Research Topics
Species | R V GueorguievaSummaryAffiliation: Yale University Country: USA Publications
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Publications
Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment responseRalitza Gueorguieva
Department of Biostatistics, Yale University School of Public Health and School of Medicine, New Haven, CT 06520, USA
Addict Behav 38:2119-27. 2013..The results of these analyses may suggest approaches to improving adherence in order to ultimately improve treatment outcome...
Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinking outcomes during treatmentRalitza Gueorguieva
Yale University School of Public Health, New Haven, CT 06520, USA
Alcohol 46:121-31. 2012....
Joint analysis of repeatedly observed continuous and ordinal measures of disease severityR V Gueorguieva
Division of Biostatistics, Department of Epidemiology and Public Health, School of Medicine, Yale University, 60 College St, New Haven, CT 06520, USA
Stat Med 25:1307-22. 2006..Data from a depression clinical trial are used for illustration...
Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-Specific OutcomesRalitza V Gueorguieva
Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, Connecticut 06520, USA
Biometrics 61:862-6; discussion 866-7. 2005..The maximum-likelihood approach considered herein is applicable to general situations with multiple clustered or longitudinally measured outcomes of different type and does not require prior specification and extensive programming...
New insights into the efficacy of naltrexone based on trajectory-based reanalyses of two negative clinical trialsRalitza Gueorguieva
Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:1290-5. 2007..The objective of this study was to identify distinct trajectories of daily drinking over time in two negative clinical trials and to determine whether naltrexone affected the probability to follow a particular trajectory...
Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE studyRalitza Gueorguieva
Yale University School of Public Health and School of Medicine, New Haven, CT 06520, USA
Drug Alcohol Depend 107:221-9. 2010..It was hypothesized that different treatments may affect different trajectories of drinking...
The impact of occupation on self-rated health: cross-sectional and longitudinal evidence from the health and retirement surveyRalitza Gueorguieva
Yale School of Public Health, New Haven, CT 06520 8034, USA
J Gerontol B Psychol Sci Soc Sci 64:118-24. 2009..The objective of this study is to estimate occupational differences in self-rated health, both in cross-section and over time, among older individuals...
A risk assessment screening test for very low birth weightRalitza V Gueorguieva
Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut, USA
Matern Child Health J 7:127-36. 2003..To develop a risk-assessment screening tool for very low birth weight (VLBW) and to compare our empirically derived tool to the nonempirically derived screening tool used by the State of Florida...
Trajectories of depression severity in clinical trials of duloxetine: insights into antidepressant and placebo responsesRalitza Gueorguieva
Division of Biostatistics, School of Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
Arch Gen Psychiatry 68:1227-37. 2011..The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response...
Length of prenatal participation in WIC and risk of delivering a small for gestational age infant: Florida, 1996-2004Ralitza Gueorguieva
Division of Biostatistics, Department of Epidemiology and Public Health, Yale University, 60 College St, Room 201, New Haven, CT 06520 8034, USA
Matern Child Health J 13:479-88. 2009..By focusing on small for gestational age, we consider one of the possible pathways through which prenatal nutrition affects fetal growth...
Baseline trajectories of drinking moderate acamprosate and naltrexone effects in the COMBINE studyRalitza Gueorguieva
Yale University School of Public Health and School of Medicine, New Haven, Connecticut, USA
Alcohol Clin Exp Res 35:523-31. 2011....
Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptorsLouis Trevisan
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Alcohol Clin Exp Res 32:36-42. 2008....
Effect of teenage pregnancy on educational disabilities in kindergartenR V Gueorguieva
Yale University, School of Medicine, New Haven, CT, USA
Am J Epidemiol 154:212-20. 2001..In contrast to teen age, older maternal age has an adverse effect on a child's educational outcome regardless of whether other factors are controlled for or not...
Enhanced sensitivity to the euphoric effects of alcohol in schizophreniaDEEPAK C D'SOUZA
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Neuropsychopharmacology 31:2767-75. 2006..The absence of 'beneficial' effects of alcohol does not support a self-medication hypothesis of alcohol use in schizophrenia...
Estradiol and tryptophan depletion interact to modulate cognition in menopausal womenZenab Amin
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 31:2489-97. 2006..These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition...
Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS studyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
Psychopharmacology (Berl) 186:425-33. 2006..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)...
Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative StudyJoel Gelernter
VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut 06516, USA
Alcohol Clin Exp Res 31:555-63. 2007..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)...
Multidimensionality of the Alcohol Withdrawal Symptom Checklist: a factor analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-ArBrian Pittman
NIAAA Center for the Translational Neuroscience of Alcoholism, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Alcohol Clin Exp Res 31:612-8. 2007....
CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychiatry Res 155:57-66. 2007..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia...
Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Schizophr Res 94:281-7. 2007..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia...
Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism"John H Krystal
Alcohol Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
Alcohol Clin Exp Res 32:85-91. 2008..It is not clear whether naltrexone is effective in reducing alcohol consumption among patients with clinically significant mood symptoms and whether naltrexone favorably interacts with antidepressant medications when they are co-prescribed...
Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabisDEEPAK CYRIL D'SOUZA
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Neuropsychopharmacology 33:2505-16. 2008..These data suggest that frequent users of cannabis are either inherently blunted in their response to, and/or develop tolerance to the psychotomimetic, perceptual altering, amnestic, endocrine, and other effects of cannabinoids...
It is time to take a stand for medical research and against terrorism targeting medical scientistsJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 63:725-7. 2008
Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidenceNaomi R Driesen
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 64:1026-34. 2008..This study featured a spatial working memory task, similar to that used in nonhuman primates, that was designed to facilitate separating brain activation into encoding, maintenance, and response phases...
Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
Biol Psychiatry 57:44-8. 2005..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers...
Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)Robert T Malison
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06437, USA
Addict Behav 36:156-60. 2011..The high concordance between instruments supports the concurrent validity of the diagnosis. Either interview provides reliable, valid OD diagnoses in Thai-speaking Hmong individuals...
Gelatin "shots" as a new method for alcohol administration in a laboratory settingElizabeth Ralevski
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut, USA
Alcohol Clin Exp Res 30:473-9. 2006....
Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholismJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 31:1793-800. 2006..However, these data suggest that at levels of NMDA receptor antagonism associated with heavy drinking, this protective effect of naltrexone on drinking is no longer present...
Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy studyC Neill Epperson
Yale Behavioral Gynecology Program, Department of Psychiatry, Yale University School of Medicine University Towers, Suite 2H, 100 York St, New Haven, CT 06511, USA
Arch Gen Psychiatry 59:851-8. 2002....
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjectsJohn H Krystal
Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Psychopharmacology (Berl) 179:303-9. 2005..Some of the behavioral consequences of deficits in N-methyl-D-aspartate (NMDA) glutamate receptor function are thought to arise from the disinhibition of cortical glutamatergic circuitry...
Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholismIsmene L Petrakis
West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
Am J Psychiatry 161:1776-82. 2004....
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosisDEEPAK CYRIL D'SOUZA
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Neuropsychopharmacology 29:1558-72. 2004..These data warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders...
Extracellular metabolites in the cortex and hippocampus of epileptic patientsIdil Cavus
Department of Psychiatry, Yale University, New Haven, CT, USA
Ann Neurol 57:226-35. 2005..Our data suggest that a different neurometabolic process underlies the neocortical epilepsies...
Addition of the alpha2-antagonist yohimbine to fluoxetine: effects on rate of antidepressant responseGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neuropsychopharmacology 29:1166-71. 2004..The addition of the alpha2-antagonist yohimbine to fluoxetine appears to hasten the antidepressant response. There is also a trend suggesting an increased percentage of responders to the combined treatment at the end of the 6-week trial...
Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addictionDEEPAK CYRIL D'SOUZA
Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Biol Psychiatry 57:594-608. 2005..Recent advances in the neurobiology of cannabinoids have renewed interest in the association between cannabis and psychotic disorders...
Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sampleRalph E Hoffman
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 58:97-104. 2005..Data from the full 50-subject sample incorporating 26 new patients are now presented to more comprehensively assess safety/tolerability, efficacy and moderators of this intervention...
Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trialVladimir Coric
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
Biol Psychiatry 58:424-8. 2005..Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD...
Baseline and modulated acoustic startle responses in adolescent girls with posttraumatic stress disorderDeborah S Lipschitz
Neuroscience Division, National Center for PTSD, and the Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06824, USA
J Am Acad Child Adolesc Psychiatry 44:807-14. 2005..To assess baseline and modulated acoustic startle responses in adolescent girls with posttraumatic stress disorder (PTSD)...
Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smokingGraeme F Mason
NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
Biol Psychiatry 59:85-93. 2006..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinationsRalph E Hoffman
Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, 20 York St LV108, New Haven, CT 06504, USA
Arch Gen Psychiatry 60:49-56. 2003..We sought to determine if a more extended trial of rTMS could significantly reduce AHs that were resistant to antipsychotic medication...
Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorderHilary P Blumberg
Mood Disorders Research Program, Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
Psychopharmacology (Berl) 183:308-13. 2005..Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets...
Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive functionJohn H Krystal
Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
Arch Gen Psychiatry 62:985-94. 2005..Studying the comparative and interactive effects of these agents may provide insights into the roles of the glutamate and monoamine systems in psychosis and cognition...
Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depressionNashaat N Boutros
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Psychiatry Res 113:245-54. 2002..The duration of the therapeutic effects of rTMS delivered to the left prefrontal cortex using the above-described parameters is highly variable...
Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smokingJulie K Staley
Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
Arch Gen Psychiatry 62:877-88. 2005..Adaptations in gamma-aminobutyric acid type A (GABA(A))-benzodiazepine receptors contribute to the neurobiology of human alcohol dependence and withdrawal...
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depressionGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Arch Gen Psychiatry 61:705-13. 2004..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects...
Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamineHyun-Sang Cho
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychopharmacology (Berl) 179:136-43. 2005..CONCLUSIONS: The current data do not provide evidence that repeated exposure to ketamine, albeit limited, is associated with sensitization to the behavioral effects of ketamine...
Posttraumatic stress disorder and substance use in inner-city adolescent girlsDeborah S Lipschitz
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
J Nerv Ment Dis 191:714-21. 2003..Inner-city adolescent girls with PTSD exhibit problematic substance use and may be at high risk of developing a comorbid substance-use disorder...
Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairsRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
Drug Alcohol Depend 84:77-84. 2006..CONCLUSIONS: Severity of cocaine dependence and age of onset appear to be important risk factors for CIP. Concordance for CIP between siblings did not emerge as significant in our analyses...
Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General PsychiatryRalitza Gueorguieva
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
Arch Gen Psychiatry 61:310-7. 2004..Their flexibility makes them the preferred choice for the analysis of repeated-measures data...
Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administrationRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 61:1310-3. 2007..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
A paradigm to investigate the self-regulation of cocaine administration in humansAtapol Sughondhabirom
Department of Psychiatry, Yale University, New Haven, CT 06519, USA
Psychopharmacology (Berl) 180:436-46. 2005..Such procedures may enhance our ability to identify effective pharmacological treatments for cocaine addiction...
Self-reported paranoia during laboratory "binge" cocaine self-administration in humansRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Pharmacol Biochem Behav 83:249-56. 2006..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
Control group bias in randomized atypical antipsychotic medication trials for schizophreniaScott W Woods
Treatment Research Program, Department of Psychiatry and Biostatistics Division, Yale University School of Medicine, New Haven, Conn. 06519, USA
Arch Gen Psychiatry 62:961-70. 2005....
