Susan M Goebel-Goody
Affiliation: Yale University
- Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse modelS M Goebel-Goody
Child Study Center, Yale University School of Medicine, New Haven, CT 06519, USA
Genes Brain Behav 11:586-600. 2012....
- Taking STEPs forward to understand fragile X syndromeSusan M Goebel-Goody
Yale University School of Medicine, New Haven, CT 06520, USA
Results Probl Cell Differ 54:223-41. 2012..We also discuss implications for STEP in FXS and other disorders, including Alzheimer's disease. As highlighted here, pharmacological interventions targeting STEP may prove successful for FXS...
- Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEPJian Xu
The Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 29:9330-43. 2009....
- Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disordersSusan M Goebel-Goody
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Pharmacol Rev 64:65-87. 2012..This comprehensive review discusses STEP expression and regulation and highlights how disrupted STEP function contributes to the pathophysiology of diverse neuropsychiatric disorders...