M Fujita

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal and extrastriatal dopamine D(2) receptors
    M Fujita
    Department of Psychiatry, Diagnostic Radiology, and Pharmacology, Yale University and VA Connecticut, West Haven, Connecticut 06516, USA
    Synapse 34:290-304. 1999
  2. ncbi request reprint Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine in healthy humans
    M Fujita
    Department of Psychiatry, Yale University, VA Connecticut, West Haven, CT 06516, USA
    Eur J Pharmacol 387:179-88. 2000
  3. ncbi request reprint Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
    Eur J Nucl Med Mol Imaging 29:183-90. 2002
  4. ncbi request reprint SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain
    J K Staley
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Nucl Med Biol 27:547-56. 2000
  5. ncbi request reprint Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans
    M Fujita
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Eur J Pharmacol 368:161-72. 1999
  6. ncbi request reprint Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS
    N P Verhoeff
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Epilepsia 40:1433-8. 1999
  7. ncbi request reprint Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
    J K Staley
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Synapse 41:275-84. 2001
  8. ncbi request reprint Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned rat
    M Fujita
    Division of Tracer Kinetics, Osaka University Medical School, Japan
    Brain Res Mol Brain Res 39:127-36. 1996
  9. ncbi request reprint Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma
    Ronald M Baldwin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Nucl Med Biol 33:549-54. 2006
  10. ncbi request reprint Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
    Am J Psychiatry 160:1522-4. 2003

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal and extrastriatal dopamine D(2) receptors
    M Fujita
    Department of Psychiatry, Diagnostic Radiology, and Pharmacology, Yale University and VA Connecticut, West Haven, Connecticut 06516, USA
    Synapse 34:290-304. 1999
    ..These results suggest that correct V'(3) values can be obtained with the one input function model both in high- and low-density regions...
  2. ncbi request reprint Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine in healthy humans
    M Fujita
    Department of Psychiatry, Yale University, VA Connecticut, West Haven, CT 06516, USA
    Eur J Pharmacol 387:179-88. 2000
    ..88, P=0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration...
  3. ncbi request reprint Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
    Eur J Nucl Med Mol Imaging 29:183-90. 2002
    ..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake...
  4. ncbi request reprint SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain
    J K Staley
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Nucl Med Biol 27:547-56. 2000
    ....
  5. ncbi request reprint Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans
    M Fujita
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Eur J Pharmacol 368:161-72. 1999
    ..Clinical effects showed corresponding changes 1-2 weeks after the changes in the receptor. Thus, the decrease of benzodiazepine receptor densities may be one of the major mechanisms for tolerance development in humans...
  6. ncbi request reprint Effects of vigabatrin on the GABAergic system as determined by [123I]iomazenil SPECT and GABA MRS
    N P Verhoeff
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Epilepsia 40:1433-8. 1999
    ....
  7. ncbi request reprint Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
    J K Staley
    Department of Psychiatry, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Synapse 41:275-84. 2001
    ..Although these findings are preliminary and need validation with a more selective 5-HT transporter radiotracer, the results suggest that brainstem 5-HT transporters may be regulated by smoking in a sex-specific manner...
  8. ncbi request reprint Expression of dopamine transporter mRNA and its binding site in fetal nigral cells transplanted into the striatum of 6-OHDA lesioned rat
    M Fujita
    Division of Tracer Kinetics, Osaka University Medical School, Japan
    Brain Res Mol Brain Res 39:127-36. 1996
    ..These results indicated that transplanted fetal dopaminergic cells maturated in CPu of host animals and extended nerve terminals where high density of DAT binding sites were found...
  9. ncbi request reprint Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma
    Ronald M Baldwin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Nucl Med Biol 33:549-54. 2006
    ....
  10. ncbi request reprint Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
    Am J Psychiatry 160:1522-4. 2003
    ..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood...
  11. ncbi request reprint Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and
    J C Soares
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychiatry Res 106:81-93. 2001
    ....
  12. ncbi request reprint Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPET
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Eur J Nucl Med Mol Imaging 31:644-54. 2004
    ..It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies...
  13. ncbi request reprint Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380
    Masahiro Fujita
    Department of Psychiatry, Yale University and VA Connecticut HCS, West Haven, Connecticut, USA
    Synapse 48:116-22. 2003
    ..However, decreased thalamic activities could have been caused by other mechanisms, including internalization of the receptor with an associated decreased affinity for radioligand...
  14. ncbi request reprint Central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorder
    Masahiro Fujita
    Department of Psychiatry, Yale University and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 56:95-100. 2004
    ..To assess the generalizability of this finding to patients with more recent history, we studied central type benzodiazepine receptors in Gulf War veterans with posttraumatic stress disorder...
  15. ncbi request reprint Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 48:2072-9. 2007
    ..The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein...
  16. pmc Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses
    David R Sprague
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Nucl Med Biol 35:493-500. 2008
    ..The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans...
  17. ncbi request reprint Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    Synapse 61:595-605. 2007
    ..A critical factor for human use will be whether the tracer has adequately fast wash out from brain relative to the half-life of the radionuclide to obtain stable values of distribution volume...
  18. ncbi request reprint Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:100-4. 2006
    ....
  19. pmc Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
    Ann Neurol 59:174-7. 2006
    ..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects...
  20. doi request reprint Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 0135, USA
    Psychiatry Res 163:171-82. 2008
    ..These results suggest that striatal dopamine denervation may contribute to some frontostriatal cognitive impairment in moderate stage PD...
  21. ncbi request reprint Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates
    Dnyanesh N Tipre
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 1 Rm B3 10, 1 Center Drive, Bethesda, MD 20892 0135, USA
    Nucl Med Commun 25:737-42. 2004
    ..The aim of the current study was to quantify the distribution of radioactivity in three rhesus monkeys after the injection of approximately 185 MBq (5 mCi) of 18F-FECNT...
  22. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003
    ..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
  23. ncbi request reprint Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities
    Kyeong Min Kim
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita City, Osaka 565 8565, Japan
    J Nucl Med 44:512-9. 2003
    ..In this work, we evaluated the accuracy gained from a method of transmission-dependent convolution subtraction (TDCS) in the quantitation of activity that is highly concentrated in the striatum (STR)...
  24. doi request reprint Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 62:399-408. 2008
    ..These findings indicate that [18F]fallypride is useful for measuring amphetamine-induced dopamine release, but may be unreliable for estimating tonic dopamine levels, in striatum and extrastriatal regions of healthy humans...
  25. pmc Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
    Neuroimage 40:43-52. 2008
    ..In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs...
  26. ncbi request reprint Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo
    Emmanuelle Briard
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:17-30. 2008
    ..11)C] 3 and [ (11)C] 10 are effective for imaging PBR in monkey brain. [ (11)C] 10 especially warrants further evaluation in human subjects...
  27. pmc Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 31, Rm B2B37, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
    Neuroimage 39:1289-98. 2008
    ..The objectives of the current study were to evaluate kinetics of brain uptake, and the influence of the peripheral binding on the arterial input function in rhesus monkey...
  28. ncbi request reprint Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain
    Yong Hoon Ryu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 48:1154-61. 2007
    ..We previously showed that miconazole, an inhibitor of CYP2E1, blocks defluorination of FCWAY in rats. Here, we used (18)F-FCWAY to test the ability of the less toxic agent disulfiram to inhibit defluorination in humans...
  29. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  30. ncbi request reprint PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 31:28-32. 2007
    ..We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics...
  31. ncbi request reprint Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis
    David R Sprague
    Molecular Imaging Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 48:100-7. 2007
    ..The aims of this study were to estimate the radiation safety profile and relative risks of [(18)F]SPA-RQ with 3 different methods of image analysis...
  32. ncbi request reprint PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neurosci Lett 411:200-5. 2007
    ..In this first study to demonstrate neuroinflammation in vivo with small animal PET, [11C]PBR28 had adequate sensitivity to localize and quantify the associated increase in PBRs...
  33. ncbi request reprint Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters
    Subroto Ghose
    Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
    Synapse 56:100-4. 2005
    ..3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports the binding specificity of this candidate in vivo NET ligand...
  34. ncbi request reprint PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:520-7. 2006
    ....
  35. ncbi request reprint Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 26:1201-10. 2005
    ..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...