- Control of TH17 cells occurs in the small intestineEnric Esplugues
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nature 475:514-8. 2011..These results identify mechanisms limiting T(H)17 cell pathogenicity and implicate the gastrointestinal tract as a site for control of T(H)17 cells...
- Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent mannerSamuel Huber
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 34:554-65. 2011..Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cell frequencies via direct signaling in T cells. Thus, IL-10 signaling directly suppresses Th17 and Th17+Th1 cells...