DANIEL ROBERT GOLDSTEIN

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation
    Hua Shen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 4:e4097. 2009
  2. pmc Role of aging on innate responses to viral infections
    Daniel R Goldstein
    MBBS, Department of Internal Medicine and Immunobiology, Yale University School of Medicine, 333 Cedar Street, 3FMP, New Haven, CT 06520, USA
    J Gerontol A Biol Sci Med Sci 67:242-6. 2012
  3. pmc Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells
    Yang Song
    Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 32:103-9. 2012
  4. doi request reprint Inflammation and transplantation tolerance
    Daniel R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Immunopathol 33:111-5. 2011
  5. pmc Aging, imbalanced inflammation and viral infection
    Daniel R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Virulence 1:295-8. 2010
  6. ncbi request reprint Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantation
    Daniel R Goldstein
    Department of Internal Medicine, Division of Cardiovascular Medicine, Yale University School of Medicine, 3FM Cardiology, 333 Cedar St, New Haven CT 06520, USA
    Am J Transplant 3:484-91. 2003
  7. ncbi request reprint The identity of innate immune activators in organ transplantation: origins from within or exterior to the host?
    D R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 7:1692-4. 2007
  8. ncbi request reprint Toll like receptors and acute allograft rejection
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine, 333 Cedar St, 3 FMP PO BOX 208017, New Haven, CT, USA
    Transpl Immunol 17:11-5. 2006
  9. ncbi request reprint Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Heart Lung Transplant 24:1721-9. 2005
  10. ncbi request reprint Toll-like receptors and other links between innate and acquired alloimmunity
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3 FMP, PO Box 208017, New Haven, Connecticut 06520 8018, USA
    Curr Opin Immunol 16:538-44. 2004

Research Grants

  1. MECHANISMS OF DONOR SPLEEN INDUCED TRANSPLANT TOLERANCE
    Daniel Goldstein; Fiscal Year: 2004
  2. Mechanisms to augment primary immunity in aging
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
  3. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
  4. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
  5. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2006
  6. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2007
  7. Mechanisms to augment primary immunity in aging
    Daniel Goldstein; Fiscal Year: 2009
  8. Strategies to enhance immunity in aging
    Daniel Goldstein; Fiscal Year: 2007
  9. Mechanisms to augment primary immunity in aging
    Daniel Goldstein; Fiscal Year: 2007
  10. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2009

Collaborators

Detail Information

Publications12

  1. pmc Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation
    Hua Shen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 4:e4097. 2009
    ..Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation...
  2. pmc Role of aging on innate responses to viral infections
    Daniel R Goldstein
    MBBS, Department of Internal Medicine and Immunobiology, Yale University School of Medicine, 333 Cedar Street, 3FMP, New Haven, CT 06520, USA
    J Gerontol A Biol Sci Med Sci 67:242-6. 2012
    ..The innate immune system acts as a first line of defense to pathogen invasion. In this review, I focus on how aging affects the innate immune response to viral infection...
  3. pmc Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells
    Yang Song
    Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 32:103-9. 2012
    ..However, the role vascular cells play in chronic inflammation induced by aging is not clear. Here, we examined the role of aging on inflammatory responses of vascular cells...
  4. doi request reprint Inflammation and transplantation tolerance
    Daniel R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Immunopathol 33:111-5. 2011
    ..Further investigation as to the innate inflammatory basis that controls the balance between immune acceptance and allograft rejection may lead us closer to the elusive goal of transplant tolerance acquisition...
  5. pmc Aging, imbalanced inflammation and viral infection
    Daniel R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Virulence 1:295-8. 2010
    ..Our results indicate that novel anti-inflammatory drugs may resolve imbalanced inflammation and improve outcomes in older people infected with viruses...
  6. ncbi request reprint Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantation
    Daniel R Goldstein
    Department of Internal Medicine, Division of Cardiovascular Medicine, Yale University School of Medicine, 3FM Cardiology, 333 Cedar St, New Haven CT 06520, USA
    Am J Transplant 3:484-91. 2003
    ..Amiodarone may modify the recipients' immune response by delaying the occurrence of rejection...
  7. ncbi request reprint The identity of innate immune activators in organ transplantation: origins from within or exterior to the host?
    D R Goldstein
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 7:1692-4. 2007
  8. ncbi request reprint Toll like receptors and acute allograft rejection
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine, 333 Cedar St, 3 FMP PO BOX 208017, New Haven, CT, USA
    Transpl Immunol 17:11-5. 2006
    ..Further investigation of how innate immunity impacts solid organ transplantation may lead to improved therapies for transplant recipients...
  9. ncbi request reprint Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Heart Lung Transplant 24:1721-9. 2005
    ..Future therapeutic modalities that target innate rather than adaptive immune mechanisms represent a promising avenue for future studies in thoracic organ transplantation...
  10. ncbi request reprint Toll-like receptors and other links between innate and acquired alloimmunity
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, 3 FMP, PO Box 208017, New Haven, Connecticut 06520 8018, USA
    Curr Opin Immunol 16:538-44. 2004
    ..A recent clinical study also suggests that recipients with a mutant TLR4 genotype manifest reduced lung allograft rejection. Thus, innate immune signaling via TLRs is important for alloimmunity...
  11. pmc Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 111:1571-8. 2003
    ..Hence, this work demonstrates that TLRs can be activated in a transplant setting and not solely by infections. These results link innate immunity to the initiation of the adaptive alloimmune response...
  12. pmc Processes of sterile inflammation
    Hua Shen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 191:2857-63. 2013
    ..Further identification of the molecular mechanisms of sterile inflammation will lead to novel therapeutics to treat a range of diseases. ..

Research Grants14

  1. MECHANISMS OF DONOR SPLEEN INDUCED TRANSPLANT TOLERANCE
    Daniel Goldstein; Fiscal Year: 2004
    ..The career development program, mentor and didactic courses are designed to allow Dr. Goldstein to become an independent investigator by the end of the award period. ..
  2. Mechanisms to augment primary immunity in aging
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
    ..The resulting information will be essential to accelerate clinically relevant therapeutic protocols that will augment the immune response and help restore health in older people. ..
  3. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
    ..g., MyD88 blockade at the time of tolerance induction). ..
  4. Role of Innate Immunity in Transplantation Tolerance
    DANIEL ROBERT GOLDSTEIN; Fiscal Year: 2010
    ..g., MyD88 blockade at the time of tolerance induction). ..
  5. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2006
    ..g., MyD88 blockade at the time of tolerance induction). ..
  6. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2007
    ..g., MyD88 blockade at the time of tolerance induction). ..
  7. Mechanisms to augment primary immunity in aging
    Daniel Goldstein; Fiscal Year: 2009
    ..The resulting information will be essential to accelerate clinically relevant therapeutic protocols that will augment the immune response and help restore health in older people. ..
  8. Strategies to enhance immunity in aging
    Daniel Goldstein; Fiscal Year: 2007
    ..Goldstein to develop expertise in the biology of aging and how it relates to immunosenescence, ensuring that Dr. Goldstein will become a leading independent physician scientist in this area. ..
  9. Mechanisms to augment primary immunity in aging
    Daniel Goldstein; Fiscal Year: 2007
    ..The resulting information will be essential to accelerate clinically relevant therapeutic protocols that will augment the immune response and help restore health in older people. ..
  10. Role of Innate Immunity in Transplantation Tolerance
    Daniel Goldstein; Fiscal Year: 2009
    ..g., MyD88 blockade at the time of tolerance induction). ..