54:969-74. 2006..To evaluate a replication of the Hospital Elder Life Program (HELP), a quality-improvement model, in a community hospital without a research infrastructure, using administrative data... - Recoverable cognitive dysfunction at hospital admission in older persons during acute illnessSharon K Inouye
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
J Gen Intern Med 21:1276-81. 2006..While acute illness and hospitalization represent pivotal events for older persons, their contribution to recoverable cognitive dysfunction (RCD) has not been well examined... - Educational disadvantage impairs functional recovery after hospitalization in older personsSarwat I Chaudhry
Special Research Fellowship Program, Veterans Affairs Medical Center, West Haven, Connecticut, USA
Am J Med 117:650-6. 2004..CONCLUSION: Educational disadvantage impairs functional recovery after hospitalization in older persons... - Prevalence and outcomes of low mobility in hospitalized older patientsCynthia J Brown
Birmingham Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham, Alabama 35294, USA
J Am Geriatr Soc 52:1263-70. 2004.... - Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unitE Wesley Ely
Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
JAMA 291:1753-62. 2004..CONCLUSION: Delirium was an independent predictor of higher 6-month mortality and longer hospital stay even after adjusting for relevant covariates including coma, sedatives, and analgesics in patients receiving mechanical ventilation... - Associations between caregiver-perceived delirium in patients with cancer and generalized anxiety in their caregiversMary K Buss
Center for Psycho Oncology and Palliative Care Research, Division of Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Palliat Med 10:1083-92. 2007..We looked for a relationship between caregiver-perceived delirium in a patient with advanced cancer and rates of caregiver psychiatric disorders... - Cholinergic deficiency hypothesis in delirium: a synthesis of current evidenceTammy T Hshieh
Warren Alpert Medical School of Brown University, Providence, RI, USA
J Gerontol A Biol Sci Med Sci 63:764-72. 2008..Understanding how the cholinergic pathway relates to delirium may yield innovative approaches in the diagnosis, prevention, and treatment of this common, costly, and morbid condition... - Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivatorsEdward R Marcantonio
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02446, USA
J Am Geriatr Soc 56:1522-7. 2008..To identify barriers and motivators to participation in long-term clinical research by high-risk elderly people and to develop procedures to maximize recruitment and retention... - Does educational attainment contribute to risk for delirium? A potential role for cognitive reserveRichard N Jones
Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
J Gerontol A Biol Sci Med Sci 61:1307-11. 2006..The objective of this study was to determine if level of educational attainment, a marker of cognitive reserve, was associated with the cumulative risk of delirium among hospitalized elders... - Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementiaZhongcong Xie
Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129-4404, USA
J Gerontol A Biol Sci Med Sci 61:1300-6. 2006..These findings suggest that isoflurane-induced Abeta oligomerization and apoptosis may contribute to the risk of postoperative cognitive dysfunction and provide a potential pathogenic link between delirium and dementia... - Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECTTamara G Fong
Department of Neurlogy, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
J Gerontol A Biol Sci Med Sci 61:1294-9. 2006..Prior studies describe variable cerebral blood flow changes in delirium. This study aims to investigate cerebral blood flow changes in older hospitalized patients with delirium, the population in which most cases of delirium occur... - The role of neuroimaging in elucidating delirium pathophysiologyDavid C Alsop
Department of Radiology, Ansin 226, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Gerontol A Biol Sci Med Sci 61:1287-93. 2006.... - Serum biomarkers for deliriumEdward R Marcantonio
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02446, USA
J Gerontol A Biol Sci Med Sci 61:1281-6. 2006..Identifying accurate biomarkers for delirium may shed further light into its pathophysiology and on the interrelationship between delirium and dementia... - Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementiaSharon K Inouye
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
J Gerontol A Biol Sci Med Sci 61:1277-80. 2006 - Prevalence and correlates of perceived societal racism in older African-American adults with type 2 diabetes mellitusSandra Y Moody-Ayers
San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Am Geriatr Soc 53:2202-8. 2005.... - Delirium in older peopleJohn Young
Academic Unit of Elderly Care and Rehabilitation, University of Leeds and Bradford Teaching Hospitals NHS Foundation Trust
BMJ 334:842-6. 2007