Research Topics
Species | Irina EsterlisSummaryAffiliation: Yale University Country: USA Publications
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Publications
Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokersIrina Esterlis
Department of Psychiatry, Yale University, New Haven, Conneticut, USA
Am J Psychiatry 170:399-407. 2013..The authors used [123I]5-I-A-85380 single photon emission computed tomography (SPECT) to evaluate the effect of 3'-AmNic-rEPA on the amount of nicotine that binds to β2*-nAChRs in smokers' brain cortical and subcortical regions...
Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking cravingIrina Esterlis
Department of Psychiatry, Yale University and the VACHS, West Haven, CT 06516, USA
Addict Biol 18:370-8. 2013....- Imaging changes in synaptic acetylcholine availability in living human subjectsIrina Esterlis
Department of Psychiatry, Yale University, New Haven, Connecticut, USA
J Nucl Med 54:78-82. 2013..We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine in humans, as suggested in nonhuman primates... - GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depressionIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
Synapse 63:1089-99. 2009..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression... - SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individualsIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
Drug Alcohol Depend 108:146-50. 2010..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers... - Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable bindingIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
J Nucl Med 51:1226-33. 2010..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety... - Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhalerIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Int J Neuropsychopharmacol 14:389-98. 2011..13, p=0.04). These results demonstrate significant differences in occupancy of β2*-nAChRs by nicotine after use of the inhaler vs. a cigarette and confirm the ability of the nicotine inhaler to relieve withdrawal symptoms... - Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokersKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Arch Gen Psychiatry 69:418-27. 2012..Sex differences in availability of nicotinic acetylcholine receptors containing the β(2) subunit (β(2)*-nAChRs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men... - beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smokingKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
Arch Gen Psychiatry 66:666-76. 2009..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence... - Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokersKelly P Cosgrove
Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
Nicotine Tob Res 12:535-9. 2010.... - Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependenceKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine and the VACHS, West Haven, CT 06516, USA
Neuropharmacology 60:1318-25. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophreniaDEEPAK CYRIL D'SOUZA
Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
Am J Psychiatry 169:326-34. 2012..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia... - Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorderAybala Saricicek
Department of Psychiatry, Yale University, New Haven, CT, USA
Am J Psychiatry 169:851-9. 2012..To understand its molecular basis, the authors also studied β2*-nAChR binding in postmortem brain samples from depressed subjects...