RALPH EDWARD HOFFMAN

..Efficacy in curtailing AVHs via 1-Hz repetitive magnetic stimulation (rTMS) targeting a site in each region ("W" and "rW") was therefore studied...

..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment...

..Determining how patients distinguish auditory verbal hallucinations (AVHs) from their everyday thoughts may shed light on neurocognitive processes leading to these symptoms...

..A more precise characterization of underlying pathophysiology may lead to more efficacious treatments...

..These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations...

..These findings and clinical observations suggest that Arieti's original formulation deserves further study...

..We consequently tested the hypothesis that auditory/verbal hallucinations (AVHs) arise from elevated functional coordination within a speech processing network...

..Computational models may provide insights into why some mechanisms are unlikely, suggest alternative mechanisms, and tie together explanations of seemingly disparate symptoms and experimental findings...

..The pathophysiology of auditory verbal hallucinations remains poorly understood...

..Arguments against the SDA hypothesis are discussed, and predictions deriving from the hypothesis are offered...

..These findings suggest that dominant hemisphere temporoparietal areas are involved in expressing AVHs, with higher levels of coactivation and/or coupling involving inferior frontal regions reinforcing underlying pathophysiology...

..A form of visualized verbal hallucinations not previously reported in the literature is described that may shed light on this controversy...

..Many clinical syndromes in neuropsychiatry suggest focal brain activation. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a method for selectively altering neural activity...

..These data suggest that the primary pathophysiology of schizophrenia arises from curtailed connectivity in working memory systems and that dopaminergic alterations reflect secondary compensatory adjustments...

..Data from the full 50-subject sample incorporating 26 new patients are now presented to more comprehensively assess safety/tolerability, efficacy and moderators of this intervention...

..We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication...

..The duration of the therapeutic effects of rTMS delivered to the left prefrontal cortex using the above-described parameters is highly variable...

..In considering neuroplasticity as a target for the treatment of psychiatric disorders, we build on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia...

..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...

..Its findings shed light on the mechanisms underlying cognitive priming more generally, and how it might emerge developmentally...

..The implications of these elementary simulations for future biological and neural modeling research on apoptosis and neurogenesis are discussed...

..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..

..These findings could advance our ability to develop more specific and efficacious treatments targeting this syndrome. ..

..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..

..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..