Steven Hebert

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University Medical School, 333 Cedar Street, P O Box 208026, SHM B147, New Haven, CT 06520 8026, USA
    Pflugers Arch 447:580-93. 2004
  2. ncbi request reprint Bartter syndrome
    Steven C Hebert
    Department of Cellular and Molecular Physiology and Medicine, Yale University, School of Medicine, New Haeven, Connecticut 06520 8026, USA
    Curr Opin Nephrol Hypertens 12:527-32. 2003
  3. ncbi request reprint Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, SHM B147, P O Box 208026, New Haven, CT 06520 8026, USA
    Cell Calcium 35:239-47. 2004
  4. pmc Molecular diversity and regulation of renal potassium channels
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    Physiol Rev 85:319-71. 2005
  5. ncbi request reprint Therapeutic use of calcimimetics
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    Annu Rev Med 57:349-64. 2006
  6. pmc Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production
    Qingshang Yan
    Dept of Cellular and Molecular Physiology, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 295:R997-R1004. 2008
  7. pmc WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)
    Qiang Leng
    Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 571:275-86. 2006
  8. pmc Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct
    Dao Hong Lin
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 286:F881-92. 2004
  9. doi request reprint Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins
    Carsten A Wagner
    Institute of Physiology, Center for Integrative Human Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 294:F1373-80. 2008
  10. pmc Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction
    John Geibel
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9390-7. 2006

Research Grants

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University Medical School, 333 Cedar Street, P O Box 208026, SHM B147, New Haven, CT 06520 8026, USA
    Pflugers Arch 447:580-93. 2004
    ..In addition, knockout mice for many members of this family have generated important new information regarding their respective physiological roles...
  2. ncbi request reprint Bartter syndrome
    Steven C Hebert
    Department of Cellular and Molecular Physiology and Medicine, Yale University, School of Medicine, New Haeven, Connecticut 06520 8026, USA
    Curr Opin Nephrol Hypertens 12:527-32. 2003
    ..Consequently, individuals with Bartter syndrome exhibit renal salt wasting and lowered blood pressure, hypokalemic metabolic alkalosis and hypercalciuria with a variable risk of renal stones...
  3. ncbi request reprint Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, SHM B147, P O Box 208026, New Haven, CT 06520 8026, USA
    Cell Calcium 35:239-47. 2004
    ..Finally, the Ca2+-sensing receptor has been suggested to provide a mechanism for the effect of calcium intake in reducing the risk of colon cancer...
  4. pmc Molecular diversity and regulation of renal potassium channels
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    Physiol Rev 85:319-71. 2005
    ..Such progress has been made possible by the application of single-channel analysis and the successful cloning of K(+) channels of renal origin...
  5. ncbi request reprint Therapeutic use of calcimimetics
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    Annu Rev Med 57:349-64. 2006
    ..On the therapeutic horizon are calcilytics that can transiently increase PTH and may prove useful in the treatment of osteoporosis...
  6. pmc Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production
    Qingshang Yan
    Dept of Cellular and Molecular Physiology, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 295:R997-R1004. 2008
    ..33% vs. 22.74% of PGE(2) and 85.67% vs. 20.36% of TXB(2). These data demonstrate a more severe Bartter phenotype in female ROMK null mice, and higher PGE(2) and TXB(2) production may be one of the mechanisms of this manifestation...
  7. pmc WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)
    Qiang Leng
    Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 571:275-86. 2006
    ..WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion...
  8. pmc Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct
    Dao Hong Lin
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 286:F881-92. 2004
    ..We conclude that c-Src is expressed in the TAL, CCD, and OMCD and that stimulation of PTK increases the ROMK channels in the intracellular compartment but decreases them in the apical/subapical membrane in the CCD...
  9. doi request reprint Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins
    Carsten A Wagner
    Institute of Physiology, Center for Integrative Human Physiology, Univ of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 294:F1373-80. 2008
    ..These adaptive changes in Romk(-/-) mice may help to limit renal Na(+) loss, and thereby, contribute to survival of these mice...
  10. pmc Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction
    John Geibel
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9390-7. 2006
    ..The reversal of cholera toxin- and STa endotoxin-induced fluid secretion by a small-molecule CaSR agonist suggests that these compounds may provide a unique therapy for secretory diarrheas...
  11. pmc Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 101:14877-82. 2004
    ....
  12. pmc ROMK1 channel activity is regulated by monoubiquitination
    Dao Hong Lin
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:4306-11. 2005
    ..This finding implicates the linking of a single ubiquitin molecule to channels as an important posttranslational regulatory signal...
  13. pmc Inhibition of MAPK stimulates the Ca2+ -dependent big-conductance K channels in cortical collecting duct
    Dimin Li
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 103:19569-74. 2006
    ..Blocking MAPKs also increased channel open probability of BK in IC and thereby it may affect K backflux and net K absorption Thus, modulation of ERK and P38 MAPK activity is involved in controlling net K secretion in the distal nephron...
  14. ncbi request reprint The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands
    Matthias M Dufner
    Institute of Physiology, University of Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 289:G1084-90. 2005
    ..Furthermore, our results show the viability of freshly isolated human gastric glands and may allow the use of this preparation for experiments investigating the physiological regulation and properties of human gastric glands in vitro...
  15. ncbi request reprint WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters
    Kristopher T Kahle
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 21:326-35. 2006
    ....
  16. pmc WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis
    Jesse Rinehart
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16777-82. 2005
    ..The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin...
  17. ncbi request reprint Activity of the renal Na+-K+-2Cl- cotransporter is reduced by mutagenesis of N-glycosylation sites: role for protein surface charge in Cl- transport
    Anahí Paredes
    Molecular Physiology Unit, Vasco de Quiroga No 15, Tlalpan 14000, Mexico City, Mexico
    Am J Physiol Renal Physiol 290:F1094-102. 2006
    ..Our data demonstrate that NKCC2 is glycosylated and suggest that prevention of glycosylation reduces its functional expression by affecting insertion into the plasma membrane and the intrinsic activity of the cotransporter...
  18. pmc Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)
    Anthony D O'Connell
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520
    Proc Natl Acad Sci U S A 102:9954-9. 2005
    ..Thus, NH(2)-terminal phosphorylation modifying a COOH-terminal ER retention signal in ROMK1 could serve as a checkpoint for proper subunit folding critical to channel gating...
  19. ncbi request reprint Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor
    Sam X Cheng
    Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA
    Gastroenterology 126:148-58. 2004
    ..In the present study, we investigated the interaction of polyamines, particularly spermine, and extracellular Ca(2+) on second messenger generation by, and on function of, rat distal colonic crypts...
  20. pmc Nucleotides and phospholipids compete for binding to the C terminus of KATP channels
    Gordon G MacGregor
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    Proc Natl Acad Sci U S A 99:2726-31. 2002
    ..Thus the COOH termini of K(ATP) channels form a nucleotide- and phospholipid-modulated channel gate on which ATP and phospholipids compete for binding...
  21. ncbi request reprint The carboxyl termini of K(ATP) channels bind nucleotides
    Carlos G Vanoye
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 6304, USA
    J Biol Chem 277:23260-70. 2002
    ..Thus, the COOH termini of K(ATP) tetrameric channels contain the nucleotide-binding pockets of these metabolically regulated channels with four potential nucleotide-binding sites/channel tetramer...
  22. ncbi request reprint Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion
    Sam X Cheng
    Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520 8026, USA
    Am J Physiol Gastrointest Liver Physiol 283:G240-50. 2002
    ....
  23. ncbi request reprint Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Biol Chem 277:37881-7. 2002
    ..Despite loss of ROMK expression, the normokalemic null mice exhibited significantly increased kaliuresis, indicating alternative mechanisms for K(+) absorption/secretion in the nephron...
  24. ncbi request reprint Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1
    Ke Dong
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    J Biol Chem 277:49366-73. 2002
    ..7 microm). These studies suggest that the first 39 COOH-terminal amino acid residues form an ATP-PIP(2) binding domain in Kir1.1 and possibly the Kir6.x ATP-sensitive K(+) channels...
  25. pmc Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD)
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 120:603-15. 2002
    ..We conclude that both ATP-dependent formation of PIP2 through membrane-bound phosphoinositide kinases and phosphorylation of SK by PKA play important roles in modulating SK channel activity...
  26. pmc Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases
    Jose Ponce-Coria
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Tlalpan, 14000 Mexico City, Mexico
    Proc Natl Acad Sci U S A 105:8458-63. 2008
    ....
  27. ncbi request reprint Regulation by glucocorticoids and osmolality of expression of ROMK (Kir 1.1), the apical K channel of thick ascending limb
    Morgan Gallazzini
    Institut National de la Santé et de la Recherche Médicale U 426, Institut Fédératif Régional Claude Bernard, Faculte de Medecine Xavier Bichat, Universite Paris 7, 75018 Paris, France
    Am J Physiol Renal Physiol 284:F977-86. 2003
    ..02). These results establish glucocorticoids and medium NaCl concentration as direct regulators of MTAL ROMK mRNA and protein expression, which may be modulated by cAMP-dependent factors...
  28. ncbi request reprint cAMP-dependent activation of the renal-specific Na+-K+-2Cl- cotransporter is mediated by regulation of cotransporter trafficking
    Patricia Meade
    Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    Am J Physiol Renal Physiol 284:F1145-54. 2003
    ..Our data suggest that the dominant-negative effect of S-mBSC1 on L-mBSC1 transport function is due to the effects of the cotransporter on trafficking...
  29. pmc CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Clin Invest 116:797-807. 2006
    ..We discuss the potential physiological role of this functional switch in renal K handling during water diuresis and the relevance to renal K homeostasis in cystic fibrosis...
  30. ncbi request reprint New aspects of renal potassium transport
    Gerhard Giebisch
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Pflugers Arch 446:289-97. 2003
    ..Recent studies on the properties and molecular identity of renal K channels have also contributed significantly to understanding the renal mechanisms that transport and regulate K excretion...
  31. pmc Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1
    Hyacinth Sterling
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Biol Chem 277:4317-23. 2002
    ..This indicates that the tyrosine phosphorylation-induced endocytosis of ROMK1 is dynamin-dependent. We conclude that inhibiting PTP increases ROMK1 phosphorylation and results in a dynamin-dependent internalization of the channel...
  32. doi request reprint Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity
    Alessandra Cantone
    Dept of Cellular and Molecular Physiology, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520 8026, USA
    Am J Physiol Renal Physiol 294:F1366-72. 2008
    ..Moreover, hydrochlorothiazide increased the fractional K(+) excretion rate in Romk(-/-) mice, confirming our recent observation that maxi-K channels contribute to distal K(+) secretion in the absence of ROMK...
  33. ncbi request reprint WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
    Kristopher T Kahle
    Howard Hughes Medical Institute, 300 Cedar Street, TAC S 341D, and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Genet 35:372-6. 2003
    ..They also identify WNK4 as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis...
  34. ncbi request reprint ROMK is required for expression of the 70-pS K channel in the thick ascending limb
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8026, USA
    Am J Physiol Renal Physiol 286:F490-5. 2004
    ..It is likely that ROMK forms a critical subunit of the 70-pS K channel, accounting for the loss of apical K secretory channel activity in ROMK Bartter syndrome...
  35. pmc WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
    Paola de los Heros
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Tlalpan, Mexico City, 14000, Mexico
    Proc Natl Acad Sci U S A 103:1976-81. 2006
    ....
  36. doi request reprint A novel protein kinase signaling pathway essential for blood pressure regulation in humans
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 19:91-5. 2008
    ..The current evidence supports a model in which WNK4 coordinates the activities of diverse aldosterone-sensitive mediators of ion transport in the distal nephron to promote normal homeostasis in response to physiological perturbation...
  37. pmc An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
    Aaron M Ring
    Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:4025-9. 2007
    ..Together, the different states of WNK4 allow the kidney to provide distinct and appropriate integrated responses to intravascular volume depletion and hyperkalemia...
  38. pmc WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
    Aaron M Ring
    Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:4020-4. 2007
    ..These findings support a key role for WNK4 in coordinating the activities of diverse flux pathways to achieve integrated fluid and electrolyte homeostasis...
  39. pmc Subunit-subunit interactions are critical for proton sensitivity of ROMK: evidence in support of an intermolecular gating mechanism
    Qiang Leng
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    Proc Natl Acad Sci U S A 103:1982-7. 2006
    ..Our results support the intermolecular model for pH gating of inward rectifier K channels...
  40. ncbi request reprint N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter
    Robert S Hoover
    Molecular Physiology Unit, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    J Am Soc Nephrol 14:271-82. 2003
    ....
  41. ncbi request reprint Localization of Mg2+-sensing shark kidney calcium receptor SKCaR in kidney of spiny dogfish, Squalus acanthias
    Hartmut Hentschel
    Max Planck Institute for Molecular Physiology, Dortmund, Germany
    Am J Physiol Renal Physiol 285:F430-9. 2003
    ..These data provide support for the possible existence of Mg2+ cycling in elasmobranch kidney in a manner analogous to that described for mammals...
  42. ncbi request reprint In vitro characterization of aldosterone and cAMP effects in mouse distal convoluted tubule cells
    Daniel Gonzalez-Nunez
    Servicio de Nefrologia, and Labrotorio de Hormonología, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universidad de Barcelona, 08036 Barcelona, Spain
    Am J Physiol Renal Physiol 286:F936-44. 2004
    ..These results suggest that in mDCT, Aldo and cAMP modulate some downstream mediators and effectors in vitro but do not influence the expression of NCC in this cell model...
  43. ncbi request reprint Physiology: orphan detectors of metabolism
    Steven C Hebert
    Nature 429:143-5. 2004
  44. ncbi request reprint Roderick MacKinnon, MD, honored by 2003 Nobel Prize in Chemistry for work on elucidating the structure of ion channels
    Steven C Hebert
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, USA
    J Am Soc Nephrol 15:1096-7. 2004
  45. pmc Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces
    Ke Dong
    Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT, USA
    EMBO J 24:1318-29. 2005
    ..The short N- and C-terminal segments comprising the novel intermolecular NBS are next to helices that likely move with channel opening/closing, suggesting a lock-and-key model for ligand gating...
  46. ncbi request reprint Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells
    Albrecht Schwab
    Institute of Physiology II, Universitat Munster, Munster, Germany
    J Cell Physiol 206:86-94. 2006
    ..However, there appears to be only little cIK1 channel activity at the front of MDCK-F cells. In our view this apparent discrepancy can be explained by differential regulation of IK1 channels at the front and rear part of migrating cells...
  47. pmc WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16783-8. 2005
    ..They suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission...
  48. ncbi request reprint Functional properties of the apical Na+-K+-2Cl- cotransporter isoforms
    Consuelo Plata
    Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan 14000, Mexico City, Mexico
    J Biol Chem 277:11004-12. 2002
    ....

Research Grants13

  1. STRUCTURE AND FUNCTION OF ROMK CHANNEL IN KIDNEY
    Steven Hebert; Fiscal Year: 2007
    ..These mice will also provide a resource for others interested in ROMK function in non- renal cells (Gl tract, brain, etc). ..
  2. REGULATION OF THE NA+ COUPLED CL- COTRANSPORTERS
    Steven Hebert; Fiscal Year: 2004
    ..This has important relevance to understanding salt and water handling by the kidney in health and disease. ..
  3. STRUCTURE AND FUNCTION OF ROMK CHANNEL IN KIDNEY
    Steven Hebert; Fiscal Year: 2004
    ..g., mechanism for continued renal K+ loss and role of prostaglandin E2 in renal NaC1 and K+ wasting) and may best be addressed using an animal model. ..
  4. Cellular and Molecular Physiology of Organ Function
    EMILE BOULPAEP; Fiscal Year: 2007
    ....