JOEL E GELERNTER

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
  2. ncbi request reprint Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Departments of Genetics and Neurobiology, Yale University School of Medicine, VA Connecticut Healthcare Center, West Haven Electronic address
    Biol Psychiatry 76:66-74. 2014
  3. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
  4. ncbi request reprint The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
    K P Jensen
    1 Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA 2 VA CT Health Care Center, West Haven, CT, USA
    Transl Psychiatry 4:e353. 2014
  5. pmc A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia
    Tetyana Zayats
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e49368. 2013
  6. doi request reprint SLC6A4 polymorphism, population genetics, and psychiatric traits
    Joel Gelernter
    Department of Psychiatry, Genetics and Neurobiology, Yale University School of Medicine and VA CT Healthcare Center, New Haven, CT, USA
    Hum Genet 133:459-61. 2014
  7. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
  8. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
  9. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
  10. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010

Research Grants

  1. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2006
  2. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2003
  3. Genetics of Alcohol Dependence in African-Americans
    Joel Gelernter; Fiscal Year: 2010
  4. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2007
  5. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2005
  6. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2005
  7. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2006
  8. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2001
  9. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2006
  10. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2000

Detail Information

Publications90

  1. ncbi request reprint Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
    ..003). These findings replicate and extend recently reported findings, which together underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence...
  2. ncbi request reprint Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Departments of Genetics and Neurobiology, Yale University School of Medicine, VA Connecticut Healthcare Center, West Haven Electronic address
    Biol Psychiatry 76:66-74. 2014
    ..We report a genome-wide association study (GWAS) of two populations, African-American and European-American (AA, EA) for opioid dependence (OD) in three sets of subjects, to identify pathways, genes, and alleles important in OD risk...
  3. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  4. ncbi request reprint The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
    K P Jensen
    1 Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA 2 VA CT Health Care Center, West Haven, CT, USA
    Transl Psychiatry 4:e353. 2014
    ..Using publically available data, we observed a consistent effect on expression in brain tissue. We conclude that pathways involving α-endomannosidase warrant further investigation in relation to anxiety disorders. ..
  5. pmc A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia
    Tetyana Zayats
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e49368. 2013
    ..This study examined if environment (marriage) or genetics (a single SNP, CHRNA5*rs16969968) would moderate the correlation of personality with CD, ND and cocaine-induced paranoia (CIP) in African and European Americans (AAs, EAs)...
  6. doi request reprint SLC6A4 polymorphism, population genetics, and psychiatric traits
    Joel Gelernter
    Department of Psychiatry, Genetics and Neurobiology, Yale University School of Medicine and VA CT Healthcare Center, New Haven, CT, USA
    Hum Genet 133:459-61. 2014
    ..In this article, the author discusses the importance of the variant in the context of a population genetics article published in Human Genetics sixteen years ago. ..
  7. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
    ..Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence...
  8. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
    ....
  9. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
    ....
  10. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
    ....
  11. pmc Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
    Rungnapa Hirunsatit
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    BMC Genet 8:71. 2007
    ....
  12. pmc Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 65:111-5. 2009
    ..Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs)...
  13. ncbi request reprint Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia
    Joel Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics and VA CT Healthcare Center, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 136:45-52. 2005
    ..35 for membership in the "Moderate Cocaine and Opioid Abuse" cluster on chromosome 18. These results provide a basis for the identification of specific genes contributing to risk for these traits...
  14. pmc Genetics of drug dependence
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Dialogues Clin Neurosci 12:77-84. 2010
    ..Although considerable progress has been made, it is likely that the application of more extensive sequencing than has previously been practical will be required to identify a fuller range of risk variants...
  15. ncbi request reprint Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Hum Mol Genet 15:3498-507. 2006
    ..Functional studies of these loci are warranted. These results provide additional information useful in evaluating the many earlier discrepant findings regarding association of DRD2 with substance dependence...
  16. pmc Genomewide linkage scan for opioid dependence and related traits
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Am J Hum Genet 78:759-69. 2006
    ..These results are an initial step in identifying genes for opioid dependence on the basis of a genomewide investigation (i.e., a study not conditioned on prior physiological candidate-gene hypotheses)...
  17. ncbi request reprint Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 61:119-26. 2007
    ..Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses...
  18. pmc Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 4:42. 2008
    ..abstract:..
  19. ncbi request reprint Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study
    Joel Gelernter
    VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 31:555-63. 2007
    ..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)...
  20. pmc Genetics of alcohol dependence
    Joel Gelernter
    Department of Psychiatry, VAMC 116A2, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Hum Genet 126:91-9. 2009
    ....
  21. ncbi request reprint Serotonin transporter: evolution and impact of polymorphic transcriptional regulation
    Karen Søeby
    Research Institute of Biological Psychiatry, Sct Hans Hospital, Roskilde, Denmark
    Am J Med Genet B Neuropsychiatr Genet 136:53-7. 2005
    ..We propose that the intronic VNTR have been selectively targeted through mammalian evolution to finetune transcriptional regulation of the serotonin expression...
  22. ncbi request reprint Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 128:94-101. 2004
    ..Interestingly, one of our most promising linkage regions, includes a region previously identified as linked to PD...
  23. ncbi request reprint A chromosome 14 risk locus for simple phobia: results from a genomewide linkage scan
    J Gelernter
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Mol Psychiatry 8:71-82. 2003
    ..This is the first genome scan linkage study for simple phobia, a common disorder that causes high morbidity in the US population...
  24. ncbi request reprint Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 120:97-108. 2003
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific...
  25. ncbi request reprint Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 161:59-66. 2004
    ..Genetic linkage analysis can provide the means to identify genomic locations harboring susceptibility loci for genetically influenced disorders. Identifying loci for social phobia was the goal of this study...
  26. ncbi request reprint Linkage genome scan for loci predisposing to panic disorder or agoraphobia
    J Gelernter
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Med Genet 105:548-57. 2001
    ..Overall, the results presented here suggest that PD and agoraphobia are complex traits that share some, but not all, of their susceptibility loci. Published 2001 Wiley-Liss, Inc...
  27. ncbi request reprint Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence
    J Gelernter
    Yale University School of Medicine, Department of Psychiatry, VA CT Healthcare System, West Haven, CT 06516, USA
    Hum Genet 107:86-8. 2000
    ..We found significant differences in allele frequency between populations, and a maximum frequency of the 80G allele of 9%, in each of two European populations. This variant could contribute to the previously reported association results...
  28. ncbi request reprint Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics
    Maggie Nellissery
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1402-8. 2003
    ..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression...
  29. ncbi request reprint ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...
  30. ncbi request reprint Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:2844-53. 2007
    ..The complexity of these relationships, many of which replicate between our independent samples, may explain prior inconsistent results...
  31. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    ..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
  32. ncbi request reprint ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    ..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence...
  33. pmc Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 141:387-93. 2006
    ..The negative results for AFDs, PTSD, and schizophrenia could be due to the low statistical power. Further study with larger samples is warranted...
  34. ncbi request reprint A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Psychiatry 116A2, West Haven, CT 06516, USA
    Arch Gen Psychiatry 59:825-31. 2002
    ..We tested whether the Pro7 allele is associated with alcohol dependence in European Americans (EA)...
  35. ncbi request reprint COMT polymorphisms and anxiety-related personality traits
    Murray B Stein
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0985, USA
    Neuropsychopharmacology 30:2092-102. 2005
    ..Other functional variants may exist that contribute to this relationship. Possible sex-specific effects remain to be further studied and explained...
  36. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  37. ncbi request reprint Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene
    Henry Kranzler
    Department of Psychiatry, Alchohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticult 06030 2103, USA
    Alcohol Clin Exp Res 26:1330-5. 2002
    ....
  38. pmc Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence
    Bao zhu Yang
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:2117-27. 2008
    ..Because comorbid AD with DD (AD+DD) is common, we hypothesized that heterogeneity of the SD diagnoses studied might have contributed to the inconsistency of prior results...
  39. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  40. pmc Variation in GABRA2 predicts drinking behavior in project MATCH subjects
    Lance O Bauer
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 31:1780-7. 2007
    ..The present study examines the association of a GABRA2 SNP with another definition of alcohol involvement and with the effects of psychosocial treatment...
  41. ncbi request reprint NOTCH4 gene haplotype is associated with schizophrenia in African Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 55:112-7. 2004
    ..The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA) subjects...
  42. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
    ....
  43. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
    ..These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD...
  44. pmc Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 35:1684-92. 2010
    ..This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs. Further study is required in other populations...
  45. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  46. pmc The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity
    Cyrus P Zabetian
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Hum Genet 72:1389-400. 2003
    ..These results provide a direct example of the potential value of constructing a haplotype map of the human genome prior to embarking on large-scale association studies...
  47. ncbi request reprint Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    Neuropsychopharmacology 26:115-22. 2002
    ..Conclusion: Despite no evidence in this study for allelic association of HTR1B to antisocial substance dependence, further evaluation of the hypothesized association is warranted in other population groups...
  48. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse...
  49. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
    ..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations...
  50. ncbi request reprint Practical population group assignment with selected informative markers: characteristics and properties of Bayesian clustering via STRUCTURE
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Genet Epidemiol 28:302-12. 2005
    ..The number of markers required is much lower than has been suggested in previous studies...
  51. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  52. ncbi request reprint CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 14:2421-34. 2005
    ..In addition, a specific diplotype might inversely affect risk for AD and DD and risk for affective disorders...
  53. ncbi request reprint A polymorphism of the beta1-adrenergic receptor is associated with low extraversion
    Murray B Stein
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Biol Psychiatry 56:217-24. 2004
    ..We examined the possibility that allelic variation leading to alterations in beta(1)-adrenergic function might be present in persons with elevated social anxiety-related traits...
  54. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes...
  55. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  56. ncbi request reprint A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  57. pmc Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2508-16. 2009
    ..We conclude that variation in KIBRA influences cognitive flexibility in a population-specific way, and that current smoking status moderates this effect...
  58. ncbi request reprint Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:1310-3. 2007
    ..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
  59. ncbi request reprint Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Pharmacogenet Genomics 17:1031-8. 2007
    ....
  60. doi request reprint BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study
    Kristina F Zdanys
    Alzheimer s Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    J Alzheimers Dis 17:887-98. 2009
    ..The effect of the Val66Met polymorphism on premorbid educational attainment is intriguing and should be verified in a larger sample...
  61. ncbi request reprint Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
    Drug Alcohol Depend 84:77-84. 2006
    ..Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood...
  62. ncbi request reprint CALCYON gene variation, schizophrenia, and cocaine dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 125:25-30. 2004
    ..Furthermore, these findings begin to establish a haplotype map for this gene in the AA and EA populations...
  63. pmc Meta-analysis of 15 genome-wide linkage scans of smoking behavior
    Shizhong Han
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 67:12-9. 2010
    ..Numerous putative susceptibility loci have been identified, but only a few of these were replicated in independent studies...
  64. ncbi request reprint Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
    ..Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena...
  65. ncbi request reprint Genomic regions controlling corticosterone levels in rats
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 55:634-41. 2004
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
  66. ncbi request reprint Typologies of drug dependence: comparative validity of a multivariate and four univariate models
    Debasish Basu
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 73:289-300. 2004
    ..This direct method of comparison seemed to demonstrate the superior validity of the multivariate cluster-analytic approach over the univariate approaches to classifying subjects with drug dependence...
  67. pmc Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1028-39. 2008
    ..Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis...
  68. ncbi request reprint Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
    John H Krystal
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 63:957-68. 2006
    ..Advances in molecular neuroscience, genetics, and neuroimaging provide new insights into the role of brain GABA systems in short- and long-term alcohol effects...
  69. ncbi request reprint Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
    Joan Kaufman
    Child and Adolescent Research and Education Program, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 59:673-80. 2006
    ..Child abuse and genotype interact to contribute to risk for depression in children. This study examined gene-by-gene and gene-by-environment interactions...
  70. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  71. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study...
  72. ncbi request reprint Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:525-31. 2004
    ..In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear...
  73. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  74. pmc Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity
    Rungnapa Hirunsatit
    Department of Psychiatry and the Yale Keck Center, Yale University School of Medicine, New Haven, CT 06511 6624, USA
    Pharmacogenet Genomics 19:53-65. 2009
    ..Here we sought to determine the functional relevance of this variation...
  75. ncbi request reprint Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
    Robert T Malison
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Psychiatr Genet 16:245-9. 2006
    ..These results do not support the involvement of genetic variation in these three circadian gene SNPs for influencing risks for either of these cocaine phenotypes...
  76. pmc Social supports and serotonin transporter gene moderate depression in maltreated children
    Joan Kaufman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 101:17316-21. 2004
    ....
  77. ncbi request reprint Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
    ..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men...
  78. ncbi request reprint Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, One Church Street, New Haven, CT 06510, USA
    J Nucl Med 46:745-51. 2005
    ..Previous investigations of the effects of the SLC6A3 polymorphism on DAT availability in smaller samples of humans have yielded divergent results...
  79. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
    ..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared...
  80. pmc Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
    Robert T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06437, USA
    Addict Behav 36:156-60. 2011
    ..The high concordance between instruments supports the concurrent validity of the diagnosis. Either interview provides reliable, valid OD diagnoses in Thai-speaking Hmong individuals...
  81. ncbi request reprint Genetic and environmental predictors of early alcohol use
    Joan Kaufman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 61:1228-34. 2007
    ..The goal of the current investigation was to examine genetic and environmental predictors of early alcohol use, a potent predictor of later alcohol dependence...
  82. pmc Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:2735-46. 2008
    ..These findings suggest that common genetic mechanisms influence certain biochemical and behavioral aspects of stimulant responsiveness...
  83. doi request reprint It is time to take a stand for medical research and against terrorism targeting medical scientists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 63:725-7. 2008
  84. pmc Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 55:278-84. 2010
    ..These results suggest that the minor G-allele of SNP rs569356 may enhance transcription factor binding and increase OPRD1 expression...
  85. ncbi request reprint Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    Ismene L Petrakis
    West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:1776-82. 2004
    ....
  86. ncbi request reprint C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 188:530-40. 2006
    ....
  87. pmc Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder
    Lara G Chepenik
    Deparment of Psychiatry, Yale University School of Medicine, New Haven, CT 6511, USA
    Neuropsychopharmacology 34:944-51. 2009
    ....
  88. ncbi request reprint CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:1557-68. 2007
    ..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD...
  89. ncbi request reprint DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
    ..Although the heritability of nicotine dependence (ND) is well documented and many candidate genetic regions have been identified, few of them were confirmed. This may be, in part, due to analytic methods that sacrifice power...
  90. ncbi request reprint Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 124:81-6. 2004
    ..Furthermore, these results suggest that common genetic variation within the GAD67 gene does not play a major role in the predisposition to unipolar depression...

Research Grants41

  1. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2006
    ..abstract_text> ..
  2. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2003
    ....
  3. Genetics of Alcohol Dependence in African-Americans
    Joel Gelernter; Fiscal Year: 2010
    ..Successful completion of this research would be expected to increase our understanding of alcohol dependence, and potentially to lead to early identification of susceptible individuals, and to new treatments. ..
  4. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2007
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  5. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2005
    ..Collection of a sample such as the one proposed here is a necessary step towards identifying specific genes that predispose for AD. Loci identified will be expected to have particular relevance for the AA community. ..
  6. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2005
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  7. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2006
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  8. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2001
    ....
  9. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2006
    ..Collection of a sample such as the one proposed here is a necessary step towards identifying specific genes that predispose for AD. Loci identified will be expected to have particular relevance for the AA community. ..
  10. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2000
    ....
  11. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 1999
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  12. 5 HT AND DA SYSTEM GENES IN ALCOHOL DEPENDENCE
    Joel Gelernter; Fiscal Year: 1999
    ..For example, the DRD4*7R allele has been reported by two groups to associate to novelty-seeking personality. We propose to evaluate this relationship in a sample of alcoholic subjects. This work all builds on the HRR sample. ..
  13. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2007
    ..abstract_text> ..
  14. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2005
    ..abstract_text> ..
  15. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2009
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  16. Alcohol Dependence Genetics in a Large Chinese Pedigree
    Joel Gelernter; Fiscal Year: 2007
    ..This study will improve understanding of the genes that influence risk for alcohol dependence, in Chinese populations, and in comparison with European-American populations. ..
  17. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2009
    ..abstract_text> ..
  18. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2002
    ..Collection of a sample such as the one proposed here is a necessary step towards identifying specific genes that predispose for AD. Loci identified will be expected to have particular relevance for the AA community. ..
  19. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2001
    ....
  20. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2002
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  21. Genetics of Alcohol Dependence in African-Americans
    Joel Gelernter; Fiscal Year: 2009
    ..Successful completion of this research would be expected to increase our understanding of alcohol dependence, and potentially to lead to early identification of susceptible individuals, and to new treatments. ..
  22. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2010
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  23. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2000
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  24. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..The conduct of these studies will provide excellent opportunities for research training. This proposal would permit the PI to make a major investment in mentorship, and allow a broadening of his research program in substance dependence. ..
  25. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2003
    ..Collection of a sample such as the one proposed here is a necessary step towards identifying specific genes that predispose for AD. Loci identified will be expected to have particular relevance for the AA community. ..
  26. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2001
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  27. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2002
    ....
  28. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2003
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  29. Linkage Disequilibrium Studies of Alcohol Dependence
    Joel Gelernter; Fiscal Year: 2004
    ..Collection of a sample such as the one proposed here is a necessary step towards identifying specific genes that predispose for AD. Loci identified will be expected to have particular relevance for the AA community. ..
  30. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2004
    ....
  31. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joel Gelernter; Fiscal Year: 2003
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  32. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2002
    ..Given that CD is a complex trait, a large ASP study that will allow genetic analysis without assumptions about trait transmission will provide the best chance to map genes related to this dangerous, prevalent disorder. ..
  33. Genetics of Alcohol Dependence in American Populations
    Joel Gelernter; Fiscal Year: 2009
    ..Successful completion of this research would be expected to increase our understanding of alcohol dependence, and potentially to lead to early identification of susceptible individuals, and to new treatments. ..
  34. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2002
    ....
  35. Genetics of Alcohol Dependence in American Populations
    Joel Gelernter; Fiscal Year: 2010
    ..Successful completion of this research would be expected to increase our understanding of alcohol dependence, and potentially to lead to early identification of susceptible individuals, and to new treatments. ..
  36. GENETICS OF OPIOID DEPENDENCE
    Joel Gelernter; Fiscal Year: 2002
    ....