Shawn M Ferguson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
    Constance S Petit
    Department of Cell Biology and 2 Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510
    J Cell Biol 202:1107-22. 2013
  2. pmc Dynamin, a membrane-remodelling GTPase
    Shawn M Ferguson
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Mol Cell Biol 13:75-88. 2012
  3. pmc Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons
    Mitsuko Hayashi
    Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:2175-80. 2008
  4. pmc Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
    Keita Soda
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 122:4401-11. 2012
  5. pmc Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
    Leiliane P Sousa
    Departments of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:4419-24. 2012
  6. pmc Overlapping role of dynamin isoforms in synaptic vesicle endocytosis
    Andrea Raimondi
    Department of Cell Biology, HHMI, Program in Cellular Neuroscience, Neurodegeneration and Repair and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 70:1100-14. 2011
  7. pmc Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
    Xuelin Lou
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 109:E515-23. 2012
  8. pmc Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors
    Ryan J Park
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Sci 126:5305-12. 2013
  9. pmc Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin
    Hongying Shen
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Biol Cell 22:493-502. 2011
  10. pmc Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits
    Shawn M Ferguson
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Dev Cell 17:811-22. 2009

Collaborators

  • Ottavio Cremona
  • Joseph Schlessinger
  • Roland Baron
  • Tobias C Walther
  • Corinne Albiges-Rizo
  • Loren L Looger
  • Tim Willinger
  • Yan Yang
  • Shuta Ishibe
  • Takahisa Murata
  • David A Calderwood
  • Gero Miesenbock
  • Rajesh Ramachandran
  • Pietro De Camilli
  • Xuelin Lou
  • Hongying Shen
  • Andrea Raimondi
  • Summer Paradise
  • Constance S Petit
  • Agnes Roczniak-Ferguson
  • Monica Y Lee
  • Ryan J Park
  • Olivier Destaing
  • Leiliane P Sousa
  • Yumei Wu
  • Keita Soda
  • Silvia Giovedi
  • Mirko Messa
  • Laura Volpicelli-Daley
  • Ya Wen Liu
  • EILEEN O'TOOLE
  • Mitsuko Hayashi
  • Satish Pasula
  • Levente Jozsef
  • Shira Landskroner-Eiger
  • Eon Joo Park
  • Athanasia Skoura
  • Yunzhou Dong
  • William C Sessa
  • Amelia K Luciano
  • Mohamed Bouaouina
  • Christiane Oddou
  • Lijuan Liu
  • Xinran Liu
  • Alexei Grichine
  • Brittany Angarola
  • Sharon Qian
  • Fan Fan
  • Rena Zheng
  • Sung Hyun Son
  • Irit Lax
  • Lawrence B Holzman
  • Xuefei Tian
  • Daniel M Balkin
  • Florian Froehlich
  • Hong Ma
  • Gilbert Moeckel
  • Jennifer Ky
  • Ira Milosevic
  • Sylvia Neumann
  • Moritz Armbruster
  • Timothy A Ryan
  • Noah Dephoure
  • Junko Takasaki
  • Nao Kono
  • Ryan Park
  • Valentina Cappello
  • Steven Gygi
  • Thomas J Pucadyil
  • Sandra L Schmid
  • Chiara Collesi

Detail Information

Publications17

  1. pmc Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
    Constance S Petit
    Department of Cell Biology and 2 Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, CT 06510
    J Cell Biol 202:1107-22. 2013
    ..These new findings define the lysosome as a site of action for FLCN and indicate a critical role for FLCN in the amino acid-dependent activation of mTOR via its direct interaction with the RagA/B GTPases. ..
  2. pmc Dynamin, a membrane-remodelling GTPase
    Shawn M Ferguson
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Mol Cell Biol 13:75-88. 2012
    ..In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues...
  3. pmc Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons
    Mitsuko Hayashi
    Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:2175-80. 2008
    ..These findings reveal a striking heterogeneity in the mode of synaptic vesicle recycling in different synapses and functional states...
  4. pmc Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
    Keita Soda
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 122:4401-11. 2012
    ..These results strongly implicate a protein network that functions at the interface between endocytosis and actin at neuronal synapses in the formation and maintenance of the kidney glomerular filtration barrier...
  5. pmc Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
    Leiliane P Sousa
    Departments of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:4419-24. 2012
    ....
  6. pmc Overlapping role of dynamin isoforms in synaptic vesicle endocytosis
    Andrea Raimondi
    Department of Cell Biology, HHMI, Program in Cellular Neuroscience, Neurodegeneration and Repair and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 70:1100-14. 2011
    ..Persistence of synaptic transmission in their absence indicates that if dynamin plays essential functions in neurons, such functions can be achieved by the very low levels of dynamin 2...
  7. pmc Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses
    Xuelin Lou
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 109:E515-23. 2012
    ....
  8. pmc Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors
    Ryan J Park
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Sci 126:5305-12. 2013
    ..Dynamin TKO cells will be useful tools for the further exploration of dynamin-dependent processes and the development of more specific dynamin inhibitors. ..
  9. pmc Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin
    Hongying Shen
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Biol Cell 22:493-502. 2011
    ..These findings reveal a link between progression of clathrin-coated pits to endocytic vesicles and an activation-deactivation cycle of Ack...
  10. pmc Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits
    Shawn M Ferguson
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Dev Cell 17:811-22. 2009
    ..Our data also demonstrate that the relationship between dynamin and actin is intimately connected to dynamin's endocytic role and that dynamin terminates a powerful actin- and BAR protein-dependent tubulating activity...
  11. pmc Selective saturation of slow endocytosis at a giant glutamatergic central synapse lacking dynamin 1
    Xuelin Lou
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:17555-60. 2008
    ..Thus, high level expression of dynamin 1 is essential to allow the slow, clathrin-mediated endocytosis, which accounts for the bulk of the endocytic response, to operate efficiently over a wide range of activity...
  12. pmc Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation
    Ya Wen Liu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:E234-42. 2011
    ..Our findings reveal opportunities for fundamental differences in the regulation of Dyn1, which mediates rapid endocytosis at the synapse, vs. Dyn2, which regulates early and late events in CME in nonneuronal cells...
  13. pmc The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
    Agnes Roczniak-Ferguson
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Sci Signal 5:ra42. 2012
    ....
  14. pmc Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling
    Tim Willinger
    Department of Immunobiology, 2 Department of Cell Biology, 3 Program in Cellular Neuroscience, Neurodegeneration, and Repair, and 4 Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520
    J Exp Med 211:685-700. 2014
    ..Our results suggest a possible mechanism by which T lymphocytes positioned at exit portals sense low S1P concentrations, promoting their egress into circulatory fluids. ..
  15. pmc Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes
    Olivier Destaing
    Institut Albert Bonniot, Université Joseph Fourier Université Joseph Fourier site Santé, Grenoble Cedex, France Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e77956. 2013
    ..Acute dynamin photo-inactivation leads to a very rapid disorganization of invadosome without affecting focal adhesions. Dynamin therefore is a key regulator of the architecture of actin in podosomes/invadosomes. ..
  16. pmc Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
    Monica Y Lee
    Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 141:1465-72. 2014
    ..Collectively, our data show that Dnm2 uncouples VEGF signaling from function and coordinates the endocytic turnover of integrins in a manner that is crucially important for angiogenesis in vitro and in vivo...
  17. ncbi request reprint A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis
    Shawn M Ferguson
    Howard Hughes Medical Institute, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 316:570-4. 2007
    ..Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity...