Genomes and Genes
Affiliation: Yale University
- Control of TH17 cells occurs in the small intestineEnric Esplugues
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 475:514-8. 2011..These results identify mechanisms limiting T(H)17 cell pathogenicity and implicate the gastrointestinal tract as a site for control of T(H)17 cells...
- Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent mannerSamuel Huber
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 34:554-65. 2011..Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells. Thus, IL-10 signaling directly suppresses Th17 and Th17+Th1 cells...
- Th17 cells transdifferentiate into regulatory T cells during resolution of inflammationNicola Gagliani
Department of Immunobiology, School of Medicine, Yale University, New Haven, 06520, USA
Nature 523:221-5. 2015..Thus, Th17 cells transdifferentiate into regulatory cells, and contribute to the resolution of inflammation. Our data suggest that Th17 cell instability and plasticity is a therapeutic opportunity for inflammatory diseases. ..
- Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cellsLark Kyun Kim
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
Mol Cell 54:56-66. 2014..Finally, defects in the association lead to enhanced IL-17 induction. Collectively, our data indicate Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF. ..