H C Fox

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 195:527-36. 2008
  2. ncbi request reprint The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals
    Helen Fox
    Yale Stress Center, Yale University School of Medicine, New Haven Connecticut USA Electronic address
    Adv Pharmacol 69:217-65. 2014
  3. pmc The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA Electronic address
    Psychoneuroendocrinology 38:1532-44. 2013
  4. pmc Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
    Helen C Fox
    Department of Psychiatry, The Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 06519, USA
    Hum Psychopharmacol 28:40-53. 2013
  5. pmc Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    J Psychopharmacol 26:958-72. 2012
  6. pmc Immune system inflammation in cocaine dependent individuals: implications for medications development
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519, USA
    Hum Psychopharmacol 27:156-66. 2012
  7. pmc Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 36:351-60. 2012
  8. ncbi request reprint Difficulties in emotion regulation and impulse control in recently abstinent alcoholics compared with social drinkers
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Addict Behav 33:388-94. 2008
  9. pmc Selective cocaine-related difficulties in emotional intelligence: relationship to stress and impulse control
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, The Connecticut Mental Health Center, New Haven, CT 06519, USA
    Am J Addict 20:151-60. 2011
  10. pmc Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women
    Helen C Fox
    Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Harv Rev Psychiatry 17:103-19. 2009

Detail Information

Publications28

  1. pmc Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 195:527-36. 2008
    ..There is growing evidence of alterations in brain stress and reward circuits associated with cocaine dependence. Sex differences are also documented and sex steroid hormones have been linked to cocaine reinforcement...
  2. ncbi request reprint The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals
    Helen Fox
    Yale Stress Center, Yale University School of Medicine, New Haven Connecticut USA Electronic address
    Adv Pharmacol 69:217-65. 2014
    ....
  3. pmc The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA Electronic address
    Psychoneuroendocrinology 38:1532-44. 2013
    ..Thus, we conducted a double-blind placebo-controlled study assessing the efficacy of progesterone in reducing provoked drug craving, stress system arousal and improving cognitive performance in cocaine dependent men and women...
  4. pmc Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
    Helen C Fox
    Department of Psychiatry, The Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 06519, USA
    Hum Psychopharmacol 28:40-53. 2013
    ..To date, little research exists defining bio-behavioral adaptations associated with both marijuana abuse and risk of craving and relapse to other drugs of abuse during early abstinence...
  5. pmc Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    J Psychopharmacol 26:958-72. 2012
    ..Data suggest further exploration of guanfacine is warranted in terms of its potential for reducing stress-induced and cue-induced drug craving and arousal...
  6. pmc Immune system inflammation in cocaine dependent individuals: implications for medications development
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06519, USA
    Hum Psychopharmacol 27:156-66. 2012
    ..We therefore examine basal and provoked changes in peripheral cytokines in cocaine dependent individuals to better understand their role in the negative reinforcing effects of cocaine...
  7. pmc Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 36:351-60. 2012
    ..Here we report findings from a preliminary efficacy study of the alpha-1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol-dependent individuals...
  8. ncbi request reprint Difficulties in emotion regulation and impulse control in recently abstinent alcoholics compared with social drinkers
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Addict Behav 33:388-94. 2008
    ..The aim of the current study was to examine potential difficulties in emotion regulation during early alcohol abstinence using the recently validated Difficulties of Emotion Regulation Scale (DERS)...
  9. pmc Selective cocaine-related difficulties in emotional intelligence: relationship to stress and impulse control
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, The Connecticut Mental Health Center, New Haven, CT 06519, USA
    Am J Addict 20:151-60. 2011
    ..Findings indicate that specific aspects of EI may be of clinical importance to cocaine dependent populations, impacting relapse-related factors such as stress dysregulation and impulse control. ..
  10. pmc Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women
    Helen C Fox
    Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Harv Rev Psychiatry 17:103-19. 2009
    ..The implications of these sex-specific variations in stress and reward system function are discussed in terms of both comorbid psychopathology and treatment outcome...
  11. pmc Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes
    Helen C Fox
    Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 209, Room 209Q, New Haven, CT 06519, USA
    Psychoneuroendocrinology 34:1198-207. 2009
    ....
  12. pmc Interactive effects of cumulative stress and impulsivity on alcohol consumption
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, The Yale Stress Center, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 34:1376-85. 2010
    ....
  13. pmc Enhanced sensitivity to stress and drug/alcohol craving in abstinent cocaine-dependent individuals compared to social drinkers
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:796-805. 2008
    ..These data suggest that recovery from chronic cocaine abuse could be hampered by a hyper-responsive stress- and drug-craving state that increases cocaine relapse susceptibility...
  14. ncbi request reprint Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 31:395-403. 2007
    ....
  15. ncbi request reprint Difficulties in emotion regulation and impulse control during cocaine abstinence
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Drug Alcohol Depend 89:298-301. 2007
    ..Prior research has shown that cocaine dependence is associated with dysfunction of brain systems involved in emotions and motivational states...
  16. ncbi request reprint Reliability of salivary cortisol assessments in cocaine dependent individuals
    H C Fox
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Psychopharmacol 20:650-5. 2006
    ..These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals...
  17. ncbi request reprint Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals
    Helen C Fox
    Substance Abuse Center, Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 185:348-57. 2006
    ..Extensive research suggests that gender may affect neuroendocrine and cardiovascular arousal mechanisms underlying biological responses to stress...
  18. ncbi request reprint Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, 06519, USA
    Psychoneuroendocrinology 30:880-91. 2005
    ..The current study examined whether frequency of cocaine and alcohol abuse alters drug craving and associated arousal with laboratory exposure to stress and to drug related cues...
  19. pmc Sex-specific dissociations in autonomic and HPA responses to stress and cues in alcohol-dependent patients with cocaine abuse
    Helen C Fox
    Yale Stress Center, Yale University School of Medicine, New Haven, CT 06519, USA
    Alcohol Alcohol 44:575-85. 2009
    ..To date, gender variations in these systems have not been fully assessed in abstinent alcohol-dependent individuals who also met criteria for cocaine abuse...
  20. pmc Behavioral arousal in response to stress and drug cue in alcohol and cocaine addicted individuals versus healthy controls
    Tara M Chaplin
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Hum Psychopharmacol 25:368-76. 2010
    ..Negative emotional arousal in response to stress and drug cues is known to play a role in the development and continuation of substance use disorders. However, studies have not examined behavioral indicators of such arousal...
  21. pmc Self-reports of interoceptive responses during stress and drug cue-related experiences in cocaine- and alcohol-dependent individuals
    Keri L Bergquist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Exp Clin Psychopharmacol 18:229-37. 2010
    ....
  22. pmc Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 34:1198-208. 2009
    ....
  23. ncbi request reprint Childhood IQ, smoking, and cognitive change from age 11 to 64 years
    Lawrence J Whalley
    Department of Mental Health, University of Aberdeen, Aberdeen, Scotland, UK
    Addict Behav 30:77-88. 2005
    ..In this sample, smoking makes a small (<1% variance) independent negative contribution to cognitive aging...
  24. ncbi request reprint Smoking and cognitive change from age 11 to 66 years: a confirmatory investigation
    John M Starr
    Department of Geriatric Medicine, University of Edinburgh, Scotland, UK
    Addict Behav 32:63-8. 2007
    ..These data confirm the adverse effect of smoking on information processing speed, and provide new evidence for a similar adverse effect on memory for people in their mid-sixties...
  25. ncbi request reprint Age at natural menopause and cognition
    Lawrence J Whalley
    Department of Mental Health, Aberdeen University, Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, UK
    Maturitas 49:148-56. 2004
    ..To examine associations between age at natural menopause, childhood IQ and cognition at age 65 years. To determine if lower age at menopause partly mediates the effect of childhood IQ on cognition at age 65 years...
  26. ncbi request reprint Gender differences in self-reported anxiety, depression, and somatization among ecstasy/MDMA polydrug users, alcohol/tobacco users, and nondrug users
    Raffaella M Milani
    School of Psychology, University of East London, Romford Road, London E15 4LZ, UK
    Addict Behav 29:965-71. 2004
    ..Interestingly, in the male sample, drug users reported higher symptom ratings than nondrug users, whereas women's scores remained constant across drug groups...
  27. ncbi request reprint The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    J Pers Soc Psychol 86:130-47. 2004
    ....
  28. ncbi request reprint Quality of Life in healthy old age: relationships with childhood IQ, minor psychological symptoms and optimism
    Gillian H Bain
    The Medical School, University of Aberdeen, Aberdeen, UK
    Soc Psychiatry Psychiatr Epidemiol 38:632-6. 2003
    ....