Irina Esterlis

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia
    Irina Esterlis
    Department of Psychiatry, School of Medicine, Yale University Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut Electronic address
    Biol Psychiatry 76:495-502. 2014
  2. pmc Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers
    Irina Esterlis
    Department of Psychiatry, Yale University, New Haven, Conneticut, USA
    Am J Psychiatry 170:399-407. 2013
  3. pmc Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving
    Irina Esterlis
    Department of Psychiatry, Yale University and the VACHS, West Haven, CT 06516, USA
    Addict Biol 18:370-8. 2013
  4. pmc Imaging changes in synaptic acetylcholine availability in living human subjects
    Irina Esterlis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    J Nucl Med 54:78-82. 2013
  5. pmc GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
    Synapse 63:1089-99. 2009
  6. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
  7. pmc Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    J Nucl Med 51:1226-33. 2010
  8. pmc Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Int J Neuropsychopharmacol 14:389-98. 2011
  9. pmc Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Gen Psychiatry 69:418-27. 2012
  10. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009

Detail Information

Publications19

  1. pmc In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia
    Irina Esterlis
    Department of Psychiatry, School of Medicine, Yale University Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut Electronic address
    Biol Psychiatry 76:495-502. 2014
    ..The latter may be related to an attempt to self-medicate symptoms and/or to alterations in function of high-affinity β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChRs)...
  2. pmc Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers
    Irina Esterlis
    Department of Psychiatry, Yale University, New Haven, Conneticut, USA
    Am J Psychiatry 170:399-407. 2013
    ..The authors used [123I]5-I-A-85380 single photon emission computed tomography (SPECT) to evaluate the effect of 3'-AmNic-rEPA on the amount of nicotine that binds to β2*-nAChRs in smokers' brain cortical and subcortical regions...
  3. pmc Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving
    Irina Esterlis
    Department of Psychiatry, Yale University and the VACHS, West Haven, CT 06516, USA
    Addict Biol 18:370-8. 2013
    ....
  4. pmc Imaging changes in synaptic acetylcholine availability in living human subjects
    Irina Esterlis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    J Nucl Med 54:78-82. 2013
    ..We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine in humans, as suggested in nonhuman primates...
  5. pmc GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
    Synapse 63:1089-99. 2009
    ..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression...
  6. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers...
  7. pmc Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    J Nucl Med 51:1226-33. 2010
    ..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety...
  8. pmc Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Int J Neuropsychopharmacol 14:389-98. 2011
    ..13, p=0.04). These results demonstrate significant differences in occupancy of β2*-nAChRs by nicotine after use of the inhaler vs. a cigarette and confirm the ability of the nicotine inhaler to relieve withdrawal symptoms...
  9. pmc Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Gen Psychiatry 69:418-27. 2012
    ..Sex differences in availability of nicotinic acetylcholine receptors containing the β(2) subunit (β(2)*-nAChRs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men...
  10. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009
    ..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence...
  11. pmc Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
    Kelly P Cosgrove
    Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
    Nicotine Tob Res 12:535-9. 2010
    ....
  12. pmc Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography
    Jonas O Hannestad
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut UCB Pharma SA, Braine l Alleud, Belgium
    Biol Psychiatry 74:768-76. 2013
    ..We quantified the availability of β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChR) in subjects with bipolar disorder...
  13. pmc Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, West Haven, CT 06516, USA
    Neuropharmacology 60:1318-25. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  14. pmc Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
    Am J Psychiatry 169:326-34. 2012
    ..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia...
  15. pmc Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal
    Kelly P Cosgrove
    Departments of Psychiatry and Clinical Neuroscience Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516 National Institute on Alcohol Abuse and Alcoholism Center for the Translational Neuroscience of Alcoholism, New Haven, CT 06510 Neurobiology, and Department of Diagnostic Radiology, Yale PET Center, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 111:18031-6. 2014
    ..These data suggest that constituents in tobacco smoke other than nicotine block the recovery of GABAA receptor systems during sustained alcohol abstinence, contributing to alcohol relapse and the perpetuation of smoking...
  16. pmc Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
    Jean Dominique Gallezot
    Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
    Synapse 68:556-64. 2014
    ..The goal of this study was to assess the sensitivity of 18F-(-)-NCFHEB-PET to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors...
  17. pmc The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study
    Jonas Hannestad
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA Electronic address
    Brain Behav Immun 33:131-8. 2013
    ....
  18. pmc Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder
    Aybala Saricicek
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Psychiatry 169:851-9. 2012
    ..To understand its molecular basis, the authors also studied β2*-nAChR binding in postmortem brain samples from depressed subjects...
  19. doi request reprint Imaging Tobacco Smoking with PET and SPECT
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 511, New Haven, CT, 06519, USA
    Curr Top Behav Neurosci 24:1-17. 2015
    ..We review the imaging literature on these topics and describe how brain imaging has helped inform the treatment of tobacco smoking. ..