Michael Girardi

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Immunosurveillance by gammadelta T cells: focus on the murine system
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    Chem Immunol Allergy 86:136-50. 2005
  2. ncbi request reprint Selective immmunotherapy through extracorporeal photochemotherapy: yesterday, today, and tomorrow
    Michael Girardi
    Department of Dermatology, Yale University, School of Medicine, Post Office Box 208059, New Haven, CT 06520 8059, USA
    Hematol Oncol Clin North Am 17:1391-403. 2003
  3. ncbi request reprint Transimmunization and the evolution of extracorporeal photochemotherapy
    Michael Girardi
    Transfus Apher Sci 26:181-90. 2002
  4. ncbi request reprint Efficient tumor antigen loading of dendritic antigen presenting cells by transimmunization
    Michael Girardi
    Department of Dermatology, Yale Univesity School of Medicine, New Haven CT 06520, USA
    Technol Cancer Res Treat 1:65-9. 2002
  5. ncbi request reprint Immunosurveillance and immunoregulation by gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Invest Dermatol 126:25-31. 2006
  6. pmc The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 065420, USA
    J Exp Med 198:747-55. 2003
  7. pmc Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
    Carole Berger
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Blood 116:4838-47. 2010
  8. pmc Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis
    Scott J Roberts
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Proc Natl Acad Sci U S A 104:6770-5. 2007
  9. pmc Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma
    Badri G Modi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 335:104-8. 2012
  10. ncbi request reprint Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Invest Dermatol 126:808-14. 2006

Research Grants

  1. TCR DNA IMMUNIZATION FOR 2B411 T CELL LYMPHOMA
    Michael Girardi; Fiscal Year: 2002
  2. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2003
  3. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2004
  4. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2005
  5. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2006
  6. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2007
  7. Local Immunoregulation of Carcinogenesis
    Michael Girardi; Fiscal Year: 2010

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Immunosurveillance by gammadelta T cells: focus on the murine system
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    Chem Immunol Allergy 86:136-50. 2005
    ....
  2. ncbi request reprint Selective immmunotherapy through extracorporeal photochemotherapy: yesterday, today, and tomorrow
    Michael Girardi
    Department of Dermatology, Yale University, School of Medicine, Post Office Box 208059, New Haven, CT 06520 8059, USA
    Hematol Oncol Clin North Am 17:1391-403. 2003
    ....
  3. ncbi request reprint Transimmunization and the evolution of extracorporeal photochemotherapy
    Michael Girardi
    Transfus Apher Sci 26:181-90. 2002
    ..To this end, we are developing and testing Transimmunization to replace conventional ECP...
  4. ncbi request reprint Efficient tumor antigen loading of dendritic antigen presenting cells by transimmunization
    Michael Girardi
    Department of Dermatology, Yale Univesity School of Medicine, New Haven CT 06520, USA
    Technol Cancer Res Treat 1:65-9. 2002
    ..We will review the scientific understanding of ECP and explain how this can lead a more efficient, potentially broadly applicable, immunotherapy for cancer...
  5. ncbi request reprint Immunosurveillance and immunoregulation by gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Invest Dermatol 126:25-31. 2006
    ..This review considers what has been discovered about the important cutaneous functions of gammadelta T cells through the study of mutant mice and offers perspectives on the roles of gammadelta T cells in human disease...
  6. pmc The distinct contributions of murine T cell receptor (TCR)gammadelta+ and TCRalphabeta+ T cells to different stages of chemically induced skin cancer
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 065420, USA
    J Exp Med 198:747-55. 2003
    ..As is likely to be the case in humans, this study also shows that the contribution of T cells to tumor immunosurveillance is regulated by modifier genes...
  7. pmc Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
    Carole Berger
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Blood 116:4838-47. 2010
    ..Appropriately modified by future advances, ECP may potentially offer a general source of therapeutic DCs...
  8. pmc Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis
    Scott J Roberts
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Proc Natl Acad Sci U S A 104:6770-5. 2007
    ....
  9. pmc Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma
    Badri G Modi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 335:104-8. 2012
    ..Thus, tissue-associated DC can enhance chemical carcinogenesis via PAH metabolism, highlighting the complex relation between immune cells and carcinogenesis...
  10. ncbi request reprint Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Invest Dermatol 126:808-14. 2006
    ....
  11. pmc Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis
    Bernice Y Kwong
    Department of Dermatology and Skin Diseases Research Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Invest Dermatol 130:1726-36. 2010
    ..The data are also likely germane to psoriasis, in which the epidermis may be infiltrated by CD8(+) IL-17-producing T cells...
  12. ncbi request reprint Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant
    Julia M Lewis
    Department of Dermatology and Yale Skin Disease Research Core Center, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Nat Immunol 7:843-50. 2006
    ....
  13. ncbi request reprint Case experience of 308-nm excimer laser therapy compatibility with PUVA and oral bexarotene for the treatment of cutaneous lesions in mycosis fungoides
    Jing Huang
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Drugs Dermatol 12:487-9. 2013
    ..Our experience suggests that adjunctive excimer laser therapy with PUVA and oral bexarotene has the potential to be a safe, well-tolerated, and effective focal treatment regimen for cutaneous MF lesions...
  14. ncbi request reprint Transimmunization for cutaneous T cell lymphoma: a Phase I study
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, CT 06520 8059, USA
    Leuk Lymphoma 47:1495-503. 2006
    ..021). Because this therapy permits the synchronous induction and tumor loading of DC, with minimal toxicity, Transimmunization may merit further investigation in CTCL and other malignancies...
  15. doi request reprint Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature
    Sarah M Morcos
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 39:40-6. 2012
    ..The potential impact of this atypical lesion on the prognosis and clinical management of this patient highlights the importance of recognizing unusual clinical presentations of more common, benign lesions within this patient population...
  16. pmc Characterization of the DNA copy-number genome in the blood of cutaneous T-cell lymphoma patients
    William M Lin
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Invest Dermatol 132:188-97. 2012
    ..Together, these studies produce the most comprehensive view of the leukemic CTCL genome to date, with implications for pathogenesis, molecular classification, and potential future therapeutic developments...
  17. ncbi request reprint Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    J Invest Dermatol 122:699-706. 2004
    ..Collectively, these data illustrate which components of the alphabeta T cell response against SCC have protective potential, and indicate which aspects of tumor physiology may be most susceptible to their activities...
  18. ncbi request reprint Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells
    Lynn M Boyden
    Department of Genetics, Yale University School of Medicine, 333 Cedar St, SHM I 308, New Haven, Connecticut 06510, USA
    Nat Genet 40:656-62. 2008
    ..Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes. These findings define a new family of proteins mediating key epithelial-immune interactions...
  19. pmc Anti-inflammatory effects in the skin of thymosin-beta4 splice-variants
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, Connecticut 06520, USA
    Immunology 109:1-7. 2003
    ..Thus, the activation-responsive expression of the lymph-specific form of Tbeta4 may be one mechanism by which DETC, and possibly other IELs, down-regulate local inflammation...
  20. ncbi request reprint Transimmunization, a novel approach for tumor immunotherapy
    Carole L Berger
    Department of Dermatology, Yale University, School of Medicine, New Haven, CT 06510 8059, USA
    Transfus Apher Sci 26:205-16. 2002
    ....
  21. doi request reprint Clinical and histological findings in nephrogenic systemic fibrosis
    Shawn E Cowper
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Eur J Radiol 66:191-9. 2008
    ....
  22. doi request reprint FDG-PET/CT in the evaluation of cutaneous T-cell lymphoma
    Phillip H Kuo
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208042, New Haven, CT, 06520 8042, USA
    Mol Imaging Biol 10:74-81. 2008
    ....
  23. doi request reprint FDG-PET/CT for the evaluation of response to therapy of cutaneous T-cell lymphoma to vorinostat (suberoylanilide hydroxamic acid, SAHA) in a phase II trial
    Phillip H Kuo
    Department of Diagnostic Radiology, Yale University School of Medicine and Yale New Haven Hospital, New Haven, CT 06520 8059, USA
    Mol Imaging Biol 10:306-14. 2008
    ..Vorinostat (also known as SAHA, suberoylanilide hydroxamic acid) is a histone deacetylase (HDAC) inhibitor which alters gene transcription to inhibit proliferation and promote apoptosis...
  24. ncbi request reprint Advances in understanding the immunobiology and immunotherapy of cutaneous T-cell lymphoma
    Carole L Berger
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Dermatol 20:217-35. 2004
  25. ncbi request reprint Cutaneous perspectives on adaptive immunity
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    Clin Rev Allergy Immunol 33:4-14. 2007
    ..It is within this context that the adaptive immune system will be considered for its role in the skin in mediating microbial defense with direct relevance to tumor immunosurveillance and inflammatory disease...
  26. pmc The contribution of Langerhans cells to cutaneous malignancy
    Julia Lewis
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Trends Immunol 31:460-6. 2010
    ..Understanding this role of LCs might provide new perspectives on the relevance of DC populations that are resident within other epithelial tissues for cancer...
  27. pmc Gamma delta T cells provide an early source of interferon gamma in tumor immunity
    Yunfei Gao
    Section of Rheumatology, Yale School of Medicine, 300 Cedar Street, CAB Building Room S517, New Haven, CT 06520, USA
    J Exp Med 198:433-42. 2003
    ..These results demonstrate that gammadelta T cells can play a necessary role in tumor immunity through provision of an early source of IFN-gamma that in turn may regulate the function of tumor-triggered alphabeta T cells...
  28. doi request reprint Renal transplantation for nephrogenic systemic fibrosis: a case report and review of the literature
    Madison C Cuffy
    Department of Renal Unit of Internal Medicine, Hachioji Medical Center of Tokyo Medical University, 1163 Tate machi, Hachioji shi, Tokyo 193 0998, Japan
    Nephrol Dial Transplant 26:1099-101. 2011
    ..We conclude that renal transplantation improves symptoms of NSF, and believe that in patients with NSF, careful consideration should be made for early renal transplantation...
  29. ncbi request reprint Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling
    Tyler S Durazzo
    Department of Dermatology, Yale University, School of Medicine, New Haven, CT, USA
    Transfus Apher Sci 50:370-8. 2014
    ..These findings clarify how ECP directly stimulates DC maturation; suggest a new clinically applicable approach to the obtainment of DC; and identify a novel mechanism that may reflect physiological induction of DC. ..
  30. ncbi request reprint Pemphigoid vegetans: a case report and review of the literature
    Jinah Kim
    Department of Dermatology, Yale University, New Haven, CT, USA
    J Cutan Pathol 35:1144-47. 2008
    ..Most reported cases were successfully treated with topical antibiotics or steroids; therefore, appropriate diagnosis of this rare lesion will assist management...
  31. ncbi request reprint The pathogenesis of mycosis fungoides
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 350:1978-88. 2004
  32. pmc Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520, USA
    J Exp Med 195:855-67. 2002
    ....
  33. ncbi request reprint The therapeutic potential of extracorporeal photopheresis
    Michael Girardi
    Immunotherapy Program, Yale Comprehensive Cancer Center, Yale University School of Medicine, USA
    Clin Adv Hematol Oncol 4:349-50. 2006
  34. ncbi request reprint Cutaneous biology of gammadelta T cells
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Dermatol 20:203-15. 2004
    ..This review will expound on the biology of gammadelta T cells, their relationship to the skin, and the implications for our understanding of cutaneous disease...
  35. ncbi request reprint Cross-comparison of patch test and lymphocyte proliferation responses in patients with a history of acute generalized exanthematous pustulosis
    Michael Girardi
    Departments of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Dermatopathol 27:343-6. 2005
    ..These findings provide additional evidence that the pathogenesis of AGEP involves a T cell-mediated immune response...
  36. doi request reprint Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma
    Youn H Kim
    Department of Dermatology, Multidisciplinary Cutaneous Lymphoma Program, Stanford Cancer Center, Stanford, California 94305, USA
    J Am Acad Dermatol 63:975-83. 2010
    ..PF-3512676 (formerly CPG 7909) is a Toll-like receptor 9 agonist that is being investigated for treatment of patients with advanced cancer...
  37. doi request reprint Cutaneous two-stage chemical carcinogenesis
    Renata B Filler
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA
    CSH Protoc 2007:pdb.prot4837. 2007
    ..Thus, two-stage chemical carcinogenesis provides an opportunity to monitor early and late events in cancer development and progression...
  38. doi request reprint Nephrogenic systemic fibrosis: a dermatologist's perspective
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
    J Am Coll Radiol 5:40-4. 2008
    ..This review considers the dermatologist's perspective on nephrogenic systemic fibrosis, including the variety of skin findings and the potential for treatment with extracorporeal photopheresis...
  39. ncbi request reprint IL-9 Regulates Allergen-Specific Th1 Responses in Allergic Contact Dermatitis
    Juan Liu
    Department of Dermatology, University of Maryland, Baltimore, Maryland, USA
    J Invest Dermatol 134:1903-11. 2014
    ..This study demonstrates that IL-9, through its direct effects on Th1 and ability to promote IL-4 secretion, has a regulatory role for Th1 lymphocytes in ACD. ..
  40. doi request reprint Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations
    Michael Girardi
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Acad Dermatol 65:1095-1106.e7. 2011
    ....
  41. doi request reprint A transient epidermolysis bullosa simplex-like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote
    Joshua W Trufant
    Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 37:1155-60. 2010
    ..We propose that the cumulative effect of drug treatment and underlying G138E polymorphism resulted in transient basal keratinocyte lysis in our patient and provides a plausible explanation for this unusual bexarotene side effect...
  42. doi request reprint More or less: copy number alterations in mycosis fungoides
    William M Lin
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Invest Dermatol 130:926-8. 2010
    ..In this issue, Salgado et al. identify regions of genomic DNA alterations from 41 MF samples and report associations with prognosis...
  43. ncbi request reprint Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
    Jessica Strid
    Peter Gorer Department of Immunobiology, King s College London School of Medicine at Guy s Hospital, London SE1 9RT, UK
    Nat Immunol 9:146-54. 2008
    ..These results provide unique insight into the early phases of tissue immunosurveillance and indicate that acute changes in NKG2D ligands may alone initiate a rapid, multifaceted immunosurveillance response in vivo...
  44. ncbi request reprint Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    David E Oppenheim
    Peter Gorer Department of Immunobiology, Guy s King s St Thomas School of Medicine, King s College, Guy s Hospital Campus, London SE1 9RT, UK
    Nat Immunol 6:928-37. 2005
    ..Thus, NKG2D engagement is a natural mediator of immunosurveillance, which can be compromised by locally sustained ligand expression but potentially restored by innate immune activation...
  45. ncbi request reprint Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
    Yuichi Wakabayashi
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA
    Nature 445:761-5. 2007
    ..We propose that Ptch occupies a critical niche in determining basal or squamous cell lineage, and that both tumour types can arise from the same target cell depending on carcinogen exposure and host genetic background...

Research Grants7

  1. TCR DNA IMMUNIZATION FOR 2B411 T CELL LYMPHOMA
    Michael Girardi; Fiscal Year: 2002
    ....
  2. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2003
    ..Aim 4 - Analyze in vivo the biological effects of plasmid driven over-expression vs. inhibition of expression (using RNAi) of collapsin, osteopontin and syndecan-1 by PDV tumor cells in the presence and absence of immune components. ..
  3. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2004
    ..Aim 4 - Analyze in vivo the biological effects of plasmid driven over-expression vs. inhibition of expression (using RNAi) of collapsin, osteopontin and syndecan-1 by PDV tumor cells in the presence and absence of immune components. ..
  4. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2005
    ..Aim 4 - Analyze in vivo the biological effects of plasmid driven over-expression vs. inhibition of expression (using RNAi) of collapsin, osteopontin and syndecan-1 by PDV tumor cells in the presence and absence of immune components. ..
  5. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2006
    ..Aim 4 - Analyze in vivo the biological effects of plasmid driven over-expression vs. inhibition of expression (using RNAi) of collapsin, osteopontin and syndecan-1 by PDV tumor cells in the presence and absence of immune components. ..
  6. T Cell Regulation of Cutaneous Malignancy
    Michael Girardi; Fiscal Year: 2007
    ..Aim 4 - Analyze in vivo the biological effects of plasmid driven over-expression vs. inhibition of expression (using RNAi) of collapsin, osteopontin and syndecan-1 by PDV tumor cells in the presence and absence of immune components. ..
  7. Local Immunoregulation of Carcinogenesis
    Michael Girardi; Fiscal Year: 2010
    ..This research will study how the immune system locally influences tumors induced by chemical exposure, ultraviolet radiation, and inflammation. ..