RALPH EDWARD HOFFMAN

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Functional connectivity studies of patients with auditory verbal hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA
    Front Hum Neurosci 6:6. 2011
  2. pmc Transcranial magnetic stimulation of Wernicke's and Right homologous sites to curtail "voices": a randomized trial
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 73:1008-14. 2013
  3. ncbi request reprint Experiential features used by patients with schizophrenia to differentiate 'voices' from ordinary verbal thought
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Psychol Med 38:1167-76. 2008
  4. ncbi request reprint Auditory/Verbal hallucinations, speech perception neurocircuitry, and the social deafferentation hypothesis
    Ralph E Hoffman
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin EEG Neurosci 39:87-90. 2008
  5. pmc Time course of regional brain activation associated with onset of auditory/verbal hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 193:424-5. 2008
  6. pmc Revisiting Arieti's "listening attitude" and hallucinated voices
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine
    Schizophr Bull 36:440-2. 2010
  7. pmc Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Biol Psychiatry 69:407-14. 2011
  8. pmc Using computational patients to evaluate illness mechanisms in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 69:997-1005. 2011
  9. pmc Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 198:277-83. 2011
  10. ncbi request reprint Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Br J Psychiatry 191:355-6. 2007

Research Grants

  1. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2003
  2. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2009
  3. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2007
  4. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2006
  5. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2006
  6. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2005
  7. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2005
  8. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2004
  9. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2004
  10. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2003

Detail Information

Publications22

  1. pmc Functional connectivity studies of patients with auditory verbal hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven CT, USA
    Front Hum Neurosci 6:6. 2011
    ....
  2. pmc Transcranial magnetic stimulation of Wernicke's and Right homologous sites to curtail "voices": a randomized trial
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 73:1008-14. 2013
    ..Efficacy in curtailing AVHs via 1-Hz repetitive magnetic stimulation (rTMS) targeting a site in each region ("W" and "rW") was therefore studied...
  3. ncbi request reprint Experiential features used by patients with schizophrenia to differentiate 'voices' from ordinary verbal thought
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Psychol Med 38:1167-76. 2008
    ..Determining how patients distinguish auditory verbal hallucinations (AVHs) from their everyday thoughts may shed light on neurocognitive processes leading to these symptoms...
  4. ncbi request reprint Auditory/Verbal hallucinations, speech perception neurocircuitry, and the social deafferentation hypothesis
    Ralph E Hoffman
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin EEG Neurosci 39:87-90. 2008
    ..A more precise characterization of underlying pathophysiology may lead to more efficacious treatments...
  5. pmc Time course of regional brain activation associated with onset of auditory/verbal hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 193:424-5. 2008
    ..These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations...
  6. pmc Revisiting Arieti's "listening attitude" and hallucinated voices
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine
    Schizophr Bull 36:440-2. 2010
    ..These findings and clinical observations suggest that Arieti's original formulation deserves further study...
  7. pmc Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Biol Psychiatry 69:407-14. 2011
    ..We consequently tested the hypothesis that auditory/verbal hallucinations (AVHs) arise from elevated functional coordination within a speech processing network...
  8. pmc Using computational patients to evaluate illness mechanisms in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 69:997-1005. 2011
    ..Computational models may provide insights into why some mechanisms are unlikely, suggest alternative mechanisms, and tie together explanations of seemingly disparate symptoms and experimental findings...
  9. pmc Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 198:277-83. 2011
    ..The pathophysiology of auditory verbal hallucinations remains poorly understood...
  10. ncbi request reprint Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Br J Psychiatry 191:355-6. 2007
    ..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment...
  11. pmc A social deafferentation hypothesis for induction of active schizophrenia
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, 184 Liberty Street, New Haven, CT 06519, USA
    Schizophr Bull 33:1066-70. 2007
    ..Arguments against the SDA hypothesis are discussed, and predictions deriving from the hypothesis are offered...
  12. pmc Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation
    Ralph E Hoffman
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Cereb Cortex 17:2733-43. 2007
    ..These findings suggest that dominant hemisphere temporoparietal areas are involved in expressing AVHs, with higher levels of coactivation and/or coupling involving inferior frontal regions reinforcing underlying pathophysiology...
  13. ncbi request reprint Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, Yale University School of Medicine, LV 108, 20 York Street, New Haven, CT 06504, USA
    Am J Psychiatry 159:1093-102. 2002
    ..Many clinical syndromes in neuropsychiatry suggest focal brain activation. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a method for selectively altering neural activity...
  14. ncbi request reprint Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 20 York St LV108, New Haven, CT 06504, USA
    Arch Gen Psychiatry 60:49-56. 2003
    ..We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication...
  15. ncbi request reprint Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 58:97-104. 2005
    ..Data from the full 50-subject sample incorporating 26 new patients are now presented to more comprehensively assess safety/tolerability, efficacy and moderators of this intervention...
  16. ncbi request reprint Using a speech perception neural network computer simulation to contrast neuroanatomic versus neuromodulatory models of auditory hallucinations
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, New Haven, CT 06519, USA
    Pharmacopsychiatry 39:S54-64. 2006
    ..These data suggest that the primary pathophysiology of schizophrenia arises from curtailed connectivity in working memory systems and that dopaminergic alterations reflect secondary compensatory adjustments...
  17. ncbi request reprint "Seeing voices": fused visual/auditory verbal hallucinations reported by three persons with schizophrenia-spectrum disorder
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Acta Psychiatr Scand 114:290-2; discussion 292. 2006
    ..A form of visualized verbal hallucinations not previously reported in the literature is described that may shed light on this controversy...
  18. pmc Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States
    Drug Discov Today 14:690-7. 2009
    ..In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia...
  19. ncbi request reprint Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychiatry Res 113:245-54. 2002
    ..The duration of the therapeutic effects of rTMS delivered to the left prefrontal cortex using the above-described parameters is highly variable...
  20. ncbi request reprint Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
    Am J Psychiatry 163:790-9. 2006
    ..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...
  21. ncbi request reprint Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex
    Peter J Siekmeier
    Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA
    Br J Psychiatry 180:345-50. 2002
    ..Many studies have found that people with schizophrenia exhibit abnormally high levels of semantic priming. Post-mortem and neuroimaging studies of schizophrenia suggest a reduction of neuritic processes (dendrites and synapses)...
  22. ncbi request reprint Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks
    R Andrew Chambers
    Division of Substance Abuse, Connecticut Mental Health Center, Yale University School of Medicine, USA
    Neuropsychopharmacology 29:747-58. 2004
    ..The implications of these elementary simulations for future biological and neural modeling research on apoptosis and neurogenesis are discussed...

Research Grants12

  1. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2003
    ..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..
  2. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2009
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
  3. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2007
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
  4. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2006
    ..These findings could advance our ability to develop more specific and efficacious treatments targeting this syndrome. ..
  5. rTMS Clinical Trial for Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2006
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
  6. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2005
    ..These findings could advance our ability to develop more specific and efficacious treatments targeting this syndrome. ..
  7. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2005
    ..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..
  8. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2004
    ..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..
  9. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2004
    ..These findings could advance our ability to develop more specific and efficacious treatments targeting this syndrome. ..
  10. Pathophysiology of Auditory Hallucinations
    Ralph Hoffman; Fiscal Year: 2003
    ..These findings could advance our ability to develop more specific and efficacious treatments targeting this syndrome. ..
  11. rTMS Clinical Trial for Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2010
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..