Research Topics
| Tony P GeorgeSummaryAffiliation: Yale University Country: USA Publications
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Publications
Current pharmacological treatments for nicotine dependenceTony P George
Center for Nicotine and Tobacco Use Research at Yale, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Room S 109, SAC, New Haven, CT 06519, USA
Trends Pharmacol Sci 25:42-8. 2004..Several existing medications are being tested as treatments for nicotine dependence and novel investigational agents are under development as effective treatments for nicotine dependence in the 'hard to treat' tobacco user...- Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanismsKristi A Sacco
Program for Research in Smokers with Mental Illness, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Arch Gen Psychiatry 62:649-59. 2005..These findings may have implications for understanding the high rates of smoking in schizophrenia and for developing pharmacotherapies for cognitive deficits and nicotine dependence in schizophrenia... 
Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophreniaAndrea H Weinberger
Program for Research on Smokers with Mental Illness PRISM, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA
Schizophr Res 91:217-25. 2007....- A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokersAndrea H Weinberger
Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Drug Alcohol Depend 107:188-95. 2010..The primary aim of this study was to determine the safety and efficacy of the monoamine oxidase-B (MAO-B) inhibitor selegiline hydrochloride (SEL, l-Deprenyl; Eldepryl) as an aid for smoking cessation in cigarette smokers... - Neuropsychological deficits in nonsmokers with schizophrenia: effects of a nicotinic antagonistKristi A Sacco
Program for Research in Smokers with Mental Illness PRISM, Yale University School of Medicine, New Haven, CT 06519, USA
Schizophr Res 85:213-21. 2006.... - Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary studySherry A McKee
Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, 2 Church St South, Suite 109, New Haven, CT 06519, United States
Schizophr Res 115:317-24. 2009..Further work is needed to assess whether nicotine levels are directly mediated by how intensely the cigarettes are smoked, and to confirm whether this effect is more pronounced in smokers with schizophrenia... - Reliability of the Fagerström Test for Nicotine Dependence, Minnesota Nicotine Withdrawal Scale, and Tiffany Questionnaire for Smoking Urges in smokers with and without schizophreniaAndrea H Weinberger
Program for Research on Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT 06511, USA
Drug Alcohol Depend 86:278-82. 2007..65 versus 0.79), and TQSU Factor 2 (0.69 versus 0.81), but did not differ between diagnostic groups for M-NWS (0.58 versus 0.64). Our findings suggest that these measures may be reliable for use in smokers with schizophrenia... - Adverse childhood experiences, smoking and mental illness in adulthood: a preliminary studyKristi A Sacco
Program for Research in Smokers with Mental Illness PRISM, Connecticut Mental Health Center, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Ann Clin Psychiatry 19:89-97. 2007..This study was designed to examine effects of ACE on the expression of smoking behavior and mental illness in adulthood... - A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanismsTony P George
Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, CT 06519, USA
Schizophr Res 87:307-15. 2006..We evaluated the effects of cigarette smoking on PPI deficits in schizophrenia, and the role of nicotinic acetylcholine receptors (nAChRs) in mediating cigarette smoking-related PPI enhancement... - Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performanceSarah W Yip
Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 2 Church Street South, Suite 215, New Haven, CT, United States
Schizophr Res 110:156-64. 2009..Studies of risk/reward decision-making in individuals with schizophrenia have yielded mixed results, and few studies have examined systematically the relationship between these domains and their relationship with clinical factors... - Neurocognitive performance among alcohol dependent men with and without physical violence toward their partners: a preliminary reportCaroline J Easton
Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine SATU, New Haven, Connecticut 06511, USA
Am J Drug Alcohol Abuse 34:29-37. 2008..The authors examined neurocognitive performance among treatment-seeking alcohol dependent men with (IPV+) and without reported physical violence (IPV-)... - Smoking cue reactivity in schizophrenia: effects of a nicotinic receptor antagonistMargaret A Fonder
Program for Research in Smokers with Mental Illness (PRISM, Connecticut Mental Health Center, and Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 57:802-8. 2005..CONCLUSIONS: Our findings suggest that blockade of CR by MEC may be more robust in schizophrenia versus control smokers, possibly due to reduced nAChR levels in the brains of patients with schizophrenia... - Changes in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessationAndrea H Weinberger
Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, SAC, Room S 211, New Haven, CT 06519, USA
Nicotine Tob Res 12:937-43. 2010..This study examined reported changes in smoking beliefs during an 8-week smoking cessation trial, which evaluated the safety and efficacy of the monoamine oxidase B inhibitor selegiline hydrochloride versus placebo... - Differences in smoking expectancies in smokers with and without a history of major depressionAndrea H Weinberger
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Addict Behav 36:434-7. 2011..Incorporating expectancies into cognitive-behavioral treatments for smoking cessation may be useful for smokers with a history of depression... 
Survey of clinician attitudes toward smoking cessation for psychiatric and substance abusing clientsAndrea H Weinberger
Program for Research in Smokers with Mental Illness PRISM, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
J Addict Dis 27:55-63. 2008..We suggest that mental health clinicians can be instrumental in providing information, encouragement, and opportunities for their patients to attempt smoking cessation...- Effects of acute tobacco abstinence in adolescent smokers compared with nonsmokersAnne E Smith
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Adolesc Health 43:46-54. 2008..This study aimed to prospectively document tobacco abstinence-induced changes during the first 48 hours of abstinence in adolescent smokers compared with nonsmokers, to distinguish effects distinct from typical adolescent lability... - Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary studyTony P George
Division of Substance Abuse, Department of Psychiatry, Program for Research in Smokers with Mental Illness, Yale University School of Medicine, New Haven, CT, USA
J Clin Psychopharmacol 28:340-4. 2008..We compared the nicotinic antagonist, mecamylamine hydrochloride (MEC), with placebo as an augmentation strategy for patients with MDD who were refractory to selective serotonin reuptake inhibitor (SSRI) treatment... - Smoking cue reactivity in adult smokers with and without depression: a pilot studyAndrea H Weinberger
Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Am J Addict 21:136-44. 2012..The association between depression symptoms and smoking urges was not significant in the Brief Deprivation Condition. Smoking cue reactivity may be a useful procedure for studying aspects of smoking behavior in adults with depression... - Age of onset of smoking among alcohol dependent men attending substance abuse treatment after a domestic violence arrestCaroline J Easton
Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine SATU, Box 18, 1 Long Wharf, New Haven, CT 06511, USA
Addict Behav 32:2020-31. 2007..The implications of these findings are discussed... - Characteristics of tobacco-smoking problem gamblers calling a gambling helplineMarc N Potenza
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Am J Addict 13:471-93. 2004..The high proportion of callers reporting daily tobacco smoking highlights the need for enhanced smoking cessation efforts in problem gamblers... - Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophreniaSara L Dolan
Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, Rm. S-109, Substance Abuse Center, New Haven, CT 06519, USA
Schizophr Res 70:263-75. 2004..These preliminary data suggest that in schizophrenics, neuropsychological deficits are associated with smoking cessation treatment failure... - Comparing gain- and loss-framed messages for smoking cessation with sustained-release bupropion: a randomized controlled trialBenjamin A Toll
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06511, USA
Psychol Addict Behav 21:534-44. 2007..These data suggest that gain-framed messages may be more persuasive than loss-framed messages in promoting early success in smoking cessation for participants who are engaged in treatment... - Non-nicotine pharmacotherapies for nicotine dependenceMelissa M Dudas
Program for Research in Smokers with Mental Illness (PRISM, Connecticut Mental Health Center, New Haven, CT, USA
Essent Psychopharmacol 6:158-72. 2005..Studies summarizing the effectiveness (or lack thereof) of other (off-label) agents, such as tricyclic antidepressants, MAO-Inhibitors, SSRIs, and clonidine, are cited... - A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessationTony P George
Program for Research in Smokers with Mental Illness (PRISM, New Haven, Connecticut 06519, USA
Biol Psychiatry 53:136-43. 2003..CONCLUSION: This preliminary study suggests that selegiline (10 mg/day) is safe for use and enhances smoking cessation rates compared with placebo in nicotine-dependent cigarette smokers... - The potential of dopamine agonists in drug addictionThomas R Kosten
Yale University School of Medicine, VA Connecticut Healthcare System, Department of Psychiatry, West Haven, CT 06516, USA
Expert Opin Investig Drugs 11:491-9. 2002..Animal studies also suggest that tailoring treatment to subgroups of patients based on genotype may improve responses... - Effects of smoking abstinence on visuospatial working memory function in schizophreniaTony P George
Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Neuropsychopharmacology 26:75-85. 2002..These results suggest that smoking abstinence differentially alters VSWM in schizophrenic vs. control smokers, and that cigarette smoking has beneficial effects on VSWM in schizophrenic, but not control, smokers... - Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disordersKristi A Sacco
Program for Research in Smokers with Mental Illness, Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
J Psychopharmacol 18:457-74. 2004..The potential benefits of nicotinic agents for therapeutic use in neuropsychiatric disorders is discussed, as well as directions for further research in this area... - A placebo controlled trial of bupropion for smoking cessation in schizophreniaTony P George
Program for Research in Smokers with Mental Illness and Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 52:53-61. 2002.... - Co-morbidity of smoking in patients with psychiatric and substance use disordersDavid Kalman
Department of Psychiatry, Boston University School of Medicine, Massachusetts, USA
Am J Addict 14:106-23. 2005..Further research is needed to increase our understanding of nicotine addiction in PD and SUD and develop more effective treatment interventions... - Daily patterns of alcohol, cigarette, and marijuana use in adolescent smokers and nonsmokersAmy M Duhig
Department of Psychiatry, Yale University School of Medicine, CHMC, S 208, 34 Park Street, New Haven, CT 06519, USA
Addict Behav 30:271-83. 2005..There were no significant differences in the patterns of alcohol and marijuana use between female and male smokers, regardless of age. Implications for clinical interventions and future research are discussed... - Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot studyGerardo Gonzalez
Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA
Addiction 98:1625-32. 2003..We sought to evaluate the safety and efficacy of the GABAergic agent tiagabine in reducing cocaine use among methadone-treated patients... - The neurobiology of opioid dependence: implications for treatmentThomas R Kosten
Yale University School of Medicine, New Haven, Connecticut, USA
Sci Pract Perspect 1:13-20. 2002..Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments... - Cigarette smoking in Chinese male inpatients with schizophrenia: a cross-sectional analysisYi lang Tang
Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
J Psychiatr Res 41:43-8. 2007..Accordingly, cigarette smoking may be associated with certain clinical features in schizophrenic patients, and should be carefully screened for when making treatment and rehabilitation plans... - Smoking cessation and panic attacks: a report of 2 casesJennifer C Vessicchio
J Clin Psychiatry 63:594-5. 2002 - Effects of galantamine on cognitive deficits in smokers and non-smokers with schizophreniaKristi A Sacco
Schizophr Res 103:326-7. 2008 - Treatment of patients with substance use disorders, second edition. American Psychiatric AssociationHerbert D Kleber
Am J Psychiatry 164:5-123. 2007 - A placebo-controlled trial of bupropion combined with nicotine patch for smoking cessation in schizophreniaTony P George
Centre for Addiction and Mental Health, Faculty of Medicine, University of Toronto, Ontario, Canada
Biol Psychiatry 63:1092-6. 2008..We determined whether the combination of sustained-release (SR) bupropion (BUP) with the transdermal nicotine patch (TNP) was well-tolerated and superior to placebo (PLO)+TNP for smoking cessation in schizophrenia... - Treatment of tobacco dependence: integrating recent progress into practiceBernard Le Foll
Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
CMAJ 177:1373-80. 2007..Specifically, we discuss the use of nicotine replacement therapy, bupropion and varenicline in primary care settings... - Acute tryptophan depletion in schizophrenic patients treated with clozapineTony P George
Arch Gen Psychiatry 59:291-2. 2002 - Effects of topiramate on smoking in patients with schizoaffective disorder, bipolar typeAndrea H Weinberger
J Clin Psychopharmacol 28:247-8. 2008 - Treatment of patients with substance use disorders, second edition. American Psychiatic AssociationHerbert D Kleber
Am J Psychiatry 163:5-82. 2006 - Alcohol use and misuseTony P George
Addiction Psychiatry Program, Department of Psychiatry, University of Toronto, Faculty of Medicine, Centre for Addiction and Mental Health, Toronto, Ont
CMAJ 176:621-2. 2007