Theodore R Holford

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Patterns of birth cohort-specific smoking histories, 1965-2009
    Theodore R Holford
    Department of Biostatistics Holford, McKay, Yale School of Public Health, New Haven, Connecticut Electronic address
    Am J Prev Med 46:e31-7. 2014
  2. pmc Chapter 14: Comparing the adequacy of carcinogenesis models in estimating U.S. population rates for lung cancer mortality
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S179-89. 2012
  3. pmc Chapter 12: Yale lung cancer model
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S151-65. 2012
  4. pmc Chapter 4: Development of the counterfactual smoking histories used to assess the effects of tobacco control
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S39-50. 2012
  5. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
  6. pmc Integrated exposure modeling: a model using GIS and GLM
    Theodore R Holford
    Division of Biostatistics, Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520, USA
    Stat Med 29:116-29. 2010
  7. ncbi request reprint Approaches to fitting age-period-cohort models with unequal intervals
    Theodore R Holford
    Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Stat Med 25:977-93. 2006
  8. pmc Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival
    Xuesong Han
    Yale University School of Public Health, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hematol 85:51-6. 2010
  9. pmc Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma
    Yawei Zhang
    School of Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 170:1222-30. 2009
  10. pmc Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 8:15. 2007

Research Grants

  1. Data Management and Biostastics Core
    Theodore Holford; Fiscal Year: 2005
  2. Modeling Interventions for Lung Cancer Mortality
    Theodore Holford; Fiscal Year: 2007
  3. Modeling Interventions for Lung Cancer Mortality
    Theodore Holford; Fiscal Year: 2006

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Patterns of birth cohort-specific smoking histories, 1965-2009
    Theodore R Holford
    Department of Biostatistics Holford, McKay, Yale School of Public Health, New Haven, Connecticut Electronic address
    Am J Prev Med 46:e31-7. 2014
    ....
  2. pmc Chapter 14: Comparing the adequacy of carcinogenesis models in estimating U.S. population rates for lung cancer mortality
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S179-89. 2012
    ..However, temporal calibration did significantly improve agreement with the population rates, especially the effect of age and cohort...
  3. pmc Chapter 12: Yale lung cancer model
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S151-65. 2012
    ..Results indicate that 35.2% and 26.5% of lung cancer deaths that could have been avoided actually were for males and females, respectively...
  4. pmc Chapter 4: Development of the counterfactual smoking histories used to assess the effects of tobacco control
    Theodore R Holford
    Yale School of Public Health, 60 College St, New Haven, CT 06520, USA
    Risk Anal 32:S39-50. 2012
    ....
  5. pmc Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania
    Briseis Aschebrook-Kilfoy
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Environ Health 11:6. 2012
    ..Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function...
  6. pmc Integrated exposure modeling: a model using GIS and GLM
    Theodore R Holford
    Division of Biostatistics, Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520, USA
    Stat Med 29:116-29. 2010
    ..In the second example, estimated levels of nitrogen dioxide (NO(2)) from the model, as well as a separate spatial model, were used to analyze traffic-related health effects in a study of 761 infants...
  7. ncbi request reprint Approaches to fitting age-period-cohort models with unequal intervals
    Theodore R Holford
    Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Stat Med 25:977-93. 2006
    ..These methods of are illustrated for three-year period and five-year age intervals using data on lung cancer mortality in Californian women...
  8. pmc Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival
    Xuesong Han
    Yale University School of Public Health, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hematol 85:51-6. 2010
    ..Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis...
  9. pmc Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma
    Yawei Zhang
    School of Public Health, Yale University, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 170:1222-30. 2009
    ..A possible role of genetic variation in xenobiotic metabolism in the carcinogenicity of hair dye use needs to be confirmed in larger studies...
  10. pmc Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 8:15. 2007
    ....
  11. ncbi request reprint Menstrual and reproductive factors and risk of non-Hodgkin's lymphoma among Connecticut women
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
    Am J Epidemiol 160:766-73. 2004
    ..These findings support a reduced risk of non-Hodgkin's lymphoma associated with multiple pregnancies and an increased risk of non-Hodgkin's lymphoma associated with later age at menarche...
  12. ncbi request reprint Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma
    Yawei Zhang
    Yale University School of Epidemiology and Public Health, New Haven, CT 06520 8034, USA
    Am J Epidemiol 165:1255-64. 2007
    ..0051). The risk appears to vary by non-Hodgkin's lymphoma subtypes. Further investigations of the role of ultraviolet radiation on the risk of non-Hodgkin's lymphoma are warranted...
  13. pmc Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma
    Xuesong Han
    Yale University School of Public Health, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 18:1429-38. 2009
    ..Our results suggest that genetic polymorphisms in oxidative stress pathway genes, especially in the NOS genes, modify the association between vegetable and fruit intake and risk of NHL...
  14. pmc Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women
    Rong Wang
    Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520 8034, USA
    Am J Epidemiol 169:176-85. 2009
    ..Results suggest an increased risk of NHL associated with occupational exposure to organic solvents for women...
  15. ncbi request reprint Blood transfusion and risk of non-Hodgkin's lymphoma in Connecticut women
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
    Am J Epidemiol 160:325-30. 2004
    ..In summary, the authors' findings do not support the hypothesis that allogeneic blood transfusion increases the risk of non-Hodgkin's lymphoma...
  16. ncbi request reprint A putative exonic splicing polymorphism in the BCL6 gene and the risk of non-Hodgkin lymphoma
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 97:1616-8. 2005
    ..2, 95% CI = 2.0 to 13.3). Our results support the hypothesis that a genetic variant that could alter mRNA transcripts of BCL6 may contribute to the etiology of NHL and suggest that this variant warrants further investigation...
  17. ncbi request reprint Breast cancer risk factors according to joint estrogen receptor and progesterone receptor status
    Jennifer A Rusiecki
    Department of Epidemiology and Public Health, Yale University, School of Medicine, New Haven, CT, USA
    Cancer Detect Prev 29:419-26. 2005
    ..We investigated risk factor patterns for subtypes of breast cancer characterized by joint estrogen receptor (ER) and progesterone receptor (PR) status in a hospital-based case-control study...
  18. pmc Vegetable and fruit intake and non-Hodgkin lymphoma survival in Connecticut women
    Xuesong Han
    School of Public Health, Yale University, New Haven, CT, USA
    Leuk Lymphoma 51:1047-54. 2010
    ..Our study suggests that increasing vegetable and citrus fruit consumption could be a useful strategy to improve survival in NHL patients...
  19. ncbi request reprint Indoor heating sources and respiratory symptoms in nonsmoking women
    Elizabeth W Triche
    Department of Epidemiology and Public Health, Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Epidemiology 16:377-84. 2005
    ....
  20. ncbi request reprint Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Causes Control 15:419-28. 2004
    ..To further investigate the role of prior medical conditions and medication use in the etiology of non-Hodgkin lymphoma (NHL), we analyzed the data from a population-based case-control study of NHL in Connecticut women...
  21. ncbi request reprint Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women
    Yawei Zhang
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, CT 06510, USA
    Am J Epidemiol 160:1177-83. 2004
    ..In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk...
  22. ncbi request reprint Hepatitis C virus and risk of non-Hodgkin lymphoma: a population-based case-control study among Connecticut women
    Lindsay McOmber Morton
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Cancer Epidemiol Biomarkers Prev 13:425-30. 2004
    ..To further investigate the link between HCV and NHL, we conducted HCV testing on serum samples of 998 women (464 cases; 534 controls) from a population-based case-control study of women in Connecticut...
  23. ncbi request reprint Nutrients contributing to one-carbon metabolism and risk of non-Hodgkin lymphoma subtypes
    Stella Koutros
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 20852, USA
    Am J Epidemiol 167:287-94. 2008
    ..lowest: OR = 0.23, 95% CI: 0.08, 0.65; p-trend = 0.002). These findings suggest that these nutrients may be important for susceptibility to NHL...
  24. ncbi request reprint Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma
    Yawei Zhang
    Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, New Haven, CT 06520, USA
    Cancer Causes Control 18:351-9. 2007
    ..The relationship between family history of specific hematopoietic and non-hematopoietic malignancies and the risk of NHL and by NHL subtypes are unclear...
  25. ncbi request reprint Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut women
    Tongzhang Zheng
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Am J Epidemiol 159:454-66. 2004
    ..The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted...
  26. ncbi request reprint Hair-coloring product use and risk of non-Hodgkin's lymphoma: a population-based case-control study in Connecticut
    Yawei Zhang
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06510, USA
    Am J Epidemiol 159:148-54. 2004
    ..Further studies are warranted to show whether the observed association reflects the change in hair dye formula contents during the past two decades or indicates that recent users are still in their induction and latent periods...
  27. pmc Urban land-use and respiratory symptoms in infants
    Keita Ebisu
    Yale University, School of Forestry and Environmental Studies, New Haven, CT 06511, USA
    Environ Res 111:677-84. 2011
    ..The impacts of urban land-use on health are not fully understood, although these relationships are of key importance given the growing populations living in urban environments...
  28. pmc CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 70:1459-68. 2010
    ..Our findings support the hypothesis that circadian genes influence tumorigenesis, and identify a set of circadian gene variants as candidate breast cancer susceptibility biomarkers...
  29. ncbi request reprint Alcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysis
    Lindsay M Morton
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Lancet Oncol 6:469-76. 2005
    ..We aimed to assess the role of alcohol consumption in NHL with sufficient sample size to analyse by both type of alcoholic beverage and disease subtype...
  30. pmc Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 7:68. 2006
    ....
  31. ncbi request reprint Association of low-level ozone and fine particles with respiratory symptoms in children with asthma
    Janneane F Gent
    Center for Perinatal, Pediatric, and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06510, USA
    JAMA 290:1859-67. 2003
    ..Exposure to ozone and particulate matter of 2.5 microm or less (PM2.5) in air at levels above current US Environmental Protection Agency (EPA) standards is a risk factor for respiratory symptoms in children with asthma...
  32. pmc Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution
    Janneane F Gent
    Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Environ Health Perspect 117:1168-74. 2009
    ..5))] is a potential factor in the exacerbation of asthma. National air quality particle standards consider total mass, not composition or sources, and may not protect against health impacts related to specific components...
  33. pmc Alcohol consumption and non-Hodgkin lymphoma survival
    Xuesong Han
    School of Public Health, Yale University, New Haven, CT 06520, USA
    J Cancer Surviv 4:101-9. 2010
    ..Alcohol drinking has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption on NHL survival by type of alcohol consumed and NHL subtype...
  34. pmc Low-level ozone exposure and respiratory symptoms in infants
    Elizabeth W Triche
    Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Environ Health Perspect 114:911-6. 2006
    ..Environmental Protection Agency (EPA) ozone standards may not protect sensitive individuals. In this study we examined respiratory effects of ozone in infants who may be vulnerable, particularly if they are children of asthmatic mothers...
  35. doi request reprint Lymphoma survival patterns by WHO subtype in the United States, 1973-2003
    Xuesong Han
    Yale University School of Epidemiology and Public Health, 60 College Street, LEPH 440, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Causes Control 19:841-58. 2008
    ..The differences in lymphoma survival patterns suggest that distinct prognostic risk factors impact survival by subtype and that future research and public health interventions should address racial disparities in lymphoma survivorship...
  36. ncbi request reprint Role of one-carbon metabolizing pathway genes and gene-nutrient interaction in the risk of non-Hodgkin lymphoma
    Qian Li
    Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06510, USA
    Cancer Causes Control 24:1875-84. 2013
    ..However, the results have been inconsistent. The objectives of this study were to examine the potential relationship between gene-nutrient interactions and the risk of non-Hodgkin lymphoma (NHL)...
  37. pmc Household levels of nitrogen dioxide and pediatric asthma severity
    Kathleen Belanger
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Public Health, New Haven, CT 06510, USA
    Epidemiology 24:320-30. 2013
    ..S. households. We investigated the effects of indoor NO2 exposure on asthma severity among an ethnically and economically diverse sample of children, controlling for season and indoor allergen exposure...
  38. pmc Clock-cancer connection in non-Hodgkin's lymphoma: a genetic association study and pathway analysis of the circadian gene cryptochrome 2
    Aaron E Hoffman
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 69:3605-13. 2009
    ..75E(-9)) and hematologic disease (B-H P = 8.01E(-8)). In conclusion, both genetic association and functional analyses suggest that the circadian gene CRY2 may play an important role in NHL development...
  39. pmc Trends in one-year recurrent ischemic stroke among the elderly in the USA: 1994-2002
    Norrina B Allen
    Division of Chronic Disease Epidemiology, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Cerebrovasc Dis 30:525-32. 2010
    ..Little is known about how the rates of recurrent stroke in the country have changed over time. Our objective was to determine national trends in 1-year recurrent ischemic stroke rates by US county among the elderly from 1994 to 2002...
  40. ncbi request reprint Estimates of active and disabled life expectancy based on different assessment intervals
    Thomas M Gill
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06504, USA
    J Gerontol A Biol Sci Med Sci 60:1013-6. 2005
    ..We performed a prospective cohort study to compare estimates of active and disabled life expectancy based on traditional assessment intervals of 1--2 years with those based on more frequent assessments at 1-month intervals...
  41. ncbi request reprint Premature death associated with delirium at 1-year follow-up
    Douglas L Leslie
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Intern Med 165:1657-62. 2005
    ..The objective of this study is to estimate the fraction of a year of life lost associated with delirium at 1-year follow-up...
  42. pmc Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma
    Janneane F Gent
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Environ Health Perspect 110:A781-6. 2002
    ..We conclude that infants in this high-risk group who are exposed to high levels of Penicillium are at significant risk for wheeze and persistent cough...
  43. ncbi request reprint Alcohol use and risk of non-Hodgkin's lymphoma among Connecticut women (United States)
    Lindsay McOmber Morton
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Causes Control 14:687-94. 2003
    ..Data from a population-based case-control study among women in Connecticut were analyzed to determine the potential impact of alcohol consumption on risk of NHL...
  44. pmc Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status
    Yong Zhu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Breast Cancer Res 7:R745-52. 2005
    ..MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The present case-control study investigated associations between two single nucleotide polymorphisms (SNPs) in the MBD2 gene and breast cancer risk...
  45. ncbi request reprint Hospitalization, restricted activity, and the development of disability among older persons
    Thomas M Gill
    Department of Internal Medicine, Yale University School of Medicine, Dorothy Adler Geriatric Assessment Center, New Haven, Conn 06504, USA
    JAMA 292:2115-24. 2004
    ..Preventing the development of disability in activities of daily living is an important goal in older adults, yet relatively little is known about the disabling process...
  46. pmc Geographic variation in one-year recurrent ischemic stroke rates for elderly Medicare beneficiaries in the USA
    Norrina B Allen
    Division of Chronic Disease Epidemiology, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Neuroepidemiology 34:123-9. 2010
    ..Accordingly, we evaluated geographic variations in 1-year recurrent ischemic stroke rates in the USA with adjustment for patient characteristics...
  47. ncbi request reprint Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction
    Laura M Grosso
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University, New Haven, CT 06510, USA
    Am J Epidemiol 163:1035-41. 2006
    ..21, 95% confidence interval: 1.07, 1.37), suggesting that CYP1A2 activity, and not the absolute levels of paraxanthine, influences fetal growth. No associations were observed between caffeine or any metabolites and preterm delivery...
  48. ncbi request reprint Forest fragmentation predicts local scale heterogeneity of Lyme disease risk
    John S Brownstein
    Department of Epidemiology and Public Health, Yale School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Oecologia 146:469-75. 2005
    ..A complete understanding of the influence of landscape fragmentation will allow for improved risk mapping and potential environmental management of Lyme disease...
  49. ncbi request reprint Cigarette smoking and risk of non-Hodgkin lymphoma: a pooled analysis from the International Lymphoma Epidemiology Consortium (interlymph)
    Lindsay M Morton
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conneticut, USA
    Cancer Epidemiol Biomarkers Prev 14:925-33. 2005
    ....
  50. pmc International patterns and trends in thyroid cancer incidence, 1973-2002
    Briseis A Kilfoy
    Yale School of Public Health, Yale University, 60 College Street, LEPH 440, P O Box 208034, New Haven, CT 06520, USA
    Cancer Causes Control 20:525-31. 2009
    ....
  51. ncbi request reprint Transitions between states of disability and independence among older persons
    Susan E Hardy
    Department of Internal Medicine, Yale University School of Medicine, 20 York Street, Tompkins Basement 15, New Haven, CT 06504, USA
    Am J Epidemiol 161:575-84. 2005
    ..To fully understand the disabling process, investigators and clinicians must consider the episodic and recurrent nature of disability...
  52. pmc Effect of pregnancy on maternal asthma symptoms and medication use
    Kathleen Belanger
    Center for Perinatal Pediatric and Environmental Epidemiology, Yale University School of Public Health, New Haven, Connecticut 06510, USA
    Obstet Gynecol 115:559-67. 2010
    ..To examine whether factors related to the patient or her treatment influence asthma severity during pregnancy...
  53. ncbi request reprint Perceived racial discrimination and nonadherence to screening mammography guidelines: results from the race differences in the screening mammography process study
    Amy B Dailey
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Am J Epidemiol 165:1287-95. 2007
    ....
  54. ncbi request reprint Consequences of preventing delirium in hospitalized older adults on nursing home costs
    Douglas L Leslie
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
    J Am Geriatr Soc 53:405-9. 2005
    ..To determine whether costs of long-term nursing home (NH) care for patients who received a multicomponent targeted intervention (MTI) to prevent delirium while hospitalized were less than for those who did not receive the intervention...
  55. ncbi request reprint Polychlorinated biphenyls and breast cancer risk by combined estrogen and progesterone receptor status
    Jennifer A Rusiecki
    Department of Epidemiology and Public Health, Yale University School of Medicine, USA
    Eur J Epidemiol 19:793-801. 2004
    ..These results confirm previous findings in the literature of no positive association between environmental exposure to PCBs and risk of breast cancer...
  56. ncbi request reprint Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women
    Shelley L Goodstine
    Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
    J Nutr 133:1409-14. 2003
    ..50, 95% CI 0.27, 0.95, P for trend = 0.02. These results are consistent with the hypothesis that a higher (n-3)/(n-6) PUFA ratio may reduce the risk of breast cancer, especially in premenopausal women...
  57. ncbi request reprint Interpreting conflicting findings from clinical trials of auricular acupuncture for cocaine addiction: does treatment context influence outcome?
    Arthur Margolin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Altern Complement Med 8:111-21. 2002
    ..To compare findings from two consecutive clinical trials of auricular acupuncture for cocaine addiction conducted at the same site in order to explore consistency of treatment effects...
  58. ncbi request reprint Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III
    Michael B Bracken
    Department of Epidemiology, School of Medicine, and Graduate School, Yale University, New Haven, Connecticut 06520 8034, USA
    J Neurosurg 96:259-66. 2002
    ..The safety of the therapy has also been questioned...
  59. ncbi request reprint Prenatal exposure to organochlorine pesticides and infant birth weight in China
    Huan Guo
    Yale School of Public Health, New Haven, CT 06510, USA School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
    Chemosphere 110:1-7. 2014
    ..Prenatal exposure to DDT, β-BHC, HCB, and mirex were associated with a decrease in birth weight, but these results need validation in larger sample-sized studies. ..
  60. ncbi request reprint Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States)
    Tongzhang Zheng
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Cancer Causes Control 13:637-45. 2002
    ..We sought to determine if there is a gene-environment interaction between GSTM I (GSTM1A and GSTM1B), and GSTT1 genotypes and cigarette smoking in the risk of breast cancer...
  61. ncbi request reprint The development of insidious disability in activities of daily living among community-living older persons
    Thomas M Gill
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med 117:484-91. 2004
    ..To determine how often disability in essential activities of daily living develops insidiously, and to evaluate whether the likelihood of insidious disability differs on the basis of physical frailty...
  62. ncbi request reprint Infant respiratory symptoms associated with indoor heating sources
    Elizabeth W Triche
    Center for Perinatal, Pediatric and Environmental Epidemology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Crit Care Med 166:1105-11. 2002
    ..Fireplace use was not associated with any of the respiratory symptoms. Use of some heating sources appears related to respiratory symptoms in infants...
  63. ncbi request reprint Strategies for identifying pregnancies in the automated medical records of the General Practice Research Database
    Janet R Hardy
    Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Public Health, 1 Church Street, 6th Floor, New Haven, CT 06510, USA
    Pharmacoepidemiol Drug Saf 13:749-59. 2004
    ..To develop a method for identifying the beginning and ending records of pregnancies in the automated medical records of the General Practice Research Database (GPRD)...
  64. ncbi request reprint Declining incidence of invasive Streptococcus pneumoniae infections among persons with AIDS in an era of highly active antiretroviral therapy, 1995-2000
    Richard T Heffernan
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut, USA
    J Infect Dis 191:2038-45. 2005
    ..Our goal was to describe trends in invasive pneumococcal disease incidence among persons with acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART)...
  65. pmc A climate-based model predicts the spatial distribution of the Lyme disease vector Ixodes scapularis in the United States
    John S Brownstein
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Environ Health Perspect 111:1152-7. 2003
    ..scapularis across the United States...
  66. ncbi request reprint Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:659-68. 2006
    ..Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies...
  67. ncbi request reprint Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Lancet Oncol 7:27-38. 2006
    ..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
  68. ncbi request reprint Safety of medications prescribed before and during early pregnancy in a cohort of 81,975 mothers from the UK General Practice Research Database
    Janet R Hardy
    Division of Preventive and Behavioral Medicine, University of Massachusetts School of Medicine, Worcester, MA 01655, USA
    Pharmacoepidemiol Drug Saf 15:555-64. 2006
    ..To demonstrate a linkage methodology for mother and baby automated medical records, and describe frequency, type, and pregnancy risk level of medications prescribed during pregnancy in a GPRD cohort, 1991-1999...
  69. ncbi request reprint Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892 7240, USA
    Carcinogenesis 28:823-7. 2007
    ..The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL...
  70. ncbi request reprint Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, EPS 8109, Bethesda, MD 20892 7240, USA
    Hum Genet 121:161-8. 2007
    ..013), but was also associated with non-significant increased risks for each of the common B-cell histologies. These results suggest that SNPs in genes related to the oxidative stress pathway may be associated with increased risk of NHL...
  71. ncbi request reprint Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA
    Pharmacogenomics 6:865-72. 2005
    ....
  72. ncbi request reprint Neighborhood-level socioeconomic predictors of nonadherence to mammography screening guidelines
    Amy B Dailey
    Department of Epidemiology and Biostatistics, University of Florida School of Public Health and Health Professions, P O Box 100231, Gainesville, FL 32610, USA
    Cancer Epidemiol Biomarkers Prev 16:2293-303. 2007
    ..67; neighborhood-level education OR, 2.31; 95% CI, 0.93-5.76]. The results of this analysis underscore the importance of examining neighborhood social context as well as individual factors in the study of mammography screening behavior...
  73. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  74. ncbi request reprint Analytic strategies for longitudinal studies
    Theodore R Holford
    Stat Methods Med Res 13:1. 2004
  75. ncbi request reprint Designing physiogenomic studies
    Theodore R Holford
    Pharmacogenomics 7:157-8. 2006
  76. ncbi request reprint Effect of fetal sex on airway lability in pregnant women with asthma
    Helen L Kwon
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 163:217-21. 2006
    ..This difference persisted throughout pregnancy. Among pregnant asthmatic women, carrying a female fetus is associated with worse maternal asthma, as assessed by greater airway lability, than is carrying a male fetus...
  77. ncbi request reprint Physiogenomic association of statin-related myalgia to serotonin receptors
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
    Muscle Nerve 36:329-35. 2007
    ..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...
  78. ncbi request reprint The natural history of periodontal disease in humans: risk factors for tooth loss in caries-free subjects receiving no oral health care
    Anthony L Neely
    Department of Periodontology and Dental Hygiene, School of Dentistry, University of Detroit, Mercy, Detroit, MI 48219 0900, USA
    J Clin Periodontol 32:984-93. 2005
    ..The purpose of this report is to identify potential risk factors for tooth loss among male Sri Lankan tea labourers who participated in a 20-year investigation of the natural history of periodontal disease...

Research Grants4

  1. Data Management and Biostastics Core
    Theodore Holford; Fiscal Year: 2005
    ....
  2. Modeling Interventions for Lung Cancer Mortality
    Theodore Holford; Fiscal Year: 2007
    ..abstract_text> ..
  3. Modeling Interventions for Lung Cancer Mortality
    Theodore Holford; Fiscal Year: 2006
    ..abstract_text> ..