Jay D Humphrey

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β
    J D Humphrey
    Department of Biomedical Engineering, Yale University, and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06520, USA
    J Vasc Res 50:1-10. 2013
  2. pmc Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
    J D Humphrey
    Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Malone Engineering Center, Yale University, New Haven, CT 06520 8260, USA
    J Biomech 45:805-14. 2012
  3. pmc Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report
    Pei Zhang
    Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 32:756-9. 2012
  4. pmc Time course of carotid artery growth and remodeling in response to altered pulsatility
    John F Eberth
    Department of Engineering Technology, University of Houston, Houston, USA
    Am J Physiol Heart Circ Physiol 299:H1875-83. 2010
  5. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
  6. pmc Toward large-scale computational fluid-solid-growth models of intracranial aneurysms
    Paolo Di Achille
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Yale J Biol Med 85:217-28. 2012
  7. pmc Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome
    Jacopo Ferruzzi
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
    Cardiovasc Res 92:287-95. 2011
  8. pmc Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation
    Heather N Hayenga
    Department of Biomedical Engineering, Texas A and M University, College Station, USA
    Ann Biomed Eng 39:2669-82. 2011
  9. pmc Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation
    Yuji Naito
    Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Cells Tissues Organs 195:60-72. 2012

Research Grants

Collaborators

Detail Information

Publications9

  1. pmc Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-β
    J D Humphrey
    Department of Biomedical Engineering, Yale University, and Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06520, USA
    J Vasc Res 50:1-10. 2013
    ..Of these, pooling of glycosaminoglycans appears to be unique to these lesions...
  2. pmc Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
    J D Humphrey
    Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Malone Engineering Center, Yale University, New Haven, CT 06520 8260, USA
    J Biomech 45:805-14. 2012
    ..We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs...
  3. pmc Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report
    Pei Zhang
    Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 32:756-9. 2012
    ..The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN...
  4. pmc Time course of carotid artery growth and remodeling in response to altered pulsatility
    John F Eberth
    Department of Engineering Technology, University of Houston, Houston, USA
    Am J Physiol Heart Circ Physiol 299:H1875-83. 2010
    ....
  5. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
    ....
  6. pmc Toward large-scale computational fluid-solid-growth models of intracranial aneurysms
    Paolo Di Achille
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Yale J Biol Med 85:217-28. 2012
    ....
  7. pmc Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome
    Jacopo Ferruzzi
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
    Cardiovasc Res 92:287-95. 2011
    ....
  8. pmc Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation
    Heather N Hayenga
    Department of Biomedical Engineering, Texas A and M University, College Station, USA
    Ann Biomed Eng 39:2669-82. 2011
    ..We show that congruency-based parameter refinement not only yielded increased consistency across scales, it also yielded predictions that are closer to in vivo observations...
  9. pmc Characterization of the natural history of extracellular matrix production in tissue-engineered vascular grafts during neovessel formation
    Yuji Naito
    Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Cells Tissues Organs 195:60-72. 2012
    ..The extracellular matrix (ECM) is a critical determinant of neovessel integrity...

Research Grants1