Research Topics
Genomes and Genes | Anna Rachel GallagherSummaryAffiliation: Yale School of Medicine Location: New Haven, USA Publications
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Detail Information
Publications
Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxisE J Goetzl
Proc Natl Acad Sci U S A 72:4123-7. 1975..Both natural and synthetic peptides were preferentially chemotactic for eosinophils and rendered them unresponsive to a subsequent stimulus...
The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiHelen Hoffmeister
Institute for Molecular and Cellular Anatomy, University of Regensburg, Germany
Biochem J 433:285-94. 2011..The results of the present study therefore provide the first experimental evidence for the topological orientation of polycystin-2...- Molecular advances in autosomal dominant polycystic kidney diseaseAnna Rachel Gallagher
Departments of Internal Medicine and Genetics, Yale School of Medicine, New Haven, CT 06520 8029, USA
Adv Chronic Kidney Dis 17:118-30. 2010.... - Loss of oriented cell division does not initiate cyst formationSaori Nishio
Section of Nephrology, Yale University School of Medicine, P O Box 208029, 333 Cedar Street, New Haven, CT 06520 8029, USA
J Am Soc Nephrol 21:295-302. 2010..In conclusion, loss of oriented cell division is a feature of Pkhd1 mutation and cyst formation, but it is neither sufficient to produce kidney cysts nor required to initiate cyst formation after mutation in Pkd1 or Pkd2... - A novel role for the chemokine receptor Cxcr4 in kidney morphogenesis: an in vitro studyJoseph Ueland
Department of Internal Medicine, Section of Nephrology, Yale School of Medicine, New Haven, Connecticut 06520, USA
Dev Dyn 238:1083-91. 2009..A number of genes important for normal tubulogenesis and MET are decreased upon CXCR4 inactivation... - Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney diseaseLarissa Osten
Institute for Molecular and Cellular Anatomy, University of Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
Histochem Cell Biol 132:199-210. 2009..Our data also add a note of caution when interpreting phenotypes of animal models based upon the tet system... - Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric budArnaud Marlier
Section of Nephrology, Department of Medicine, Yale University School of Medicine, 1 Gillbert St TAC S 240, New Haven, CT 06510, USA
Mech Dev 126:91-8. 2009..These data place Vegf in a unique position of being able to modulate vascular as well as epithelial development in the embryonic kidney... - The stumpy gene is required for mammalian ciliogenesisTerrence Town
Department of Immunobiology and Neurobiology, Section of Nephrology, Yale University School of Medicine, 300 Cedar Street, TAC S 569, New Haven, CT 06519 8011, USA
Proc Natl Acad Sci U S A 105:2853-8. 2008..Therefore, stumpy is essential for ciliogenesis and may be involved in the pathogenesis of human congenital malformations such as HC and PKD... - Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1Anna Rachel Gallagher
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Pathol 172:417-29. 2008.... 
A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic ratsAnna Rachel Gallagher
Institute for Molecular and Cellular Anatomy, University of Regensburg, , 93053 Regensburg, Germany
J Am Soc Nephrol 17:2719-30. 2006..Other experimental approaches, such as a knock-in strategy, will be necessary to validate these results, but this is the first preliminary evidence that cyst formation is due not only to somatic mutations...- Use of the tetracycline system for inducible protein synthesis in the kidneyAnna Rachel Gallagher
Institute for Anatomy and Cell Biology I, University of Heidelberg, Germany
J Am Soc Nephrol 14:2042-51. 2003..Finally, the rTA(LAP)-1 line was used to inducibly express the human PKD2 cDNA in proximal tubules of transgenic mice, but no cystic changes were detected, even after 6 mo of induction... - Molecular basis of autosomal-dominant polycystic kidney diseaseA R Gallagher
Institute for Anatomy and Cell Biology I, University of Heidelberg, Germany
Cell Mol Life Sci 59:682-93. 2002..Our increasing knowledge of the molecular events in ADPKD has also started to be useful in designing novel diagnostic and therapeutic strategies... - An ever-expanding story of cyst formationA R Gallagher
Institute for Anatomy and Cell Biology I, University of Heidelberg, Germany
Cell Tissue Res 300:361-71. 2000..We will discuss new evidence which suggests that autosomal-dominant polycystic kidney disease actually behaves recessively on a cellular level. Finally, a model will be presented that tries to explain the available data... - The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeletonA R Gallagher
Institute for Anatomy and Cell Biology I, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 97:4017-22. 2000..We speculate that PKD2 is involved in the formation of cell-matrix contacts, which are dysfunctional without a wild-type PKD2 protein, thus leading to cystic enlargement of tubular structures in the kidney, liver, and pancreas... - A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formationSorin V Fedeles
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
Nat Genet 43:639-47. 2011....