Affiliation: Yale University
- Intensified specimen collection to improve tuberculosis diagnosis in children from Rural South Africa, an observational studyTania A Thomas
Division of Infectious Diseases and International Health, University of Virginia, PO BOX 801337, Charlottesville, VA 22908 1337, USA
BMC Infect Dis 14:11. 2014..This observational study included multiple specimen types collected from pediatric TB suspects with the aim to determine diagnostic yield and inform clinical practice in children with drug-resistant and drug-susceptible TB...
- Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South AfricaMelissa Lygizos
Yale University School of Medicine, AIDS Program, New Haven, CT, USA
BMC Infect Dis 13:300. 2013..We evaluated air exchange and the impact of natural ventilation on estimated TB transmission risk in traditional Zulu homes in rural South Africa...
- Blood cultures for the diagnosis of multidrug-resistant and extensively drug-resistant tuberculosis among HIV-infected patients from rural South Africa: a cross-sectional studyScott K Heysell
Tugela Ferry Care and Research Collaboration, Tugela Ferry, South Africa
BMC Infect Dis 10:344. 2010..The yield of mycobacterial blood cultures for multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR-TB) among drug-resistant TB suspects has not been described...
- Utility of tuberculosis directly observed therapy programs as sites for access to and provision of antiretroviral therapy in resource-limited countriesGerald Friedland
AIDS Program, Yale University School of Medicine, New Haven, Connecticut 06510 2483, USA
Clin Infect Dis 38:S421-8. 2004..This strategy could address the related issues of inadequate access and infrastructure and need for enhanced adherence to medication and thereby potentially improve the outcome for both diseases...
- Tuberculosis and HIV coinfection: current state of knowledge and research prioritiesGerald Friedland
AIDS Program, Section of Infectious Diseases, Department of Internal Medicine and Epidemiology, Yale School of Medicine, New Haven, CT 06510, USA
J Infect Dis 196:S1-3. 2007
- Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIVGerald Friedland
Yale University School of Medicine AIDS Program, New Haven, CT 06510 2483, USA
J Antimicrob Chemother 58:1299-302. 2006....
- Implementation issues in tuberculosis/HIV program collaboration and integration: 3 case studiesGerald Friedland
AIDS Program, Section of Infectious Diseases, Department of Internal Medicine and Epidemiology, Yale University School of Medicine, New Haven, CT 06510, USA
J Infect Dis 196:S114-23. 2007..Conversely, smaller demonstration projects, even with successful outcomes, must grapple with issues related to generalization of findings, wider implementation, and scale up, to benefit larger populations of those in need...
- Lack of an effect of atazanavir on steady-state pharmacokinetics of methadone in patients chronically treated for opiate addictionGerald Friedland
AIDS Program, Yale School of Medicine, New Haven, Connecticut 06510, USA
AIDS 19:1635-41. 2005..Pharmacological interactions between antiretroviral drugs and methadone may result in opiate withdrawal or increased side effects...
- HIV medication adherence. The intersection of biomedical, behavioral, and social science research and clinical practiceGerald H Friedland
AIDS Program, Yale University School of Medicine, New Haven, Connecticut 06510 2483, USA
J Acquir Immune Defic Syndr 43:S3-9. 2006....
- A pilot study of once-daily antiretroviral therapy integrated with tuberculosis directly observed therapy in a resource-limited settingChristopher Jack
Nelson R Mandela School of Medicine, University of Kwa Zulu Natal, Durban, South Africa
J Acquir Immune Defic Syndr 36:929-34. 2004..This pilot study demonstrates that TB/DOT programs can be feasible and effective sites for HIV identification and the introduction and monitoring of a once-daily HAART regimen in resource-limited settings...
- Infectious disease comorbidities adversely affecting substance users with HIV: hepatitis C and tuberculosisGerald Friedland
AIDS Program, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA
J Acquir Immune Defic Syndr 55:S37-42. 2010..All of these require structural changes directed at comprehensive prevention and treatment programs and increased collaboration and integration of needed services for substance abusers...
- Successful integration of tuberculosis and HIV treatment in rural South Africa: the Sizonq'oba studyNeel R Gandhi
Yale University School of Medicine, New Haven, CT, USA
J Acquir Immune Defic Syndr 50:37-43. 2009..In KwaZulu-Natal, South Africa, 80% of TB patients are HIV coinfected, with high treatment default and mortality rates. Integrating TB and HIV care may be an effective strategy for improving outcomes for both diseases...
- Integration of antiretroviral therapy with tuberculosis treatmentSalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa, Durban, South Africa
N Engl J Med 365:1492-501. 2011..We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains unresolved...
- HIV drug resistance and HIV transmission risk behaviors among active injection drug usersMichael J Kozal
AIDS Program, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06510, USA
J Acquir Immune Defic Syndr 40:106-9. 2005..Strategies to reduce injection drug use risk behaviors among patients in clinical care are needed to reduce the transmission of sensitive and resistant HIV...
- Timing of initiation of antiretroviral drugs during tuberculosis therapySalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
N Engl J Med 362:697-706. 2010..The optimal timing for the initiation of antiretroviral therapy in relation to tuberculosis therapy remains controversial...
- The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trialKogieleum Naidoo
Doris Duke Medical Research Institute, 2nd Floor, University of KwaZulu Natal, 719 Umbilo Road, Private Bag X7, Congella, 4013, Durban, South Africa
Ann Intern Med 157:313-24. 2012..Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients...
- A population-based and longitudinal study of sexual behavior and multidrug-resistant HIV among patients in clinical careMichael J Kozal
Yale University School of Medicine, New Haven, Connecticut 06510, USA
MedGenMed 8:72. 2006..Population-based and longitudinal information regarding sexual risk behavior among patients with multidrug resistant (MDR) HIV and their sexual partners is of great public health and clinical importance...
- Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South AfricaNeel R Gandhi
AIDS Program, Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
Lancet 368:1575-80. 2006..We assessed the prevalence and consequences of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in a rural area in KwaZulu Natal, South Africa...
- Therapeutic response of HIV-1 subtype C in African patients coinfected with either Mycobacterium tuberculosis or human herpesvirus-8Edana Cassol
HIV 1 Molecular Virology and Bioinformatics Unit, Africa Centre for Health and Population Studies, and Centre for HIV AIDS Networking, Doris Duke Medical Research Institute, Durban, South Africa
J Infect Dis 191:324-32. 2005..OI-induced immune activation can interfere with HIV-1 clearance by increasing viral replication and target cell availability...
- Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a prospective, randomized, controlled trialFrederick L Altice
Yale University AIDS Program, Yale University, New Haven, CT 06510 2283, USA
Clin Infect Dis 45:770-8. 2007..Directly administered antiretroviral therapy (DAART) is one approach to improve treatment adherence among human immunodeficiency virus (HIV)-infected drug users...
- Multidrug-resistant and extensively drug-resistant tuberculosis: implications for the HIV epidemic and antiretroviral therapy rollout in South AfricaJason R Andrews
Yale University School of Medicine, New Haven, Connecticut 06510 2483, USA
J Infect Dis 196:S482-90. 2007..A successful response to the emergence of MDR-TB and XDR-TB will necessitate increased resources for and collaboration between TB and HIV programs...
- Attitudes toward needle-sharing and HIV transmission risk behavior among HIV+ injection drug users in clinical careWynne E Norton
Department of Psychology, University of Connecticut, Storrs, CT, USA
AIDS Care 20:462-9. 2008..Interventions targeting needle-sharing attitudes deployed within the clinical care setting may be well-positioned to reduce HIV transmission among HIV-positive IDUs...
- Use of total lymphocyte count for monitoring response to antiretroviral therapyTanya Schreibman
Yale University School of Medicine, AIDS Program, Yale New Haven Hospital, New Haven, Connecticut 06510, USA
Clin Infect Dis 38:257-62. 2004..The role of the TLC in the initiation of antiretroviral therapy and opportunistic infection prophylaxis, as well as the role of the TLC in monitoring the response to antiretroviral therapy, are also addressed...
- Spread of extensively drug-resistant tuberculosis in KwaZulu-Natal province, South AfricaPrashini Moodley
KwaZulu Natal Research Institute for Tuberculosis and HIV K RITH, Durban, South Africa
PLoS ONE 6:e17513. 2011..KZN is divided into 11 healthcare districts. We sought to determine the distribution of XDR TB cases in the province in relation to population density...
- Antiretroviral resistance and high-risk transmission behavior among HIV-positive patients in clinical careMichael J Kozal
AIDS Program, Section of Infectious Diseases, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, Connecticut 06510, USA
AIDS 18:2185-9. 2004..However, little is known about the risk behaviors of these patients, potential partners exposed and the relationship of these to ART resistance...
- Transmission of drug-susceptible and drug-resistant tuberculosis and the critical importance of airborne infection control in the era of HIV infection and highly active antiretroviral therapy rolloutsSheela V Shenoi
AIDS Program, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06510 2483, USA
Clin Infect Dis 50:S231-7. 2010..New research and resources are required to fully realize the potential benefits of infection control in the era of TB and HIV epidemics...
- Extensively drug-resistant tuberculosis: a new face to an old pathogenSheela Shenoi
Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06510 8002, USA
Annu Rev Med 60:307-20. 2009..In this article, we describe the current global status of drug-resistant tuberculosis. We discuss the development of resistance, current management, and strategies for control...
- Averting epidemics of extensively drug-resistant tuberculosisSanjay Basu
Tugela Ferry Care and Research Collaboration, Tugela Ferry, KwaZulu Natal 3010, South Africa
Proc Natl Acad Sci U S A 106:7672-7. 2009....
- Antiretroviral treatment regimen outcomes among HIV-infected prisonersSandra A Springer
Yale University AIDS Program, New Haven, CT 06510 2283, USA
HIV Clin Trials 8:205-12. 2007..Despite the high prevalence of HIV in correctional settings, the duration of therapy and response to various highly active antiretroviral therapy (HAART) regimens in this setting is unknown...
- Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling studySanjay Basu
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
Lancet 370:1500-7. 2007..We modelled the plausible effect of rapidly available infection control strategies on the overall course of the XDR tuberculosis epidemic in a rural area of South Africa...
- Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugsFrederick L Altice
Department of Medicine, Section of Infectious Diseases, Yale University, New Haven, CT 06510 2283, USA
Lancet 376:367-87. 2010..Multifaceted, interdisciplinary approaches are urgently needed to achieve parity in health outcomes in HIV-infected drug users...
- Preparing for highly active antiretroviral therapy rollout in rural South Africa: an assessment using the information, motivation, and behavioral skills modelMargo D Simon
AIDS Program, Yale University School of Medicine, New Haven, CT, USA
AIDS Care 22:462-74. 2010..Community-based assessments are urgently needed as HAART rollouts continue. Adaptation of this IMB-based survey may better inform efforts to enhance HAART-program implementation in resource-limited settings globally...
- Pharmacokinetic interactions between buprenorphine/naloxone and tipranavir/ritonavir in HIV-negative subjects chronically receiving buprenorphine/naloxoneR Douglas Bruce
Yale University AIDS Program, 135 College Street, Suite 323, New Haven, CT, United States
Drug Alcohol Depend 105:234-9. 2009..BUP/NLX and TPV/r should therefore be used cautiously to avoid decreased efficacy of TPV in patients taking these agents concomitantly...
- Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practiceR Douglas Bruce
Yale University AIDS Program, 135 College Street, New Haven, CT 06511, USA
J Acquir Immune Defic Syndr 41:563-72. 2006..Global access to opioid agonist therapy and HIV treatment is expanding but when concurrently used, problematic pharmacokinetic drug interactions can occur...
- Opioid dependence: rationale for and efficacy of existing and new treatmentsDavid A Fiellin
Yale University School of Medicine, New Haven, CT 06520 8025, USA
Clin Infect Dis 43:S173-7. 2006..This review focuses on the neurobiological basis of opioid dependence, the rationale for methadone and buprenorphine treatments, and issues in prescribing these medications to patients with HIV infection...
- Pharmacokinetic interactions between buprenorphine/naloxone and once-daily lopinavir/ritonavirRobert Douglas Bruce
Department of Medicine, Yale University AIDS Program, New Haven, CT, USA
J Acquir Immune Defic Syndr 54:511-4. 2010..This study was conducted to examine the pharmacokinetic interactions between buprenorphine/naloxone (BUP/NLX) and lopinavir/ritonavir (LPV/r) in HIV-seronegative subjects chronically maintained on BUP/NLX...
- Developing a directly administered antiretroviral therapy intervention for HIV-infected drug users: implications for program replicationFrederick L Altice
Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06510 2283, USA
Clin Infect Dis 38:S376-87. 2004..Moreover, DAART should incorporate enhanced elements such as convenience, flexibility, confidentiality, cues and reminders, responsive pharmacy and medical services, and specialized training for staff...
- Pilot study to enhance HIV care using needle exchange-based health services for out-of-treatment injecting drug usersFrederick L Altice
Yale University AIDS Program, New Haven, Connecticut 06510, USA
J Urban Health 80:416-27. 2003..In addition, it demonstrates that this population can benefit from this therapy with the support of a nontraditional, community-based health intervention...
- Multidrug-resistant and extensively drug-resistant tuberculosis: consequences for the global HIV communitySheela Shenoi
Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
Curr Opin Infect Dis 22:11-7. 2009..Physicians, researchers and policy makers must understand the myriad consequences of multidrug and extensively drug-resistant tuberculosis (TB) within the HIV community in order to guide clinical care, research and resource allocation...
- The pharmacokinetics of methadone following co-administration with a lamivudine/zidovudine combination tablet in opiate-dependent subjectsPetrie M Rainey
Yale University School of Medicine, New Haven, Conn, USA
Am J Addict 11:66-74. 2002..3 +/- 61.0 vs. 35.0 +/- 17.5 h) were detected. These results suggest that methadone dose change is not likely to be necessary for patients treated with lamivudine/zidovudine combination pharmacotherapy...
- Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan AfricaAnisa Mosam
Department of Dermatology, Africa Centre for Health and Population Studies, Durban, South Africa
AIDS 19:441-3. 2005..At 52 weeks, 74% achieved an undetectable viral load of < 50 copies/ml, 86% achieved < 400 copies/ml, and a 3.1 log10 decline from baseline. Side-effects were minimal. The outcomes support the use of generic antiretroviral therapy...
- An inter-professional 'advocacy and activism in global health': module for the training of physician-advocatesMichael J Peluso
Global Health Working Group, Yale School of Medicine, USA
Glob Health Promot 20:70-3. 2013..We plan to continue to develop this program in the future, and we believe that other medical institutions should consider a similar model for introducing students to their future role as health advocates. ..
- Human immunodeficiency virus infection prevention: strategies for cliniciansTanya Schreibman
AIDS Program, Yale School of Medicine, Yale University, Yale New Haven Hospital, New Haven, Connecticut 06437, USA
Clin Infect Dis 36:1171-6. 2003....
- Sexual risk behaviour among HIV-positive individuals in clinical care in urban KwaZulu-Natal, South AfricaSusan M Kiene
Center for Health HIV Intervention and Prevention, Department of Psychology, University of Connecticut, Storrs, CT, USA
AIDS 20:1781-4. 2006..These findings highlight the need for linking HIV prevention and care in Africa...
- A phase II randomized study of the virologic and immunologic effect of zidovudine + stavudine versus stavudine alone and zidovudine + lamivudine in patients with >300 CD4 cells who were antiretroviral naive (ACTG 298)Richard B Pollard
University of California Davis Medical Center, Patient Support Services Building, 4150 V Street, Suite G500, Sacramento, CA 95817, USA
AIDS Res Hum Retroviruses 18:699-704. 2002..Based on this study and other data, combining d4T and ZDV is not recommended...
- Report on the XIV International AIDS ConferenceSalim S Abdool Karim
AIDS Clin Care 14:77-85. 2002
- Meeting report from the XV International AIDS Conference. Opportunistic infectionsGerald H Friedland
AIDS Clin Care 16:74. 2004
- Meeting report from the XV International AIDS Conference. AdherenceGerald H Friedland
AIDS Clin Care 16:74-5. 2004
- Report from the 12th Retrovirus Conference. AdherenceGerald H Friedland
AIDS Clin Care 17:36. 2005
- Report from the 12th Retrovirus Conference. HIV/AIDS in resource-limited settingsCarlos del Rio
AIDS Clin Care 17:39-40. 2005
- Development and assessment of an innovative culturally sensitive educational videotape to improve adherence to highly active antiretroviral therapy in Soweto, South AfricaIlene Y Wong
Stanford Hospital and Clinics, Department of Urology, Stanford, California, USA
J Acquir Immune Defic Syndr 43:S142-8. 2006....
- Report from the XVI International AIDS Conference. Extensively drug-resistant TB in HIV/TB-coinfected patients in rural South AfricaGerald H Friedland
AIDS Clin Care 18:102. 2006
- Report from the XVI International AIDS Conference. Which antiretroviral regimen first? Data from CPCRAGerald H Friedland
AIDS Clin Care 18:98-9. 2006
- Sustained benefit from a long-term antiretroviral adherence intervention. Results of a large randomized clinical trialSharon B Mannheimer
Harlem Hospital and Columbia University College of Physicians and Surgeons, New York, NY 10037, USA
J Acquir Immune Defic Syndr 43:S41-7. 2006..To assess the efficacy of 2 adherence interventions, medication managers (MM) and medication alarms (ALR), among antiretroviral (ARV)-naive persons with HIV initiating ARV therapy...
- Report from the 13th retrovirus conference. Antiretroviral therapy in resource-limited settingsGerald H Friedland
AIDS Clin Care 18:38. 2006
- Report from the 14th Retrovirus Conference. Antiviral therapy outcomes: large survey highlights differences and similarities worldwideGerald H Friedland
AIDS Clin Care 19:38. 2007
- Report from the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Further exploring the findings from SMARTGerald H Friedland
AIDS Clin Care 19:83. 2007
- Meeting notes from the 3rd IAS Conference. Treating TB and HIV concurrentlyGerald H Friedland
AIDS Clin Care 17:98. 2005..Several IAS reports focused on strategies for overcoming reduced levels of nevirapine due to rifampin coadministration...
- Clinic-based intervention reduces unprotected sexual behavior among HIV-infected patients in KwaZulu-Natal, South Africa: results of a pilot studyDeborah H Cornman
Center for Health, Intervention, and Prevention, University of Connecticut, Storrs, CT 06269, USA
J Acquir Immune Defic Syndr 48:553-60. 2008..To evaluate the feasibility, fidelity, and effectiveness of a human immunodeficiency virus (HIV) prevention intervention delivered to HIV-infected patients by counselors during routine clinical care in KwaZulu-Natal, South Africa...
- Report from the 12th Retrovirus Conference. TuberculosisGerald H Friedland
AIDS Clin Care 17:40-1. 2005
- Increasing drug users' adherence to HIV treatment: results of a peer-driven intervention feasibility studyRobert S Broadhead
Department of Sociology, University of Connecticut, Storrs 06269 2068, USA
Soc Sci Med 55:235-46. 2002..Innovative mechanisms that harness drug users' peer pressure to promote positive behavioral changes deserve greater study...
- Meeting report from the XV International AIDS Conference. Access in the developing worldGerald H Friedland
AIDS Clin Care 16:69-70. 2004
- Clinician-delivered intervention during routine clinical care reduces unprotected sexual behavior among HIV-infected patientsJeffrey D Fisher
Department of Psychology, Center for Health HIV Intervention and Prevention, University of Connecticut, Storrs, CT 06269 1248, USA
J Acquir Immune Defic Syndr 41:44-52. 2006..To evaluate the effectiveness of a clinician-delivered intervention, implemented during routine clinical care, in reducing unprotected sexual behavior of HIV-infected patients...
- AIDS: the first 25 yearsGerald H Friedland
AIDS Clin Care 18:53-4. 2006
- Meeting notes from the 3rd IAS Conference. Male circumcision: a new prevention strategy?Gerald H Friedland
AIDS Clin Care 17:93-4. 2005..New trial data confirm that male circumcision could substantially reduce heterosexual transmission of HIV...