B G Haffty

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
    Susan A Higgins
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Breast Cancer Res 7:R1017-22. 2005
  2. ncbi Molecular markers in clinical radiation oncology
    Bruce G Haffty
    Department of Therapeutic Radiology, HRT 133, 333 Cedar St, New Haven, CT 06520 8040, USA
    Oncogene 22:5915-25. 2003
  3. ncbi Can molecular markers predict local, regional and distant metastasis in head and neck cancer?
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale School of Medicine and Yale New Haven Hospital, New Haven, CT 06520 8040, USA
    Nat Clin Pract Oncol 2:132-3. 2005
  4. ncbi Molecular and genetic markers in the local-regional management of breast cancer
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Semin Radiat Oncol 12:329-40. 2002
  5. ncbi Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 61:119-28. 2005
  6. ncbi Concurrent chemoradiation in the treatment of head and neck cancer
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Hematol Oncol Clin North Am 13:719-42, vi-vii. 1999
  7. ncbi Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications
    B G Haffty
    Department of Radiation Oncology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 45:13-20. 1999
  8. ncbi Molecular markers for prognosis after isolated postmastectomy chest wall recurrence
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer 100:252-63. 2004
  9. ncbi Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Clin Oncol 15:268-76. 1997
  10. ncbi Reappraisal of the role of axillary lymph node dissection in the conservative treatment of breast cancer
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Clin Oncol 15:691-700. 1997

Detail Information

Publications96

  1. pmc Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
    Susan A Higgins
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Breast Cancer Res 7:R1017-22. 2005
    ..However, we observed a significantly lower proportion of fluid-yielding subjects in a similar series of high-risk women. The purpose of the present study was to identify variables associated with this reduction...
  2. ncbi Molecular markers in clinical radiation oncology
    Bruce G Haffty
    Department of Therapeutic Radiology, HRT 133, 333 Cedar St, New Haven, CT 06520 8040, USA
    Oncogene 22:5915-25. 2003
    ..The majority of molecular markers that have potential clinical significance with respect to radiation sensitivity and local control will be highlighted...
  3. ncbi Can molecular markers predict local, regional and distant metastasis in head and neck cancer?
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale School of Medicine and Yale New Haven Hospital, New Haven, CT 06520 8040, USA
    Nat Clin Pract Oncol 2:132-3. 2005
  4. ncbi Molecular and genetic markers in the local-regional management of breast cancer
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Semin Radiat Oncol 12:329-40. 2002
    ..The available rature regarding the use of genetic and molecular markers in the local-regional management of breast cancer is summarized in this review...
  5. ncbi Concurrent chemo-radiotherapy with mitomycin C compared with porfiromycin in squamous cell cancer of the head and neck: final results of a randomized clinical trial
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 61:119-28. 2005
    ..We conducted a randomized trial comparing MC with porfiromycin (POR) in combination with RT in the management of SCCHN...
  6. ncbi Concurrent chemoradiation in the treatment of head and neck cancer
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Hematol Oncol Clin North Am 13:719-42, vi-vii. 1999
    ..Current ongoing trials and future directions in concurrent chemoradiation are discussed...
  7. ncbi Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications
    B G Haffty
    Department of Radiation Oncology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 45:13-20. 1999
    ....
  8. ncbi Molecular markers for prognosis after isolated postmastectomy chest wall recurrence
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer 100:252-63. 2004
    ..The objective of the current study was to assess the prognostic value of molecular markers at the time of local recurrence and to compare these markers with clinical variables...
  9. ncbi Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Clin Oncol 15:268-76. 1997
    ....
  10. ncbi Reappraisal of the role of axillary lymph node dissection in the conservative treatment of breast cancer
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Clin Oncol 15:691-700. 1997
    ....
  11. ncbi Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Radiat Oncol Investig 5:235-45. 1997
    ..Further investigations, including large-scale multiinstitutional trials employing bioreductive alkylating agents or other hypoxic cell cytotoxins as adjuncts to RT, are warranted...
  12. ncbi Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status
    Bruce G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Lancet 359:1471-7. 2002
    ..This study assessed the long-term risks of ipsilateral and contralateral breast cancer in a cohort of young women who underwent breast-conserving surgery followed by radiotherapy...
  13. ncbi Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903 2681, USA
    J Clin Oncol 24:5652-7. 2006
    ..To determine the prognostic significance of triple negative breast cancers with respect to locoregional relapse and distant metastasis in conservatively managed breast cancer patients...
  14. ncbi BRCA status, molecular markers, and clinical variables in early, conservatively managed breast cancer
    Sung Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Breast J 9:167-74. 2003
    ..Patients with BRCA mutations have a unique molecular profile. These data can be helpful in understanding differences in the biologic behavior of patients with familial breast cancers...
  15. ncbi Immunohistochemical biomarkers in patients with early-onset breast carcinoma by tissue microarray
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 11:404-11. 2005
    ..We investigated the association of estrogen receptor, progesterone receptor, Bcl-2, HER-2/neu, p53, and Ki-67 with clinicopathologic features and outcome in young women with breast cancer...
  16. ncbi Ten-year multi-institutional results of breast-conserving surgery and radiotherapy in BRCA1/2-associated stage I/II breast cancer
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0010, USA
    J Clin Oncol 24:2437-43. 2006
    ..We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls...
  17. ncbi Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation
    Bruce G Haffty
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 71:1006-13. 2008
    ..To evaluate the prognostic significance of cyclooxygenase-2 (COX-2) in breast cancer patients treated with conservative surgery and radiation therapy (CS+RT)...
  18. pmc Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy
    Lori J Pierce
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive Room 4308, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 121:389-98. 2010
    ..However, women undergoing BCT have an elevated risk of a second in-breast event that is significantly reduced in the presence of chemotherapy. Contralateral breast cancer events are very common...
  19. ncbi Molecular marker expression in oral and oropharyngeal squamous cell carcinoma
    B D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, Conn 06520-8040, USA
    Arch Otolaryngol Head Neck Surg 127:780-5. 2001
    ..If confirmed, these results have potential implications for the determination of patient prognosis and the development of biologically based pharmacotherapies...
  20. ncbi Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 70:35-42. 2008
    ..In this study, we evaluated the luminal cytokeratin marker CK-19 in young women with breast cancer treated with conservative surgery and radiation therapy (CS+RT)...
  21. ncbi Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways
    B C Turner
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Cancer Res 58:5466-72. 1998
    ..Thus, AP-2 proteins may directly regulate the transcription of this growth factor receptor. Taken together, these data strongly support a role for the AP-2 gene family in the control of cell growth and differentiation in breast cancer...
  22. ncbi Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence
    M G Maher
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Clin Cancer Res 4:1851-6. 1998
    ..The CSF-1R antibody showed a positive correlation for local relapse, but no correlation was found between CSF-1R expression and distant metastasis. In summary, our findings provide evidence for the poor prognostic role of CSF-1R in IBTR...
  23. ncbi BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer
    B C Turner
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 19:992-1000. 2001
    ..We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients...
  24. ncbi Cisplatin, fluorouracil, and leucovorin induction chemotherapy followed by concurrent cisplatin chemoradiotherapy for organ preservation and cure in patients with advanced head and neck cancer: long-term follow-up
    A Psyrri
    Departments of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8032, USA
    J Clin Oncol 22:3061-9. 2004
    ..We conducted a phase II study of induction chemotherapy followed by concurrent chemoradiotherapy for organ preservation in patients with advanced resectable and unresectable (nasopharyngeal) tumors...
  25. ncbi Molecular markers in head and neck squamous cell carcinoma: their biological function and prognostic significance
    B D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann Otol Rhinol Laryngol 110:221-8. 2001
    ..The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field...
  26. ncbi Adenoid cystic carcinoma: a retrospective clinical review
    A J Khan
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520-8040, USA
    Int J Cancer 96:149-58. 2001
    ..Similarly, perineural invasion, radiation dose and field size, and HER-2/neu positivity did not prove to be important factors in our experience...
  27. doi Prognosis for mammographically occult, early-stage breast cancer patients treated with breast-conservation therapy
    Tzu I J Yang
    Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 76:79-84. 2010
    ..To compare mammographically occult (MamOcc) and mammographically positive (MamPos) early-stage breast cancer patients treated with breast-conservation therapy (BCT), to analyze differences between the two cohorts...
  28. doi Prognostic value of triple-negative phenotype at the time of locally recurrent, conservatively treated breast cancer
    Rahul R Parikh
    Department of Radiation Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Int J Radiat Oncol Biol Phys 72:1056-63. 2008
    ..To evaluate the prognostic value of triple-negative (TN) ER, PR, Her2/neu basal-like carcinoma of the breast, at the time of ipsilateral breast tumor recurrence (IBTR) after conservative surgery and radiation treatment (RT)...
  29. ncbi Cyclooxygenase-2 expression in postmastectomy chest wall relapse
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 11:5199-205. 2005
    ..The purpose of this study was to assess the prognostic significance and clinical correlations of COX-2 expression (COX) in a cohort of patients treated with radiation for postmastectomy chest wall relapse...
  30. doi Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups
    B G Haffty
    Department of Radiation Oncology, UMDNJ RWJMS and Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
    Ann Oncol 20:1653-9. 2009
    ..The purpose of this study is to evaluate the prevalence of BRCA1/2 mutations and the association between BRCA1/2 mutation status and secondary malignancies among young women with breast cancer in these three racially diverse groups...
  31. doi Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
    Qifeng Yang
    Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School UMDNJ, 195 Little Albany St, New Brunswick, NJ 08901, USA
    Breast Cancer Res Treat 115:343-8. 2009
    ..This study was undertaken to evaluate the prognostic significance of Bcl-2, a apoptosis-related protein, in patients with early stage breast cancer treated with breast conservation treatment (BCT)...
  32. ncbi Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Oncol 22:1638-45. 2004
    ..The prevalence of BRCA-associated breast carcinoma in the Korean population has not been evaluated extensively...
  33. ncbi Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women
    Neesha A Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 97:1393-403. 2003
    ....
  34. ncbi Local-regional breast cancer recurrence: prognostic groups based on patterns of failure
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Breast J 8:81-7. 2002
    ..Placing patients with breast cancer and local-regional relapse into these prognostic categories may be helpful in decision making regarding the role of systemic therapy at the time of local-regional relapse...
  35. doi Six-year analysis of treatment-related toxicities in patients treated with accelerated partial breast irradiation on the American Society of Breast Surgeons MammoSite Breast Brachytherapy registry trial
    A J Khan
    Department of Radiation Oncology, Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 19:1477-83. 2012
    ..The American Society of Breast Surgeons (ASBrS) enrolled women in a registry trial to prospectively study patients treated with the MammoSite RTS device. This report presents 6-year data on treatment-related toxicities from the trial...
  36. ncbi The location of contralateral breast cancers after radiation therapy
    A J Khan
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Breast J 7:331-6. 2001
    ..These data should be reassuring to women considering breast conserving surgery and radiation...
  37. ncbi Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer
    Paul M Weinberger
    Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 10:5684-91. 2004
    ..Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma...
  38. ncbi Breast-conserving therapy in the setting of collagen vascular disease
    A M Chen
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer J 7:480-91. 2001
    ..The presence of other collagen vascular diseases should not be considered a contraindication for this treatment modality...
  39. ncbi Evaluation of HER-2 neu oncoprotein expression as a prognostic indicator of local recurrence in conservatively treated breast cancer: a case-control study
    B G Haffty
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 35:751-7. 1996
    ..The purpose of this study is to determine the prognostic significance of overexpression of the HER-2 neu oncoprotein with respect to local relapse following conservative surgery and radiation therapy (CS + RT)...
  40. ncbi Conservative management of Paget disease of the breast with radiotherapy: 10- and 15-year results
    Jennifer K Marshall
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Cancer 97:2142-9. 2003
    ....
  41. ncbi Chest wall relapse after mastectomy for ductal carcinoma in situ: a report of 10 cases with a review of the literature
    Janet H Kim
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 12:92-101. 2006
    ..Postmastectomy chest wall relapses in patients with DCIS are an uncommon event. Patients treated aggressively with resection of the lesion followed by radiation therapy to the chest wall have a favorable prognosis...
  42. doi Clinicopathologic significance of excision repair cross-complementation 1 expression in patients treated with breast-conserving surgery and radiation therapy
    Sharad Goyal
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Int J Radiat Oncol Biol Phys 76:679-84. 2010
    ..The purpose of this study was to evaluate the clinicopathologic and prognostic significance of ERCC1 expression in a cohort of early-stage breast cancer patients treated with breast conservation therapy...
  43. ncbi Local recurrence of breast cancer after breast conservation therapy in patients examined by means of stereotactic core-needle biopsy
    Allen M Chen
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520 8042, USA
    Radiology 225:707-12. 2002
    ....
  44. ncbi Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database
    Brian E Lally
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:2998-3006. 2006
    ..To investigate the association between survival and postoperative radiotherapy (PORT) in patients with resected non-small-cell lung cancer (NSCLC)...
  45. ncbi Rationalization and regionalization of treatment for ductal carcinoma in situ of the breast
    Grace L Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 65:1397-403. 2006
    ..We evaluated national patterns of DCIS treatment from 1996 to 2001 by patient risk profile...
  46. ncbi Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy
    Neil K Taunk
    Department of Radiation Oncology, The Cancer Institute of New Jersey, NJ, USA
    Radiother Oncol 96:204-8. 2010
    ..The purpose of this study is to evaluate the prognostic significance of IGF-1R expression in patients with breast cancer treated with breast conserving therapy...
  47. doi Timing of Chemotherapy after MammoSite radiation therapy system breast brachytherapy: analysis of the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial
    Bruce G Haffty
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Radiat Oncol Biol Phys 72:1441-8. 2008
    ..To evaluate cosmetic outcome and radiation recall in the American Society of Breast Surgeons registry trial, as a function of the interval between accelerated partial breast irradiation (APBI) and initiation of chemotherapy (CTX)...
  48. ncbi Effectiveness of radiation therapy for older women with early breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    J Natl Cancer Inst 98:681-90. 2006
    ..Recent clinical trials have questioned the necessity of breast radiation therapy for older women with early breast cancer. However, the effectiveness of radiation therapy for older women in the community setting has not been addressed...
  49. ncbi Effectiveness of radiation therapy in older women with ductal carcinoma in situ
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Natl Cancer Inst 98:1302-10. 2006
    ..In a cohort of older women with DCIS, we sought to determine whether radiation therapy was associated with a clinically significant benefit...
  50. ncbi Regional nodal recurrence in breast cancer patients treated with conservative surgery and radiation therapy (BCS+RT)
    Sunanda Pejavar
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 66:1320-7. 2006
    ..To review regional nodal (RN) management and identify predictors of RN relapse in patients treated with breast conserving surgery and radiation therapy (BCS+RT)...
  51. ncbi Postmastectomy radiation and survival in older women with breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 24:4901-7. 2006
    ..As recent evidence suggests that certain adjuvant treatments appropriate for younger women may only be marginally beneficial for older women, we sought to determine whether PMRT improves survival for older women with breast cancer...
  52. doi Long-term outcomes and clinicopathologic differences of African-American versus white patients treated with breast conservation therapy for early-stage breast cancer
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Cancer 113:2565-74. 2008
    ..African-American (AA) and white patients with early-stage disease who were treated with breast conservation therapy (BCT) were examined to detect differences in clinicopathologic features and outcomes as a function of race...
  53. doi Does compliance with radiation therapy differ in African-American patients with early-stage breast cancer?
    Charu Sharma
    University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Breast J 16:193-6. 2010
    ..Further exploration of compliance for adjuvant chemotherapy regimens in AA patients is warranted...
  54. ncbi Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy
    Alice Y Ho
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 69:677-84. 2007
    ..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer...
  55. doi The Yale University experience of early-stage invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) treated with breast conservation treatment (BCT): analysis of clinical-pathologic features, long-term outcomes, and molecular expression of
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Breast J 15:571-8. 2009
    ..Future investigations of chemo-preventive strategies to decrease contralateral breast cancers are warranted...
  56. doi Radiation techniques and toxicities for locally advanced breast cancer
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Semin Radiat Oncol 19:244-55. 2009
    ..This article reviews the technical aspects of radiation therapy for locally advanced breast cancer with emphasis on 3-dimensional radiotherapy techniques and discusses potential toxicities and how to reduce them...
  57. doi Clinical-pathologic features and long-term outcomes of tubular carcinoma of the breast compared with invasive ductal carcinoma treated with breast conservation therapy
    Gene Fu F Liu
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 75:1304-8. 2009
    ..To evaluate our institutional experience of treating tubular carcinoma of the breast (TC) and invasive ductal carcinoma (IDC) with conservative surgery and radiation therapy, to compare clinical-pathologic features and long-term outcomes...
  58. ncbi Current application and research directions for partial-breast irradiation
    Sharad Goyal
    Department of Radiation Oncology, UMDNJ Robert Wood Johnson, Medical School, New Brunswick, NJ 08903, USA
    Oncology (Williston Park) 21:449-61; discussion 461-2, 464, 470. 2007
    ..In this review, we hope to clarify the rationale behind APBI and discuss in depth data concerning various partial-breast irradiation techniques that are being used throughout the United States and around the world...
  59. ncbi Postoperative concurrent chemoradiotherapy with mitomycin in advanced squamous cell carcinoma of the head and neck: results from three prospective randomized trials
    Amar N Rewari
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 12:123-9. 2006
    ....
  60. ncbi Evaluation of the National Resident Matching Program (NRMP) radiation oncology data (1993-2003)
    Lynn D Wilson
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 57:1033-7. 2003
    ..Much of this effort continues. This communication endeavors to examine the National Residency Matching Program (NRMP) results as they pertain to radiation oncology to identify and document applicant trends over the last decade...
  61. ncbi Management of suspicious or indeterminate calcifications and impact on local control
    Brian E Lally
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 103:2236-40. 2005
    ..The current study was undertaken to determine the potential advantage associated with complete removal of suspicious or indeterminate calcifications (SIC) before the initiation of irradiation as part of breast conservation therapy (BCT)...
  62. ncbi beta-Catenin functions mainly as an adhesion molecule in patients with squamous cell cancer of the head and neck
    Ziwei Yu
    Department of Otolaryngology, Yale University School of Medicine, New Haven, Connecticut 06514, USA
    Clin Cancer Res 11:2471-7. 2005
    ..In this study, we sought to determine the role of beta-catenin in head and neck carcinogenesis...
  63. ncbi Postmastectomy radiation and mortality in women with T1-2 node-positive breast cancer
    Benjamin D Smith
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    J Clin Oncol 23:1409-19. 2005
    ..To determine the relationship between postmastectomy radiotherapy (PMRT) and mortality in a population-based cohort of women with T1-2 node-positive breast cancer...
  64. ncbi Prognostic significance of pretreatment hemoglobin for local control and overall survival in T1-T2N0 larynx cancer treated with external beam radiotherapy
    Edward I Cho
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Radiat Oncol Biol Phys 58:1135-40. 2004
    ..To elucidate a relationship between pretreatment hemoglobin and local control in patients with T1-T2N0 larynx cancer treated with radiotherapy...
  65. ncbi End results of salvage therapy after failure of breast-conservation surgery
    Donald R Lannin
    Department of Surgery, Yale Breast Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Oncology (Williston Park) 18:272-9; discussion 280-2, 285-6, 292. 2004
    ..Prognostic factors at the time of IBTR and implications for local and systemic therapy are discussed...
  66. ncbi Conservative management of breast cancer in BRCA1/2 mutation carriers
    Tracy E Alpert
    Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY, USA
    Clin Breast Cancer 5:37-42. 2004
    ..The potential role of tamoxifen and oophorectomy in modifying the rate of second events is discussed...
  67. ncbi Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1-2N0 larynx cancer treated with primary radiation therapy
    Edward I Cho
    Departments of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Laryngoscope 114:2001-8. 2004
    ....
  68. pmc Radiation oncology: the new deal
    Lynn D Wilson
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06512, USA
    Yale J Biol Med 76:125-7. 2003
  69. ncbi Radiation oncology career decision variables for graduating trainees seeking positions in 2003-2004
    Lynn D Wilson
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Int J Radiat Oncol Biol Phys 62:519-25. 2005
    ..This prospective evaluation of the 2004 graduating radiation oncology trainees, evaluates such variables and provides additional descriptive data...
  70. ncbi National Residency Matching Program results for radiation oncology, 2005 update
    Lynn D Wilson
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Int J Radiat Oncol Biol Phys 63:3-4. 2005
  71. ncbi A comparison of five immunohistochemical biomarkers and HER-2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early-onset breast carcinoma
    Doo Ho Choi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 98:1587-95. 2003
    ..The objective of this article was to compare five tumor markers between white women in the U.S. and native Korean women with early-onset breast carcinoma...
  72. ncbi Clinical outcome and cosmesis in African-American patients treated with conservative surgery and radiation therapy
    Nimi L Tuamokumo
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8040, USA
    Cancer J 9:313-20. 2003
    ..The purpose of this study was to evaluate the prognostic significance of race in breast cancer patients treated with lumpectomy and radiation therapy...
  73. ncbi Immunocytochemical analysis of breast cells obtained by ductal lavage
    Bonnie L King
    Department of Therapeutic Radiology, Yale University School of Medicine, Hunter Radiation Therapy, New Haven, Connecticut 06520, USA
    Cancer 96:244-9. 2002
    ..In the current study, the authors performed immunocytochemical analysis with epithelial specific and macrophage specific antibodies to characterize and quantify breast cells obtained by ductal lavage...
  74. ncbi Effects of breast-conserving therapy on lactation after pregnancy
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut 06520 8040, USA
    Cancer J 11:399-403. 2005
    ..Our objective was to evaluate lactation outcomes in patients with early-stage breast cancer treated with breast-conserving therapy...
  75. ncbi Clinicopathologic features and long-term outcome of patients with medullary breast carcinoma managed with breast-conserving therapy (BCT)
    Ha Vu-Nishino
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Int J Radiat Oncol Biol Phys 62:1040-7. 2005
    ..The purpose of this study is to compare the clinical characteristics and outcome of medullary carcinoma to infiltrating ductal carcinoma of the breast in a large cohort of conservatively managed patients with long-term follow-up...
  76. doi BCCIP as a prognostic marker for radiotherapy of laryngeal cancer
    Amar Rewari
    Yale University School of Medicine, New Haven, CT, USA
    Radiother Oncol 90:183-8. 2009
    ..We analyzed the expression of BCCIP and p53 in a cohort of laryngeal cancer treated with radiotherapy and assessed whether BCCIP and p53, alone or in combination, would correlate with local control and overall survival...
  77. ncbi Ipsilateral breast tumor recurrence after breast conservation therapy: outcomes of salvage mastectomy vs. salvage breast-conserving surgery and prognostic factors for salvage breast preservation
    Tracy E Alpert
    Department of Radiation Oncology, Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 63:845-51. 2005
    ..To compare outcomes of salvage mastectomy (SM) and salvage breast-conserving surgery (SBCS) and study the feasibility of SBCS...
  78. ncbi Correlation of clinical and pathologic features with outcome in patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery and radiotherapy
    Neesha Rodrigues
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 54:1331-5. 2002
    ..The purpose of this study was to evaluate the impact of clinical and pathologic features on long-term outcome in a cohort of DCIS patients treated with breast-conserving surgery plus RT...
  79. ncbi Cyclin d1 is a valuable prognostic marker in oropharyngeal squamous cell carcinoma
    Ziwei Yu
    Department of Otolaryngology, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 11:1160-6. 2005
    ..In this study, we sought to determine the prognostic significance of the cell cycle regulator cyclin D1 in oropharyngeal squamous cell carcinoma (OSCC)...
  80. ncbi Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger
    Scott R Floyd
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:358-64. 2006
    ..To assess the need for adjuvant radiotherapy following mastectomy for patients with node-negative breast tumors 5 cm or larger...
  81. ncbi Basal subtype, as approximated by triple-negative phenotype, is associated with locoregional recurrence in a case-control study of women with 0-3 positive lymph nodes after mastectomy
    A J Khan
    Department of Radiation Oncology, Robert Wood Johnson University Hospital, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
    Ann Surg Oncol 21:1963-8. 2014
    ..Indications for postmastectomy RT (PMRT) in women with 0-3 positive lymph nodes remain unclear. We evaluated the importance of biologic subtype in a cohort of women with LRR after mastectomy...
  82. ncbi Evaluation of local recurrence and second malignancy in patients with T1 and T2 squamous cell carcinoma of the larynx
    Joseph M Colasanto
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Cancer J 10:61-6. 2004
    ..Evaluate outcome in patients with T1 and T2 laryngeal cancer treated with radiation therapy...
  83. ncbi Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study
    Wen Xie
    Division of Medical Oncology, Department of Internal Medicine, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Cancer Res 62:497-505. 2002
    ..Finally, analysis of a small cohort of hereditary breast cancers failed to reveal any association between BRCA1 or BRCA2 genotype and alterations in Smad signaling...
  84. ncbi Repeat breast-conserving surgery for in-breast local breast carcinoma recurrence: the potential role of partial breast irradiation
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:2269-80. 2004
    ..Recent advances in conformal radiation delivery and single-center published reports concerning repeat breast-conserving therapy support well designed prospective trials to formally test this hypothesis...
  85. ncbi Double heterozygotes for non-Caucasian families with mutations in BRCA-1 and BRCA-2 genes
    Doo Ho Choi
    Department of Radiation Oncology and Surgery, College of Medicine, Soonchungyang University, Seoul, Korea
    Breast J 12:216-20. 2006
    ..We describe here two cases of deleterious mutations in both genes in a cohort of Korean women with early onset breast cancer...
  86. ncbi Five-year update of an expanded phase II study of dose-dense and -intense doxorubicin, paclitaxel and cyclophosphamide (ATC) in high-risk breast cancer
    Maysa M Abu-Khalaf
    Jersey Shore University Medical Center, Neptune, N J, USA
    Oncology 69:372-83. 2005
    ..This study evaluated the safety and efficacy of dose-dense and -intense sequential doxorubicin (A), paclitaxel (T) and cyclophosphamide (C) as adjuvant therapy for breast cancer (BC) with >or=4 ipsilateral axillary lymph nodes...
  87. ncbi Initial outcomes for patients treated on the American Society of Breast Surgeons MammoSite clinical trial for ductal carcinoma-in-situ of the breast
    Jacqueline S Jeruss
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann Surg Oncol 13:967-76. 2006
    ..We hypothesized that APBI delivered with the MammoSite device would be well tolerated and be associated with a good cosmetic outcome in patients with ductal carcinoma-in-situ (DCIS)...
  88. ncbi National Residency Matching Program results for radiation oncology: 2006 update
    Lynn D Wilson
    Int J Radiat Oncol Biol Phys 66:321-2. 2006
  89. ncbi Accelerated partial breast irradiation: where do we go from here?
    Bruce G Haffty
    Breast J 11:303-5. 2005
  90. ncbi Prognostic significance of vascular endothelial growth factor protein levels in T1-2 N0 laryngeal cancer treated with primary radiation therapy
    Rahul R Parikh
    Albany Medical College, Albany, New York, USA
    Cancer 109:566-73. 2007
    ..The purpose of this study was to assess the prognostic value of vascular endothelial growth factor protein levels in a large cohort of patients with T1-T2 N0 laryngeal cancer treated with primary radiation therapy (XRT)...
  91. ncbi National Residency Matching Program (NRMP) results for radiation oncology: 2007 update
    Lynn D Wilson
    Int J Radiat Oncol Biol Phys 69:326-7. 2007
  92. ncbi Use of postmastectomy radiotherapy in older women
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    Int J Radiat Oncol Biol Phys 71:98-106. 2008
    ..Using the Surveillance, Epidemiology, and End Results-Medicare cohort, we sought to characterize the adoption of PMRT from 1992 to 2002 and identify risk factors for PMRT omission among high-risk older patients...
  93. ncbi Sequence of radiotherapy with tamoxifen in conservatively managed breast cancer does not affect local relapse rates
    Peter H Ahn
    Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    J Clin Oncol 23:17-23. 2005
    ..To evaluate whether the sequencing of tamoxifen (TAM) relative to radiation (RT) affects outcome in breast cancer patients treated with conservative surgery (CS) plus RT (lumpectomy with RT)...
  94. ncbi Should intensity-modulated radiation therapy be the standard of care in the conservatively managed breast cancer patient?
    Bruce G Haffty
    J Clin Oncol 26:2072-4. 2008
  95. doi American College of Radiology appropriateness criteria on conservative surgery and radiation: stages I and II breast carcinoma
    Julia R White
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 4801, USA
    J Am Coll Radiol 5:701-13. 2008
    ..Successful breast conservation relies on understanding key elements for patient selection, evaluation, treatment contraindications, radiation therapy methods, and integration with systemic therapy...
  96. ncbi Should all patients undergoing breast conserving therapy for DCIS receive radiation therapy? Yes. Radiation therapy, an important component of breast conserving treatment for patients with ductal carcinoma in situ of the breast
    Thomas A Buchholz
    J Surg Oncol 95:610-3. 2007