Oluwole Fadare

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..5%), but does not appear to affect their overall outcome. Although this is a small single site study, it raises questions about the value of this procedure in patients with endometrial cancer...

..However, there was no concentration of the mucin pools near the areas with the most viable tumor cells, which would have provided evidence for a temporal sequence that eventuates in lack of mucin in the most sclerotic regions...

..Although the significance of the latter finding remains unclear, the differential diagnosis between decidual changes and endometrial serous carcinoma is rarely problematic...

..We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants...

..BMP2 is rarely expressed in the other nonendothelial tissues of the human uterine corpus that were evaluated. The significance of frequent BMP2 expression in small vessels of the uterus requires further investigation...

..Further studies are needed to clarify the relationship between these two cancers in this age group and whether this increased risk is reflective of a genetic predisposition...

..The histologic subtype of the underlying ovarian tumor was found to have an effect on the likelihood of detection of peritoneal involvement using this diagnostic assay...

..The full composite of histopathologic features should form the basis for this determination...

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..However, LVSI does not denote an increased likelihood of vaginal recurrences in S1EE. The presence of LVSI should not, in of itself, alter clinical staging, or trigger unnecessary therapeutic intervention...

..Further studies are required to conclusively define the nature of these lesions. However, such studies can only be performed if diagnostic surgical pathologists recognize, highlight, and segregate these lesions for further analysis...

..We conclude that in erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups...

..The differential diagnosis for these sarcomas is often extensive and varies by histotype, but their accurate diagnosis fundamentally requires the careful exclusion of biphasic malignancies...

..Similarly to tumors of luminal epithelial differentiation, carcinomas of the 'basal' type have a spectrum of morphologic and clinical characteristics...

..These data indicate that pleomorphic rhabdomyosarcoma of the uterine corpus is a highly aggressive, rapidly progressive tumor with a high case-fatality rate...

..A mitotic count of >1/10 HPF and/or coagulative necrosis are features that, if present, raise the definite potential for aggressive behavior...

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..03), consistent with smaller extent of disease. These findings further illustrate that lesional factors are important potential contributors to the false-negative rate of the Papanicolaou test...

..The historical and evidentiary basis for the Bethesda 2001 recommendations, which calls for the reporting of cytologically benign endometrial cells only in patients 40 years and older, is reviewed in detail...

..Further studies are required to address the significance of marked atypia in grade 1 cervical intraepithelial neoplasia and whether patients with this finding should be managed differently...

..The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied...

..However, because classic LIN with necrosis is apparently rare in its pure form, reexcision is recommended when this lesion is detected in isolation in a core biopsy...

..Future studies are required to define the prognostic significance of CK5/6 expression in ILCs...

..However, the extraordinary rarity of the most clinically significant interpretations of HGSIL and carcinoma in this setting can be confirmed because no such cases were identified during the follow-up of either group...

..48% in the >66% group). If confirmed, our findings suggest that in an LEEP specimen with CIN 2 to 3 that was excised with negative margins, the extent of disease lacks prognostic significance and need not be reported...

..If corroborated in other laboratories, the expression patterns of proteins in this pathway, especially pan-Akt, may be of diagnostic use...

..It is critical to promote lucid morphologic definitions of the molecular subtypes, if this information is intended for use in targeted therapies and patient management...

..However, if the latter staining pattern is confirmed, our findings herein suggest that CD1a may be a useful immunohistochemical adjunct in distinguishing uterine epithelioid smooth muscle tumors from uterine PEComas...

..Historical, prognostic, and diagnostic aspects of margins in EST, especially in those borderline cases such as ours, are also discussed...

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..This increased risk may be related, at least partially, to an increased rate of tissue factor expression in endometrial CCC...

..This may have adjuvant management implications for patients with these rare tumors...

..5) When 1 or more psammoma bodies are identified on a cervicovaginal smear, this finding should not be ignored and should generate some clinical investigation to identify its source...

..Using our clinical efficacy standard, when no pathologic findings are initially identified in a colposcopic-directed biopsy, at least 5 levels (a priori or in recuts) are required to ensure a 100% diagnostic accuracy for CIN 2-3...

..In general, strikingly divergent morphologic features in an otherwise typical thyroid neoplasm should elicit a differential diagnosis that takes into consideration the possibility of metastasis...

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..It is concluded that this is an example of a purely signet ring variant of pleomorphic LCIS...

..01). In conclusion, our study demonstrated that hypocellular MDS has characteristic clinicopathologic features, and bone marrow hypocellularity in MDS is an independent factor which predicts a favorable outcome...

..Potential differential diagnostic considerations are discussed. It is postulated that this lesion is an unusual reparative stromal change that may be related to atrophy-related vaginal irritation or injury...

..This amelogenin marker results in a product of low molecular weight, enabling unequivocal resolution of identity despite a poor DNA yield. The prevalence of errors in pathology due to specimen misidentifications is reviewed...

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..These cases further expand the morphologic spectrum of epithelioid sarcoma...

..Morphologic and molecular observations suggest an association, perhaps in a nonobligate precursor role, between some columnar cell lesions and a variety of other neoplastic lesions...

..However, our preliminary analysis suggests that the isolated presence of CIN 1 at the margin of a LEEP specimen, whose margins are otherwise negative, lacks adverse prognostic significance...

..Detection of aneuploid neoplastic T cells in peripheral blood samples of patients with CTCL is associated with LCT in skin, lymph node, or other tissues...

..Deciphering the molecular basis for endometrial serous carcinogenesis should uncover potential targets for diagnosis, therapy, and/or disease surveillance...

..The term "localized vulvar lymphedema" is an appropriate generic descriptor for the spectrum of lesions whose fundamental and underlying etiology is thought to be chronic lymphedema...

..This case supports the theory that the various primary carcinomas of the thyroid may represent points along a spectrum rather than distinct entities...

..This is, to the authors' knowledge, the first detailed clinicopathologic description of such a case as an ovarian lesion...

..Finally, the most common tumor metastatic to the male breast in this series was cutaneous melanoma...

..Our case series shows that extramedullary relapse of MM is characterized by high-grade histology, loss of CD56 expression, frequent resistance to current therapeutic regimens, aggressive biological behavior, and very short survival...