Noam Y Harel

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients
    Noam Y Harel
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Biomarkers 14:414-7. 2009
  2. pmc Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Neurotrauma 27:2055-66. 2010
  3. pmc Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci 29:13850-9. 2009
  4. pmc Recovery from chronic spinal cord contusion after Nogo receptor intervention
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
    Ann Neurol 70:805-21. 2011
  5. pmc LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology
    Katherine Owuor
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 42:448-57. 2009
  6. pmc Functional MRI and other non-invasive imaging technologies: providing visual biomarkers for spinal cord structure and function after injury
    Noam Y Harel
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, P O Box 9812, New Haven, Connecticut 06536, USA
    Exp Neurol 211:324-8. 2008
  7. pmc Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
    Noam Y Harel
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 7:603-16. 2006
  8. pmc Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice
    James H Park
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:13279-86. 2006
  9. pmc Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, P O Box 208018, New Haven, CT 06520, USA Electronic address
    Brain Res 1538:17-25. 2013

Research Grants

  1. Nogo's role in intracellular trafficking
    Noam Harel; Fiscal Year: 2007

Collaborators

Detail Information

Publications9

  1. pmc Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients
    Noam Y Harel
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Biomarkers 14:414-7. 2009
    ..0% vs 4.7%) displayed markedly elevated levels of Nogo-A. Additional study is required to determine the factors that lead to elevated Nogo-A levels in a subset of both ALS patients and healthy controls...
  2. pmc Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Neurotrauma 27:2055-66. 2010
    ..In this lesion model, the effects of NgR deletion and training were not synergistic for the tasks assessed. Further work is required to optimize the interaction between pharmacological and physical interventions for SCI...
  3. pmc Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis
    Yvonne S Yang
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    J Neurosci 29:13850-9. 2009
    ..Our results provide a novel intracellular role for reticulon proteins and support the hypothesis that modulation of PDI function is a potential therapeutic approach to ALS...
  4. pmc Recovery from chronic spinal cord contusion after Nogo receptor intervention
    Xingxing Wang
    Cellular Neuroscience, Neurodegeneration, and Repair Program, and Department of Neurology, Yale School of Medicine, New Haven, CT 06536 0812, USA
    Ann Neurol 70:805-21. 2011
    ..We examined the efficacy of this intervention in the much more prevalent and refractory condition of chronic spinal cord injury...
  5. pmc LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology
    Katherine Owuor
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 42:448-57. 2009
    ..Thus, LGI1 binding to ADAM23 is necessary to correctly pattern neuronal morphology and altered anatomical patterning contributes to ADPEAF...
  6. pmc Functional MRI and other non-invasive imaging technologies: providing visual biomarkers for spinal cord structure and function after injury
    Noam Y Harel
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, P O Box 9812, New Haven, Connecticut 06536, USA
    Exp Neurol 211:324-8. 2008
    ..Evolving technologies such as functional magnetic resonance imaging and other non-invasive imaging techniques will be reviewed. These technologies should revolutionize our ability to track changes in both CNS structure and function...
  7. pmc Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
    Noam Y Harel
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 7:603-16. 2006
    ..In addition to focusing on methods to stimulate growth in the adult, we also expand on approaches to recapitulate development itself...
  8. pmc Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice
    James H Park
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:13279-86. 2006
    ..The benefits of peripheral NgR administration are evident when therapy is initiated after disease onset. Thus, the peripheral association of NgR(310)ecto-Fc with central Abeta residues provides an effective therapeutic approach for AD...
  9. pmc Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion
    Noam Y Harel
    Department of Neurology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, P O Box 208018, New Haven, CT 06520, USA Electronic address
    Brain Res 1538:17-25. 2013
    ..Further studies should incorporate electrophysiological assessment to gauge changes in synaptic strength of direct and indirect pathways between the cortex and spinal cord in response to multimodal exercises. ..

Research Grants2

  1. Nogo's role in intracellular trafficking
    Noam Harel; Fiscal Year: 2007
    ....