Research Topics
| M FujitaSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal and extrastriatal dopamine D(2) receptorsM Fujita
Department of Psychiatry, Diagnostic Radiology, and Pharmacology, Yale University and VA Connecticut, West Haven, Connecticut 06516, USA
Synapse 34:290-304. 1999..These results suggest that correct V'(3) values can be obtained with the one input function model both in high- and low-density regions...- Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine in healthy humansM Fujita
Department of Psychiatry, Yale University, VA Connecticut, West Haven, CT 06516, USA
Eur J Pharmacol 387:179-88. 2000..88, P=0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration... - Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjectsMasahiro Fujita
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
Eur J Nucl Med Mol Imaging 29:183-90. 2002..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake... - SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brainJ K Staley
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut, USA
Nucl Med Biol 27:547-56. 2000.... - Changes of benzodiazepine receptors during chronic benzodiazepine administration in humansM Fujita
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Eur J Pharmacol 368:161-72. 1999..Clinical effects showed corresponding changes 1-2 weeks after the changes in the receptor. Thus, the decrease of benzodiazepine receptor densities may be one of the major mechanisms for tolerance development in humans... - Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRSN P Verhoeff
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Epilepsia 40:1433-8. 1999.... - Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokersJ K Staley
Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
Synapse 41:275-84. 2001..Although these findings are preliminary and need validation with a more selective 5-HT transporter radiotracer, the results suggest that brainstem 5-HT transporters may be regulated by smoking in a sex-specific manner... - Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned ratM Fujita
Division of Tracer Kinetics, Osaka University Medical School, Japan
Brain Res Mol Brain Res 39:127-36. 1996..These results indicated that transplanted fetal dopaminergic cells maturated in CPu of host animals and extended nerve terminals where high density of DAT binding sites were found... - Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasmaRonald M Baldwin
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Nucl Med Biol 33:549-54. 2006.... - Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal womenAkira Kugaya
Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
Am J Psychiatry 160:1522-4. 2003..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood... - Reproducibility of in vivo brain measures of 5-HT2A receptors with PET andJ C Soares
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Psychiatry Res 106:81-93. 2001.... - Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPETMasahiro Fujita
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
Eur J Nucl Med Mol Imaging 31:644-54. 2004..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies... - Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380Masahiro Fujita
Department of Psychiatry, Yale University and VA Connecticut HCS, West Haven, Connecticut, USA
Synapse 48:116-22. 2003..However, decreased thalamic activities could have been caused by other mechanisms, including internalization of the receptor with an associated decreased affinity for radioligand... - Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorderMasahiro Fujita
Department of Psychiatry, Yale University and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
Biol Psychiatry 56:95-100. 2004..CONCLUSIONS: Less severe symptoms and shorter duration of the illness in the current group than the prior one may be the source of the difference in the results of the two studies... - Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammationAmira K Brown
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
J Nucl Med 48:2072-9. 2007..The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein... 
Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analysesDavid R Sprague
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
Nucl Med Biol 35:493-500. 2008..The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans...- Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brainMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
Synapse 61:595-605. 2007..A critical factor for human use will be whether the tracer has adequately fast wash out from brain relative to the half-life of the radionuclide to obtain stable values of distribution volume... - Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humansVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 47:100-4. 2006.... - Widespread decrease of nicotinic acetylcholine receptors in Parkinson's diseaseMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
Ann Neurol 59:174-7. 2006..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects... 
Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPAVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
Psychiatry Res 163:171-82. 2008..These results suggest that striatal dopamine denervation may contribute to some frontostriatal cognitive impairment in moderate stage PD...- Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primatesDnyanesh N Tipre
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
Nucl Med Commun 25:737-42. 2004..The aim of the current study was to quantify the distribution of radioactivity in three rhesus monkeys after the injection of approximately 185 MBq (5 mCi) of 18F-FECNT... - Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPETMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
Eur J Nucl Med Mol Imaging 30:1620-9. 2003..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies... - Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activitiesKyeong Min Kim
Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita City, Osaka 565-8565, Japan
J Nucl Med 44:512-9. 2003..This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities... - Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humansVanessa L Cropley
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
Synapse 62:399-408. 2008..These findings indicate that [18F]fallypride is useful for measuring amphetamine-induced dopamine release, but may be unreliable for estimating tonic dopamine levels, in striatum and extrastriatal regions of healthy humans... - Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammationMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
Neuroimage 40:43-52. 2008..In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs... - Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivoEmmanuelle Briard
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Med Chem 51:17-30. 2008..11)C] 3 and [ (11)C] 10 are effective for imaging PBR in monkey brain. [ (11)C] 10 especially warrants further evaluation in human subjects... - Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptorsMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 31, Rm B2B37, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
Neuroimage 39:1289-98. 2008..The objectives of the current study were to evaluate kinetics of brain uptake, and the influence of the peripheral binding on the arterial input function in rhesus monkey... - Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brainYong Hoon Ryu
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 48:1154-61. 2007..We previously showed that miconazole, an inhibitor of CYP2E1, blocks defluorination of FCWAY in rats. Here, we used (18)F-FCWAY to test the ability of the less toxic agent disulfiram to inhibit defluorination in humans... - Consensus nomenclature for in vivo imaging of reversibly binding radioligandsRobert B Innis
National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
J Cereb Blood Flow Metab 27:1533-9. 2007..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands... - PET [11C]DASB imaging of serotonin transporters in patients with alcoholismAmira K Brown
Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
Alcohol Clin Exp Res 31:28-32. 2007..We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics... - Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysisDavid R Sprague
Molecular Imaging Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 48:100-7. 2007..The aims of this study were to estimate the radiation safety profile and relative risks of [(18)F]SPA-RQ with 3 different methods of image analysis... - PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in ratMasao Imaizumi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neurosci Lett 411:200-5. 2007..In this first study to demonstrate neuroinflammation in vivo with small animal PET, [11C]PBR28 had adequate sensitivity to localize and quantify the associated increase in PBRs... - Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transportersSubroto Ghose
Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
Synapse 56:100-4. 2005..3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports the binding specificity of this candidate in vivo NET ligand... - PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurementsSami S Zoghbi
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
J Nucl Med 47:520-7. 2006.... - Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PETMasahiro Fujita
Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neuroimage 26:1201-10. 2005..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...