Genomes and Genes
A S Fanning
Affiliation: Yale University
- Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7T K Mohandas
Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Genomics 30:594-7. 1995..FISH studies on metaphases from patients with the Prader-Willi (PWS) or the Angelman syndrome (AS) showed that TJP1 maps close but distal to the PWS/AS chromosome region...
- The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonA S Fanning
Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 273:29745-53. 1998..These observations suggest that one functional role of ZO-1 is to organize components of the tight junction and link them to the cortical actin cytoskeleton...
- PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membraneA S Fanning
Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
J Clin Invest 103:767-72. 1999
- Protein modules as organizers of membrane structureA S Fanning
Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, PO Box 208019, New Haven, CT 06520 8019, USA
Curr Opin Cell Biol 11:432-9. 1999..The organization of these proteins into discreet structures has functional consequences for downstream signaling...
- The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctionsE Willott
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510
Proc Natl Acad Sci U S A 90:7834-8. 1993..The C-terminal domain of ZO-1, and its alternatively spliced region, appears to confer variable properties unique to tight junctions...
- Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contactsL L Mitic
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Cell Biol 146:683-93. 1999..Such a scaffolding and cytoskeletal coupling function for ZO MAGUKs is analogous to that of other members of the MAGUK family...
- Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoformsA S Fanning
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06521 8019
Cell Motil Cytoskeleton 29:29-45. 1994..These results demonstrate that bacterially produced tropomyosins can differentially regulate myosin enzymology and mechanochemistry, and suggest a role for tropomyosin in the coordinated regulation of myosin isoforms in vivo...