J Gelernter

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects
    J Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Molecular Psychiatry and VA Connecticut Healthcare System, West Haven Campus, Department of Psychiatry, USA
    Mol Psychiatry 4:476-83. 1999
  2. ncbi request reprint Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic facto
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, 06516, USA
    Genomics 52:289-97. 1998
  3. ncbi request reprint Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven Campus, 06516, USA
    Am J Psychiatry 155:1332-8. 1998
  4. ncbi request reprint Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Hum Genet 101:243-6. 1997
  5. pmc D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
    J Gelernter
    Psychiatry 116A2, VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Am J Hum Genet 61:1144-52. 1997
  6. ncbi request reprint DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects
    J Gelernter
    Division of Molecular Psychiatry, Yale University School of Medicine, West Haven, Connecticut, 06516, USA
    Genomics 51:21-6. 1998
  7. ncbi request reprint A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 5:56-63. 2000
  8. pmc The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
    H Zhang
    VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Mol Psychiatry 13:531-43. 2008
  9. ncbi request reprint Prediction of dopamine transporter binding availability by genotype: a preliminary report
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1700-3. 2000
  10. ncbi request reprint Human GABA(B) receptor 1 gene: eight novel sequence variants
    F M Hisama
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Hum Mutat 17:349-50. 2001

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects
    J Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Molecular Psychiatry and VA Connecticut Healthcare System, West Haven Campus, Department of Psychiatry, USA
    Mol Psychiatry 4:476-83. 1999
    ..Finally, we demonstrated linkage disequilibrium between the two exon 1 markers, and a previously described short tandem repeat (STR) marker...
  2. ncbi request reprint Population studies of polymorphisms at loci of neuropsychiatric interest (tryptophan hydroxylase (TPH), dopamine transporter protein (SLC6A3), D3 dopamine receptor (DRD3), apolipoprotein E (APOE), mu opioid receptor (OPRM1), and ciliary neurotrophic facto
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, 06516, USA
    Genomics 52:289-97. 1998
    ..Knowledge of this variation can be important for study design and data interpretation when individuals from various population groups are research subjects and may eventually help lead to a better understanding of behavioral adaptation...
  3. ncbi request reprint Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven Campus, 06516, USA
    Am J Psychiatry 155:1332-8. 1998
    ..The authors attempted to replicate this finding...
  4. ncbi request reprint Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Hum Genet 101:243-6. 1997
    ....
  5. pmc D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
    J Gelernter
    Psychiatry 116A2, VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Am J Hum Genet 61:1144-52. 1997
    ..We conclude that the most likely explanation of these results is that the DRD4 VNTR does not influence directly the trait of novelty seeking, in these samples...
  6. ncbi request reprint DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects
    J Gelernter
    Division of Molecular Psychiatry, Yale University School of Medicine, West Haven, Connecticut, 06516, USA
    Genomics 51:21-6. 1998
    ..This newly described functional variant therefore does not provide a straightforward physiological explanation for previously reported genetic associations with DRD2*A1 in European-American subjects...
  7. ncbi request reprint A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 5:56-63. 2000
    ..Molecular Psychiatry (2000) 5, 56-63...
  8. pmc The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
    H Zhang
    VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Mol Psychiatry 13:531-43. 2008
    ..90). Population stratification artifact was not observed in the sample. Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs...
  9. ncbi request reprint Prediction of dopamine transporter binding availability by genotype: a preliminary report
    L K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 157:1700-3. 2000
    ..Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes...
  10. ncbi request reprint Human GABA(B) receptor 1 gene: eight novel sequence variants
    F M Hisama
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Hum Mutat 17:349-50. 2001
    ..These DNA variants may be useful in association and linkage studies of neurobehavioral disorders, and in pharmacogenetic studies of drugs targeting GABBR1...
  11. ncbi request reprint Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion
    F A Moreno
    Department of Psychiatry, College of Medicine, The University of Arizona Health Sciences Center, Tucson, AR 85724, USA
    Mol Psychiatry 7:213-6. 2002
    ..The use of endophenotypic markers for affective disorders such as the mood response to TRP depletion may facilitate studies of complex genetic traits such as depression by decreasing its heterogeneity...
  12. ncbi request reprint Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence
    J Gelernter
    Yale University School of Medicine, Department of Psychiatry, VA CT Healthcare System, West Haven, CT 06516, USA
    Hum Genet 107:86-8. 2000
    ..We found significant differences in allele frequency between populations, and a maximum frequency of the 80G allele of 9%, in each of two European populations. This variant could contribute to the previously reported association results...
  13. ncbi request reprint Absence of an apolipoprotein E epsilon4 allele is associated with increased parietal regional cerebral blood flow asymmetry in Alzheimer disease
    C H van Dyck
    Alzheimer s Disease Research Unit, Yale University School of Medicine, New Haven, Conn 06520, USA
    Arch Neurol 55:1460-6. 1998
    ..However, previous research has shown minimal effect of the epsilon4 allele on regional cerebral blood flow (rCBF) and metabolism in patients with probable AD...
  14. ncbi request reprint Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence
    C P Zabetian
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet 96:638-45. 2000
    ..The population results suggest that in many populations the frequencies of the variants examined are quite low, and might therefore limit the power of future genetic association studies of tobacco dependence based on these variants...
  15. ncbi request reprint D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
    M Laruelle
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 3:261-5. 1998
    ..Similarly, we found no effect of the B1 allele on [123I]IBZM-binding potential. In conclusion, the results of this study failed to replicate the previously reported association between A1 allele and lower D2 receptor expression...
  16. ncbi request reprint Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus
    J Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 9:312-9. 2004
    ..16 cM on chromosome 1. In addition, these results provide independent confirmation of the linkage finding regarding the identification of at least one gene in this region increasing the risk for alcohol dependence...
  17. pmc Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
    J Gelernter
    1 Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 2 VA CT Healthcare Center, Department of Psychiatry, West Haven, CT, USA 3 Department of Genetics, Yale University School of Medicine, New Haven, CT, USA 4 Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 19:717-23. 2014
    ..68 × 10(-8)). This is the first study to identify risk variants for CD using GWAS. Our results implicate novel risk loci and provide insights into potential therapeutic and prevention strategies. ..
  18. pmc A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus
    C P Zabetian
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Hum Genet 68:515-22. 2001
    ..Our findings demonstrate that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease...
  19. ncbi request reprint Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine
    P A Rao
    Department of Psychiatry, West Haven, Conn Veterans Affairs Medical Center
    Arch Gen Psychiatry 51:912-7. 1994
    ..Clinical response to clozapine therapy varies among patients. The observation that, in vitro, clozapine binds the protein products of different DRD4 alleles with differing affinity characteristics suggested this hypothesis...
  20. ncbi request reprint Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17
    J Gelernter
    West Haven VA Medical Center, CT 06516, USA
    Hum Genet 95:677-80. 1995
    ..These data should be useful for linkage studies of neuropsychiatric disorders...
  21. pmc Southeast Asian origins of five Hill Tribe populations and correlation of genetic to linguistic relationships inferred with genome-wide SNP data
    J B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Phys Anthropol 144:300-8. 2011
    ..In addition, the inferred level of shared ancestry among the Hill Tribes corresponds well to relationships among their languages...
  22. ncbi request reprint Linkage genome scan for loci predisposing to panic disorder or agoraphobia
    J Gelernter
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Am J Med Genet 105:548-57. 2001
    ..Overall, the results presented here suggest that PD and agoraphobia are complex traits that share some, but not all, of their susceptibility loci. Published 2001 Wiley-Liss, Inc...
  23. pmc The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder
    K P Jensen
    1 Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA 2 VA CT Health Care Center, West Haven, CT, USA
    Transl Psychiatry 4:e353. 2014
    ..Using publically available data, we observed a consistent effect on expression in brain tissue. We conclude that pathways involving α-endomannosidase warrant further investigation in relation to anxiety disorders. ..
  24. pmc GABRA2 and KIBRA genotypes predict early relapse to substance use
    L O Bauer
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 123:154-9. 2012
    ..The ability of these SNPs to predict re-involvement, defined here as abstinence failure during treatment, has not been thoroughly tested...
  25. doi request reprint Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
    J Gelernter
    1 Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, USA 2 Departments of Genetics and Neurobiology, Yale University School of Medicine, West Haven, CT, USA
    Mol Psychiatry 19:41-9. 2014
    ..The findings support a convergence of risk genes (but not necessarily risk alleles) between populations, and, to a lesser extent, between psychiatric traits. ..
  26. pmc COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
    A I Herman
    Department of Psychiatry and VA Connecticut Healthcare System, Yale University, School of Medicine, West Haven, CT, USA
    Pharmacogenomics J 13:490-7. 2013
    ..These results support the rationale of pharmacologically inhibiting COMT to aid with smoking cessation among Val/Val genotype smokers...
  27. ncbi request reprint Suicide, impulsive aggression, and HTR1B genotype
    A S New
    Psychiatry Service, Bronx VA Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 50:62-5. 2001
    ..CONCLUSIONS: This preliminary finding suggests that allelic variability at the HTR1B locus may be associated with the susceptibility to suicide attempts in patients with personality disorders...
  28. ncbi request reprint Family-based association study of serotonin transporter promoter in suicidal adolescents: no association with suicidality but possible role in violence traits
    G Zalsman
    Adolescent Inpatient Unit, Geha Psychiatric Hospital, Petach Tikva, Israel
    Am J Med Genet 105:239-45. 2001
    ..04 vs. 5.36+/-4.03; P = 0.029). This study suggests that the 5-HTTLPR polymorphism is unlikely to have major relevance to the pathogenesis of suicidal behavior in adolescence but may contribute to violent behavior in this population...
  29. ncbi request reprint A chromosome 14 risk locus for simple phobia: results from a genomewide linkage scan
    J Gelernter
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Mol Psychiatry 8:71-82. 2003
    ..This is the first genome scan linkage study for simple phobia, a common disorder that causes high morbidity in the US population...
  30. ncbi request reprint An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans
    J Feng
    Department of Molecular Genetics, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
    Mol Psychiatry 6:168-72. 2001
    ..Although these data do not suggest an association of TIDRU(1) with schizophrenia, additional studies are needed to see whether TIDRU(1) confers a clinical phenotype...
  31. ncbi request reprint Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome
    J Gelernter
    Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA
    Genomics 26:207-9. 1995
    ..37 at 0% recombination between HTR7 and D10S20 (a chromosome 10 reference marker). Finally, we excluded genetic linkage between this locus and Tourette syndrome under a reasonable set of assumptions...
  32. ncbi request reprint The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
    J Gelernter
    Yale University School of Medicine, New Haven, Connecticut
    Genomics 13:208-10. 1992
    ..Crossovers identified in one kindred place DRD4 distal to TH, providing further evidence for its location close to HRAS, making DRD4 one of the most telomeric of 11p markers. (This also places DRD4 in band 11p15.5.)..